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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cephalexin
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Accession:CHEBI:3534 term browser browse the term
Definition:A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.
Synonyms:exact_synonym: 7beta-[(2R)-2-amino-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid;   7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid;   CEX;   Cefalexin;   Celexin;   Cepastar;   Cepexin;   Cephacillin;   Ceporexin;   Formula=C16H17N3O4S;   InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1;   InChIKey=ZAIPMKNFIOOWCQ-UEKVPHQBSA-N;   SMILES=[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O;   cefalexina;   cefalexine;   cefalexinum
 xref: Beilstein:965503;   CAS:15686-71-2;   DrugBank:DB00567;   Drug_Central:571;   HMDB:HMDB0014707;   KEGG:C06895;   KEGG:D00263;   LINCS:LSM-5957
 xref_mesh: MESH:D002506
 xref: PMID:10930630;   PMID:12569987;   PMID:12833570;   PMID:1384868;   PMID:2083978;   PMID:22559990;   PMID:23061564;   PMID:23457080;   PMID:23545436;   PMID:23688276;   PMID:23811740;   PMID:24268227;   PMID:24548092;   PMID:29017833;   Patent:US3275626;   Patent:US3507861;   Reaxys:4238892;   VSDB:1791;   Wikipedia:Cefalexin
 cyclic_relationship: is_conjugate_acid_of CHEBI:59392


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cephalexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Ha RT1 class II, locus Ha affects expression ISO Cephalexin affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
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G Slc15a1 solute carrier family 15 member 1 increases transport EXP SLC15A1 protein results in increased transport of Cephalexin CTD PMID:19881305 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        antimicrobial agent 17373
          antibacterial agent 13457
            antibacterial drug 3174
              cephalexin 2
                cefalexin pivoxil 0
                cephalexin monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        carboacyl group 17416
                                          univalent carboacyl group 17416
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                lactam 8049
                                                  beta-lactam 794
                                                    beta-lactam antibiotic 779
                                                      cephem 544
                                                        cephalosporin 543
                                                          cephalexin 2
                                                            cefalexin pivoxil 0
                                                            cephalexin monohydrate 0
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