CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cephalotaxine
Accession: CHEBI:3540
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Definition: A benzazepine alkaloid isolated from Cephalotaxus harringtonia.
Synonyms: related_synonym: (1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol; Formula=C18H21NO4; InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1; InChIKey=YMNCVRSYJBNGLD-KURKYZTESA-N; SMILES=[H][C@@]12[C@H](O)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21
xref: Beilstein:628324; CAS:24316-19-6; KEGG:C10580; KNApSAcK:C00002324; KNApSAcK:C00027319; Reaxys:628324
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Ahi1
Abelson helper integration site 1
increases expression
ISO
Homoharringtonine results in increased expression of AHI1 protein alternative form
CTD
PMID:19379585
NCBI chr 1:16,478,127...16,601,769
Ensembl chr 1:16,478,127...16,601,769
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of AKT1 protein
CTD
PMID:31726078
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
Homoharringtonine results in increased expression of BAD protein
CTD
PMID:31726078
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Homoharringtonine results in increased expression of BAX protein
CTD
PMID:31726078
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Homoharringtonine results in decreased expression of BCL2 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Casp3
caspase 3
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP3 protein Homoharringtonine results in increased cleavage of CASP3 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp7
caspase 7
increases cleavage
ISO
Homoharringtonine results in increased cleavage of CASP7 protein
CTD
PMID:31726078
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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Casp9
caspase 9
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP9 protein Homoharringtonine results in increased cleavage of CASP9 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Ccna2
cyclin A2
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNA2 protein
CTD
PMID:31726078
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Ccnb1
cyclin B1
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNB1 protein
CTD
PMID:31726078
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Ccne1
cyclin E1
increases expression
ISO
Homoharringtonine results in increased expression of CCNE1 protein
CTD
PMID:31726078
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Homoharringtonine results in increased expression of CDK1 protein
CTD
PMID:31726078
NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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Cdk2
cyclin dependent kinase 2
increases expression
ISO
Homoharringtonine results in increased expression of CDK2 protein
CTD
PMID:31726078
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Ephb4
EPH receptor B4
multiple interactions decreases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein]
CTD
PMID:31726078
NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:31726078
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:31726078
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Homoharringtonine results in decreased expression of MCL1 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 2:197,786,212...197,788,992
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Homoharringtonine results in decreased expression of MKI67 protein
CTD
PMID:31726078
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MTOR protein
CTD
PMID:31726078
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
decreases expression
ISO
Homoharringtonine results in decreased expression of PIK3CA protein
CTD
PMID:31726078
NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
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Pten
phosphatase and tensin homolog
increases expression
ISO
Homoharringtonine results in increased expression of PTEN protein
CTD
PMID:31726078
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
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Tyr
tyrosinase
increases expression
ISO
Homoharringtonine results in increased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
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