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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cephalexin
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Accession:CHEBI:3534 term browser browse the term
Definition:A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.
Synonyms:exact_synonym: 7beta-[(2R)-2-amino-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid;   7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid;   CEX;   Cefalexin;   Celexin;   Cepastar;   Cepexin;   Cephacillin;   Ceporexin;   Formula=C16H17N3O4S;   InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1;   InChIKey=ZAIPMKNFIOOWCQ-UEKVPHQBSA-N;   SMILES=[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O;   cefalexina;   cefalexine;   cefalexinum
 xref: Beilstein:965503;   CAS:15686-71-2;   DrugBank:DB00567;   Drug_Central:571;   HMDB:HMDB0014707;   KEGG:C06895;   KEGG:D00263;   LINCS:LSM-5957
 xref_mesh: MESH:D002506
 xref: PMID:10930630;   PMID:12569987;   PMID:12833570;   PMID:1384868;   PMID:2083978;   PMID:22559990;   PMID:23061564;   PMID:23457080;   PMID:23545436;   PMID:23688276;   PMID:23811740;   PMID:24268227;   PMID:24548092;   PMID:29017833;   Patent:US3275626;   Patent:US3507861;   Reaxys:4238892;   VSDB:1791;   Wikipedia:Cefalexin
 cyclic_relationship: is_conjugate_acid_of CHEBI:59392


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cephalexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Ha RT1 class II, locus Ha affects expression ISO Cephalexin affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 increases transport EXP SLC15A1 protein results in increased transport of Cephalexin CTD PMID:19881305 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        antimicrobial agent 18273
          antibacterial agent 16370
            antibacterial drug 7392
              cephalexin 2
                cefalexin pivoxil 0
                cephalexin monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      carboacyl group 17724
                                        univalent carboacyl group 17724
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              lactam 8394
                                                beta-lactam 831
                                                  beta-lactam antibiotic 816
                                                    cephem 551
                                                      cephalosporin 550
                                                        cephalexin 2
                                                          cefalexin pivoxil 0
                                                          cephalexin monohydrate 0
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