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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antinematodal drug
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Accession:CHEBI:35444 term browser browse the term
Definition:A substance used in the treatment or control of nematode infestations.
Synonyms:related_synonym: antinematodal agent;   antinematodal drugs;   antinematodals


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2-naphthol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects sulfation ISO ABCC1 protein affects the sulfation of 2-naphthol CTD PMID:14742140 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO [2-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AR androgen receptor multiple interactions ISO 2-naphthol inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CES1 carboxylesterase 1 affects metabolic processing EXP CES1 protein affects the metabolism of 2-naphthol CTD PMID:12837533 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases abundance EXP CYP1A1 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases abundance
affects binding
decreases activity
EXP CYP1A2 protein results in increased abundance of 2-naphthol
2-naphthol binds to CYP1A2 protein
2-naphthol results in decreased activity of CYP1A2 protein
CTD PMID:15916432, PMID:16243959, PMID:32278787 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions ISO [2-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases abundance EXP CYP2B6 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases abundance EXP CYP2E1 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases abundance EXP CYP3A4 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G SULT4A1 sulfotransferase family 4A member 1 increases metabolic processing EXP
ISO
SULT4A1 protein results in increased metabolism of 2-naphthol CTD PMID:12039030 NCBI chr22:43,824,509...43,862,513
Ensembl chr22:43,824,509...43,862,513
JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP 2-naphthol binds to and results in decreased activity of THRB protein CTD PMID:18584933 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756
JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-naphthol CTD PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation ISO UGT2B1 protein results in increased glucuronidation of 2-naphthol CTD PMID:8302279 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527
JBrowse link
ascaridole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC6 ERCC excision repair 6, chromatin remodeling factor affects response to substance EXP ERCC6 protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,470...49,539,538
JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor affects response to substance EXP XPC protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr 3:14,145,145...14,178,601
Ensembl chr 3:14,145,147...14,178,783
Ensembl chr 3:14,145,147...14,178,783
JBrowse link
carbendazim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABI2 abl interactor 2 increases expression ISO carbendazim results in increased expression of ABI2 mRNA CTD PMID:22952946 NCBI chr 2:203,325,013...203,432,169
Ensembl chr 2:203,328,280...203,447,728
Ensembl chr 2:203,328,280...203,447,728
JBrowse link
G ACACA acetyl-CoA carboxylase alpha increases expression ISO carbendazim results in increased expression of ACACA mRNA CTD PMID:26071454 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of AGPAT2 mRNA CTD PMID:26071454 NCBI chr 9:136,673,143...136,687,457
Ensembl chr 9:136,673,143...136,687,457
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]
carbendazim affects the localization of AHR protein
CTD PMID:27286660 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G BAG1 BAG cochaperone 1 increases expression ISO carbendazim results in increased expression of BAG1 mRNA CTD PMID:22952946 NCBI chr 9:33,252,471...33,264,708
Ensembl chr 9:33,247,820...33,264,720
JBrowse link
G BCL2L14 BCL2 like 14 increases expression ISO carbendazim results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr12:12,049,849...12,099,695
Ensembl chr12:12,049,844...12,211,084
JBrowse link
G CASP3 caspase 3 increases activity EXP carbendazim results in increased activity of CASP3 protein CTD PMID:30851412 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CLCA2 chloride channel accessory 2 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 1:86,424,144...86,456,553
Ensembl chr 1:86,424,171...86,456,553
JBrowse link
G CLDN11 claudin 11 multiple interactions ISO [carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein CTD PMID:28576679 NCBI chr 3:170,418,868...170,434,691
Ensembl chr 3:170,418,865...170,454,733
Ensembl chr 3:170,418,865...170,454,733
JBrowse link
G CLU clusterin decreases expression
increases expression
ISO carbendazim results in decreased expression of CLU mRNA
carbendazim results in increased expression of CLU mRNA
CTD PMID:22952946, PMID:27466211 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 increases activity
increases expression
EXP carbendazim results in increased activity of CYP19A1 protein
carbendazim results in increased expression of CYP19A1 mRNA
CTD PMID:14691014 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
EXP
ISO
carbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]; salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:10103034, PMID:21784029, PMID:27286660 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP carbendazim results in increased expression of CYP1A2 mRNA; carbendazim results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression EXP carbendazim results in increased expression of CYP2A6 mRNA CTD PMID:22310298 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP carbendazim results in increased expression of CYP2B6 mRNA CTD PMID:22310298 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP carbendazim results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 increases expression ISO carbendazim results in increased expression of DGAT1 mRNA CTD PMID:26071454 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of DGAT2 mRNA CTD PMID:26071454 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
JBrowse link
G DPP7 dipeptidyl peptidase 7 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 9:137,110,540...137,117,980
Ensembl chr 9:137,110,546...137,115,177
JBrowse link
G ESR1 estrogen receptor 1 decreases expression ISO carbendazim results in decreased expression of ESR1 mRNA CTD PMID:28576679 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 decreases expression ISO carbendazim results in decreased expression of ESR2 mRNA CTD PMID:28576679 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FANK1 fibronectin type III and ankyrin repeat domains 1 increases expression ISO carbendazim results in increased expression of FANK1 mRNA CTD PMID:22952946 NCBI chr10:125,896,223...126,009,599
Ensembl chr10:125,896,564...126,009,592
Ensembl chr10:125,896,564...126,009,592
JBrowse link
G FOXA2 forkhead box A2 increases expression ISO carbendazim results in increased expression of FOXA2 mRNA CTD PMID:26071454 NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,581,005...22,585,455
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G IFT81 intraflagellar transport 81 decreases expression ISO carbendazim results in decreased expression of IFT81 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr12:110,124,335...110,218,793
Ensembl chr12:110,124,335...110,218,793
JBrowse link
G IL1B interleukin 1 beta increases expression ISO carbendazim results in increased expression of IL1B mRNA; carbendazim results in increased expression of IL1B protein CTD PMID:26071454 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression ISO carbendazim results in increased expression of IL6 mRNA; carbendazim results in increased expression of IL6 protein CTD PMID:26071454 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGA5 integrin subunit alpha 5 decreases expression EXP carbendazim results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr12:54,395,261...54,419,266
Ensembl chr12:54,395,261...54,419,266
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP carbendazim results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G LOXL1 lysyl oxidase like 1 multiple interactions
increases expression
ISO 2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA CTD PMID:22382377 NCBI chr15:73,926,462...73,952,137
Ensembl chr15:73,925,989...73,952,137
JBrowse link
G LPL lipoprotein lipase decreases expression ISO carbendazim results in decreased expression of LPL protein CTD PMID:30496565 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G LRRC6 leucine rich repeat containing 6 decreases expression ISO carbendazim results in decreased expression of LRRC6 mRNA CTD PMID:27466211 NCBI chr 8:132,570,416...132,685,039
Ensembl chr 8:132,570,416...132,675,592
JBrowse link
G MACROD1 mono-ADP ribosylhydrolase 1 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA CTD PMID:22382377 NCBI chr11:63,998,554...64,166,652
Ensembl chr11:63,998,558...64,166,113
JBrowse link
G MFAP3L microfibril associated protein 3 like increases expression ISO carbendazim results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr 4:169,986,602...170,033,003
Ensembl chr 4:169,986,597...170,033,031
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression EXP carbendazim results in decreased expression of MMP2 mRNA CTD PMID:25530041 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP carbendazim results in decreased expression of MMP9 mRNA CTD PMID:25530041 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression EXP carbendazim results in increased expression of NFE2L2 protein CTD PMID:30851412 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO carbendazim results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428
JBrowse link
G PLAU plasminogen activator, urokinase decreases expression EXP carbendazim results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PTGDS prostaglandin D2 synthase decreases expression ISO carbendazim results in decreased expression of PTGDS mRNA CTD PMID:22952946 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742
JBrowse link
G SERPINE2 serpin family E member 2 increases expression EXP carbendazim results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318
JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr22:50,672,823...50,733,212
Ensembl chr22:50,674,415...50,733,298
JBrowse link
G SIL1 SIL1 nucleotide exchange factor decreases expression ISO carbendazim results in decreased expression of SIL1 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr 5:138,946,724...139,198,368
Ensembl chr 5:138,946,724...139,293,557
JBrowse link
G SOD3 superoxide dismutase 3 increases expression ISO carbendazim results in increased expression of SOD3 mRNA CTD PMID:27466211 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression ISO carbendazim results in increased expression of SREBF1 mRNA CTD PMID:26071454 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TBC1D5 TBC1 domain family member 5 decreases expression ISO carbendazim results in decreased expression of TBC1D5 mRNA CTD PMID:27466211 NCBI chr 3:17,157,162...17,742,739
Ensembl chr 3:17,157,162...18,444,817
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP carbendazim results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP carbendazim results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TNP1 transition protein 1 increases expression ISO carbendazim results in increased expression of TNP1 mRNA CTD PMID:28576679 NCBI chr 2:216,859,458...216,860,064
Ensembl chr 2:216,859,458...216,860,064
JBrowse link
G TNP2 transition protein 2 increases expression ISO carbendazim results in increased expression of TNP2 mRNA CTD PMID:28576679 NCBI chr16:11,267,857...11,269,325
Ensembl chr16:11,267,748...11,269,533
JBrowse link
closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
decreases response to substance
ISO closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
ABCB1A protein results in decreased susceptibility to closantel
CTD PMID:20513441 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G BCL3 BCL3 transcription coactivator increases expression ISO closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr19:44,742,620...44,760,044
Ensembl chr19:44,747,705...44,760,044
JBrowse link
G SLC25A31 solute carrier family 25 member 31 decreases activity EXP closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 4:127,730,372...127,774,299
Ensembl chr 4:127,730,400...127,774,292
JBrowse link
G SLC25A4 solute carrier family 25 member 4 decreases activity EXP closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382
JBrowse link
G SLC25A5 solute carrier family 25 member 5 decreases activity EXP closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396
JBrowse link
G SLC25A6 solute carrier family 25 member 6 decreases activity EXP closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr  X:1,386,152...1,392,113
NCBI chr  Y:1,386,152...1,392,113
Ensembl chr  X:1,386,152...1,392,113
JBrowse link
G THRA thyroid hormone receptor alpha increases activity ISO closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G THRB thyroid hormone receptor beta increases activity ISO closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756
JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity EXP Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 increases expression EXP Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 4:83,535,634...83,605,875
Ensembl chr 4:83,535,914...83,605,875
JBrowse link
G LIF LIF interleukin 6 family cytokine increases expression EXP Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr22:30,240,453...30,257,487
Ensembl chr22:30,240,453...30,246,759
JBrowse link
G RARA retinoic acid receptor alpha increases activity EXP Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
eprinomectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity ISO eprinomectin results in decreased activity of ABCB1A protein CTD PMID:17134887 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 8:70,109,770...70,405,390
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
ethoprophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity EXP ethoprop metabolite results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions ISO ethoprophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
fenbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AURKB aurora kinase B increases expression ISO Fenbendazole results in increased expression of AURKB protein CTD PMID:23411599 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G CBX5 chromobox 5 increases expression ISO Fenbendazole results in increased expression of CBX5 protein CTD PMID:23411599 NCBI chr12:54,230,942...54,280,122
Ensembl chr12:54,230,942...54,280,133
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Fenbendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 increases expression ISO Fenbendazole results in increased expression of CCND1 mRNA CTD PMID:23411599 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE2 cyclin E2 increases expression ISO Fenbendazole results in increased expression of CCNE2 mRNA CTD PMID:23411599 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression ISO Fenbendazole results in increased expression of CDK1 mRNA; Fenbendazole results in increased expression of CDK1 protein CTD PMID:23411599 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO Fenbendazole results in increased expression of CDKN1A mRNA; Fenbendazole results in increased expression of CDKN1A protein CTD PMID:23411599 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A decreases expression
increases methylation
increases expression
ISO Fenbendazole results in decreased expression of CDKN2A protein
Fenbendazole results in increased methylation of CDKN2A gene
Fenbendazole results in increased expression of CDKN2A protein
CTD PMID:22659510, PMID:23411599 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,753...21,995,301
JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B increases expression ISO Fenbendazole results in increased expression of CDKN2B mRNA CTD PMID:23411599 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305
JBrowse link
G CDR2 cerebellar degeneration related protein 2 increases expression ISO Fenbendazole results in increased expression of CDR2 mRNA CTD PMID:23411599 NCBI chr16:22,345,936...22,374,619
Ensembl chr16:22,345,936...22,437,165
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion
increases expression
multiple interactions
EXP Fenbendazole results in increased secretion of CXCL8 protein
Fenbendazole results in increased expression of CXCL8 protein
U 0126 inhibits the reaction [Fenbendazole results in increased secretion of CXCL8 protein]
CTD PMID:20116850, PMID:20848085 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity ISO Fenbendazole results in decreased activity of CYP1A2 protein CTD PMID:22048645 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Fenbendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G IL6R interleukin 6 receptor increases expression EXP Fenbendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G INCENP inner centromere protein increases expression ISO Fenbendazole results in increased expression of INCENP protein CTD PMID:23411599 NCBI chr11:62,123,998...62,155,474
Ensembl chr11:62,123,998...62,153,169
JBrowse link
G MAPT microtubule associated protein tau decreases expression EXP Fenbendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression ISO Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MKI67 marker of proliferation Ki-67 increases expression ISO Fenbendazole results in increased expression of MKI67 protein CTD PMID:23411599 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G TMEM70 transmembrane protein 70 multiple interactions ISO [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of TMEM70 protein CTD PMID:27914986 NCBI chr 8:73,976,195...73,982,783
Ensembl chr 8:73,972,437...73,982,783
JBrowse link
G TNF tumor necrosis factor increases secretion
multiple interactions
EXP Fenbendazole results in increased secretion of TNF protein
U 0126 inhibits the reaction [Fenbendazole results in increased secretion of TNF protein]
CTD PMID:20848085 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 increases expression ISO Fenbendazole results in increased expression of TP53 protein CTD PMID:23411599 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UBE2E2 ubiquitin conjugating enzyme E2 E2 multiple interactions ISO [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of UBE2E2 protein CTD PMID:27914986 NCBI chr 3:23,203,007...23,591,925
Ensembl chr 3:23,203,020...23,591,794
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP Fenbendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WEE1 WEE1 G2 checkpoint kinase decreases expression ISO Fenbendazole results in decreased expression of WEE1 protein modified form CTD PMID:23411599 NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457
JBrowse link
flubendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 decreases expression EXP flubendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 1:155,946,851...155,991,262
Ensembl chr 1:155,946,851...156,007,070
JBrowse link
G CDH1 cadherin 1 multiple interactions EXP flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 multiple interactions EXP flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G PTK2 protein tyrosine kinase 2 decreases expression EXP flubendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G RAC1 Rac family small GTPase 1 decreases expression EXP flubendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RHOA ras homolog family member A decreases expression EXP flubendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects binding
increases expression
decreases activity
multiple interactions
increases response to substance
increases export
decreases response to substance
affects abundance
affects response to substance
EXP
ISO
Ivermectin binds to ABCB1 protein
Ivermectin results in increased expression of ABCB1A mRNA
Ivermectin results in decreased activity of ABCB1A protein
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin results in increased expression of and results in increased stability of ABCB1A mRNA; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
Ivermectin results in decreased activity of ABCB1 protein
Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
ABCB1A gene mutant form results in increased susceptibility to Ivermectin; ABCB1A protein mutant form results in increased susceptibility to Ivermectin
ABCB1A protein results in increased export of Ivermectin
ABCB1A protein results in decreased susceptibility to Ivermectin
ABCB1 protein affects the abundance of Ivermectin
ABCB1 gene polymorphism affects the susceptibility to Ivermectin
ABCB1 gene polymorphism affects the abundance of Ivermectin
CTD PMID:8917702, PMID:8949985, PMID:9144452, PMID:17134887, PMID:18633165, PMID:19161460, PMID:20513441, PMID:20595473, PMID:20630055, PMID:22024132, PMID:22834856, PMID:24998875, PMID:25865432 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
EXP
ISO
Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin results in decreased activity of ABCC1 protein
CTD PMID:25865432 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO Ivermectin results in increased expression of ABCC2 mRNA CTD PMID:24998875 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression ISO Ivermectin results in increased expression of ABCG2 mRNA CTD PMID:24998875 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions
affects expression
decreases expression
ISO
EXP
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein]
Ivermectin affects the expression of ACACA mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in decreased phosphorylation of ACACA protein]
Ivermectin results in decreased expression of ACACA mRNA
CTD PMID:30738135, PMID:31199990 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ADCY7 adenylate cyclase 7 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA CTD PMID:16861626 NCBI chr16:50,246,138...50,318,135
Ensembl chr16:50,246,137...50,318,135
JBrowse link
G ADM adrenomedullin decreases expression ISO Ivermectin results in decreased expression of ADM mRNA CTD PMID:28942281 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 increases expression ISO Ivermectin results in increased expression of ALDH1L2 mRNA CTD PMID:28942281 NCBI chr12:105,019,784...105,084,609
Ensembl chr12:105,019,784...105,107,643
JBrowse link
G ANGPTL6 angiopoietin like 6 increases expression ISO Ivermectin results in increased expression of ANGPTL6 mRNA CTD PMID:28942281 NCBI chr19:10,092,337...10,106,407
Ensembl chr19:10,092,338...10,102,796
JBrowse link
G ARL4C ADP ribosylation factor like GTPase 4C multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA CTD PMID:16861626 NCBI chr 2:234,493,041...234,497,081
Ensembl chr 2:234,493,041...234,497,081
JBrowse link
G ATF4 activating transcription factor 4 increases expression EXP
ISO
Ivermectin results in increased expression of ATF4 mRNA CTD PMID:28942281 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G ATF5 activating transcription factor 5 increases expression EXP
ISO
Ivermectin results in increased expression of ATF5 mRNA CTD PMID:28942281 NCBI chr19:49,928,702...49,933,936
Ensembl chr19:49,928,702...49,933,935
JBrowse link
G ATF6 activating transcription factor 6 increases expression ISO Ivermectin results in increased expression of ATF6 mRNA CTD PMID:28942281 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
JBrowse link
G BAG3 BAG cochaperone 3 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA CTD PMID:16861626 NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,370...119,677,819
Ensembl chr10:119,651,370...119,677,819
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Ivermectin results in increased expression of BAX protein CTD PMID:28811376 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP Ivermectin inhibits the reaction [geranylgeranic acid results in increased expression of BBC3 mRNA] CTD PMID:24658405 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BNIP3 BCL2 interacting protein 3 decreases expression ISO Ivermectin results in decreased expression of BNIP3 mRNA CTD PMID:28942281 NCBI chr10:131,967,683...131,982,013
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G CAMP cathelicidin antimicrobial peptide decreases expression EXP Ivermectin results in decreased expression of CAMP mRNA; Ivermectin results in decreased expression of CAMP protein CTD PMID:28653460 NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491
JBrowse link
G CAT catalase multiple interactions
decreases activity
ISO Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein] CTD PMID:28880400 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein CTD PMID:16861626 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCR7 C-C motif chemokine receptor 7 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA CTD PMID:16861626 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472
JBrowse link
G CCT3 chaperonin containing TCP1 subunit 3 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA CTD PMID:16861626 NCBI chr 1:156,308,968...156,338,292
Ensembl chr 1:156,308,968...156,367,873
JBrowse link
G CD36 CD36 molecule affects expression ISO Ivermectin affects the expression of CD36 mRNA CTD PMID:31199990 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CDH1 cadherin 1 increases expression EXP
ISO
Ivermectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Ivermectin results in increased expression of CDKN1A protein CTD PMID:28811376 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Ivermectin results in increased expression of CDKN1B protein CTD PMID:28811376 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions
affects expression
ISO Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of CEBPA mRNA] CTD PMID:31199990 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G COX6A2 cytochrome c oxidase subunit 6A2 increases expression ISO Ivermectin results in increased expression of COX6A2 mRNA; Ivermectin results in increased expression of COX6A2 protein CTD PMID:28942281 NCBI chr16:31,427,731...31,428,360
Ensembl chr16:31,427,731...31,428,360
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A affects expression
multiple interactions
ISO
EXP
Ivermectin affects the expression of CPT1A mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
CTD PMID:30738135, PMID:31199990 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CRP C-reactive protein increases expression EXP Ivermectin results in increased expression of CRP protein CTD PMID:8555762 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CTSL cathepsin L multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA CTD PMID:16861626 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,726,109...87,731,469
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
EXP [Ivermectin co-treated with Albendazole] results in increased expression of CXCL8 protein
Ivermectin results in decreased expression of CXCL8 mRNA; Ivermectin results in decreased expression of CXCL8 protein
CTD PMID:16861626, PMID:28653460 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
increases expression
ISO Ivermectin results in decreased activity of CYP1A1 protein
Ivermectin results in increased expression of CYP1A1 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO Ivermectin results in increased expression of CYP1A2 mRNA CTD PMID:24998875 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity ISO Ivermectin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 decreases activity ISO Ivermectin results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 decreases activity
increases expression
ISO Ivermectin results in decreased activity of CYP2B10 protein
Ivermectin results in increased expression of CYP2B10 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity ISO Ivermectin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Ivermectin results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP
ISO
Ivermectin results in decreased activity of CYP2D6 protein
Ivermectin results in decreased activity of CYP2D22 protein
CTD PMID:11124226, PMID:18420780 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity ISO Ivermectin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
increases expression
EXP
ISO
Ivermectin results in decreased activity of CYP3A4 protein
Ivermectin results in decreased activity of CYP3A11 protein
Ivermectin results in increased expression of CYP3A11 mRNA
CTD PMID:11124226, PMID:18420780, PMID:24998875 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
affects expression
ISO
EXP
Ivermectin results in increased expression of DDIT3 mRNA
Ivermectin promotes the reaction [Palmitic Acid results in increased expression of DDIT3 protein]
Ivermectin affects the expression of DDIT3 mRNA
CTD PMID:28942281, PMID:30738135, PMID:31199990 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA CTD PMID:16861626 NCBI chr19:14,514,769...14,530,597
Ensembl chr19:14,514,769...14,529,770
JBrowse link
G DPYSL2 dihydropyrimidinase like 2 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA CTD PMID:16861626 NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178
JBrowse link
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression EXP Ivermectin results in increased expression of EDEM1 mRNA CTD PMID:28942281 NCBI chr 3:5,187,707...5,219,963
Ensembl chr 3:5,187,646...5,219,958
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 decreases expression ISO Ivermectin results in decreased expression of EGLN3 mRNA CTD PMID:28942281 NCBI chr14:33,924,227...33,951,074
Ensembl chr14:33,924,227...34,462,774
JBrowse link
G ESR1 estrogen receptor 1 increases expression EXP
ISO
Ivermectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions
affects expression
ISO Rosiglitazone affects the reaction [Ivermectin affects the expression of FABP4 mRNA] CTD PMID:31199990 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FASN fatty acid synthase affects expression ISO Ivermectin affects the expression of FASN mRNA CTD PMID:31199990 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G GDF15 growth differentiation factor 15 increases expression ISO Ivermectin results in increased expression of GDF15 mRNA CTD PMID:28942281 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GEM GTP binding protein overexpressed in skeletal muscle multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA CTD PMID:16861626 NCBI chr 8:94,249,249...94,262,345
Ensembl chr 8:94,249,253...94,262,350
JBrowse link
G GLRA1 glycine receptor alpha 1 increases activity
multiple interactions
affects activity
EXP Ivermectin results in increased activity of GLRA1 protein mutant form
Ivermectin affects the reaction [Glycine affects the activity of GLRA1 protein mutant form]
Ivermectin affects the activity of GLRA1 protein mutant form
CTD PMID:25231486, PMID:27958714 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,842
Ensembl chr 5:151,822,513...151,924,842
JBrowse link
G GLRA3 glycine receptor alpha 3 affects expression ISO Ivermectin affects the expression of GLRA3 mRNA CTD PMID:31199990 NCBI chr 4:174,636,920...174,829,568
Ensembl chr 4:174,636,920...174,829,247
JBrowse link
G GLRB glycine receptor beta affects expression ISO Ivermectin affects the expression of GLRB mRNA CTD PMID:31199990 NCBI chr 4:157,076,146...157,172,090
Ensembl chr 4:157,076,125...157,172,090
JBrowse link
G GPR183 G protein-coupled receptor 183 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA CTD PMID:16861626 NCBI chr13:99,294,273...99,307,399
Ensembl chr13:99,294,539...99,307,399
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA CTD PMID:16861626 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA CTD PMID:16861626 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO Ivermectin results in increased expression of HSPA1A mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA]
CTD PMID:28880400 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA CTD PMID:16861626 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ivermectin results in increased expression of HSPA5 protein CTD PMID:30738135 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA CTD PMID:16861626 NCBI chr11:123,057,489...123,062,366
Ensembl chr11:123,057,489...123,063,230
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 increases expression EXP
ISO
Ivermectin results in increased expression of HSPA9 mRNA CTD PMID:28942281 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,416
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
EXP
ISO
[Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA
Ivermectin results in increased expression of HSPD1 mRNA
CTD PMID:16861626, PMID:28942281 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA CTD PMID:16861626 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA CTD PMID:16861626 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions
increases expression
ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein CTD PMID:16861626 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1R1 interleukin 1 receptor type 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA CTD PMID:16861626 NCBI chr 2:102,069,638...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G LONP1 lon peptidase 1, mitochondrial increases expression ISO
EXP
Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572
JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA CTD PMID:16861626 NCBI chr10:30,434,021...30,461,833
Ensembl chr10:30,434,021...30,461,833
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:19168156 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:19168156 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:19168156 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MXD1 MAX dimerization protein 1 multiple interactions EXP
ISO
Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945
JBrowse link
G NANOG Nanog homeobox decreases expression EXP Ivermectin results in decreased expression of NANOG mRNA; Ivermectin results in decreased expression of NANOG protein CTD PMID:29257278 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146
JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 8:70,109,770...70,405,390
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G NDRG1 N-myc downstream regulated 1 decreases expression ISO Ivermectin results in decreased expression of NDRG1 mRNA CTD PMID:28942281 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022
Ensembl chr 8:133,237,175...133,302,022
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:19168156 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPB natriuretic peptide B multiple interactions EXP Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression EXP Ivermectin results in decreased expression of NQO1 mRNA; Ivermectin results in decreased expression of NQO1 protein CTD PMID:22021338 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions
increases expression
affects expression
EXP
ISO
Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
Ivermectin results in increased expression of NR1H4 mRNA
Ivermectin affects the expression of NR1H4 mRNA
CTD PMID:27773686, PMID:30738135, PMID:31199990 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression ISO Ivermectin results in increased expression of NUPR1 mRNA CTD PMID:28942281 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G P2RX4 purinergic receptor P2X 4 multiple interactions
increases activity
ISO
EXP
Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
Ivermectin results in increased activity of P2RX4 protein
CTD PMID:19560503, PMID:21638035, PMID:30545933 NCBI chr12:121,210,096...121,234,106
Ensembl chr12:121,209,861...121,234,106
Ensembl chr12:121,209,861...121,234,106
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases expression EXP Ivermectin results in increased expression of PARP1 protein modified form CTD PMID:28811376 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PFKL phosphofructokinase, liver type decreases expression ISO Ivermectin results in decreased expression of PFKL mRNA CTD PMID:28942281 NCBI chr21:44,300,040...44,327,373
Ensembl chr21:44,300,051...44,327,376
JBrowse link
G POU5F1 POU class 5 homeobox 1 decreases expression EXP Ivermectin results in decreased expression of POU5F1 mRNA; Ivermectin results in decreased expression of POU5F1 protein CTD PMID:29257278 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]
Ivermectin results in decreased expression of PPARA mRNA
CTD PMID:30738135 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
affects expression
ISO Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of PPARG mRNA] CTD PMID:31199990 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPID peptidylprolyl isomerase D multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA CTD PMID:16861626 NCBI chr 4:158,709,127...158,723,396
Ensembl chr 4:158,709,127...158,723,396
JBrowse link
G PPIF peptidylprolyl isomerase F multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA CTD PMID:16861626 NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334
JBrowse link
G PTGES3 prostaglandin E synthase 3 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 NCBI chr12:56,663,349...56,689,575
Ensembl chr12:56,663,341...56,688,408
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:19168156 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RPP14 ribonuclease P/MRP subunit p14 increases expression ISO Ivermectin results in increased expression of RPP14 mRNA CTD PMID:28942281 NCBI chr 3:58,306,245...58,320,193
Ensembl chr 3:58,306,247...58,324,695
JBrowse link
G SERPINE1 serpin family E member 1 decreases expression ISO Ivermectin results in decreased expression of SERPINE1 mRNA CTD PMID:28942281 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SIN3A SIN3 transcription regulator family member A multiple interactions EXP
ISO
Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr15:75,369,379...75,455,819
Ensembl chr15:75,369,379...75,455,842
JBrowse link
G SKAP2 src kinase associated phosphoprotein 2 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA CTD PMID:16861626 NCBI chr 7:26,654,772...26,864,623
Ensembl chr 7:26,667,068...26,995,239
JBrowse link
G SLC2A1 solute carrier family 2 member 1 decreases expression ISO Ivermectin results in decreased expression of SLC2A1 mRNA CTD PMID:28942281 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G SLC2A4 solute carrier family 2 member 4 affects expression ISO Ivermectin affects the expression of SLC2A4 mRNA CTD PMID:31199990 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression EXP Ivermectin results in decreased expression of SOX2 mRNA; Ivermectin results in decreased expression of SOX2 protein CTD PMID:29257278 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G SPHK1 sphingosine kinase 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860
JBrowse link
G ST13 ST13 Hsp70 interacting protein multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA CTD PMID:16861626 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639
JBrowse link
G TCP1 t-complex 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA CTD PMID:16861626 NCBI chr 6:159,778,498...159,789,602
Ensembl chr 6:159,778,498...159,789,703
JBrowse link
G TFRC transferrin receptor decreases expression ISO Ivermectin results in decreased expression of TFRC mRNA CTD PMID:28942281 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link
G TGIF1 TGFB induced factor homeobox 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA CTD PMID:16861626 NCBI chr18:3,412,009...3,459,978
Ensembl chr18:3,411,608...3,459,978
JBrowse link
G TLR2 toll like receptor 2 decreases expression EXP Ivermectin results in decreased expression of TLR2 protein CTD PMID:28653460 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR4 toll like receptor 4 decreases expression EXP Ivermectin results in decreased expression of TLR4 mRNA CTD PMID:28653460 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Ivermectin results in decreased expression of TNF mRNA CTD PMID:28653460 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Ivermectin inhibits the reaction [geranylgeranic acid affects the localization of TP53 protein mutant form] CTD PMID:24658405 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIB3 tribbles pseudokinase 3 increases expression ISO Ivermectin results in increased expression of TRIB3 mRNA CTD PMID:28942281 NCBI chr20:380,629...397,559
Ensembl chr20:362,835...397,559
JBrowse link
G TSC22D1 TSC22 domain family member 1 multiple interactions EXP [Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA CTD PMID:16861626 NCBI chr13:44,432,143...44,576,825
Ensembl chr13:44,432,143...44,577,147
JBrowse link
kainic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression ISO Kainic Acid results in increased expression of ABCB1A mRNA; Kainic Acid results in increased expression of ABCB1A protein CTD PMID:14706787 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression ISO Kainic Acid results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACO2 aconitase 2 multiple interactions
decreases activity
ISO 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein] CTD PMID:11520895 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,469,117...41,528,989
JBrowse link
G ACP1 acid phosphatase 1 decreases expression ISO Kainic Acid results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 2:264,947...278,283
Ensembl chr 2:264,140...278,283
JBrowse link
G ADK adenosine kinase increases expression ISO Kainic Acid results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr10:74,151,185...74,709,300
Ensembl chr10:74,151,202...74,709,963
JBrowse link
G ADNP activity dependent neuroprotector homeobox multiple interactions
decreases expression
ISO Enzyme Inhibitors inhibits the reaction [Kainic Acid results in decreased expression of ADNP protein]
Kainic Acid results in decreased expression of ADNP mRNA; Kainic Acid results in decreased expression of ADNP protein
CTD PMID:18375135 NCBI chr20:50,888,918...50,931,437
Ensembl chr20:50,888,916...50,931,437
JBrowse link
G ADRA1B adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Kainic Acid CTD PMID:19125850 NCBI chr 5:159,916,482...159,989,205
Ensembl chr 5:159,865,080...159,973,012
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases localization
multiple interactions
ISO Kainic Acid results in increased localization of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
CTD PMID:16469440 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein increases expression ISO Kainic Acid results in increased expression of ALOX5AP mRNA CTD PMID:19700661 NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression ISO Kainic Acid results in increased expression of APAF1 mRNA CTD PMID:17997037 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G APOE apolipoprotein E decreases expression ISO Kainic Acid results in decreased expression of APOE mRNA CTD PMID:17997037 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G ARC activity regulated cytoskeleton associated protein increases expression ISO Kainic Acid results in increased expression of ARC mRNA; Kainic Acid results in increased expression of ARC protein CTD PMID:17632064, PMID:30557575 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
JBrowse link
G ATF7IP activating transcription factor 7 interacting protein decreases expression ISO Kainic Acid results in decreased expression of ATF7IP mRNA CTD PMID:19700661 NCBI chr12:14,365,640...14,502,935
Ensembl chr12:14,365,632...14,502,935
JBrowse link
G B4GALT2 beta-1,4-galactosyltransferase 2 decreases expression ISO Kainic Acid results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 1:43,979,210...43,991,171
Ensembl chr 1:43,978,943...43,991,170
JBrowse link
G BAG3 BAG cochaperone 3 increases expression ISO Kainic Acid results in increased expression of BAG3 mRNA CTD PMID:19700661 NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,370...119,677,819
Ensembl chr10:119,651,370...119,677,819
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Kainic Acid results in increased expression of BAX mRNA; Kainic Acid results in increased expression of BAX protein
oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]
Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of BAX protein]
CTD PMID:18711747, PMID:19700661, PMID:25453207, PMID:31430510 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]
Kainic Acid results in decreased expression of BCL2 mRNA
oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]
CTD PMID:25453207, PMID:31430510 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
increases expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]
Kainic Acid results in increased expression of BDNF mRNA; Kainic Acid results in increased expression of BDNF protein
CTD PMID:1641125, PMID:9073163, PMID:11279263, PMID:16166269, PMID:17827730, PMID:19700661 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G C1QB complement C1q B chain increases expression ISO Kainic Acid results in increased expression of C1QB mRNA CTD PMID:17997037 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637
JBrowse link
G C4B complement C4B (Chido blood group) increases expression ISO Kainic Acid results in increased expression of C4B mRNA CTD PMID:17997037 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G CALB1 calbindin 1 decreases expression ISO Kainic Acid results in decreased expression of CALB1 mRNA CTD PMID:17997037 NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475
JBrowse link
G CAMK4 calcium/calmodulin dependent protein kinase IV decreases expression ISO Kainic Acid results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr 5:111,223,583...111,498,503
Ensembl chr 5:111,223,653...111,494,886
JBrowse link
G CAPNS1 calpain small subunit 1 increases expression ISO Kainic Acid results in increased expression of CAPNS1 mRNA CTD PMID:19700661 NCBI chr19:36,140,066...36,150,353
Ensembl chr19:36,139,953...36,150,353
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
ISO
EXP
Kainic Acid results in increased activity of CASP3 protein
oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]
Kainic Acid results in increased cleavage of CASP3 protein
Kainic Acid results in increased expression of CASP3 mRNA; Kainic Acid results in increased expression of CASP3 protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]]; Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]
CTD PMID:16469440, PMID:18711747, PMID:19700661, PMID:25453207, PMID:31430510 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase decreases expression
decreases activity
multiple interactions
ISO Kainic Acid results in decreased expression of CAT mRNA; Kainic Acid results in decreased expression of CAT protein
Kainic Acid results in decreased activity of CAT protein
oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein]
CTD PMID:29208536, PMID:31430510 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCK cholecystokinin decreases expression ISO Kainic Acid results in decreased expression of CCK protein CTD PMID:7774662 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Kainic Acid results in increased expression of CCL2 mRNA CTD PMID:19700661 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCNE1 cyclin E1 increases expression ISO Kainic Acid results in increased expression of CCNE1 protein CTD PMID:12941380 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CD68 CD68 molecule increases expression ISO Kainic Acid results in increased expression of CD68 mRNA CTD PMID:19700661 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
JBrowse link
G CDC42 cell division cycle 42 increases expression ISO Kainic Acid results in increased expression of CDC42 mRNA CTD PMID:19700661 NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,025,511...22,101,360
JBrowse link
G CDH13 cadherin 13 increases expression ISO Kainic Acid results in increased expression of CDH13 mRNA CTD PMID:17997037 NCBI chr16:82,626,823...83,800,640
Ensembl chr16:82,626,965...83,800,640
JBrowse link
G CDK2 cyclin dependent kinase 2 increases expression ISO Kainic Acid results in increased expression of CDK2 protein CTD PMID:12941380 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 increases expression ISO Kainic Acid results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CHGB chromogranin B increases expression ISO Kainic Acid results in increased expression of CHGB mRNA CTD PMID:9427505 NCBI chr20:5,911,510...5,925,353
Ensembl chr20:5,911,510...5,925,353
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 increases expression ISO Kainic Acid results in increased expression of CITED2 mRNA CTD PMID:19700661 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CNR1 cannabinoid receptor 1 increases expression ISO Kainic Acid results in increased expression of CNR1 mRNA CTD PMID:22079489 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,359
JBrowse link
G CNRIP1 cannabinoid receptor interacting protein 1 increases expression ISO Kainic Acid results in increased expression of CNRIP1 mRNA CTD PMID:22079489 NCBI chr 2:68,284,171...68,319,949
Ensembl chr 2:68,284,171...68,320,051
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression ISO Kainic Acid results in increased expression of COL1A1 mRNA CTD PMID:17997037 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 increases expression ISO Kainic Acid results in increased expression of CRHR1 mRNA CTD PMID:12093084 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,280...45,835,828
JBrowse link
G CTSS cathepsin S increases expression ISO Kainic Acid results in increased expression of CTSS mRNA; Kainic Acid results in increased expression of CTSS protein CTD PMID:17997037 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,188...150,765,792
JBrowse link
G CTSZ cathepsin Z increases expression ISO Kainic Acid results in increased expression of CTSZ mRNA CTD PMID:17997037 NCBI chr20:58,995,185...59,007,254
Ensembl chr20:58,995,185...59,007,254
JBrowse link
G CYCS cytochrome c, somatic increases localization
increases expression
multiple interactions
ISO Kainic Acid results in increased localization of CYCS protein
Kainic Acid results in increased expression of CYCS mRNA
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
CTD PMID:16469440, PMID:19700661 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G DGCR6 DiGeorge syndrome critical region gene 6 decreases expression ISO Kainic Acid results in decreased expression of DGCR6 mRNA CTD PMID:17997037 NCBI chr22:18,906,320...18,912,088
Ensembl chr22:18,906,028...18,914,238
JBrowse link
G DHX36 DEAH-box helicase 36 increases expression ISO Kainic Acid results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 3:154,272,546...154,324,487
Ensembl chr 3:154,272,546...154,324,487
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein increases expression ISO Kainic Acid results in increased expression of DIABLO mRNA CTD PMID:19700661 NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,663...122,227,456
Ensembl chr12:122,207,663...122,227,456
JBrowse link
G DRD2 dopamine receptor D2 decreases response to substance ISO DRD2 protein results in decreased susceptibility to Kainic Acid CTD PMID:11860278 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G EGR1 early growth response 1 decreases expression
affects expression
ISO Kainic Acid results in decreased expression of EGR1 mRNA
Kainic Acid affects the expression of EGR1 mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EIF4A3 eukaryotic translation initiation factor 4A3 increases expression ISO Kainic Acid results in increased expression of EIF4A3 protein CTD PMID:17632064 NCBI chr17:80,134,369...80,147,128
Ensembl chr17:80,134,369...80,147,151
JBrowse link
G EMC3 ER membrane protein complex subunit 3 decreases expression ISO Kainic Acid results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 3:9,962,682...10,011,118
Ensembl chr 3:9,962,537...10,011,116
JBrowse link
G EN2 engrailed homeobox 2 affects response to substance
decreases expression
ISO EN2 protein affects the susceptibility to Kainic Acid
Kainic Acid results in decreased expression of EN2 mRNA
CTD PMID:19186208 NCBI chr 7:155,458,129...155,464,831
Ensembl chr 7:155,458,129...155,464,831
JBrowse link
G ENC1 ectodermal-neural cortex 1 decreases expression ISO Kainic Acid results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424
JBrowse link
G EPO erythropoietin multiple interactions EXP EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G EPOR erythropoietin receptor multiple interactions
decreases expression
EXP
ISO
EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342
JBrowse link
G ETFB electron transfer flavoprotein subunit beta decreases expression ISO Kainic Acid results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr19:51,345,155...51,366,388
Ensembl chr19:51,345,169...51,366,418
Ensembl chr19:51,345,169...51,366,418
JBrowse link
G FBXW5 F-box and WD repeat domain containing 5 decreases expression ISO Kainic Acid results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 9:136,940,435...136,944,774
Ensembl chr 9:136,940,435...136,944,738
JBrowse link
G FGF2 fibroblast growth factor 2 increases expression ISO Kainic Acid results in increased expression of FGF2 mRNA CTD PMID:7649223 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FGF5 fibroblast growth factor 5 increases expression ISO Kainic Acid results in increased expression of FGF5 mRNA CTD PMID:7649223 NCBI chr 4:80,266,588...80,291,017
Ensembl chr 4:80,266,599...80,336,680
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 increases expression ISO Kainic Acid results in increased expression of FGFR1 mRNA CTD PMID:7649223 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
ISO 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in increased expression of FOS mRNA; Kainic Acid results in increased expression of FOS protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in decreased expression of FOS mRNA
CTD PMID:7655348, PMID:7887109, PMID:8417141, PMID:8758711, PMID:15723099, PMID:16686654, PMID:17827730, PMID:17997037, PMID:26348896 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Kainic Acid results in increased expression of FOSL2 mRNA CTD PMID:19700661 NCBI chr 2:28,392,855...28,417,317
Ensembl chr 2:28,392,448...28,417,317
JBrowse link
G FXYD1 FXYD domain containing ion transport regulator 1 decreases expression ISO Kainic Acid results in decreased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr19:35,137,206...35,143,109
Ensembl chr19:35,138,824...35,143,109
Ensembl chr19:35,138,824...35,143,109
JBrowse link
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 increases expression
multiple interactions
ISO Kainic Acid results in increased expression of GABRB1 mRNA
Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB1 mRNA]
CTD PMID:27386150 NCBI chr 4:46,993,560...47,438,409
Ensembl chr 4:46,993,723...47,426,447
JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA] CTD PMID:27386150 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,546...26,939,539
JBrowse link
G GAD1 glutamate decarboxylase 1 increases expression ISO Kainic Acid results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GAD2 glutamate decarboxylase 2 increases expression ISO Kainic Acid results in increased expression of GAD2 mRNA CTD PMID:16797850 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression ISO Kainic Acid results in increased expression of GADD45A mRNA; Kainic Acid results in increased expression of GADD45A protein CTD PMID:20955365 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GADD45B growth arrest and DNA damage inducible beta decreases expression ISO Kainic Acid results in decreased expression of GADD45B mRNA CTD PMID:17997037 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259
JBrowse link
G GADD45G growth arrest and DNA damage inducible gamma decreases expression ISO Kainic Acid results in decreased expression of GADD45G mRNA CTD PMID:17997037 NCBI chr 9:89,605,009...89,606,555
Ensembl chr 9:89,605,012...89,606,555
JBrowse link
G GAP43 growth associated protein 43 multiple interactions
increases expression
ISO Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr 3:115,623,510...115,721,485
Ensembl chr 3:115,623,324...115,721,490
Ensembl chr 3:115,623,324...115,721,490
JBrowse link
G GCNT2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Kainic Acid results in increased expression of GCNT2 mRNA CTD PMID:17997037 NCBI chr 6:10,521,283...10,629,368
Ensembl chr 6:10,492,223...10,629,368
JBrowse link
G GFAP glial fibrillary acidic protein increases expression
multiple interactions
ISO
EXP
Kainic Acid results in increased expression of GFAP mRNA; Kainic Acid results in increased expression of GFAP protein
EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]
CTD PMID:17997037, PMID:18711747, PMID:19700661, PMID:21589914, PMID:22790971 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GLUL glutamate-ammonia ligase decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GLUL mRNA
oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA]
CTD PMID:31430510 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,381,704...182,392,206
Ensembl chr 1:182,381,704...182,392,206
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression ISO Kainic Acid results in decreased expression of GPX1 protein CTD PMID:29208536 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
decreases expression
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]; Kainic Acid binds to and results in increased activity of GRIA1 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]
Kainic Acid results in decreased expression of GRIA1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]
Kainic Acid results in decreased expression of GRIA1 mRNA; Kainic Acid results in decreased expression of GRIA1 protein
CTD PMID:7529610, PMID:11812690, PMID:17585341, PMID:21589914 NCBI chr 5:153,490,670...153,813,873
Ensembl chr 5:153,489,615...153,813,869
JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
increases methylation
decreases expression
affects response to substance
ISO Kainic Acid binds to and results in increased activity of GRIA2 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]
Kainic Acid results in increased methylation of GRIA2 gene
Kainic Acid results in decreased expression of GRIA2 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA]; RG108 inhibits the reaction [Kainic Acid results in increased methylation of GRIA2 gene]
GRIA2 protein affects the susceptibility to Kainic Acid
CTD PMID:7529610, PMID:10551584, PMID:11812690, PMID:21589914, PMID:24098468 NCBI chr 4:157,220,120...157,370,583
Ensembl chr 4:157,204,182...157,366,075
JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression
multiple interactions
increases expression
ISO Kainic Acid results in decreased expression of GRIA3 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]
Kainic Acid results in increased expression of GRIA3 mRNA
CTD PMID:7529610, PMID:21589914 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915
JBrowse link
G GRIA4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIA4 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]
CTD PMID:21589914 NCBI chr11:105,609,540...105,982,090
Ensembl chr11:105,609,994...105,982,092
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 decreases expression
increases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIK1 mRNA
Kainic Acid results in increased expression of GRIK1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]
CTD PMID:21589914, PMID:29208536 NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033
JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 increases expression
multiple interactions
ISO Kainic Acid results in increased expression of GRIK2 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA
CTD PMID:17997037, PMID:21589914, PMID:29208536 NCBI chr 6:101,393,708...102,070,083
Ensembl chr 6:101,181,257...102,070,083
JBrowse link
G GRIK3 glutamate ionotropic receptor kainate type subunit 3 decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIK3 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA
CTD PMID:21589914 NCBI chr 1:36,795,527...37,034,515
Ensembl chr 1:36,795,527...37,034,515
JBrowse link
G GRIK4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions
decreases expression
ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA
Kainic Acid results in decreased expression of GRIK4 mRNA
CTD PMID:21589914 NCBI chr11:120,511,748...120,988,906
Ensembl chr11:120,511,700...120,988,904
Ensembl chr11:120,511,700...120,988,904
JBrowse link
G GRIK5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr19:41,998,316...42,071,804
Ensembl chr19:41,998,321...42,069,498
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects expression
decreases expression
ISO celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]
Kainic Acid affects the expression of GRIN1
CTD PMID:21589914, PMID:23159308 NCBI chr 9:137,139,092...137,168,759
Ensembl chr 9:137,139,154...137,168,756
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN2A mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]
CTD PMID:21589914 NCBI chr16:9,753,404...10,182,928
Ensembl chr16:9,753,404...10,182,928
Ensembl chr16:9,753,404...10,182,928
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression
ISO celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr12:13,537,337...13,982,012
Ensembl chr12:13,437,942...13,982,002
Ensembl chr12:13,437,942...13,982,002
JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN2C mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]
CTD PMID:21589914 NCBI chr17:74,842,021...74,860,843
Ensembl chr17:74,842,023...74,861,504
JBrowse link
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN2D mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]
CTD PMID:21589914 NCBI chr19:48,393,668...48,444,937
Ensembl chr19:48,394,875...48,444,931
JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 9:101,569,352...101,738,647
Ensembl chr 9:101,569,352...101,738,647
Ensembl chr 9:101,569,352...101,738,647
JBrowse link
G GRIN3B glutamate ionotropic receptor NMDA type subunit 3B decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN3B mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]
CTD PMID:21589914 NCBI chr19:1,000,419...1,009,748
Ensembl chr19:1,000,419...1,009,732
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases activity
decreases phosphorylation
multiple interactions
ISO Kainic Acid results in decreased activity of GSK3B protein
Kainic Acid results in decreased phosphorylation of GSK3B protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]
CTD PMID:18619545, PMID:25453207 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
decreases activity
ISO oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 multiple interactions
decreases expression
ISO Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
Kainic Acid results in decreased expression of HCN1 mRNA; Kainic Acid results in decreased expression of HCN1 protein
CTD PMID:21905079 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498
JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO Kainic Acid results in increased expression of HMOX1 mRNA CTD PMID:7655348 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HOMER1 homer scaffold protein 1 increases expression ISO Kainic Acid results in increased expression of HOMER1 mRNA CTD PMID:19700661 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134
JBrowse link
G HPCA hippocalcin decreases response to substance ISO HPCA protein results in decreased susceptibility to Kainic Acid CTD PMID:15607944 NCBI chr 1:32,885,965...32,894,646
Ensembl chr 1:32,885,994...32,898,441
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Kainic Acid results in decreased expression of HSD11B1 mRNA CTD PMID:17997037 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions ISO [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]; GYKI 52466 inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Kainic Acid results in decreased expression of IDI1 mRNA CTD PMID:17997037 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,170
JBrowse link
G IL10 interleukin 10 decreases expression ISO Kainic Acid results in decreased expression of IL10 protein CTD PMID:15591643 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12A interleukin 12A affects response to substance ISO IL12A protein affects the susceptibility to Kainic Acid CTD PMID:15474355 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
JBrowse link
G IL1B interleukin 1 beta increases secretion
increases expression
multiple interactions
ISO Kainic Acid results in increased secretion of IL1B protein
Kainic Acid results in increased expression of IL1B mRNA; Kainic Acid results in increased expression of IL1B protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]
CTD PMID:7655348, PMID:11306611, PMID:21589914, PMID:31430510 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases response to substance
multiple interactions
increases expression
ISO IL6 protein results in increased susceptibility to Kainic Acid
oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
Kainic Acid results in increased expression of IL6 mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]
CTD PMID:12836160, PMID:21589914, PMID:31430510 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M increases expression
multiple interactions
ISO Kainic Acid results in increased expression of ITGAM mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]
CTD PMID:21589914 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G JAGN1 jagunal homolog 1 decreases expression ISO Kainic Acid results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 3:9,890,610...9,894,349
Ensembl chr 3:9,890,574...9,894,349
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
decreases expression
EXP
ISO
EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]] CTD PMID:18711747 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,128,183
Ensembl chr 9:4,984,390...5,128,183
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of JUN protein]
Kainic Acid results in increased expression of JUN mRNA; Kainic Acid results in increased expression of JUN protein
CTD PMID:8417141, PMID:15723099, PMID:17827730 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
ISO Kainic Acid results in decreased expression of JUNB mRNA
Kainic Acid results in increased expression of JUNB mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KALRN kalirin RhoGEF kinase increases expression ISO Kainic Acid results in increased expression of KALRN mRNA CTD PMID:19700661 NCBI chr 3:124,033,341...124,726,325
Ensembl chr 3:124,080,023...124,726,325
JBrowse link
G KCNC2 potassium voltage-gated channel subfamily C member 2 increases expression ISO Kainic Acid results in increased expression of KCNC2 protein CTD PMID:7643197 NCBI chr12:75,040,078...75,209,839
Ensembl chr12:75,040,077...75,209,868
Ensembl chr12:75,040,077...75,209,868
JBrowse link
G KCNC4 potassium voltage-gated channel subfamily C member 4 decreases expression ISO Kainic Acid results in decreased expression of KCNC4 protein CTD PMID:21905079 NCBI chr 1:110,210,314...110,282,649
Ensembl chr 1:110,210,314...110,283,100
Ensembl chr 1:110,210,314...110,283,100
JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 increases response to substance EXP KCNQ2 protein mutant form results in increased susceptibility to Kainic Acid CTD PMID:26910900 NCBI chr20:63,400,208...63,472,655
Ensembl chr20:63,400,210...63,472,677
JBrowse link
G KIF20A kinesin family member 20A decreases expression ISO Kainic Acid results in decreased expression of KIF20A mRNA CTD PMID:17997037 NCBI chr 5:138,179,112...138,187,723
Ensembl chr 5:138,178,719...138,187,723
JBrowse link
G KLF10 Kruppel like factor 10 decreases expression ISO Kainic Acid results in decreased expression of KLF10 mRNA CTD PMID:17997037 NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
JBrowse link
G KNG1 kininogen 1 multiple interactions ISO Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G KRAS KRAS proto-oncogene, GTPase increases expression ISO Kainic Acid results in increased expression of KRAS mRNA CTD PMID:19700661 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G LEP leptin decreases response to substance ISO LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LMO1 LIM domain only 1 decreases expression ISO Kainic Acid results in decreased expression of LMO1 mRNA CTD PMID:17997037 NCBI chr11:8,224,304...8,268,787
Ensembl chr11:8,224,309...8,268,716
JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions
increases expression
ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA] CTD PMID:21589914 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,058...209,734,118
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Kainic Acid results in decreased expression of MAP3K5 mRNA CTD PMID:17997037 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases expression ISO Kainic Acid results in increased expression of MAPK3 mRNA CTD PMID:17997037 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAST3 microtubule associated serine/threonine kinase 3 decreases expression ISO Kainic Acid results in decreased expression of MAST3 mRNA CTD PMID:17997037 NCBI chr19:18,097,764...18,151,692
Ensembl chr19:18,097,793...18,151,692
JBrowse link
G MMP9 matrix metallopeptidase 9 increases activity
multiple interactions
ISO Kainic Acid results in increased activity of MMP9 protein
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]
CTD PMID:30772382 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPDZ multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Kainic Acid CTD PMID:14960011 NCBI chr 9:13,105,296...13,279,692
Ensembl chr 9:13,105,704...13,279,590
JBrowse link
G MPEG1 macrophage expressed 1 increases expression ISO Kainic Acid results in increased expression of MPEG1 mRNA CTD PMID:17997037 NCBI chr11:59,208,510...59,212,927
Ensembl chr11:59,208,510...59,212,927
JBrowse link
G MSMO1 methylsterol monooxygenase 1 decreases expression ISO Kainic Acid results in decreased expression of MSMO1 mRNA CTD PMID:17997037 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164
JBrowse link
G MT1A metallothionein 1A increases expression ISO Kainic Acid results in increased expression of MT1A mRNA CTD PMID:7655348 NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
JBrowse link
G MT1X metallothionein 1X decreases response to substance ISO MT1 protein results in decreased susceptibility to Kainic Acid CTD PMID:10947810 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MT2A metallothionein 2A decreases response to substance ISO MT2 protein results in decreased susceptibility to Kainic Acid CTD PMID:10947810 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MYO5B myosin VB decreases expression ISO Kainic Acid results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:49,822,789...50,195,147
Ensembl chr18:49,822,789...50,195,147
JBrowse link
G MYO9A myosin IXA increases expression ISO Kainic Acid results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr15:71,822,291...72,118,577
Ensembl chr15:71,822,291...72,118,577
JBrowse link
G NAIP NLR family apoptosis inhibitory protein increases expression ISO Kainic Acid results in increased expression of NAIP mRNA; Kainic Acid results in increased expression of NAIP protein CTD PMID:12547647, PMID:15046874 NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,483...71,025,114
Ensembl chr 5:70,968,483...71,025,114
JBrowse link
G NCAM1 neural cell adhesion molecule 1 decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of NCAM1 mRNA
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]
CTD PMID:19700661, PMID:30772382 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,247...113,278,436
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization ISO Kainic Acid affects the localization of NFE2L2 protein CTD PMID:18619545 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions
decreases expression
increases expression
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]
Kainic Acid results in increased expression of NOS1 mRNA; Kainic Acid results in increased expression of NOS1 protein
CTD PMID:17585341, PMID:18375135 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Kainic Acid results in increased expression of NOS2 mRNA
Kainic Acid results in increased expression of NOS2 mRNA; Kainic Acid results in increased expression of NOS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
CTD PMID:17827730, PMID:18375135, PMID:21589914 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPY neuropeptide Y decreases response to substance
multiple interactions
increases expression
ISO NPY protein results in decreased susceptibility to Kainic Acid
Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]
CTD PMID:9427505, PMID:15451008 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 decreases expression
increases expression
ISO Kainic Acid results in decreased expression of NR4A1 mRNA
Kainic Acid results in increased expression of NR4A1 mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 increases expression ISO Kainic Acid results in increased expression of NR4A2 mRNA
Kainic Acid results in increased expression of NR4A2 protein
CTD PMID:19700661, PMID:24813937 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 increases expression ISO Kainic Acid results in increased expression of NR4A3 mRNA CTD PMID:19700661 NCBI chr 9:99,821,885...99,866,893
Ensembl chr 9:99,821,855...99,866,891
JBrowse link
G NRP2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Kainic Acid CTD PMID:18657176 NCBI chr 2:205,682,501...205,798,131
Ensembl chr 2:205,681,990...205,798,133
JBrowse link
G NTN1 netrin 1 increases expression ISO Kainic Acid results in increased expression of NTN1 mRNA CTD PMID:19700661 NCBI chr17:9,021,510...9,244,000
Ensembl chr17:9,021,510...9,244,000
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Kainic Acid results in increased expression of NTRK2 mRNA CTD PMID:19700661 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,070
JBrowse link
G NUDCD2 NudC domain containing 2 increases expression ISO Kainic Acid results in increased expression of NUDCD2 mRNA CTD PMID:17997037 NCBI chr 5:163,446,526...163,460,102
Ensembl chr 5:163,446,526...163,460,102
JBrowse link
G NUDT4 nudix hydrolase 4 increases expression ISO Kainic Acid results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr12:93,377,925...93,408,146
Ensembl chr12:93,377,883...93,408,146
JBrowse link
G OTX2 orthodenticle homeobox 2 decreases expression ISO Kainic Acid results in decreased expression of OTX2 mRNA CTD PMID:19700661 NCBI chr14:56,799,905...56,810,479
Ensembl chr14:56,799,905...56,816,693
JBrowse link
G PAK3 p21 (RAC1) activated kinase 3 decreases expression ISO Kainic Acid results in decreased expression of PAK3 mRNA CTD PMID:19700661 NCBI chr  X:110,944,324...111,227,361
Ensembl chr  X:110,944,285...111,227,361
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity ISO Kainic Acid results in increased activity of PARP1 protein CTD PMID:28704930 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PDYN prodynorphin multiple interactions
increases expression
ISO Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285
JBrowse link
G PENK proenkephalin multiple interactions
increases expression
ISO Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141, PMID:9427505 NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671
JBrowse link
G PICK1 protein interacting with PRKCA 1 decreases expression ISO Kainic Acid results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr22:38,056,311...38,075,704
Ensembl chr22:38,056,311...38,075,701
JBrowse link
G PKP2 plakophilin 2 decreases expression ISO Kainic Acid results in decreased expression of PKP2 mRNA CTD PMID:17997037 NCBI chr12:32,790,755...32,896,777
Ensembl chr12:32,790,745...32,896,840
Ensembl chr12:32,790,745...32,896,840
JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Kainic Acid results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr 7:101,205,984...101,217,581
Ensembl chr 7:101,205,977...101,218,420
JBrowse link
G PPIF peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Kainic Acid CTD PMID:21378209 NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334
JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B increases expression ISO Kainic Acid results in increased expression of PPP1R9B protein CTD PMID:17443789 NCBI chr17:50,133,737...50,150,677
Ensembl chr17:50,133,737...50,150,677
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases response to substance
increases expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein]
[PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]
Kainic Acid results in increased expression of PTGS2; Kainic Acid results in increased expression of PTGS2 mRNA; Kainic Acid results in increased expression of PTGS2 protein
CTD PMID:11168565, PMID:12618123, PMID:17827730, PMID:18834901, PMID:19700661, PMID:21589914, PMID:31430510 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G QKI QKI, KH domain containing RNA binding increases expression ISO Kainic Acid results in increased expression of QK mRNA CTD PMID:17997037 NCBI chr 6:163,414,486...163,578,592
Ensembl chr 6:163,414,000...163,578,592
JBrowse link
G RAC1 Rac family small GTPase 1 increases expression ISO Kainic Acid results in increased expression of RAC1 mRNA CTD PMID:19700661 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein increases expression ISO Kainic Acid results in increased expression of RAD23A mRNA CTD PMID:19700661 NCBI chr19:12,945,846...12,953,642
Ensembl chr19:12,945,855...12,953,642
JBrowse link
G RASD1 ras related dexamethasone induced 1 decreases expression ISO Kainic Acid results in decreased expression of RASD1 mRNA CTD PMID:17997037 NCBI chr17:17,494,437...17,496,395
Ensembl chr17:17,494,437...17,496,395
JBrowse link
G RBFOX1 RNA binding fox-1 homolog 1 increases response to substance ISO RBFOX1 gene mutant form results in increased susceptibility to Kainic Acid CTD PMID:21623373 NCBI chr16:5,239,752...7,713,343
Ensembl chr16:5,239,802...7,713,340
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA] CTD PMID:21589914 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REST RE1 silencing transcription factor increases expression
multiple interactions
ISO Kainic Acid results in increased expression of REST protein
Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
CTD PMID:21905079 NCBI chr 4:56,907,900...56,935,847
Ensembl chr 4:56,907,876...56,966,808
Ensembl chr 4:56,907,876...56,966,808
JBrowse link
G RGS16 regulator of G protein signaling 16 decreases expression ISO Kainic Acid results in decreased expression of RGS16 mRNA CTD PMID:17997037 NCBI chr 1:182,598,623...182,604,389
Ensembl chr 1:182,598,623...182,604,389
JBrowse link
G RHOA ras homolog family member A increases expression ISO Kainic Acid results in increased expression of RHOA mRNA CTD PMID:19700661 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 decreases expression ISO Kainic Acid results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 1:101,236,899...101,241,518
Ensembl chr 1:101,236,865...101,243,713
JBrowse link
G SAP30L SAP30 like decreases expression ISO Kainic Acid results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr 5:154,445,969...154,461,053
Ensembl chr 5:154,445,997...154,461,053
JBrowse link
G SEMA4D semaphorin 4D increases expression ISO Kainic Acid results in increased expression of SEMA4D mRNA CTD PMID:19700661 NCBI chr 9:89,360,787...89,498,113
Ensembl chr 9:89,360,787...89,498,130
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions
increases expression
ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SFPQ splicing factor proline and glutamine rich increases expression ISO Kainic Acid results in increased expression of SFPQ mRNA CTD PMID:17997037 NCBI chr 1:35,176,380...35,193,174
Ensembl chr 1:35,176,378...35,193,145
JBrowse link
G SIGMAR1 sigma non-opioid intracellular receptor 1 multiple interactions ISO SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] CTD PMID:15723099 NCBI chr 9:34,634,722...34,637,787
Ensembl chr 9:34,634,722...34,637,809
JBrowse link
G SIRT1 sirtuin 1 decreases expression
increases expression
ISO Kainic Acid results in decreased expression of SIRT1 protein
Kainic Acid results in increased expression of SIRT1 protein
CTD PMID:18538940 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC11A2 solute carrier family 11 member 2 increases expression ISO Kainic Acid results in increased expression of SLC11A2 CTD PMID:16552559 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566
JBrowse link
G SLC1A1 solute carrier family 1 member 1 decreases expression ISO Kainic Acid results in decreased expression of SLC1A1 mRNA CTD PMID:17997037 NCBI chr 9:4,490,466...4,587,469
Ensembl chr 9:4,490,468...4,587,469
JBrowse link
G SLC1A2 solute carrier family 1 member 2 multiple interactions
increases expression
ISO [Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein
Kainic Acid results in increased expression of SLC1A2 protein
Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
CTD PMID:19061913, PMID:28257918 NCBI chr11:35,251,205...35,420,058
Ensembl chr11:35,251,205...35,420,063
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Kainic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC6A2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Kainic Acid CTD PMID:15911120 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,604...55,706,192
JBrowse link
G SLC8A3 solute carrier family 8 member A3 multiple interactions
increases expression
increases cleavage
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]
Kainic Acid results in increased expression of SLC8A3 protein
CTD PMID:17585341, PMID:20928830 NCBI chr14:70,044,215...70,189,626
Ensembl chr14:70,044,217...70,189,070
Ensembl chr14:70,044,217...70,189,070
JBrowse link
G SNRK SNF related kinase decreases expression ISO Kainic Acid results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 3:43,286,512...43,351,143
Ensembl chr 3:43,286,512...43,424,764
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression ISO Kainic Acid results in decreased expression of SOD1 protein CTD PMID:29208536 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 decreases expression
increases expression
ISO Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in decreased expression of SOD2 mRNA; Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in increased expression of SOD2 protein
CTD PMID:10686417, PMID:29208536 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 increases expression ISO Kainic Acid results in increased expression of SPTAN1 protein modified form CTD PMID:22790971 NCBI chr 9:128,552,564...128,633,662
Ensembl chr 9:128,552,558...128,633,662
JBrowse link
G SST somatostatin decreases expression ISO Kainic Acid results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr 3:187,668,912...187,670,394
Ensembl chr 3:187,668,912...187,670,394
JBrowse link
G TAC1 tachykinin precursor 1 decreases expression ISO Kainic Acid results in decreased expression of TAC1 protein CTD PMID:6205719 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Kainic Acid results in increased uptake of Cobalt]
oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein]
Kainic Acid results in increased expression of TNF mRNA; Kainic Acid results in increased expression of TNF protein
CTD PMID:15869941, PMID:19700661, PMID:21589914, PMID:31430510 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 increases expression ISO Kainic Acid results in increased expression of TP53 protein CTD PMID:20955365 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRH thyrotropin releasing hormone decreases expression
increases expression
ISO Kainic Acid results in decreased expression of TRH mRNA
Kainic Acid results in increased expression of TRH mRNA
CTD PMID:10443546 NCBI chr 3:129,974,720...129,977,935
Ensembl chr 3:129,974,688...129,977,935
JBrowse link
G TRHR thyrotropin releasing hormone receptor decreases expression ISO Kainic Acid results in decreased expression of TRHR protein CTD PMID:10443546 NCBI chr 8:109,086,585...109,121,565
Ensembl chr 8:109,086,621...109,119,584
Ensembl chr 8:109,086,621...109,119,584
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP increases expression ISO Kainic Acid results in increased expression of TYROBP mRNA CTD PMID:17997037 NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295
JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 increases expression ISO Kainic Acid results in increased expression of UCHL1 protein CTD PMID:22790971 NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455
JBrowse link
G UHMK1 U2AF homology motif kinase 1 decreases expression ISO Kainic Acid results in decreased expression of UHMK1 mRNA CTD PMID:17997037 NCBI chr 1:162,497,174...162,529,631
Ensembl chr 1:162,497,251...162,529,631
JBrowse link
G URI1 URI1 prefoldin like chaperone increases expression ISO Kainic Acid results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr19:29,923,650...30,016,612
Ensembl chr19:29,923,644...30,016,612
JBrowse link
G UTP3 UTP3 small subunit processome component decreases expression ISO Kainic Acid results in decreased expression of UTP3 mRNA CTD PMID:17997037 NCBI chr 4:70,688,532...70,690,551
Ensembl chr 4:70,688,532...70,690,551
JBrowse link
G VAMP7 vesicle associated membrane protein 7 decreases expression ISO Kainic Acid results in decreased expression of VAMP7 mRNA CTD PMID:19700661 NCBI chr  X:155,881,318...155,943,769
NCBI chr  Y:57,067,838...57,130,289
Ensembl chr  X:155,881,345...155,943,769
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO Kainic Acid results in decreased expression of VEGFA mRNA CTD PMID:17997037 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein increases expression ISO Kainic Acid results in increased expression of WFS1 mRNA CTD PMID:17997037 NCBI chr 4:6,260,368...6,303,265
Ensembl chr 4:6,269,849...6,303,265
JBrowse link
G XPA XPA, DNA damage recognition and repair factor increases expression ISO Kainic Acid results in increased expression of XPA mRNA CTD PMID:19700661 NCBI chr 9:97,654,398...97,697,403
Ensembl chr 9:97,674,909...97,697,357
Ensembl chr 9:97,674,909...97,697,357
JBrowse link
G ZCCHC7 zinc finger CCHC-type containing 7 increases expression ISO Kainic Acid results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 9:37,120,166...37,358,149
Ensembl chr 9:37,120,574...37,358,149
Ensembl chr 9:37,120,574...37,358,149
JBrowse link
levamisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated multiple interactions
increases response to substance
decreases activity
EXP
ISO
Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]
ALPL gene mutant form results in increased susceptibility to Levamisole
Levamisole results in decreased activity of ALPL protein
[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA
CTD PMID:18500657, PMID:27466191 NCBI chr 1:21,508,984...21,578,412
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G ATG5 autophagy related 5 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein] CTD PMID:32151603 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G ATG7 autophagy related 7 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein] CTD PMID:32151603 NCBI chr 3:11,272,348...11,564,652
Ensembl chr 3:11,272,309...11,557,665
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP Levamisole results in increased expression of BAK1 protein CTD PMID:11139434 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Levamisole results in decreased expression of BCL2 protein CTD PMID:11139434 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein] CTD PMID:32151603 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G CLDN1 claudin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
JBrowse link
G CLU clusterin decreases expression EXP Levamisole results in decreased expression of CLU mRNA CTD PMID:11139434 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G DCC DCC netrin 1 receptor multiple interactions EXP DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] CTD PMID:15148649 NCBI chr18:52,340,172...53,535,899
Ensembl chr18:52,340,197...53,535,903
JBrowse link
G EDN1 endothelin 1 decreases expression EXP Levamisole results in decreased expression of EDN1 mRNA CTD PMID:11139434 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions EXP Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA] CTD PMID:18500657 NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA CTD PMID:27466191 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXP3 forkhead box P3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein] CTD PMID:32151603 NCBI chr  X:49,250,436...49,264,932
Ensembl chr  X:49,250,438...49,270,477
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G GATA3 GATA binding protein 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein] CTD PMID:32151603 NCBI chr10:8,045,420...8,075,198
Ensembl chr10:8,045,378...8,075,198
JBrowse link
G IFNG interferon gamma multiple interactions
increases expression
ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]
Levamisole results in increased expression of IFNG mRNA; Levamisole results in increased expression of IFNG protein
CTD PMID:10886398, PMID:23395935, PMID:32151603 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL15 interleukin 15 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987
JBrowse link
G IL17A interleukin 17A multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein] CTD PMID:32151603 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein] CTD PMID:32151603 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein] CTD PMID:23395935, PMID:32151603 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL21 interleukin 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066
JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein] CTD PMID:23395935, PMID:32151603 NCBI chr12:56,334,159...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression
ISO Levamisole inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Levamisole results in decreased expression of IL4 mRNA
CTD PMID:10886398, PMID:32151603 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein] CTD PMID:23395935 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP Levamisole results in decreased expression of NOS3 protein CTD PMID:11139434 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G PHEX phosphate regulating endopeptidase homolog X-linked multiple interactions EXP Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:22,032,325...22,251,310
Ensembl chr  X:22,032,325...22,251,310
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15047127 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Levamisole inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] CTD PMID:15047127 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RORC RAR related orphan receptor C multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of RORC protein] CTD PMID:32151603 NCBI chr 1:151,806,071...151,832,451
Ensembl chr 1:151,806,071...151,831,845
JBrowse link
G TBX21 T-box transcription factor 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TBX21 protein] CTD PMID:32151603 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
JBrowse link
G TGFB3 transforming growth factor beta 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TGFB3 protein] CTD PMID:32151603 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
G TJP1 tight junction protein 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein] CTD PMID:32151603 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,865
JBrowse link
G TLR2 toll like receptor 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR2 mRNA] CTD PMID:32151603 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR6 toll like receptor 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR6 mRNA] CTD PMID:32151603 NCBI chr 4:38,823,680...38,857,767
Ensembl chr 4:38,823,715...38,856,817
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Levamisole results in decreased expression of TNF protein CTD PMID:17397355 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 decreases expression EXP Levamisole results in decreased expression of TP53 mRNA; Levamisole results in decreased expression of TP53 protein CTD PMID:11139434 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
mebendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression EXP Mebendazole results in decreased expression of ABCB1 mRNA; Mebendazole results in decreased expression of ABCB1 protein CTD PMID:28606429 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases expression EXP Mebendazole results in decreased expression of ABCC1 mRNA CTD PMID:28606429 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G AGER advanced glycosylation end-product specific receptor increases expression EXP Mebendazole results in increased expression of AGER mRNA CTD PMID:24747151 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 decreases expression EXP Mebendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 1:155,946,851...155,991,262
Ensembl chr 1:155,946,851...156,007,070
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein] CTD PMID:18667591 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator affects response to substance
increases phosphorylation
multiple interactions
EXP BCL2 protein affects the susceptibility to Mebendazole
Mebendazole results in increased phosphorylation of BCL2 protein
[Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]
CTD PMID:18667591 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Mebendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CDH1 cadherin 1 multiple interactions EXP Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 multiple interactions EXP Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
increases secretion
multiple interactions
EXP Mebendazole results in increased expression of CXCL8 mRNA; Mebendazole results in increased expression of CXCL8 protein
Mebendazole results in increased secretion of CXCL8 protein
U 0126 inhibits the reaction [Mebendazole results in increased secretion of CXCL8 protein]
CTD PMID:20116850, PMID:20848085, PMID:24747151 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP
ISO
Mebendazole results in increased expression of CYP1A1 mRNA; Mebendazole results in increased expression of CYP1A1 protein CTD PMID:9860486, PMID:12841937 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP
ISO
Mebendazole results in increased expression of CYP1A2 protein CTD PMID:12841937 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mebendazole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Mebendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HES1 hes family bHLH transcription factor 1 decreases expression EXP Mebendazole results in decreased expression of HES1 protein CTD PMID:32277947 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
JBrowse link
G IL6R interleukin 6 receptor increases expression EXP Mebendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Mebendazole results in increased phosphorylation of MAPK1 protein CTD PMID:20848085 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Mebendazole results in increased phosphorylation of MAPK3 protein CTD PMID:20848085 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Mebendazole results in increased phosphorylation of MAPK8 protein CTD PMID:20848085 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Mebendazole results in increased phosphorylation of MAPK9 protein CTD PMID:20848085 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MAPT microtubule associated protein tau decreases expression EXP Mebendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Mebendazole results in decreased expression of MYC mRNA; Mebendazole results in decreased expression of MYC protein CTD PMID:31207347, PMID:32277947 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression EXP Mebendazole results in increased expression of NLRP3 mRNA CTD PMID:24747151 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOTCH1 notch receptor 1 decreases expression EXP Mebendazole results in decreased expression of NOTCH1 protein CTD PMID:32277947 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PTK2 protein tyrosine kinase 2 decreases expression EXP Mebendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G RAC1 Rac family small GTPase 1 decreases expression EXP Mebendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RHOA ras homolog family member A decreases expression EXP Mebendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G S100A8 S100 calcium binding protein A8 increases expression EXP Mebendazole results in increased expression of S100A8 mRNA CTD PMID:24747151 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
JBrowse link
G S100A9 S100 calcium binding protein A9 increases expression EXP Mebendazole results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases expression EXP Mebendazole results in decreased expression of SLC47A1 mRNA CTD PMID:28606429 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP Mebendazole binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
increases secretion
EXP U 0126 inhibits the reaction [Mebendazole results in increased secretion of TNF protein]
Mebendazole results in increased expression of TNF mRNA
CTD PMID:20848085, PMID:24747151 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP Mebendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
oxamyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity ISO
EXP
oxamyl results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949, PMID:27132127 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G PGR progesterone receptor multiple interactions EXP oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PON1 paraoxonase 1 multiple interactions EXP
ISO
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl
[Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl
CTD PMID:27132127 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
oxfendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) affects transport
decreases activity
multiple interactions
EXP
ISO
ABCG2 protein affects the transport of oxfendazole
oxfendazole results in decreased activity of ABCG2 protein
oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]
CTD PMID:15703302 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G CASP3 caspase 3 increases cleavage ISO oxfendazole results in increased cleavage of CASP3 protein CTD PMID:26558467 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO oxfendazole results in increased expression of CDKN1A protein CTD PMID:26558467 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CHEK1 checkpoint kinase 1 affects expression ISO oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 NCBI chr11:125,624,910...125,676,256
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 protein; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GPX2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,905
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 multiple interactions ISO [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GSTM1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTM1 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 decreases expression ISO oxfendazole results in decreased expression of MAD2L1 mRNA CTD PMID:26558467 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
JBrowse link
G MDM2 MDM2 proto-oncogene decreases phosphorylation
increases expression
ISO oxfendazole results in decreased phosphorylation of MDM2 protein
oxfendazole results in increased expression of MDM2 mRNA
CTD PMID:26558467 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G ME1 malic enzyme 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression ISO oxfendazole results in decreased expression of MKI67 protein CTD PMID:26558467 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of NQO1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G TOP2A DNA topoisomerase II alpha decreases expression ISO oxfendazole results in decreased expression of TOP2A protein CTD PMID:26558467 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TP53 tumor protein p53 decreases expression ISO oxfendazole results in decreased expression of TP53 mRNA CTD PMID:26558467 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
pyrantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 affects metabolic processing EXP CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP Pyrantel results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
Sudan I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB5A cytochrome b5 type A multiple interactions ISO
EXP
CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775, PMID:19358889 NCBI chr18:74,250,846...74,291,980
Ensembl chr18:74,250,846...74,291,973
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
increases oxidation
EXP
ISO
CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
1-phenylazo-2-naphthol results in increased expression of CYP1A1 mRNA; 1-phenylazo-2-naphthol results in increased expression of CYP1A1 protein
1-phenylazo-2-naphthol promotes the reaction [aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein]; 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of CYP1A1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
CTD PMID:12384524, PMID:15766589, PMID:17159775, PMID:18418879, PMID:23289503, PMID:24530354, PMID:26845733 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases expression
increases oxidation
EXP
ISO
CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]
1-phenylazo-2-naphthol results in increased expression of CYP1A2 mRNA
1-phenylazo-2-naphthol affects the expression of and affects the activity of CYP1A2 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A2 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:17159775, PMID:26845733 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases oxidation EXP CYP1B1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
increases oxidation
EXP CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases oxidation
multiple interactions
EXP CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
increases oxidation
EXP CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases oxidation EXP CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases oxidation EXP CYP2C9 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions
increases oxidation
EXP CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases oxidation EXP CYP2E1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases oxidation
multiple interactions
EXP CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775, PMID:19358889 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP 1-phenylazo-2-naphthol results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO 1-phenylazo-2-naphthol results in increased expression of GSTP1 mRNA CTD PMID:2563599 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of NQO1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of NQO1 protein
1-phenylazo-2-naphthol results in increased expression of NQO1 mRNA
CTD PMID:23289503, PMID:26845733 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol CTD PMID:24530354 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
Sudan III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor affects localization
multiple interactions
EXP
ISO
sudan III affects the localization of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
CTD PMID:15585952, PMID:15788368, PMID:22287322 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions EXP [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:22287322 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
increases activity
multiple interactions
EXP
ISO
sudan III results in increased expression of CYP1A1 mRNA
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
sudan III results in increased activity of CYP1A1 protein
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]
CTD PMID:18418879, PMID:20308224, PMID:22287322 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO sudan III results in increased expression of CYP1A2 protein CTD PMID:20308224 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 decreases expression ISO sudan III results in decreased expression of CYP4A1 mRNA CTD PMID:15585952 NCBI chr 1:47,137,441...47,149,738
Ensembl chr 1:47,137,435...47,149,735
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO sudan III results in increased expression of NQO1 mRNA CTD PMID:20308224 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] CTD PMID:22287322 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
EXP
ISO
sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]
CTD PMID:15585952, PMID:15788368 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP sudan III results in decreased expression of RXRA protein CTD PMID:15585952 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
Sudan IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein CTD PMID:18418879 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
suramin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCA calcitonin related polypeptide alpha multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]] CTD PMID:12044622 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP1 caspase 1 multiple interactions ISO Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein] CTD PMID:21832250 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]; Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3] CTD PMID:19448140 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit increases expression ISO Suramin results in increased expression of CHRNA7 protein CTD PMID:23516405 NCBI chr15:32,030,462...32,173,018
Ensembl chr15:31,923,438...32,173,018
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein] CTD PMID:18612546 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP Suramin results in decreased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP Suramin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP Suramin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein] CTD PMID:9710602 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G FGF2 fibroblast growth factor 2 increases expression EXP Suramin results in increased expression of FGF2 CTD PMID:8394679 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FGF5 fibroblast growth factor 5 increases expression EXP Suramin results in increased expression of FGF5 CTD PMID:8394679 NCBI chr 4:80,266,588...80,291,017
Ensembl chr 4:80,266,599...80,336,680
JBrowse link
G FGF7 fibroblast growth factor 7 affects localization
multiple interactions
EXP Suramin affects the localization of FGF7 protein
Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]
CTD PMID:15733146 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775
Ensembl chr15:49,423,237...49,488,775
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 multiple interactions EXP Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein] CTD PMID:15733146 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,334...121,598,458
Ensembl chr10:121,478,334...121,598,458
JBrowse link
G FMR1 FMRP translational regulator 1 multiple interactions ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,951...147,951,125
Ensembl chr  X:147,911,951...147,951,125
JBrowse link
G HPGDS hematopoietic prostaglandin D synthase decreases activity EXP Suramin results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:94,298,535...94,342,876
Ensembl chr 4:94,298,535...94,342,876
JBrowse link
G IL10 interleukin 10 multiple interactions
decreases activity
EXP Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of IL10 protein]
Suramin results in decreased activity of IL10 protein
CTD PMID:15914193 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B increases expression EXP Suramin results in increased expression of IL12B protein CTD PMID:15914193 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO
Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]; Suramin inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]
Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:24793913, PMID:24849676 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LMNA lamin A/C multiple interactions EXP Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] CTD PMID:23217256 NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,573...156,140,089
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Suramin inhibits the reaction [2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]
CTD PMID:8758915, PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G P2RX3 purinergic receptor P2X 3 multiple interactions ISO Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein] CTD PMID:23666265 NCBI chr11:57,335,943...57,372,399
Ensembl chr11:57,338,352...57,372,396
JBrowse link
G P2RX7 purinergic receptor P2X 7 multiple interactions ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein] CTD PMID:23516405 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G P2RY2 purinergic receptor P2Y2 decreases activity
multiple interactions
ISO Suramin results in decreased activity of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
CTD PMID:15654852, PMID:23516405 NCBI chr11:73,200,416...73,246,743
Ensembl chr11:73,218,281...73,242,427
Ensembl chr11:73,218,281...73,242,427
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] CTD PMID:18612546 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G SHC1 SHC adaptor protein 1 multiple interactions
increases expression
ISO
EXP
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]
Suramin results in increased expression of SHC1 mRNA; Suramin results in increased expression of SHC1 protein
CTD PMID:9710602, PMID:21778425 NCBI chr 1:154,962,298...154,974,492
Ensembl chr 1:154,962,298...154,974,395
JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP
ISO
Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]; Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein]
[Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol
CTD PMID:18482975, PMID:23217256, PMID:24252177 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G TACR1 tachykinin receptor 1 multiple interactions ISO Suramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:23666265 NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
JBrowse link
G TNF tumor necrosis factor increases expression EXP Suramin results in increased expression of TNF protein CTD PMID:15914193 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:18482975 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G VDR vitamin D receptor multiple interactions EXP Suramin inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
thiabendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin decreases expression ISO Thiabendazole results in decreased expression of ALB mRNA CTD PMID:18539377 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G CASP3 caspase 3 increases activity ISO Thiabendazole results in increased activity of CASP3 protein CTD PMID:26748015 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity ISO Thiabendazole results in increased activity of CASP8 protein CTD PMID:26748015 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity ISO Thiabendazole results in increased activity of CASP9 protein CTD PMID:26748015 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CHMP5 charged multivesicular body protein 5 affects expression ISO Thiabendazole affects the expression of CHMP5 mRNA CTD PMID:18539377 NCBI chr 9:33,265,049...33,282,070
Ensembl chr 9:33,264,879...33,282,070
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
increases activity
ISO
EXP
herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
Thiabendazole results in increased expression of CYP1A1 mRNA; Thiabendazole results in increased expression of CYP1A1 protein
CTD PMID:8900397, PMID:10103034, PMID:11226373, PMID:14987951, PMID:15110098 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases expression
affects metabolic processing
decreases activity
EXP
ISO
beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole]
Thiabendazole results in increased expression of CYP1A2 mRNA; Thiabendazole results in increased expression of CYP1A2 protein
Thiabendazole results in decreased activity of CYP1A2 protein
CTD PMID:10936227, PMID:11124226, PMID:12920490, PMID:15110098, PMID:16261361, PMID:18539377, PMID:18570159 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP Thiabendazole results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Thiabendazole results in decreased activity of CYP2C9 protein CTD PMID:11124226 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP Thiabendazole results in increased expression of CYP3A4 mRNA CTD PMID:18570159 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression ISO Thiabendazole results in increased expression of GADD45A mRNA CTD PMID:18539377 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases activity
multiple interactions
ISO Thiabendazole results in increased activity of GCLC protein
[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein
CTD PMID:11019651 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO Thiabendazole results in increased expression of GSTP1 mRNA CTD PMID:15110098 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT1 glutathione S-transferase theta 1 increases expression ISO Thiabendazole results in increased expression of GSTT1 mRNA CTD PMID:15110098
G MPO myeloperoxidase increases metabolic processing EXP MPO protein results in increased metabolism of Thiabendazole metabolite CTD PMID:21513789 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NPPB natriuretic peptide B increases expression ISO Thiabendazole results in increased expression of NPPB mRNA CTD PMID:18539377 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Thiabendazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G OXCT1 3-oxoacid CoA-transferase 1 affects expression ISO Thiabendazole affects the expression of OXCT1 mRNA CTD PMID:18539377 NCBI chr 5:41,730,065...41,870,535
Ensembl chr 5:41,730,065...41,870,425
JBrowse link
G PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression ISO Thiabendazole results in increased expression of PFKFB1 mRNA CTD PMID:18539377 NCBI chr  X:54,932,961...55,000,052
Ensembl chr  X:54,932,961...54,998,534
JBrowse link
G PRKCB protein kinase C beta increases expression ISO Thiabendazole results in increased expression of PRKCB mRNA CTD PMID:18539377 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G TAF9B TATA-box binding protein associated factor 9b affects expression ISO Thiabendazole affects the expression of TAF9B mRNA CTD PMID:18539377 NCBI chr  X:78,129,748...78,139,650
Ensembl chr  X:78,129,748...78,139,650
JBrowse link
G TP53 tumor protein p53 increases expression ISO Thiabendazole results in increased expression of TP53 mRNA CTD PMID:18539377 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIM3 tripartite motif containing 3 increases expression ISO Thiabendazole results in increased expression of TRIM3 mRNA CTD PMID:18539377 NCBI chr11:6,448,613...6,474,459
Ensembl chr11:6,448,613...6,474,459
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression ISO Thiabendazole results in increased expression of UGDH mRNA CTD PMID:18539377 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
G UTRN utrophin increases expression EXP Thiabendazole results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 6:144,284,955...144,853,034
Ensembl chr 6:144,285,701...144,853,034
JBrowse link
tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI1 GLI family zinc finger 1 multiple interactions EXP
ISO
Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr12:57,459,785...57,472,451
Ensembl chr12:57,459,785...57,472,268
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression
decreases secretion
EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533, PMID:15284827 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 multiple interactions
decreases secretion
decreases expression
EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533, PMID:15284827 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G SHH sonic hedgehog signaling molecule multiple interactions EXP
ISO
Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24161
    role 24056
      application 23470
        pesticide 18147
          nematicide 3715
            antinematodal drug 462
              2-naphthol + 33
              amocarzine 0
              ascaridole 2
              carbendazim 52
              closantel 8
              coumaphos 5
              emodepside 0
              eprinomectin 3
              ethoprophos 2
              fenbendazole + 37
              flubendazole 7
              ivermectin 113
              kainic acid + 198
              levamisole + 36
              mebendazole 35
              methyl nonanoate 0
              oxamyl 5
              oxfendazole 18
              piperazine adipate 0
              pyrantel 2
              schaftoside 0
              suramin 31
              tetramisole 0
              thiabendazole 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 24161
    role 24056
      application 23470
        pharmaceutical 22970
          drug 22970
            antiinfective agent 14317
              antiparasitic agent 6561
                anthelminthic drug 907
                  antinematodal drug 462
                    2-naphthol + 33
                    amocarzine 0
                    ascaridole 2
                    carbendazim 52
                    closantel 8
                    coumaphos 5
                    emodepside 0
                    eprinomectin 3
                    ethoprophos 2
                    fenbendazole + 37
                    flubendazole 7
                    ivermectin 113
                    kainic acid + 198
                    levamisole + 36
                    mebendazole 35
                    methyl nonanoate 0
                    oxamyl 5
                    oxfendazole 18
                    piperazine adipate 0
                    pyrantel 2
                    schaftoside 0
                    suramin 31
                    tetramisole 0
                    thiabendazole 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.