ortho- and peri-fused polycyclic arene - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ortho- and peri-fused polycyclic arene	go back to main search page
Accession:	CHEBI:35300	browse the term
Synonyms:	related_synonym:	ortho- and peri-fused polycyclic arenes

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Rat (16278) Mouse (16906) Human (18727) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (25) Green Monkey (0) Naked Mole-rat (0) All
Genes (25)

benzo[a]pyrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Benzo(a)pyrene results in decreased expression of and results in decreased secretion of ADIPOQ protein

NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646

G

adiponectin receptor 1

decreases expression

Benzo(a)pyrene results in decreased expression of ADIPOR1 protein

NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686

G

adiponectin receptor 2

decreases expression

Benzo(a)pyrene results in decreased expression of ADIPOR2 protein

NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235

G

activating transcription factor 4

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF6 protein]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

increases expression

Benzo(a)pyrene results in increased expression of BAX protein

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

decreases expression

Benzo(a)pyrene results in decreased expression of BCL2 protein

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL2 like 1

decreases expression
multiple interactions

Benzo(a)pyrene results in decreased expression of BCL2L1 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein]

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

cyclin B1

decreases expression

Benzo(a)pyrene results in decreased expression of CCNB1 protein

NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377

G

claudin 1

decreases expression
multiple interactions

Benzo(a)pyrene results in decreased expression of CLDN1 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

claudin 3

decreases expression
multiple interactions

Benzo(a)pyrene results in decreased expression of CLDN3 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN3 protein]

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

cytochrome P450 19A3

multiple interactions

Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

G

cytochrome P450 family 1 subfamily A member 1

increases expression
multiple interactions

Benzo(a)pyrene results in increased expression of CYP1A1 protein
7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein

PMID:11042205 PMID:18636242

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

DNA damage inducible transcript 3

increases expression
multiple interactions

Benzo(a)pyrene results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of DDIT3 protein]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Benzo(a)pyrene results in increased phosphorylation of EIF2S1 protein

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

increases phosphorylation
multiple interactions

Benzo(a)pyrene results in increased phosphorylation of ERN1 protein
4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of ERN1 protein]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

H2A.X variant histone

increases expression

Benzo(a)pyrene results in increased expression of H2AX protein

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

lysosomal associated membrane protein 2

multiple interactions
decreases expression

bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein]

NCBI chr X:98,586,718...98,623,939
Ensembl chr X:98,556,710...98,623,940

G

microtubule associated protein 1 light chain 3 beta

decreases lipidation
multiple interactions

Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein
bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]; Benzo(a)pyrene promotes the reaction [3-methyladenine results in decreased lipidation of MAP1LC3B protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

NFE2 like bZIP transcription factor 2

decreases expression

Benzo(a)pyrene results in decreased expression of NFE2L2 protein

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

occludin

decreases expression
multiple interactions

Benzo(a)pyrene results in decreased expression of OCLN protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

proliferating cell nuclear antigen

decreases expression

Benzo(a)pyrene results in decreased expression of PCNA protein

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

tight junction protein 1

decreases expression
multiple interactions

Benzo(a)pyrene results in decreased expression of TJP1 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tight junction protein 2

decreases expression

Benzo(a)pyrene results in decreased expression of TJP2 protein

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5052
role	5044
biological role	5016
aetiopathogenetic role	4604
carcinogenic agent	251
polycyclic arene	35
ortho- and peri-fused polycyclic arene	25
10-Hydroxybenzo[a]pyrene	0
11,12-Dihydroxybenzo[a]pyrene	0
11-Hydroxybenzo[a]pyrene	0
12-Hydroxybenzo[a]pyrene	0
2,2',7,7'-Tetrachlorohypericin	0
2-Hydroxybenzo[a]pyrene	0
3-Hydroxybenzo[a]pyrene	0
3-methylcholanthrene +	0
4,5-Dihydroxybenzo[a]pyrene	0
4-Hydroxybenzo[a]pyrene	0
5-Hydroxybenzo[a]pyrene	0
6-Hydroxybenzo[a]pyrene	0
6-Nitrobenzo[a]pyrene	0
7,7'-Dichlorohypericin	0
7-Hydroxybenzo[a]pyrene	0
8-Hydroxybenzo[a]pyrene	0
8H-cyclopenta[a]acenaphthylene +	0
9,10-Dihydroxybenzo[a]pyrene	0
9-Hydroxybenzo[a]pyrene	0
Anthanthrene	0
Benzo[ghi]perylene	0
Dibenzo[a,e]pyrene	0
Dibenzo[a,h]pyrene	0
Dibenzo[a,i]pyrene	0
Dibenzo[e,l]pyrene	0
Dibenzo[h,rst]pentaphene	0
Fagopyrine	0
Naphtho[2,3-e]pyrene	0
Pseudohypericin +	0
Vat Yellow 4	0
aceanthrylene	0
acenaphthylene	0
acephenanthrylene	0
benzo[a]pyrene +	25
benzo[b]fluoranthene	0
benzo[e]pyrene	0
bisanthene +	0
circumanthracene	0
circumbiphenyl	0
circumcircumcoronene	0
circumcircumpyrene	0
circumcoronene	0
circumovalene	0
circumpyrene	0
circumtrindene	0
coronene	0
dibenzo[a,l]pyrene	0
fluoranthene +	0
hexacyclopentacoronene	0
kekulene	0
ovalene	0
perylene	0
phenalene +	0
pleiadene	0
pyranthrene	0
pyrene +	0
quaterrylene	0
rubicene	0
terrylene	0
Path 2
Term	Annotations
CHEBI ontology	5052
subatomic particle	5043
composite particle	5043
hadron	5071
baryon	5043
nucleon	5043
atomic nucleus	5043
atom	5043
main group element atom	5013
main group molecular entity	5012
s-block molecular entity	4970
hydrogen molecular entity	4964
hydrides	4544
organic hydride	4388
organic fundamental parent	4388
hydrocarbon	4348
cyclic hydrocarbon	106
arene	110
polycyclic arene	35
ortho- and peri-fused polycyclic arene	25
10-Hydroxybenzo[a]pyrene	0
11,12-Dihydroxybenzo[a]pyrene	0
11-Hydroxybenzo[a]pyrene	0
12-Hydroxybenzo[a]pyrene	0
2,2',7,7'-Tetrachlorohypericin	0
2-Hydroxybenzo[a]pyrene	0
3-Hydroxybenzo[a]pyrene	0
3-methylcholanthrene +	0
4,5-Dihydroxybenzo[a]pyrene	0
4-Hydroxybenzo[a]pyrene	0
5-Hydroxybenzo[a]pyrene	0
6-Hydroxybenzo[a]pyrene	0
6-Nitrobenzo[a]pyrene	0
7,7'-Dichlorohypericin	0
7-Hydroxybenzo[a]pyrene	0
8-Hydroxybenzo[a]pyrene	0
8H-cyclopenta[a]acenaphthylene +	0
9,10-Dihydroxybenzo[a]pyrene	0
9-Hydroxybenzo[a]pyrene	0
Anthanthrene	0
Benzo[ghi]perylene	0
Dibenzo[a,e]pyrene	0
Dibenzo[a,h]pyrene	0
Dibenzo[a,i]pyrene	0
Dibenzo[e,l]pyrene	0
Dibenzo[h,rst]pentaphene	0
Fagopyrine	0
Naphtho[2,3-e]pyrene	0
Pseudohypericin +	0
Vat Yellow 4	0
aceanthrylene	0
acenaphthylene	0
acephenanthrylene	0
benzo[a]pyrene +	25
benzo[b]fluoranthene	0
benzo[e]pyrene	0
bisanthene +	0
circumanthracene	0
circumbiphenyl	0
circumcircumcoronene	0
circumcircumpyrene	0
circumcoronene	0
circumovalene	0
circumpyrene	0
circumtrindene	0
coronene	0
dibenzo[a,l]pyrene	0
fluoranthene +	0
hexacyclopentacoronene	0
kekulene	0
ovalene	0
perylene	0
phenalene +	0
pleiadene	0
pyranthrene	0
pyrene +	0
quaterrylene	0
rubicene	0
terrylene	0

paths to the root