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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iminium ion
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Accession:CHEBI:35286 term browser browse the term
Definition:Cations of structure R2C=N(+)R2.
Synonyms:related_synonym: iminium cations;   iminium ions


show annotations for term's descendants           Sort by:
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression
multiple interactions		 ISO Benzophenoneidum results in increased expression of ALDH1A1 protein
ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]		 CTD PMID:28722353 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr15:95,688,724...95,873,353
Ensembl chr15:95,688,724...95,872,632 		JBrowse link
G Araf Araf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:20,663,946...20,726,760
Ensembl chr  X:20,664,053...20,726,758 		JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288 		JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:7,460,048...7,471,659
Ensembl chr  X:7,460,048...7,471,756 		JBrowse link
G Ccdc39 coiled-coil domain containing 39 increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 3:33,864,906...33,898,473
Ensembl chr 3:33,866,511...33,898,459 		JBrowse link
G Cd44 CD44 antigen increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Chtf18 CTF18, chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr17:25,938,004...25,946,409
Ensembl chr17:25,937,900...25,946,393 		JBrowse link
G Commd1 COMM domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr11:22,849,728...22,934,539
Ensembl chr11:22,846,136...22,932,382 		JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 1:86,510,363...86,534,550
Ensembl chr 1:86,510,626...86,537,097 		JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 1:80,242,640...80,318,426
Ensembl chr 1:80,242,640...80,318,197 		JBrowse link
G Dynlt1b dynein light chain Tctex-type 1B increases expression ISO Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr17:6,697,511...6,703,695
Ensembl chr17:6,697,511...6,703,695 		JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 4:137,719,090...137,934,397
Ensembl chr 4:137,720,333...137,935,819 		JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 1:63,769,758...63,792,544
Ensembl chr 1:63,769,773...63,793,814 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Benzophenoneidum results in increased phosphorylation of H2AX protein CTD PMID:37527026 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hook3 hook microtubule tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr 8:26,511,449...26,609,646
Ensembl chr 8:26,511,449...26,609,252 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810 		JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 3:87,989,309...88,028,355
Ensembl chr 3:87,989,278...88,028,355 		JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr 1:163,589,711...163,744,676
Ensembl chr 1:163,607,152...163,744,678 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO Benzophenoneidum results in increased expression of MKI67 protein CTD PMID:37527026 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr 5:77,442,016...77,458,276
Ensembl chr 5:77,442,029...77,457,931 		JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 7:44,465,512...44,481,260
Ensembl chr 7:44,465,512...44,480,236 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr17:66,089,253...66,148,921
Ensembl chr17:66,089,568...66,148,921 		JBrowse link
G Prim2 DNA primase, p58 subunit increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 1:33,492,889...33,708,867
Ensembl chr 1:33,492,891...33,708,876 		JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374 		JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr12:55,349,422...55,429,276
Ensembl chr12:55,346,362...55,429,318 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544 		JBrowse link
G Srsf11 serine and arginine-rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 3:157,716,552...157,742,304
Ensembl chr 3:157,716,110...157,742,276 		JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr10:115,031,459...115,087,343
Ensembl chr10:115,033,777...115,087,372 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 4:106,173,179...106,303,798
Ensembl chr 4:106,173,417...106,298,519 		JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr15:59,203,712...59,246,043
Ensembl chr15:59,203,846...59,246,016 		JBrowse link
brilliant green term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO brilliant green results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:26177467 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO brilliant green results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:26177467 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO brilliant green results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases expression ISO brilliant green results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO brilliant green results in increased expression of LONP1 mRNA CTD PMID:21215310 NCBI chr17:56,921,297...56,933,903
Ensembl chr17:56,921,297...56,933,887 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Txn1 thioredoxin 1 increases oxidation ISO brilliant green results in increased oxidation of TXN protein CTD PMID:21215310 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions
decreases expression
affects response to substance		 ISO brilliant green results in increased oxidation of and results in increased degradation of TXN2 protein
brilliant green results in decreased expression of TXN2 protein
TXN2 protein affects the susceptibility to brilliant green		 CTD PMID:21215310 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
crystal violet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]] CTD PMID:24535435 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO Gentian Violet promotes the reaction [TP53 protein binds to BBC3 promoter]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]] CTD PMID:24535435 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Gentian Violet results in decreased expression of BCL2 protein CTD PMID:27373978 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Gentian Violet results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:26177467 PMID:27373978 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Gentian Violet results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:26177467 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Gentian Violet results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO Gentian Violet promotes the reaction [TP53 protein binds to CDKN1A promoter]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA] CTD PMID:24535435 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Gentian Violet inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases expression ISO Gentian Violet results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Gentian Violet results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO Gentian Violet inhibits the reaction [NOX1 protein results in decreased activity of TP53 protein] CTD PMID:24535435 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Gentian Violet results in increased cleavage of PARP1 protein CTD PMID:24535435 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Gentian Violet promotes the reaction [Thiostrepton affects the expression of PRDX3 protein modified form] CTD PMID:22761781 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Gentian Violet inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 multiple interactions ISO [Gentian Violet results in decreased phosphorylation of and affects the localization of STAT3 protein] inhibits the reaction [STAT3 protein binds to SOX2 promoter] CTD PMID:27373978 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Gentian Violet results in decreased phosphorylation of and affects the localization of STAT3 protein] inhibits the reaction [STAT3 protein binds to SOX2 promoter]; Gentian Violet results in decreased phosphorylation of and affects the localization of STAT3 protein CTD PMID:27373978 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
affects activity		 ISO Gentian Violet inhibits the reaction [NOX1 protein results in decreased activity of TP53 protein]; Gentian Violet promotes the reaction [TP53 protein binds to BBC3 promoter]; Gentian Violet promotes the reaction [TP53 protein binds to CDKN1A promoter]; Gentian Violet promotes the reaction [TP53 protein binds to TP53AIP1 promoter]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA]; Gentian Violet results in increased stability of and results in increased activity of TP53 protein; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]
Gentian Violet affects the activity of TP53 protein		 CTD PMID:24535435 PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txn2 thioredoxin 2 decreases expression ISO Gentian Violet results in decreased expression of TXN2 protein CTD PMID:22761781 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
diminazene diaceturate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases expression
multiple interactions
increases activity		 EXP
ISO		 diminazene aceturate results in increased expression of ACE2 mRNA; diminazene aceturate results in increased expression of ACE2 protein
[Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 mRNA; [Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 protein; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]
PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]
diminazene aceturate results in increased activity of ACE2 protein		 CTD PMID:25301841 PMID:26862037 PMID:27550926 PMID:28688122 PMID:31982938 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta decreases expression ISO diminazene aceturate results in decreased expression of ACTA2 protein CTD PMID:29977014 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Agt angiotensinogen increases expression
multiple interactions		 EXP
ISO		 diminazene aceturate results in increased expression of AGT protein modified form
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]; diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]
diminazene aceturate results in increased expression of AGT protein alternative form		 CTD PMID:25301841 PMID:26862037 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA] CTD PMID:26862037 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G App amyloid beta precursor protein affects expression EXP diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO diminazene aceturate results in decreased expression of MCP1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]		 CTD PMID:26862037 PMID:29977014 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO diminazene aceturate results in decreased expression of COL1A1 protein CTD PMID:29977014 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein] CTD PMID:26862037 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide decreases expression ISO diminazene aceturate results in decreased expression of CYBB protein CTD PMID:29977014 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) increases phosphorylation EXP diminazene aceturate results in increased phosphorylation of GRIN2B protein CTD PMID:31982938 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO
EXP		 diminazene aceturate results in decreased expression of IL1B mRNA
diminazene aceturate results in decreased expression of IL1B protein		 CTD PMID:25883526 PMID:31982938 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO diminazene aceturate results in decreased expression of IL6 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:25883526 PMID:26862037 PMID:29977014 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 diminazene aceturate results in increased phosphorylation of MAPK1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:26862037 PMID:31982938 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of MAPK14 protein CTD PMID:25883526 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP
ISO		 diminazene aceturate results in increased phosphorylation of MAPK3 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]		 CTD PMID:26862037 PMID:31982938 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mas1 MAS1 oncogene increases expression EXP diminazene aceturate results in increased expression of MAS1 protein CTD PMID:31982938 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression ISO diminazene aceturate results in decreased expression of NCF1 protein CTD PMID:29977014 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases transport ISO diminazene aceturate results in decreased transport of NCF2 protein CTD PMID:29977014 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:26862037 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal decreases expression ISO diminazene aceturate results in decreased expression of NOS1 mRNA CTD PMID:25883526 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO diminazene aceturate results in decreased expression of NOX1 protein CTD PMID:29977014 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases activity
decreases expression		 ISO diminazene aceturate results in decreased activity of RELA protein
diminazene aceturate results in decreased expression of RELA mRNA; diminazene aceturate results in decreased expression of RELA protein		 CTD PMID:25883526 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD2 protein CTD PMID:29977014 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion		 ISO diminazene aceturate results in decreased expression of TNF protein
diminazene aceturate results in decreased expression of TNF mRNA; diminazene aceturate results in decreased expression of TNF protein
diminazene aceturate results in decreased secretion of TNF protein		 CTD PMID:25883526 PMID:29977014 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
malachite green cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO malachite green results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein CTD PMID:12616621 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:10906429 PMID:12616621 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein CTD PMID:12616621 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk4 cyclin dependent kinase 4 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein CTD PMID:12616621 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 decreases activity
multiple interactions		 ISO malachite green results in decreased activity of KCNA3 protein
[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 3:106,943,486...106,947,223
Ensembl chr 3:106,943,485...106,945,386 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions		 ISO malachite green results in decreased activity of KCNH2 protein
[malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Khnyn KH and NYN domain containing affects response to substance ISO KHNYN gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr14:56,122,269...56,136,237
Ensembl chr14:56,122,404...56,136,232 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of PCNA protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:10906429 PMID:11831363 PMID:12616621 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Rnf150 ring finger protein 150 affects response to substance ISO RNF150 gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr 8:83,589,889...83,817,900
Ensembl chr 8:83,589,985...83,817,897 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      molecular entity 22169
        ion 17696
          organic ion 10063
            organic cation 9099
              iminium ion 90
                1-piperideinium 0
                11-beta-hydroxy-beta-saxitoxinol(2+) 0
                11-beta-hydroxysaxitoxin(2+) 0
                2-amino-6-(aminomethyl)-5-methylidene-4-oxo-1,4,5,6,7,8-hexahydropteridin-5-ium 0
                2-methyl-1-pyrrolinium 0
                4-(21-amino-4,9,12-trioxo-16,19-dioxa-5,8,13-triazahenicos-1-yloxy)-malachite green cation 0
                Fast green FCF(1+) 0
                Guinee green B(1+) 0
                Methyl violet 2B(1+) + 0
                N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium 0
                QSY21 succinimidyl ester(1+) + 0
                QSY7 succinimidyl ester(1+) + 0
                QSY9 succinimidyl ester(1+) + 0
                ToTo-3(4+) + 0
                X-rhod-1(1+) + 0
                YoYo-3(4+) + 0
                acid green 5(1+) 0
                acridine red 3B(1+) + 0
                alcian yellow cation + 0
                auramine O(1+) + 37
                beta-saxitoxinol(2+) 0
                brilliant green cation + 8
                carboxamidinium ion + 25
                crystal violet cation + 18
                dehydrocoformycin(1+) 0
                ethyl green(1+) + 0
                ethyl violet cation + 0
                guanidinium ion + 0
                huprine W(1+) 0
                iminium salt + 0
                iodine green(2+) + 0
                magenta II(1+) + 0
                malachite green cation + 11
                malachite green isothiocyanate cation + 0
                methyl green(2+) + 0
                new fuchsin(1+) + 0
                night blue(1+) + 0
                pararosaniline(1+) + 0
                patent blue V 0
                pyronin B(1+) + 0
                pyronin Y cation + 0
                rhod-2(1+) + 0
                rosanilin(1+) + 0
                saxitoxin(2+) 0
                tacrine(1+) 0
                tetramethylrosamine + 0
                tetrodotoxin(1+) 0
                victoria blue 4R(1+) + 0
                victoria blue B(1+) + 0
                victoria blue R(1+) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      p-block molecular entity 22104
                        carbon group molecular entity 21904
                          organic molecular entity 21830
                            organic ion 10063
                              organic cation 9099
                                iminium ion 90
                                  1-piperideinium 0
                                  11-beta-hydroxy-beta-saxitoxinol(2+) 0
                                  11-beta-hydroxysaxitoxin(2+) 0
                                  2-amino-6-(aminomethyl)-5-methylidene-4-oxo-1,4,5,6,7,8-hexahydropteridin-5-ium 0
                                  2-methyl-1-pyrrolinium 0
                                  4-(21-amino-4,9,12-trioxo-16,19-dioxa-5,8,13-triazahenicos-1-yloxy)-malachite green cation 0
                                  Fast green FCF(1+) 0
                                  Guinee green B(1+) 0
                                  Methyl violet 2B(1+) + 0
                                  N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium 0
                                  QSY21 succinimidyl ester(1+) + 0
                                  QSY7 succinimidyl ester(1+) + 0
                                  QSY9 succinimidyl ester(1+) + 0
                                  ToTo-3(4+) + 0
                                  X-rhod-1(1+) + 0
                                  YoYo-3(4+) + 0
                                  acid green 5(1+) 0
                                  acridine red 3B(1+) + 0
                                  alcian yellow cation + 0
                                  auramine O(1+) + 37
                                  beta-saxitoxinol(2+) 0
                                  brilliant green cation + 8
                                  carboxamidinium ion + 25
                                  crystal violet cation + 18
                                  dehydrocoformycin(1+) 0
                                  ethyl green(1+) + 0
                                  ethyl violet cation + 0
                                  guanidinium ion + 0
                                  huprine W(1+) 0
                                  iminium salt + 0
                                  iodine green(2+) + 0
                                  magenta II(1+) + 0
                                  malachite green cation + 11
                                  malachite green isothiocyanate cation + 0
                                  methyl green(2+) + 0
                                  new fuchsin(1+) + 0
                                  night blue(1+) + 0
                                  pararosaniline(1+) + 0
                                  patent blue V 0
                                  pyronin B(1+) + 0
                                  pyronin Y cation + 0
                                  rhod-2(1+) + 0
                                  rosanilin(1+) + 0
                                  saxitoxin(2+) 0
                                  tacrine(1+) 0
                                  tetramethylrosamine + 0
                                  tetrodotoxin(1+) 0
                                  victoria blue 4R(1+) + 0
                                  victoria blue B(1+) + 0
                                  victoria blue R(1+) + 0
paths to the root