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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antinematodal drug
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Accession:CHEBI:35444 term browser browse the term
Definition:A substance used in the treatment or control of nematode infestations.
Synonyms:related_synonym: antinematodal agent;   antinematodal drugs;   antinematodals


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emodepside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance EXP ABCB1 protein affects the susceptibility to emodepside CTD PMID:25660379 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects abundance
increases response to substance
multiple interactions
EXP ABCB1 protein affects the abundance of Ivermectin
ABCB1 gene mutant form results in increased susceptibility to Ivermectin; ABCB1 mutant form results in increased susceptibility to Ivermectin; ABCB1 protein mutant form results in increased susceptibility to Ivermectin
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]
CTD PMID:20595473, PMID:22834856, PMID:22924731, PMID:23186803, PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238
JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022
JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343
JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376
JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034
JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993
JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      application 195
        pesticide 60
          nematicide 13
            antinematodal drug 11
              2-naphthol + 0
              amocarzine 0
              ascaridole 0
              carbendazim 0
              closantel 0
              coumaphos 0
              emodepside 1
              eprinomectin 0
              ethoprophos 0
              fenbendazole + 0
              flubendazole 0
              ivermectin 11
              kainic acid + 0
              levamisole + 0
              mebendazole 0
              methyl nonanoate 0
              oxamyl 0
              oxfendazole 0
              piperazine adipate 0
              pyrantel 0
              schaftoside 0
              suramin 0
              tetramisole 0
              thiabendazole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      application 195
        pharmaceutical 192
          drug 192
            antiinfective agent 78
              antiparasitic agent 20
                anthelminthic drug 13
                  antinematodal drug 11
                    2-naphthol + 0
                    amocarzine 0
                    ascaridole 0
                    carbendazim 0
                    closantel 0
                    coumaphos 0
                    emodepside 1
                    eprinomectin 0
                    ethoprophos 0
                    fenbendazole + 0
                    flubendazole 0
                    ivermectin 11
                    kainic acid + 0
                    levamisole + 0
                    mebendazole 0
                    methyl nonanoate 0
                    oxamyl 0
                    oxfendazole 0
                    piperazine adipate 0
                    pyrantel 0
                    schaftoside 0
                    suramin 0
                    tetramisole 0
                    thiabendazole 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.