CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cephalotaxine
Accession: CHEBI:3540
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Definition: A benzazepine alkaloid isolated from Cephalotaxus harringtonia.
Synonyms: related_synonym: (1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol; Formula=C18H21NO4; InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1; InChIKey=YMNCVRSYJBNGLD-KURKYZTESA-N; SMILES=[H][C@@]12[C@H](O)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21
xref: CAS:24316-19-6; KEGG:C10580; KNApSAcK:C00002324; KNApSAcK:C00027319; Reaxys:628324
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Ahi1
Abelson helper integration site 1
increases expression
ISO
Homoharringtonine results in increased expression of AHI1 protein alternative form
CTD
PMID:19379585
NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:15,762,462...15,891,041
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of AKT1 protein
CTD
PMID:31726078
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
Homoharringtonine results in increased expression of BAD protein
CTD
PMID:31726078
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
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Bak1
BCL2-antagonist/killer 1
decreases expression
ISO
Homoharringtonine results in decreased expression of BAK1 mRNA
CTD
PMID:32431164
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Homoharringtonine results in increased expression of BAX protein
CTD
PMID:31726078
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
Homoharringtonine results in increased expression of BBC3 mRNA
CTD
PMID:32431164
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Homoharringtonine results in decreased expression of BCL2 mRNA; Homoharringtonine results in decreased expression of BCL2 protein
CTD
PMID:23980369 PMID:31726078 PMID:32431164
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP3 protein Homoharringtonine results in increased cleavage of CASP3 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases cleavage
ISO
Homoharringtonine results in increased cleavage of CASP7 protein
CTD
PMID:31726078
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP9 protein Homoharringtonine results in increased cleavage of CASP9 protein
CTD
PMID:23980369 PMID:31726078
Ensembl chr 5:154,109,046...154,126,626
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Ccna2
cyclin A2
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNA2 protein
CTD
PMID:31726078
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNB1 protein
CTD
PMID:31726078
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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Ccne1
cyclin E1
increases expression
ISO
Homoharringtonine results in increased expression of CCNE1 protein
CTD
PMID:31726078
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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Cd34
CD34 molecule
multiple interactions decreases expression
ISO
Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA]
CTD
PMID:31307525
NCBI chr13:109,008,786...109,029,317
Ensembl chr13:106,480,043...106,499,832
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Cd38
CD38 molecule
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of CD38 mRNA [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA
CTD
PMID:31307525
NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986
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Cd96
CD96 molecule
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA
CTD
PMID:31307525
NCBI chr11:68,164,926...68,239,266
Ensembl chr11:54,702,290...54,776,621
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Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Homoharringtonine results in increased expression of CDK1 protein
CTD
PMID:31726078
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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Cdk2
cyclin dependent kinase 2
increases expression
ISO
Homoharringtonine results in increased expression of CDK2 protein
CTD
PMID:31726078
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Homoharringtonine results in increased expression of CDKN1A mRNA
CTD
PMID:32431164
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions increases phosphorylation
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]
CTD
PMID:31307525
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression
ISO
Homoharringtonine results in increased expression of CYP2C19 mRNA
CTD
PMID:32431164
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
Homoharringtonine results in increased expression of CYP2E1 mRNA
CTD
PMID:32431164
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression
ISO
Homoharringtonine results in increased expression of EIF2AK3 mRNA
CTD
PMID:32431164
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
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Ephb4
EPH receptor B4
multiple interactions decreases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein]
CTD
PMID:31726078
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
Homoharringtonine results in increased expression of ERN1 mRNA
CTD
PMID:32431164
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
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Id4
inhibitor of DNA binding 4
increases expression
ISO
Homoharringtonine results in increased expression of ID4 mRNA
CTD
PMID:32431164
NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,389,387...16,392,470
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:31726078
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:31726078
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Homoharringtonine results in decreased expression of MCL1 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Homoharringtonine results in decreased expression of MKI67 protein
CTD
PMID:31726078
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MTOR protein
CTD
PMID:31726078
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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Nfkb1
nuclear factor kappa B subunit 1
increases expression
ISO
Homoharringtonine results in increased expression of NFKB1 mRNA
CTD
PMID:32431164
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Nfkb2
nuclear factor kappa B subunit 2
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein]
CTD
PMID:31307525
NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
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Notch1
notch receptor 1
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein]
CTD
PMID:31307525
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
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Notch2
notch receptor 2
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein
CTD
PMID:31307525
NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
decreases expression
ISO
Homoharringtonine results in decreased expression of PIK3CA protein
CTD
PMID:31726078
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
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Pten
phosphatase and tensin homolog
increases expression
ISO
Homoharringtonine results in increased expression of PTEN protein
CTD
PMID:31726078
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein]
CTD
PMID:31307525
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Relb
RELB proto-oncogene, NF-kB subunit
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of RELB protein Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein]
CTD
PMID:31307525
NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507
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Tnf
tumor necrosis factor
increases expression
ISO
Homoharringtonine results in increased expression of TNF mRNA
CTD
PMID:32431164
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein]
CTD
PMID:31307525
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Traf2
Tnf receptor-associated factor 2
increases expression
ISO
Homoharringtonine results in increased expression of TRAF2 mRNA
CTD
PMID:32431164
NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538
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Tyr
tyrosinase
increases expression
ISO
Homoharringtonine results in increased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
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