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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antiparasitic agent
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Accession:CHEBI:35442 term browser browse the term
Definition:A substance used to treat or prevent parasitic infections.
Synonyms:related_synonym: antiparasitic drugs;   antiparasitics;   parasiticides
 xref: Wikipedia:Antiparasitic



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amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 increases expression
multiple interactions
EXP Amphotericin B results in increased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions
increases expression
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:129,520,397...129,636,207
Ensembl chr 6:129,519,962...129,635,517
JBrowse link
chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSP70 protein] CTD PMID:17727805 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G IFIT5 interferon induced protein with tetratricopeptide repeats 5 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA] CTD PMID:27079946 NCBI chr14:101,254,818...101,266,105
Ensembl chr14:101,254,768...101,267,654
JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,147,247...64,158,952
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:371,606...375,381
JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]
CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of ACHE protein CTD PMID:21467751 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP Dichlorvos results in decreased activity of APEH protein CTD PMID:10953051 NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,523
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr13:104,946,732...105,007,568 JBrowse link
dihydroartemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression EXP artenimol results in increased expression of ATF4 mRNA; artenimol results in increased expression of ATF4 protein CTD PMID:32721431 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP artenimol results in increased expression of BAX mRNA CTD PMID:29309768 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G CASP3 caspase 3 increases expression EXP artenimol results in increased expression of CASP3 mRNA CTD PMID:29309768 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression EXP artenimol results in increased expression of EIF2AK3 protein modified form CTD PMID:32721431 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases expression EXP artenimol results in increased expression of EIF2S1 protein modified form CTD PMID:32721431 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,829
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP artenimol results in increased expression of HSPA5 mRNA CTD PMID:32721431 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP artenimol results in decreased phosphorylation of MAPK1 protein CTD PMID:29309768 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP artenimol results in decreased phosphorylation of MAPK3 protein CTD PMID:29309768 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Doxycycline
Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
fenbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 affects expression EXP Fenbendazole affects the expression of ABCB1 mRNA CTD PMID:26366864 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects expression EXP Fenbendazole affects the expression of CYP1A2 mRNA CTD PMID:26366864 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects expression EXP Fenbendazole affects the expression of CYP2E1 mRNA CTD PMID:26366864 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 affects expression EXP Fenbendazole affects the expression of CYP3A22 mRNA CTD PMID:26366864 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817
JBrowse link
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 affects expression EXP Fenbendazole affects the expression of CYP3A29 mRNA CTD PMID:26366864 NCBI chr 3:6,738,502...6,778,121 JBrowse link
G LOC110262013 sulfotransferase 1 family member D1 affects expression EXP Fenbendazole affects the expression of SULT1A1 mRNA CTD PMID:26366864 NCBI chr 8:66,762,885...66,789,582 JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 decreases expression EXP Ivermectin results in decreased expression of CCND1 mRNA CTD PMID:31400776 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Ivermectin results in decreased expression of CCNE1 mRNA CTD PMID:31400776 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,366
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein] CTD PMID:31400776 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein] CTD PMID:31400776 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein] CTD PMID:31400776 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein] CTD PMID:31400776 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP Ivermectin results in decreased expression of PCNA mRNA; Ivermectin results in decreased expression of PCNA protein CTD PMID:31400776 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP Wortmannin promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6 protein] CTD PMID:31400776 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein] CTD PMID:31400776 NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,076...83,950,984
JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B increases expression EXP Rifampin results in increased expression of CYP2B6B mRNA CTD PMID:19464568 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
tetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Tetracycline
Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 1018
    role 958
      application 795
        pharmaceutical 638
          drug 638
            antiinfective agent 162
              antiparasitic agent 40
                (-)-anisomycin 0
                4-terpineol + 0
                E64 0
                ELQ-271 0
                GNF5343 0
                acaricide drug + 0
                annomontine 0
                anthelminthic drug + 17
                antiamoebic agent + 3
                antiplasmodial drug + 23
                antiprotozoal drug + 31
                aureothin 0
                costunolide + 0
                cycloguanil + 0
                diaveridine 0
                dimetridazole 0
                diminazene 0
                diminazene diaceturate 0
                diminazene(2+) + 0
                ectoparasiticide + 0
                eprinomectin 0
                geneticin 0
                leflunomide 0
                metronidazole + 0
                metronidazole benzoate 0
                metronidazole hydrochloride 0
                niclosamide 0
                paromomycin + 0
                paromomycin sulfate 0
                ronidazole 0
                tinidazole 0
paths to the root