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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cephalotaxine
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Accession:CHEBI:3540 term browser browse the term
Definition:A benzazepine alkaloid isolated from Cephalotaxus harringtonia.
Synonyms:related_synonym: (1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol;   Formula=C18H21NO4;   InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1;   InChIKey=YMNCVRSYJBNGLD-KURKYZTESA-N;   SMILES=[H][C@@]12[C@H](O)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21
 xref: CAS:24316-19-6;   KEGG:C10580;   KNApSAcK:C00002324;   KNApSAcK:C00027319;   Reaxys:628324



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omacetaxine mepesuccinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 increases expression ISO Homoharringtonine results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:15,762,462...15,891,041
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of AKT1 protein CTD PMID:31726078 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Homoharringtonine results in increased expression of BAD protein CTD PMID:31726078 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression ISO Homoharringtonine results in decreased expression of BAK1 mRNA CTD PMID:32431164 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Homoharringtonine results in increased expression of BAX protein CTD PMID:31726078 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Homoharringtonine results in increased expression of BBC3 mRNA CTD PMID:32431164 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Homoharringtonine results in decreased expression of BCL2 mRNA; Homoharringtonine results in decreased expression of BCL2 protein CTD PMID:23980369 PMID:31726078 PMID:32431164 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO Homoharringtonine results in increased expression of CASP3 protein
Homoharringtonine results in increased cleavage of CASP3 protein
CTD PMID:23980369 PMID:31726078 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases cleavage ISO Homoharringtonine results in increased cleavage of CASP7 protein CTD PMID:31726078 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
ISO Homoharringtonine results in increased expression of CASP9 protein
Homoharringtonine results in increased cleavage of CASP9 protein
CTD PMID:23980369 PMID:31726078 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Homoharringtonine results in decreased expression of CCNA2 protein CTD PMID:31726078 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Homoharringtonine results in decreased expression of CCNB1 protein CTD PMID:31726078 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Homoharringtonine results in increased expression of CCNE1 protein CTD PMID:31726078 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd34 CD34 molecule multiple interactions
decreases expression
ISO Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA] CTD PMID:31307525 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions
ISO Homoharringtonine results in increased expression of CD38 mRNA
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA
CTD PMID:31307525 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd96 CD96 molecule multiple interactions ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA CTD PMID:31307525 NCBI chr11:68,164,926...68,239,266
Ensembl chr11:54,702,290...54,776,621
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Homoharringtonine results in increased expression of CDK1 protein CTD PMID:31726078 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Homoharringtonine results in increased expression of CDK2 protein CTD PMID:31726078 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Homoharringtonine results in increased expression of CDKN1A mRNA CTD PMID:32431164 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
increases phosphorylation
ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein] CTD PMID:31307525 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO Homoharringtonine results in increased expression of CYP2C19 mRNA CTD PMID:32431164 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Homoharringtonine results in increased expression of CYP2E1 mRNA CTD PMID:32431164 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Homoharringtonine results in increased expression of EIF2AK3 mRNA CTD PMID:32431164 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ephb4 EPH receptor B4 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein] CTD PMID:31726078 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Homoharringtonine results in increased expression of ERN1 mRNA CTD PMID:32431164 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Id4 inhibitor of DNA binding 4 increases expression ISO Homoharringtonine results in increased expression of ID4 mRNA CTD PMID:32431164 NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,389,387...16,392,470
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK1 protein CTD PMID:31726078 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK3 protein CTD PMID:31726078 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Homoharringtonine results in decreased expression of MCL1 protein CTD PMID:23980369 PMID:31726078 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Homoharringtonine results in decreased expression of MKI67 protein CTD PMID:31726078 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MTOR protein CTD PMID:31726078 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Homoharringtonine results in increased expression of NFKB1 mRNA CTD PMID:32431164 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions
increases expression
ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein] CTD PMID:31307525 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Notch1 notch receptor 1 multiple interactions
increases expression
ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein] CTD PMID:31307525 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Notch2 notch receptor 2 multiple interactions ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein CTD PMID:31307525 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Homoharringtonine results in decreased expression of PIK3CA protein CTD PMID:31726078 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein] CTD PMID:31307525 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression
multiple interactions
ISO Homoharringtonine results in increased expression of RELB protein
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein]
CTD PMID:31307525 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Homoharringtonine results in increased expression of TNF mRNA CTD PMID:32431164 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein] CTD PMID:31307525 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression ISO Homoharringtonine results in increased expression of TRAF2 mRNA CTD PMID:32431164 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Tyr tyrosinase increases expression ISO Homoharringtonine results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        biochemical role 19579
          metabolite 19566
            alkaloid 8035
              benzazepine alkaloid 60
                cephalotaxine 43
                  omacetaxine mepesuccinate 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organic heteropolycyclic compound 18322
                                    organic heterobicyclic compound 17272
                                      benzazepine 544
                                        benzazepine alkaloid 60
                                          cephalotaxine 43
                                            omacetaxine mepesuccinate 43
paths to the root