Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ammonium betaine
go back to main search page
Accession:CHEBI:35284 term browser browse the term
Definition:Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:related_synonym: ammonium betaines


show annotations for term's descendants           Sort by:
 
(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO Carnitine results in increased expression of ADIPOQ protein CTD PMID:30256492 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein] CTD PMID:29186614 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] CTD PMID:33290254 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO Carnitine results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]
CTD PMID:29186614 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBOX1 gamma-butyrobetaine hydroxylase 1 multiple interactions
increases chemical synthesis
EXP Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]; Ketoglutaric Acids inhibits the reaction [Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] CTD PMID:21439360 NCBI chr11:27,040,705...27,127,809
Ensembl chr11:27,040,725...27,127,809
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA] CTD PMID:23213347 PMID:29186614 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein] CTD PMID:19491382 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP
Carnitine inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]
CTD PMID:19491382 PMID:23213347 PMID:26562095 PMID:32478940 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions ISO
EXP
Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]
Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]
CTD PMID:23213347 PMID:32478940 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Carnitine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA] CTD PMID:16889571 PMID:19294768 PMID:23213347 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions ISO Carnitine inhibits the reaction [Sunitinib results in increased expression of CCN2 mRNA] CTD PMID:26581635 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CDH1 cadherin 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein] CTD PMID:28973641 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of COL1A1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of COL1A1 mRNA] CTD PMID:26581635 PMID:28973641 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] affects the abundance of Carnitine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine] CTD PMID:24709313 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO
EXP
valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Carnitine]
[Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNA; [Genistein co-treated with Carnitine] results in increased expression of CPT1A protein; Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]
CTD PMID:16283381 PMID:16362726 PMID:19854160 PMID:32478940 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CPT2 carnitine palmitoyltransferase 2 multiple interactions EXP Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] CTD PMID:21816645 NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of NOX2 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of NOX2 protein] CTD PMID:26581635 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA] CTD PMID:29710542 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:8130774 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G FABP3 fatty acid binding protein 3 multiple interactions ISO Carnitine inhibits the reaction [Doxorubicin results in decreased expression of FABP3 mRNA] CTD PMID:20470772 NCBI chr 1:31,359,595...31,373,618
Ensembl chr 1:31,365,253...31,376,850
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA] CTD PMID:23213347 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein] CTD PMID:32478940 NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672
JBrowse link
G HRK harakiri, BCL2 interacting protein multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein] CTD PMID:16239342 NCBI chr12:116,856,144...116,881,441
Ensembl chr12:116,856,144...116,881,441
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO Carnitine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA2 protein] CTD PMID:22359436 NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G IL10 interleukin 10 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in decreased expression of IL10 mRNA] CTD PMID:26581635 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Carnitine inhibits the reaction [sunitinib results in increased expression of IL1B mRNA] CTD PMID:26562095 PMID:26581635 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of IL6 mRNA] CTD PMID:26581635 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LEPR leptin receptor affects abundance ISO LEPR affects the abundance of Carnitine CTD PMID:20567778 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in decreased expression of MMP9 mRNA] CTD PMID:26581635 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions
increases activity
ISO [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased activity of MPO protein] CTD PMID:18597074 PMID:18852009 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] CTD PMID:21419151 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions ISO Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA] CTD PMID:21419151 NCBI chr MT:14,149...14,673
Ensembl chr MT:14,149...14,673
JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] CTD PMID:18299183 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA] CTD PMID:23213347 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression ISO Carnitine results in increased expression of NOS3 CTD PMID:20123095 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases activity
ISO [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine]; PPARA protein promotes the reaction [Carnitine results in decreased susceptibility to Gentamicins]
Carnitine results in increased activity of PPARA protein
CTD PMID:19491382 PMID:19735737 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression
ISO Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]
Carnitine results in increased expression of PPARG protein
CTD PMID:30256492 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGIS prostaglandin I2 synthase increases expression
increases response to substance
multiple interactions
ISO Carnitine results in increased expression of PTGIS mRNA
PTGIS protein results in increased susceptibility to Carnitine
[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
CTD PMID:19491382 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137
JBrowse link
G SLC22A4 solute carrier family 22 member 4 increases uptake EXP SLC22A4 protein results in increased uptake of Carnitine CTD PMID:21256917 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G SLC22A5 solute carrier family 22 member 5 multiple interactions
decreases expression
increases transport
increases uptake
increases expression
affects uptake
affects binding
EXP
ISO
[Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA; Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine results in decreased expression of SLC22A5 mRNA; Carnitine results in decreased expression of SLC22A5 protein
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine deficiency results in increased expression of SLC22A5 mRNA
SLC22A5 protein results in increased uptake of Carnitine; SLC22A5 protein results in increased uptake of Carnitine analog
SLC22A5 protein affects the uptake of Carnitine
Carnitine binds to SLC22A5 protein
CTD PMID:12644265 PMID:15486076 PMID:16283381 PMID:16928358 PMID:18762717 PMID:18981167 PMID:19041296 PMID:19539806 PMID:19735737 PMID:20303936 PMID:20470772 PMID:21256917 PMID:21641380 PMID:22701146 PMID:30465787 PMID:31437515 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,710...132,395,613
JBrowse link
G SLC22A8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Carnitine CTD PMID:15100168 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G SLC25A20 solute carrier family 25 member 20 multiple interactions
increases transport
ISO Ampicillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Carnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cefonicid inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Piperacillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 PMID:23402788 NCBI chr 3:48,856,926...48,898,882
Ensembl chr 3:48,856,926...48,898,904
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions
increases expression
ISO Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Carnitine results in increased expression of SLC2A4 protein
CTD PMID:30256492 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein] CTD PMID:28973641 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA] CTD PMID:18299183 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TGFB1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of TGFB1 mRNA] CTD PMID:26562095 PMID:26581635 PMID:28973641 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA] CTD PMID:26581635 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TJP1 tight junction protein 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein] CTD PMID:28973641 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
decreases expression
ISO Carnitine deficiency results in increased expression of TNF mRNA
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased expression of TNF mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]
Carnitine results in decreased expression of TNF protein
CTD PMID:18597074 PMID:18629605 PMID:18852009 PMID:26562095 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VIM vimentin multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of VIM protein] CTD PMID:28973641 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein] CTD PMID:19041333 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G IL6 interleukin 6 multiple interactions EXP 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein] CTD PMID:19041333 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G PRNP prion protein multiple interactions
affects folding
EXP Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590
JBrowse link
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FECH ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine CTD PMID:29906468 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,377...57,586,732
JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FECH ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,377...57,586,732
JBrowse link
1-O-oleoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR5A2 nuclear receptor subfamily 5 group A member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420
JBrowse link
G SMAD3 SMAD family member 3 decreases abundance ISO SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,173
JBrowse link
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA CTD PMID:16386258 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
JBrowse link
G CD68 CD68 molecule increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CD68 mRNA CTD PMID:16386258 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
JBrowse link
G CRP C-reactive protein increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CXCL8 mRNA CTD PMID:16386258 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]; resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein] CTD PMID:24079413 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G IL1A interleukin 1 alpha increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1B mRNA CTD PMID:16386258 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 multiple interactions ISO [KCNAB2 protein co-treated with NADP] results in increased reduction of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine CTD PMID:21296056 NCBI chr 1:5,992,639...6,101,186
Ensembl chr 1:5,990,927...6,101,193
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein
resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein]
CTD PMID:24079413 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK3 protein] CTD PMID:24079413 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G PTAFR platelet activating factor receptor affects binding
multiple interactions
EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine binds to PTAFR protein
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
CTD PMID:16386258 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SELE selectin E increases expression
increases secretion
EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of SELE mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of SELE protein
CTD PMID:16386258 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein] CTD PMID:24079413 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 increases expression EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912
JBrowse link
G TNF tumor necrosis factor increases expression
increases secretion
EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TNF mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of TNF protein
CTD PMID:16386258 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPG lipase G, endothelial type increases hydrolysis EXP LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPC lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 increases expression EXP Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type increases expression EXP Platelet Activating Factor results in increased expression of ALOX12 mRNA CTD PMID:16386258 NCBI chr17:6,993,791...7,010,754
Ensembl chr17:6,996,049...7,010,754
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression
multiple interactions
EXP Platelet Activating Factor results in increased expression of ALOX5 mRNA
[sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]
CTD PMID:8387780 PMID:10779545 PMID:16386258 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CCL2 protein] CTD PMID:15149885 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression EXP Platelet Activating Factor results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
JBrowse link
G CRP C-reactive protein increases expression EXP Platelet Activating Factor results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 increases expression EXP Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 NCBI chr 3:39,263,494...39,281,735
Ensembl chr 3:39,263,495...39,281,735
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CXCL8 protein] CTD PMID:15149885 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G EDN1 endothelin 1 multiple interactions
increases abundance
ISO Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G EGR1 early growth response 1 increases expression EXP Platelet Activating Factor results in increased expression of EGR1 mRNA CTD PMID:16386258 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr 7:65,960,684...65,982,230
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G IL1A interleukin 1 alpha increases expression EXP Platelet Activating Factor results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions
increases secretion
EXP Platelet Activating Factor results in increased expression of IL1B mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]
CTD PMID:16386258 PMID:32830409 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases secretion
multiple interactions
EXP Platelet Activating Factor results in increased secretion of IL6 protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]
CTD PMID:32830409 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions
increases expression
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein] CTD PMID:9762784 PMID:11116075 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G LTB4R leukotriene B4 receptor affects response to substance ISO LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 NCBI chr14:24,311,502...24,318,036
Ensembl chr14:24,311,450...24,318,036
JBrowse link
G MIR149 microRNA 149 decreases expression
multiple interactions
EXP Platelet Activating Factor results in decreased expression of MIR149 mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; [Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA
CTD PMID:32830409 NCBI chr 2:240,456,001...240,456,089
Ensembl chr 2:240,456,001...240,456,089
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression EXP Platelet Activating Factor results in increased expression of MMP13 mRNA CTD PMID:16386258 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor increases expression
multiple interactions
EXP Platelet Activating Factor results in increased expression of MYD88 protein
PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]
CTD PMID:32830409 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022
JBrowse link
G NCEH1 neutral cholesterol ester hydrolase 1 multiple interactions ISO NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
increases degradation
ISO Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Genistein inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP Platelet Activating Factor results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G PLA2G7 phospholipase A2 group VII multiple interactions
increases expression
EXP [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA; bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA] CTD PMID:21432021 NCBI chr 6:46,700,558...46,735,836
Ensembl chr 6:46,704,201...46,735,693
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression EXP Platelet Activating Factor results in decreased expression of PPARA mRNA CTD PMID:16386258 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTAFR platelet activating factor receptor multiple interactions
increases expression
increases phosphorylation
affects binding
EXP
ISO
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
Platelet Activating Factor results in increased expression of PTAFR mRNA
Platelet Activating Factor results in increased phosphorylation of PTAFR protein
bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
CTD PMID:9065783 PMID:10447766 PMID:11297424 PMID:11529688 PMID:16386258 PMID:18205269 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression EXP Platelet Activating Factor results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Platelet Activating Factor results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PVT1 Pvt1 oncogene increases expression
multiple interactions
EXP Platelet Activating Factor results in increased expression of PVT1 mRNA
[Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
CTD PMID:32830409 NCBI chr 8:127,794,533...128,101,253
Ensembl chr 8:127,794,526...128,187,101
JBrowse link
G RGS4 regulator of G protein signaling 4 multiple interactions ISO RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein] CTD PMID:11297424 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
G SELE selectin E increases expression EXP Platelet Activating Factor results in increased expression of SELE mRNA CTD PMID:16386258 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SELL selectin L multiple interactions
increases secretion
EXP Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein] CTD PMID:9762784 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
JBrowse link
G SELP selectin P multiple interactions
increases expression
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 increases expression EXP Platelet Activating Factor results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912
JBrowse link
G TNF tumor necrosis factor increases secretion
multiple interactions
increases expression
EXP
ISO
Platelet Activating Factor results in increased secretion of TNF protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
Platelet Activating Factor results in increased expression of TNF mRNA
Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]
CTD PMID:9065783 PMID:10921504 PMID:16386258 PMID:32830409 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor increases expression ISO platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
3-dehydrocarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine]
CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
4-(trimethylammonio)butanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BBOX1 gamma-butyrobetaine hydroxylase 1 multiple interactions EXP [BBOX1 protein co-treated with Ketoglutaric Acids] results in increased metabolism of gamma-butyrobetaine CTD PMID:21439360 NCBI chr11:27,040,705...27,127,809
Ensembl chr11:27,040,725...27,127,809
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
CAR(3:0(Me2)) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 affects binding
multiple interactions
increases transport
increases uptake
EXP
ISO
pivaloylcarnitine binds to SLC22A5 protein
Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]
SLC22A5 protein results in increased uptake of pivaloylcarnitine
CTD PMID:18762717 PMID:19539806 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,710...132,395,613
JBrowse link
ergothioneine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Ergothioneine inhibits the reaction [Cisplatin results in decreased activity of ACHE protein] CTD PMID:20932872 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA CTD PMID:33549593 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABI3BP ABI family member 3 binding protein increases expression ISO Betaine results in increased expression of ABI3BP mRNA CTD PMID:26391144 NCBI chr 3:100,749,156...100,993,508
Ensembl chr 3:100,749,156...100,993,515
JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA CTD PMID:22648174 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACACB acetyl-CoA carboxylase beta multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ACACB mRNA CTD PMID:33549593 NCBI chr12:109,112,666...109,268,226
Ensembl chr12:109,116,595...109,268,226
JBrowse link
G ADGRG2 adhesion G protein-coupled receptor G2 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ADGRG2 mRNA CTD PMID:33549593 NCBI chr  X:18,989,307...19,122,956
Ensembl chr  X:18,989,307...19,122,637
JBrowse link
G ADSS2 adenylosuccinate synthase 2 decreases expression ISO Betaine results in decreased expression of ADSS mRNA CTD PMID:26391144 NCBI chr 1:244,408,494...244,452,060
Ensembl chr 1:244,408,494...244,451,909
JBrowse link
G AHCY adenosylhomocysteinase decreases expression ISO Betaine results in decreased expression of AHCY mRNA CTD PMID:22945834 PMID:26391144 NCBI chr20:34,235,012...34,311,976
Ensembl chr20:34,280,268...34,311,802
JBrowse link
G AKIP1 A-kinase interacting protein 1 increases expression ISO Betaine results in increased expression of AKIP1 mRNA CTD PMID:26391144 NCBI chr11:8,911,117...8,920,079
Ensembl chr11:8,911,139...8,920,084
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B decreases expression ISO Betaine results in decreased expression of AKR1B1 mRNA CTD PMID:26391144 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA CTD PMID:33549593 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein CTD PMID:20118189 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO Betaine results in decreased expression of APEX1 mRNA CTD PMID:26391144 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Betaine inhibits the reaction [Azacitidine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [Azacitidine results in increased expression of and results in increased cleavage of APP protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein] CTD PMID:19635394 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions ISO ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine]; Betaine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Betaine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA] CTD PMID:22945834 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G AXIN1 axin 1 multiple interactions ISO [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene CTD PMID:16868943 NCBI chr16:287,440...355,226
Ensembl chr16:287,440...352,723
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression ISO Betaine results in decreased expression of BAX protein CTD PMID:25080425 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator affects binding
increases expression
EXP
ISO
Betaine analog binds to BCL2 protein
Betaine results in increased expression of BCL2 protein
CTD PMID:25080425 PMID:25765238 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BHLHE40 basic helix-loop-helix family member e40 increases expression ISO Betaine results in increased expression of BHLHE40 mRNA CTD PMID:26391144 NCBI chr 3:4,979,420...4,985,323
Ensembl chr 3:4,979,437...4,985,323
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase increases metabolic processing EXP BHMT protein results in increased metabolism of Betaine CTD PMID:18230605 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
JBrowse link
G BRF1 BRF1 RNA polymerase III transcription initiation factor subunit multiple interactions EXP Betaine inhibits the reaction [Ethanol results in increased expression of BRF1 mRNA]; Betaine inhibits the reaction [Ethanol results in increased expression of BRF1 protein] CTD PMID:32418914 NCBI chr14:105,209,286...105,315,589
Ensembl chr14:105,209,286...105,315,589
JBrowse link
G CAB39L calcium binding protein 39 like decreases expression ISO Betaine results in decreased expression of CAB39L mRNA CTD PMID:26391144 NCBI chr13:49,308,650...49,444,851
Ensembl chr13:49,308,650...49,444,064
JBrowse link
G CASP1 caspase 1 increases expression ISO Betaine results in increased expression of CASP1 mRNA CTD PMID:26391144 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions ISO Betaine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:24632105 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein
Betaine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Betaine inhibits the reaction [Carbon Tetrachloride results in increased activity of CAT protein]
CTD PMID:12893363 PMID:20118189 PMID:24632105 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCDC113 coiled-coil domain containing 113 increases expression ISO Betaine results in increased expression of CCDC113 mRNA CTD PMID:26391144 NCBI chr16:58,196,862...58,283,836
Ensembl chr16:58,231,157...58,283,836
JBrowse link
G CCL15 C-C motif chemokine ligand 15 increases expression ISO Betaine results in increased expression of CCL6 mRNA CTD PMID:26391144 NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA CTD PMID:22648174 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases expression ISO Betaine results in increased expression of CCL5 mRNA CTD PMID:26391144 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCNB2 cyclin B2 decreases expression ISO Betaine results in decreased expression of CCNB2 mRNA CTD PMID:26391144 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045
JBrowse link
G CD44 CD44 molecule (Indian blood group) decreases expression ISO Betaine results in decreased expression of CD44 mRNA CTD PMID:26391144 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CDC42EP2 CDC42 effector protein 2 decreases expression ISO Betaine results in decreased expression of CDC42EP2 mRNA CTD PMID:26391144 NCBI chr11:65,314,866...65,322,417
Ensembl chr11:65,314,866...65,322,417
JBrowse link
G CDH13 cadherin 13 decreases expression ISO Betaine results in decreased expression of CDH13 mRNA CTD PMID:26391144 NCBI chr16:82,626,823...83,800,640
Ensembl chr16:82,626,965...83,800,640
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CDK1 mRNA CTD PMID:33549593 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A multiple interactions ISO Betaine promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA] CTD PMID:19642983 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CES3 carboxylesterase 3 increases expression ISO Betaine results in increased expression of CES3 mRNA CTD PMID:26391144 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149
JBrowse link
G CKB creatine kinase B increases expression ISO Betaine results in increased expression of CKB mRNA CTD PMID:26391144 NCBI chr14:103,519,667...103,522,833
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G CKS1B CDC28 protein kinase regulatory subunit 1B decreases expression ISO Betaine results in decreased expression of CKS1B mRNA CTD PMID:26391144 NCBI chr 1:154,974,681...154,979,251
Ensembl chr 1:154,974,653...154,979,251
JBrowse link
G CLCF1 cardiotrophin like cytokine factor 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CLCF1 mRNA CTD PMID:33549593 NCBI chr11:67,364,168...67,374,177
Ensembl chr11:67,364,168...67,374,177
JBrowse link
G COTL1 coactosin like F-actin binding protein 1 decreases expression ISO Betaine results in decreased expression of COTL1 mRNA CTD PMID:26391144 NCBI chr16:84,565,596...84,618,078
Ensembl chr16:84,565,596...84,618,078
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions
decreases expression
ISO Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]
Betaine results in decreased expression of CPT1A mRNA
CTD PMID:22945834 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CXCL16 C-X-C motif chemokine ligand 16 decreases expression ISO Betaine results in decreased expression of CXCL16 mRNA CTD PMID:26391144 NCBI chr17:4,733,533...4,739,928
Ensembl chr17:4,733,533...4,739,928
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP26A1 mRNA CTD PMID:33549593 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA CTD PMID:33549593 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2C55 mRNA CTD PMID:33549593 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO
EXP
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]
Betaine promotes the reaction [Ethanol results in increased expression of CYP2E1]
CTD PMID:20118189 PMID:21352821 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP4Z1 cytochrome P450 family 4 subfamily Z member 1 multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of CYP4A10 protein CTD PMID:20118189 NCBI chr 1:47,055,525...47,118,320
Ensembl chr 1:47,067,231...47,118,318
JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 increases expression ISO Betaine results in increased expression of CYSLTR1 mRNA CTD PMID:26391144 NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691
JBrowse link
G DAPK1 death associated protein kinase 1 decreases expression ISO Betaine results in decreased expression of DAPK1 mRNA CTD PMID:26391144 NCBI chr 9:87,497,228...87,708,634
Ensembl chr 9:87,497,228...87,708,634
JBrowse link
G DEPP1 DEPP1 autophagy regulator multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of DEPP1 mRNA CTD PMID:33549593 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809
JBrowse link
G DLX2 distal-less homeobox 2 increases expression ISO Betaine results in increased expression of DLX2 mRNA CTD PMID:26391144 NCBI chr 2:172,099,438...172,102,900
Ensembl chr 2:172,099,438...172,102,900
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions
increases expression
ISO Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]
Betaine results in increased expression of DNMT1 mRNA
CTD PMID:22945834 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression ISO Betaine results in decreased expression of DNMT3B mRNA CTD PMID:22945834 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G E2F8 E2F transcription factor 8 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of E2F8 mRNA CTD PMID:33549593 NCBI chr11:19,224,063...19,241,655
Ensembl chr11:19,224,063...19,241,620
JBrowse link
G ECT2 epithelial cell transforming 2 decreases expression ISO Betaine results in decreased expression of ECT2 mRNA CTD PMID:26391144 NCBI chr 3:172,750,694...172,829,273
Ensembl chr 3:172,750,682...172,821,474
JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase increases expression ISO Betaine results in increased expression of EEF2K mRNA CTD PMID:26391144 NCBI chr16:22,206,278...22,288,738
Ensembl chr16:22,206,278...22,288,738
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA CTD PMID:33549593 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 increases expression
multiple interactions
ISO Betaine results in increased expression of EGR1 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGR1 mRNA
CTD PMID:26391144 PMID:33549593 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ELF3 E74 like ETS transcription factor 3 decreases expression ISO Betaine results in decreased expression of ELF3 mRNA CTD PMID:26391144 NCBI chr 1:202,010,583...202,017,183
Ensembl chr 1:202,007,945...202,017,183
JBrowse link
G EMC9 ER membrane protein complex subunit 9 increases expression ISO Betaine results in increased expression of EMC9 mRNA CTD PMID:26391144 NCBI chr14:24,138,959...24,142,602
Ensembl chr14:24,138,959...24,141,591
JBrowse link
G EPHB6 EPH receptor B6 increases expression ISO Betaine results in increased expression of EPHB6 mRNA CTD PMID:26391144 NCBI chr 7:142,854,639...142,871,093
Ensembl chr 7:142,855,061...142,871,094
JBrowse link
G ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA CTD PMID:33549593 NCBI chr 8:27,771,949...27,812,430
Ensembl chr 8:27,771,949...27,812,640
JBrowse link
G F8 coagulation factor VIII multiple interactions
increases secretion
EXP Betaine affects the localization of and results in increased secretion of F8 protein; Betaine affects the localization of and results in increased secretion of F8 protein mutant form
Betaine results in increased secretion of F8 protein; Betaine results in increased secretion of F8 protein mutant form
CTD PMID:22973456 NCBI chr  X:154,835,792...155,022,723
Ensembl chr  X:154,835,788...155,026,940
JBrowse link
G F9 coagulation factor IX increases secretion EXP Betaine results in increased secretion of F9 protein CTD PMID:22973456 NCBI chr  X:139,530,720...139,563,459
Ensembl chr  X:139,530,739...139,563,459
JBrowse link
G FABP5 fatty acid binding protein 5 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of FABP5 mRNA CTD PMID:33549593 NCBI chr 8:81,280,536...81,284,775
Ensembl chr 8:81,280,536...81,284,777
JBrowse link
G FASN fatty acid synthase multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] CTD PMID:22648174 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FLRT3 fibronectin leucine rich transmembrane protein 3 increases expression ISO Betaine results in increased expression of FLRT3 mRNA CTD PMID:26391144 NCBI chr20:14,322,985...14,337,847
Ensembl chr20:14,322,985...14,337,614
JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 decreases expression ISO Betaine results in decreased expression of FXYD2 mRNA; Betaine results in decreased expression of FXYD2 mRNA alternative form CTD PMID:26391144 NCBI chr11:117,820,057...117,828,089
Ensembl chr11:117,800,844...117,828,698
JBrowse link
G GADD45B growth arrest and DNA damage inducible beta multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GADD45B mRNA CTD PMID:33549593 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259
JBrowse link
G GADD45G growth arrest and DNA damage inducible gamma multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GADD45G mRNA CTD PMID:33549593 NCBI chr 9:89,605,009...89,606,555
Ensembl chr 9:89,605,012...89,606,555
JBrowse link
G GAL galanin and GMAP prepropeptide multiple interactions ISO Betaine inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:19294532 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GCK glucokinase multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GCK mRNA CTD PMID:33549593 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GNA14 G protein subunit alpha 14 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GNA14 mRNA CTD PMID:33549593 NCBI chr 9:77,423,079...77,648,322
Ensembl chr 9:77,423,079...77,648,322
JBrowse link
G GPCPD1 glycerophosphocholine phosphodiesterase 1 increases expression
multiple interactions
ISO Betaine results in increased expression of GPCPD1 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GPCPD1 mRNA
CTD PMID:26391144 PMID:33549593 NCBI chr20:5,544,439...5,611,046
Ensembl chr20:5,544,439...5,611,006
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTA5 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GSTA5 mRNA CTD PMID:33549593 NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843
JBrowse link
G GSTM3 glutathione S-transferase mu 3 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA CTD PMID:33549593 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO Betaine inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:19294532 NCBI chr 7:65,960,684...65,982,230
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G H2AZ1 H2A.Z variant histone 1 decreases expression ISO Betaine results in decreased expression of H2AZ1 mRNA CTD PMID:26391144 NCBI chr 4:99,948,088...99,950,275
Ensembl chr 4:99,948,086...99,950,355
JBrowse link
G HIP1 huntingtin interacting protein 1 decreases expression ISO Betaine results in decreased expression of HIP1 mRNA CTD PMID:26391144 NCBI chr 7:75,533,298...75,738,976
Ensembl chr 7:75,533,298...75,738,962
JBrowse link
G HMGB2 high mobility group box 2 decreases expression ISO Betaine results in decreased expression of HMGB2 mRNA CTD PMID:26391144 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Betaine results in decreased expression of HSPA5 mRNA CTD PMID:22945834 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G ID2 inhibitor of DNA binding 2 increases expression ISO Betaine results in increased expression of ID2 mRNA CTD PMID:26391144 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Betaine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G IRX4 iroquois homeobox 4 decreases expression ISO Betaine results in decreased expression of IRX4 mRNA CTD PMID:26391144 NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236
JBrowse link
G ITGA8 integrin subunit alpha 8 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGA8 mRNA CTD PMID:33549593 NCBI chr10:15,513,954...15,720,329
Ensembl chr10:15,513,954...15,719,922
JBrowse link
G ITGB4 integrin subunit beta 4 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGB4 mRNA CTD PMID:33549593 NCBI chr17:75,721,339...75,757,819
Ensembl chr17:75,721,328...75,757,818
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Betaine results in increased expression of JUN mRNA CTD PMID:26391144 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KHDRBS3 KH RNA binding domain containing, signal transduction associated 3 decreases expression ISO Betaine results in decreased expression of KHDRBS3 mRNA CTD PMID:26391144 NCBI chr 8:135,457,456...135,656,516
Ensembl chr 8:135,457,456...135,656,722
JBrowse link
G KIF1B kinesin family member 1B increases expression ISO Betaine results in increased expression of KIF1B mRNA CTD PMID:26391144 NCBI chr 1:10,210,570...10,381,603
Ensembl chr 1:10,210,570...10,381,603
JBrowse link
G KIF22 kinesin family member 22 decreases expression ISO Betaine results in decreased expression of KIF22 mRNA CTD PMID:26391144 NCBI chr16:29,790,734...29,805,543
Ensembl chr16:29,790,719...29,805,384
JBrowse link
G KLF10 Kruppel like factor 10 increases expression ISO Betaine results in increased expression of KLF10 mRNA CTD PMID:26391144 NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
JBrowse link
G KRT2 keratin 2 increases expression ISO Betaine results in increased expression of KRT2 mRNA; Betaine results in increased expression of KRT2 protein CTD PMID:26391144 NCBI chr12:52,644,558...52,652,211
Ensembl chr12:52,644,558...52,652,211
JBrowse link
G KRT4 keratin 4 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of KRT4 mRNA CTD PMID:33549593 NCBI chr12:52,806,549...52,814,116
Ensembl chr12:52,806,549...52,814,116
JBrowse link
G LARS1 leucyl-tRNA synthetase 1 decreases expression ISO Betaine results in decreased expression of LARS mRNA CTD PMID:26391144 NCBI chr 5:146,113,034...146,182,731
Ensembl chr 5:146,110,566...146,182,696
JBrowse link
G LEPR leptin receptor multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA CTD PMID:33549593 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LIN9 lin-9 DREAM MuvB core complex component decreases expression ISO Betaine results in decreased expression of LIN9 mRNA CTD PMID:26391144 NCBI chr 1:226,231,149...226,310,082
Ensembl chr 1:226,231,149...226,309,869
JBrowse link
G LRATD1 LRAT domain containing 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRATD1 mRNA CTD PMID:33549593 NCBI chr 2:14,632,717...14,651,916
Ensembl chr 2:14,632,700...14,650,814
JBrowse link
G LRRC24 leucine rich repeat containing 24 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRRC24 mRNA CTD PMID:33549593 NCBI chr 8:144,522,388...144,527,033
Ensembl chr 8:144,522,388...144,527,033
JBrowse link
G MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MAP4K1 mRNA CTD PMID:33549593 NCBI chr19:38,587,641...38,617,953
Ensembl chr19:38,587,641...38,618,882
JBrowse link
G MARCHF6 membrane associated ring-CH-type finger 6 multiple interactions
decreases stability
EXP Cholesterol inhibits the reaction [Betaine results in decreased stability of MARCHF6 protein] CTD PMID:30545937 NCBI chr 5:10,353,693...10,440,388
Ensembl chr 5:10,353,695...10,440,388
JBrowse link
G MCM3 minichromosome maintenance complex component 3 decreases expression ISO Betaine results in decreased expression of MCM3 mRNA CTD PMID:26391144 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881
JBrowse link
G MCM4 minichromosome maintenance complex component 4 decreases expression ISO Betaine results in decreased expression of MCM4 mRNA CTD PMID:26391144 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MCM5 minichromosome maintenance complex component 5 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM5 mRNA CTD PMID:33549593 NCBI chr22:35,400,133...35,454,942
Ensembl chr22:35,400,134...35,425,431
JBrowse link
G MCM6 minichromosome maintenance complex component 6 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM6 mRNA CTD PMID:33549593 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G MCM7 minichromosome maintenance complex component 7 decreases expression ISO Betaine results in decreased expression of MCM7 mRNA CTD PMID:26391144 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,728...100,101,940
JBrowse link
G MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MICAL1 mRNA CTD PMID:33549593 NCBI chr 6:109,444,062...109,465,968
Ensembl chr 6:109,444,062...109,465,968
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MKI67 mRNA CTD PMID:33549593 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like decreases expression ISO Betaine results in decreased expression of MTHFD1L mRNA CTD PMID:26391144 NCBI chr 6:150,865,684...151,101,887
Ensembl chr 6:150,865,679...151,101,887
JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression ISO Betaine results in decreased expression of MTHFD2 mRNA CTD PMID:26391144 NCBI chr 2:74,198,591...74,217,565
Ensembl chr 2:74,186,172...74,217,565
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Betaine inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA] CTD PMID:19642983 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYCL MYCL proto-oncogene, bHLH transcription factor multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MYCL mRNA CTD PMID:33549593 NCBI chr 1:39,895,428...39,901,917
Ensembl chr 1:39,895,426...39,902,256
JBrowse link
G NBL1 NBL1, DAN family BMP antagonist increases expression ISO Betaine results in increased expression of NBL1 mRNA CTD PMID:26391144 NCBI chr 1:19,643,229...19,658,452
Ensembl chr 1:19,596,979...19,658,456
JBrowse link
G NCKIPSD NCK interacting protein with SH3 domain decreases expression ISO Betaine results in decreased expression of NCKIPSD mRNA CTD PMID:26391144 NCBI chr 3:48,663,814...48,685,941
Ensembl chr 3:48,673,844...48,686,364
JBrowse link
G NDRG4 NDRG family member 4 decreases expression ISO Betaine results in decreased expression of NDRG4 mRNA CTD PMID:26391144 NCBI chr16:58,463,704...58,515,403
Ensembl chr16:58,462,846...58,513,628
JBrowse link
G NLRP12 NLR family pyrin domain containing 12 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of NLRP12 mRNA CTD PMID:33549593 NCBI chr19:53,793,584...53,824,403
Ensembl chr19:53,793,741...53,824,394
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator decreases expression ISO Betaine results in decreased expression of NUPR1 mRNA CTD PMID:26391144 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,008
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase multiple interactions ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter] CTD PMID:22064374 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PCP4 Purkinje cell protein 4 increases expression ISO Betaine results in increased expression of PCP4 mRNA CTD PMID:26391144 NCBI chr21:39,867,438...39,929,392
Ensembl chr21:39,867,438...39,929,397
JBrowse link
G PCTP phosphatidylcholine transfer protein decreases expression ISO Betaine results in decreased expression of PCTP mRNA CTD PMID:26391144 NCBI chr17:55,750,979...55,845,001
Ensembl chr17:55,751,051...55,842,830
JBrowse link
G PER2 period circadian regulator 2 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of PER2 mRNA CTD PMID:33549593 NCBI chr 2:238,244,038...238,290,102
Ensembl chr 2:238,244,044...238,290,102
JBrowse link
G POLA2 DNA polymerase alpha 2, accessory subunit decreases expression ISO Betaine results in decreased expression of POLA2 mRNA CTD PMID:26391144 NCBI chr11:65,261,917...65,306,269
Ensembl chr11:65,261,920...65,305,589
JBrowse link
G POLE2 DNA polymerase epsilon 2, accessory subunit decreases expression ISO Betaine results in decreased expression of POLE2 mRNA CTD PMID:26391144 NCBI chr14:49,643,555...49,688,417
Ensembl chr14:49,643,555...49,688,422
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein
Betaine results in decreased expression of PPARA mRNA
CTD PMID:20118189 PMID:22945834 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPP1R3G protein phosphatase 1 regulatory subunit 3G multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of PPP1R3G mRNA CTD PMID:33549593 NCBI chr 6:5,085,341...5,089,487
Ensembl chr 6:5,085,341...5,089,487
JBrowse link
G PRSS23 serine protease 23 increases expression ISO Betaine results in increased expression of PRSS23 mRNA CTD PMID:26391144 NCBI chr11:86,791,071...86,952,910
Ensembl chr11:86,791,059...86,952,910
JBrowse link
G PRSS8 serine protease 8 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593 NCBI chr16:31,131,433...31,135,727
Ensembl chr16:31,131,433...31,135,727
JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO Betaine inhibits the reaction [Azacitidine results in decreased methylation of PSEN1 promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter] CTD PMID:19635394 NCBI chr14:73,136,436...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Betaine results in decreased expression of PTGS1 mRNA CTD PMID:26391144 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G RANBP3L RAN binding protein 3 like decreases expression ISO Betaine results in decreased expression of RANBP3L mRNA CTD PMID:26391144 NCBI chr 5:36,246,913...36,301,902
Ensembl chr 5:36,246,913...36,302,114
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein] CTD PMID:25559852 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RFX4 regulatory factor X4 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RFX4 mRNA CTD PMID:33549593 NCBI chr12:106,583,004...106,762,803
Ensembl chr12:106,583,004...106,762,803
JBrowse link
G RGS16 regulator of G protein signaling 16 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RGS16 mRNA CTD PMID:33549593 NCBI chr 1:182,598,623...182,604,389
Ensembl chr 1:182,598,623...182,604,389
JBrowse link
G RGS2 regulator of G protein signaling 2 increases expression ISO Betaine results in increased expression of RGS2 mRNA CTD PMID:26391144 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 decreases expression
multiple interactions
ISO Betaine results in decreased expression of RRM2 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA
CTD PMID:26391144 PMID:33549593 NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725
JBrowse link
G S100A8 S100 calcium binding protein A8 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of S100A8 mRNA CTD PMID:33549593 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression ISO Betaine results in decreased expression of SCD1 mRNA CTD PMID:26391144 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SECTM1 secreted and transmembrane 1 increases expression ISO Betaine results in increased expression of SECTM1A mRNA CTD PMID:26391144 NCBI chr17:82,321,024...82,333,951
Ensembl chr17:82,321,024...82,334,074
JBrowse link
G SERINC2 serine incorporator 2 decreases expression ISO Betaine results in decreased expression of SERINC2 mRNA CTD PMID:26391144 NCBI chr 1:31,409,777...31,434,678
Ensembl chr 1:31,409,565...31,434,680
JBrowse link
G SLC16A6 solute carrier family 16 member 6 increases expression ISO Betaine results in increased expression of SLC16A6 mRNA CTD PMID:26391144 NCBI chr17:68,267,026...68,291,439
Ensembl chr17:68,267,026...68,291,267
JBrowse link
G SLC22A5 solute carrier family 22 member 5 multiple interactions EXP Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,710...132,395,613
JBrowse link
G SLC25A30 solute carrier family 25 member 30 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SLC25A30 mRNA CTD PMID:33549593 NCBI chr13:45,393,316...45,434,016
Ensembl chr13:45,393,316...45,418,455
JBrowse link
G SLC36A1 solute carrier family 36 member 1 increases uptake ISO SLC36A1 protein results in increased uptake of Betaine CTD PMID:18845132 NCBI chr 5:151,411,344...151,556,318
Ensembl chr 5:151,437,046...151,492,379
JBrowse link
G SLC6A12 solute carrier family 6 member 12 multiple interactions ISO Betaine inhibits the reaction [Lipopolysaccharides results in increased expression of SLC6A12 mRNA] CTD PMID:22053950 NCBI chr12:190,081...214,157
Ensembl chr12:190,077...214,570
JBrowse link
G SLC6A20 solute carrier family 6 member 20 increases uptake ISO SLC6A20B protein results in increased uptake of Betaine CTD PMID:18845132 NCBI chr 3:45,755,449...45,796,553
Ensembl chr 3:45,755,449...45,796,536
JBrowse link
G SLC6A9 solute carrier family 6 member 9 decreases expression ISO Betaine results in decreased expression of SLC6A9 mRNA CTD PMID:26391144 NCBI chr 1:43,996,483...44,031,462
Ensembl chr 1:43,991,500...44,031,467
JBrowse link
G SNX10 sorting nexin 10 decreases expression ISO Betaine results in decreased expression of SNX10 mRNA CTD PMID:26391144 NCBI chr 7:26,291,862...26,374,383
Ensembl chr 7:26,291,862...26,374,383
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SOCS2 mRNA CTD PMID:33549593 NCBI chr12:93,569,849...93,626,236
Ensembl chr12:93,569,814...93,583,487
JBrowse link
G SOSTDC1 sclerostin domain containing 1 increases expression ISO Betaine results in increased expression of SOSTDC1 mRNA CTD PMID:26391144 NCBI chr 7:16,461,481...16,465,738
Ensembl chr 7:16,461,481...16,530,580
JBrowse link
G SPC25 SPC25 component of NDC80 kinetochore complex decreases expression ISO Betaine results in decreased expression of SPC25 mRNA CTD PMID:26391144 NCBI chr 2:168,865,045...168,890,443
Ensembl chr 2:168,834,132...168,913,371
JBrowse link
G SSR4 signal sequence receptor subunit 4 decreases expression ISO Betaine results in decreased expression of SSR4 mRNA CTD PMID:26391144 NCBI chr  X:153,794,159...153,798,512
Ensembl chr  X:153,793,516...153,798,499
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO Betaine promotes the reaction [Isoproterenol results in increased phosphorylation of STAT3 protein] CTD PMID:25080425 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,540
JBrowse link
G STMN1 stathmin 1 decreases expression ISO Betaine results in decreased expression of STMN1 mRNA CTD PMID:26391144 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
JBrowse link
G STXBP1 syntaxin binding protein 1 decreases expression ISO Betaine results in decreased expression of STXBP1 mRNA CTD PMID:26391144 NCBI chr 9:127,611,912...127,696,029
Ensembl chr 9:127,579,370...127,696,027
JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of SULT1E1 mRNA CTD PMID:33549593 NCBI chr 4:69,841,212...69,860,151
Ensembl chr 4:69,841,212...69,860,145
JBrowse link
G TGFB2 transforming growth factor beta 2 increases expression ISO Betaine results in increased expression of TGFB2 mRNA CTD PMID:26391144 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Betaine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA] CTD PMID:22945834 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRIB2 tribbles pseudokinase 2 decreases expression ISO Betaine results in decreased expression of TRIB2 mRNA CTD PMID:26391144 NCBI chr 2:12,716,936...12,742,734
Ensembl chr 2:12,716,910...12,742,734
JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ULK1 mRNA CTD PMID:33549593 NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150
JBrowse link
G UPK3BL1 uroplakin 3B like 1 decreases expression ISO Betaine results in decreased expression of UPK3BL1 mRNA CTD PMID:26391144 NCBI chr 7:102,637,025...102,642,791
Ensembl chr 7:102,637,025...102,642,791
JBrowse link
G USP2 ubiquitin specific peptidase 2 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of USP2 mRNA CTD PMID:33549593 NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711
JBrowse link
G VNN1 vanin 1 multiple interactions ISO [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of VNN1 mRNA CTD PMID:33549593 NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055
JBrowse link
G WNK4 WNK lysine deficient protein kinase 4 decreases expression ISO Betaine results in decreased expression of WNK4 mRNA CTD PMID:26391144 NCBI chr17:42,779,701...42,797,066
Ensembl chr17:42,780,610...42,797,066
JBrowse link
G YBX2 Y-box binding protein 2 decreases expression ISO Betaine results in decreased expression of YBX2 mRNA CTD PMID:26391144 NCBI chr17:7,288,254...7,294,639
Ensembl chr17:7,288,263...7,294,639
JBrowse link
L-proline betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein] CTD PMID:32417162 NCBI chr 1:161,184,302...161,202,339
Ensembl chr 1:161,184,302...161,199,054
JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein] CTD PMID:32417162 NCBI chr21:26,917,922...26,967,758
Ensembl chr21:26,917,922...26,967,088
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:32417162 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein] CTD PMID:32417162 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP3 matrix metallopeptidase 3 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:32417162 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein] CTD PMID:32417162 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:32417162 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:32417162 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein] CTD PMID:32417162 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
meldonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADL acyl-CoA dehydrogenase long chain increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of ACADL mRNA CTD PMID:32389661 NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of ACADM mRNA CTD PMID:32389661 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575
JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACADVL mRNA CTD PMID:32389661 NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266
JBrowse link
G ACOX1 acyl-CoA oxidase 1 affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACOX1 mRNA CTD PMID:32389661 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G CPT1B carnitine palmitoyltransferase 1B decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1B mRNA CTD PMID:32389661 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465
JBrowse link
G CPT1C carnitine palmitoyltransferase 1C decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1C mRNA CTD PMID:32389661 NCBI chr19:49,690,672...49,713,731
Ensembl chr19:49,690,898...49,713,731
JBrowse link
G HK1 hexokinase 1 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of HK1 mRNA CTD PMID:32389661 NCBI chr10:69,269,991...69,401,882
Ensembl chr10:69,269,984...69,401,884
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of PDK1 mRNA CTD PMID:32389661 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARA mRNA CTD PMID:32389661 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of PPARGC1A mRNA CTD PMID:27559315 PMID:32389661 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPARGC1B PPARG coactivator 1 beta affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARGC1B mRNA CTD PMID:27559315 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G SLC22A5 solute carrier family 22 member 5 increases uptake EXP
ISO
SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate CTD PMID:18981167 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,710...132,395,613
JBrowse link
G SLC2A4 solute carrier family 2 member 4 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of SLC2A4 mRNA CTD PMID:32389661 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC5A2 solute carrier family 5 member 2 affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of SLC5A2 mRNA CTD PMID:32389661 NCBI chr16:31,482,535...31,490,769
Ensembl chr16:31,483,002...31,490,860
JBrowse link
G TFAM transcription factor A, mitochondrial decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of TFAM mRNA CTD PMID:27559315 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression ISO Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G ATP6V1F ATPase H+ transporting V1 subunit F increases expression ISO Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 7:128,862,856...128,865,847
Ensembl chr 7:128,862,856...128,865,847
JBrowse link
G C1QA complement C1q A chain decreases expression ISO Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,636,628...22,639,678
JBrowse link
G C4B complement C4B (Chido blood group) decreases expression ISO Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G CASP3 caspase 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G COL2A1 collagen type II alpha 1 chain multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CTSS cathepsin S decreases expression ISO Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 decreases expression ISO Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression ISO Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HMOX2 heme oxygenase 2 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr16:4,474,697...4,510,347
Ensembl chr16:4,474,690...4,510,347
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 decreases expression ISO Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression ISO Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G NGF nerve growth factor multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,904...115,338,770
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PAH phenylalanine hydroxylase decreases expression ISO Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression
multiple interactions
EXP Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
CTD PMID:20414966 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,775
JBrowse link
G PSMB6 proteasome 20S subunit beta 6 increases expression ISO Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr17:4,796,164...4,798,495
Ensembl chr17:4,796,144...4,798,502
JBrowse link
G PTMA prothymosin alpha increases expression ISO Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 2:231,708,525...231,713,551
Ensembl chr 2:231,706,895...231,713,551
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RPS17 ribosomal protein S17 increases expression ISO Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr15:82,536,750...82,540,457
Ensembl chr15:82,536,750...82,540,459
JBrowse link
G SKAP2 src kinase associated phosphoprotein 2 decreases expression ISO Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 7:26,654,772...26,864,623
Ensembl chr 7:26,667,068...26,995,239
JBrowse link
G SLC25A20 solute carrier family 25 member 20 multiple interactions ISO Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 3:48,856,926...48,898,882
Ensembl chr 3:48,856,926...48,898,904
JBrowse link
G SNCA synuclein alpha multiple interactions EXP [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
O-butanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
O-octanoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CROT carnitine O-octanoyltransferase increases chemical synthesis ISO CROT protein results in increased chemical synthesis of octanoylcarnitine CTD PMID:6838215 NCBI chr 7:87,345,646...87,399,794
Ensembl chr 7:87,345,664...87,399,794
JBrowse link
O-palmitoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL2A1 collagen type II alpha 1 chain multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Palmitoylcarnitine CTD PMID:24709313 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G GLS glutaminase increases chemical synthesis EXP GLS protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G PPP3R1 protein phosphatase 3 regulatory subunit B, alpha decreases metabolic processing ISO PPP3R1 gene mutant form results in decreased metabolism of Palmitoylcarnitine CTD PMID:19700627 NCBI chr 2:68,178,857...68,252,532
Ensembl chr 2:68,178,857...68,256,237
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases chemical synthesis EXP PRKAA1 protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,379...40,798,374
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658 PMID:21267448 PMID:30265530 PMID:31445927 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
EXP [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658 PMID:25416439 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein CTD PMID:15781658 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with Vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G EGF epidermal growth factor multiple interactions EXP perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G FAS Fas cell surface death receptor affects response to substance EXP perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP
ISO
[perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA
perifosine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of FOXO1 protein]
CTD PMID:30265530 PMID:33078829 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G LAT2 linker for activation of T cells family member 2 multiple interactions
decreases response to substance
decreases expression
EXP ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 NCBI chr 7:74,210,006...74,229,834
Ensembl chr 7:74,199,652...74,229,834
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions EXP MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Vorinostat] CTD PMID:15781658 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,544
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G TNF tumor necrosis factor increases response to substance EXP perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
phosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects export
affects transport
EXP ABCB1 protein affects the export of Phosphatidylcholines
ABCB1 protein affects the transport of Phosphatidylcholines
CTD PMID:11147995 PMID:11745043 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 increases secretion ISO ABCB11 protein results in increased secretion of Phosphatidylcholines CTD PMID:14570929 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 affects transport
affects export
ISO
EXP
ABCB4 protein affects the transport of Phosphatidylcholines
ABCB4 protein affects the export of Phosphatidylcholines
CTD PMID:11745043 PMID:15696852 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,696...87,480,435
JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 decreases activity ISO Phosphatidylcholines results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr11:108,116,705...108,148,822
Ensembl chr11:108,116,695...108,147,603
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression ISO Phosphatidylcholines results in decreased expression of ADIPOQ mRNA CTD PMID:23911798 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
increases abundance
ISO
EXP
PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of AIFM1 protein CTD PMID:21695227 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ARNTL aryl hydrocarbon receptor nuclear translocator like increases abundance ISO ARNTL gene mutant form results in increased abundance of Phosphatidylcholines CTD PMID:27056296 NCBI chr11:13,276,552...13,387,268
Ensembl chr11:13,276,652...13,387,266
JBrowse link
G AS3MT arsenite methyltransferase affects metabolic processing ISO AS3MT gene mutant form affects the metabolism of Phosphatidylcholines CTD PMID:27591999 NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of BAX protein CTD PMID:21695227 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of BCL2 protein CTD PMID:21695227 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP3 protein CTD PMID:21695227 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP9 protein CTD PMID:21695227 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Phosphatidylcholines results in increased expression of CCL2 mRNA CTD PMID:23911798 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CCND1 protein CTD PMID:21695227 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 multiple interactions EXP Phosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein] CTD PMID:21695227 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CDK2 protein CTD PMID:21695227 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1A protein CTD PMID:21695227 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions EXP [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein CTD PMID:21695227 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CES1 carboxylesterase 1 decreases expression ISO Phosphatidylcholines results in decreased expression of CES1D mRNA CTD PMID:23911798 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CRP C-reactive protein affects binding
decreases activity
EXP CRP protein binds to Phosphatidylcholines
Phosphatidylcholines results in decreased activity of CRP protein
CTD PMID:16962105 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects activity EXP Phosphatidylcholines affects the activity of CYP1A2 protein CTD PMID:15966743 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases activity ISO Phosphatidylcholines results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis EXP ENPP7 protein results in increased hydrolysis of Phosphatidylcholines CTD PMID:12885774 NCBI chr17:79,730,919...79,742,926
Ensembl chr17:79,730,943...79,742,219
JBrowse link
G FASN fatty acid synthase multiple interactions EXP [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines CTD PMID:18723500 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FGF19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases activity ISO Phosphatidylcholines results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G IGF1 insulin like growth factor 1 increases degradation ISO IGF1 protein results in increased degradation of Phosphatidylcholines CTD PMID:2120207 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL10 interleukin 10 increases expression ISO Phosphatidylcholines results in increased expression of IL10 mRNA CTD PMID:23911798 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions
ISO Phosphatidylcholines results in increased expression of IL1B mRNA
Phosphatidylcholines results in increased expression of and results in increased secretion of IL1B protein
CTD PMID:23911798 PMID:30958839 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression ISO Phosphatidylcholines results in increased expression of IL6 mRNA CTD PMID:23911798 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LEP leptin decreases expression ISO Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LIPC lipase C, hepatic type multiple interactions
increases abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPC gene mutant form results in increased abundance of Phosphatidylcholines
CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPE lipase E, hormone sensitive type increases expression ISO Phosphatidylcholines results in increased expression of LIPE mRNA CTD PMID:23911798 NCBI chr19:42,401,512...42,427,421
Ensembl chr19:42,401,514...42,427,388
JBrowse link
G LIPG lipase G, endothelial type multiple interactions
increases abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPG gene mutant form results in increased abundance of Phosphatidylcholines
CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
G LTF lactotransferrin multiple interactions ISO [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA] CTD PMID:16169303 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions EXP NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Phosphatidylcholines CTD PMID:29515023 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 multiple interactions
increases secretion
ISO PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines]; PAFAH1B1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Phosphatidylcholines]
PAFAH1B1 protein results in increased secretion of Phosphatidylcholines
CTD PMID:12013527 NCBI chr17:2,593,210...2,685,617
Ensembl chr17:2,593,210...2,685,615
JBrowse link
G PAFAH2 platelet activating factor acetylhydrolase 2 multiple interactions EXP PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 1:25,959,764...25,998,164
Ensembl chr 1:25,959,767...25,998,117
JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline multiple interactions EXP PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr 3:196,234,368...196,287,726
Ensembl chr 3:196,214,222...196,287,957
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase multiple interactions EXP
ISO
PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr17:17,505,561...17,591,987
Ensembl chr17:17,505,563...17,591,708
JBrowse link
G PLIN1 perilipin 1 increases expression ISO Phosphatidylcholines results in increased expression of PLIN1 mRNA CTD PMID:23911798 NCBI chr15:89,664,365...89,679,367
Ensembl chr15:89,664,367...89,679,427
JBrowse link
G PLPP6 phospholipid phosphatase 6 multiple interactions
increases chemical synthesis
EXP PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr 9:4,662,294...4,665,258
Ensembl chr 9:4,662,294...4,665,258
JBrowse link
G PNPLA2 patatin like phospholipase domain containing 2 decreases expression ISO Phosphatidylcholines results in decreased expression of PNPLA2 mRNA CTD PMID:23911798 NCBI chr11:818,914...825,573
Ensembl chr11:818,914...825,573
JBrowse link
G PON2 paraoxonase 2 increases activity
increases expression
ISO Phosphatidylcholines results in increased activity of PON2 protein
Phosphatidylcholines results in increased expression of PON2 mRNA
CTD PMID:12615656 NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329
JBrowse link
G PON3 paraoxonase 3 multiple interactions ISO Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin] CTD PMID:12615656 NCBI chr 7:95,359,872...95,396,375
Ensembl chr 7:95,359,872...95,396,375
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO Phosphatidylcholines results in increased expression of PPARG mRNA CTD PMID:23911798 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1B PPARG coactivator 1 beta increases abundance ISO PPARGC1B results in increased abundance of Phosphatidylcholines CTD PMID:17932310 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G PTEN phosphatase and tensin homolog affects binding
multiple interactions
EXP PTEN protein binds to Phosphatidylcholines
[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]
CTD PMID:15313215 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G RETN resistin decreases expression ISO Phosphatidylcholines results in decreased expression of RETN mRNA CTD PMID:23911798 NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455
JBrowse link
G SFTPA1 surfactant protein A1 multiple interactions EXP [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPA2 surfactant protein A2 multiple interactions EXP [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines] CTD PMID:15065867 NCBI chr10:79,555,852...79,560,459
Ensembl chr10:79,555,852...79,560,407
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
increases abundance
EXP
ISO
GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]
Phosphatidylcholines results in increased expression of TNF mRNA
[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Phosphatidylcholines results in increased expression of and results in increased secretion of TNF protein
CTD PMID:16141546 PMID:22433871 PMID:23911798 PMID:30958839 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Phosphatidylcholines inhibits the reaction [rubitecan results in increased expression of TP53 protein] CTD PMID:21695227 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TXN thioredoxin multiple interactions EXP [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24775
    chemical entity 24745
      molecular entity 24712
        ion 17258
          organic ion 8792
            organic cation 7525
              quaternary ammonium ion 5196
                quaternary nitrogen compound 637
                  ammonium betaine 336
                    (11Z)-eicoseneoylcarnitine 0
                    (11Z,14Z)-eicosadienoylcarnitine 0
                    (13Z,16Z)-docosadienoylcarnitine 0
                    (2E)-7-carboxyhept-2-enoylcarnitine 0
                    (2E)-octenoylcarnitine 0
                    (2E,4Z)-decadienoylcarnitine 0
                    (5Z)-13-carboxytridec-5-enoylcarnitine 0
                    (9Z)-3-hydroxydodecenoylcarnitine 0
                    (9Z,12Z,15Z)-3-hydroxyoctadecatrienoylcarnitine 0
                    (R)-carnitinyl-CoA betaine 0
                    (S)-carnitinyl-CoA betaine 0
                    1,2-diacyl-sn-glycero-3-phosphocholine + 24
                    1,2-diacyl-sn-glycero-3-phosphonocholine + 0
                    1-O-acyl-sn-glycero-3-phosphocholine + 4
                    1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine betaine + 1
                    1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine + 0
                    15-methylhexadecasphing-4-enine-1-phosphocholine + 0
                    2,6-dimethylheptanoyl carnitine + 0
                    2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + 35
                    2-acyl-1-alkyl-sn-glycero-3-phosphocholine + 35
                    2-acyl-sn-glycero-3-phosphocholine + 0
                    2-ethylacryloylcarnitine 0
                    3-dehydrocarnitine + 1
                    3-hydroxy-cis-5-octenoylcarnitine 0
                    3-hydroxyarachidonoylcarnitine 0
                    3-hydroxybutyrylcarnitine 0
                    3-hydroxydecanoylcarnitine 0
                    3-hydroxydodecanoylcarnitine 0
                    3-hydroxyeicosanoylcarnitine 0
                    3-hydroxyhexadecanoylcarnitine 0
                    3-hydroxylinoleoylcarnitine 0
                    3-hydroxyoctadecanoylcarnitine 0
                    3-hydroxytetradecanoylcarnitine 0
                    4-[(2S)-2-ammonio-2-carboxyethyl]-5-tert-butylisothiazol-3-olate 0
                    6-(O-phosphocholine)oxyhexanoate 0
                    6-(O-phosphocholine)oxyhexanoic acid betaine 0
                    7-methylguanosine 5'-diphosphate 0
                    D-ribosylnicotinate 0
                    N(2),N(2),N(7)-trimethylguanosine 5'-phosphate 0
                    N(7)-methylguanosine 5'-phosphate + 0
                    N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                    N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                    NDSB 221 0
                    NSDB 211 0
                    O-(11-carboxyundecanoyl)carnitine 0
                    O-(13-carboxytridecanoyl)carnitine 0
                    O-(17-carboxyheptadecanoyl)carnitine 0
                    O-(4,8-dimethylnonanoyl)carnitine 0
                    O-[(9Z)-17-carboxyheptadec-9-enoyl]carnitine 0
                    O-acylcarnitine + 43
                    O-arachidonoylcarnitine 0
                    O-heptanoylcarnitine 0
                    O-icosanoylcarnitine 0
                    O-linoleoylcarnitine 0
                    O-methylmalonylcarnitine 0
                    O-palmitoleoylcarnitine 0
                    O-pimeloylcarnitine 0
                    O-sebacoylcarnitine 0
                    amino-acid betaine + 238
                    calcium crimson 0
                    choline sulfate 0
                    hercynylcysteine sulfoxide 0
                    hercynylselenocysteine 0
                    homostachydrine 0
                    lauramidopropyl betaine + 0
                    lauryl sulfobetaine 0
                    meldonium 15
                    perifosine 18
                    phosphatidylcholine + 83
                    phosphonocholine + 0
                    sphinganine-1-phosphocholine 0
                    sphingomyelin + 0
                    sphingosine-1-phosphocholine + 0
                    thiaminium carboxylate betaine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24775
    subatomic particle 24735
      composite particle 24735
        hadron 24735
          baryon 24735
            nucleon 24735
              atomic nucleus 24735
                atom 24735
                  main group element atom 24601
                    main group molecular entity 24601
                      s-block molecular entity 23907
                        hydrogen molecular entity 23745
                          hydrides 21962
                            inorganic hydride 19168
                              pnictogen hydride 19141
                                nitrogen hydride 18819
                                  ammonium 8050
                                    ammonium ion derivative 8046
                                      quaternary ammonium ion 5196
                                        quaternary nitrogen compound 637
                                          ammonium betaine 336
                                            (11Z)-eicoseneoylcarnitine 0
                                            (11Z,14Z)-eicosadienoylcarnitine 0
                                            (13Z,16Z)-docosadienoylcarnitine 0
                                            (2E)-7-carboxyhept-2-enoylcarnitine 0
                                            (2E)-octenoylcarnitine 0
                                            (2E,4Z)-decadienoylcarnitine 0
                                            (5Z)-13-carboxytridec-5-enoylcarnitine 0
                                            (9Z)-3-hydroxydodecenoylcarnitine 0
                                            (9Z,12Z,15Z)-3-hydroxyoctadecatrienoylcarnitine 0
                                            (R)-carnitinyl-CoA betaine 0
                                            (S)-carnitinyl-CoA betaine 0
                                            1,2-diacyl-sn-glycero-3-phosphocholine + 24
                                            1,2-diacyl-sn-glycero-3-phosphonocholine + 0
                                            1-O-acyl-sn-glycero-3-phosphocholine + 4
                                            1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine betaine + 1
                                            1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine + 0
                                            15-methylhexadecasphing-4-enine-1-phosphocholine + 0
                                            2,6-dimethylheptanoyl carnitine + 0
                                            2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + 35
                                            2-acyl-1-alkyl-sn-glycero-3-phosphocholine + 35
                                            2-acyl-sn-glycero-3-phosphocholine + 0
                                            2-ethylacryloylcarnitine 0
                                            3-dehydrocarnitine + 1
                                            3-hydroxy-cis-5-octenoylcarnitine 0
                                            3-hydroxyarachidonoylcarnitine 0
                                            3-hydroxybutyrylcarnitine 0
                                            3-hydroxydecanoylcarnitine 0
                                            3-hydroxydodecanoylcarnitine 0
                                            3-hydroxyeicosanoylcarnitine 0
                                            3-hydroxyhexadecanoylcarnitine 0
                                            3-hydroxylinoleoylcarnitine 0
                                            3-hydroxyoctadecanoylcarnitine 0
                                            3-hydroxytetradecanoylcarnitine 0
                                            4-[(2S)-2-ammonio-2-carboxyethyl]-5-tert-butylisothiazol-3-olate 0
                                            6-(O-phosphocholine)oxyhexanoate 0
                                            6-(O-phosphocholine)oxyhexanoic acid betaine 0
                                            7-methylguanosine 5'-diphosphate 0
                                            D-ribosylnicotinate 0
                                            N(2),N(2),N(7)-trimethylguanosine 5'-phosphate 0
                                            N(7)-methylguanosine 5'-phosphate + 0
                                            N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                                            N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                                            NDSB 221 0
                                            NSDB 211 0
                                            O-(11-carboxyundecanoyl)carnitine 0
                                            O-(13-carboxytridecanoyl)carnitine 0
                                            O-(17-carboxyheptadecanoyl)carnitine 0
                                            O-(4,8-dimethylnonanoyl)carnitine 0
                                            O-[(9Z)-17-carboxyheptadec-9-enoyl]carnitine 0
                                            O-acylcarnitine + 43
                                            O-arachidonoylcarnitine 0
                                            O-heptanoylcarnitine 0
                                            O-icosanoylcarnitine 0
                                            O-linoleoylcarnitine 0
                                            O-methylmalonylcarnitine 0
                                            O-palmitoleoylcarnitine 0
                                            O-pimeloylcarnitine 0
                                            O-sebacoylcarnitine 0
                                            amino-acid betaine + 238
                                            calcium crimson 0
                                            choline sulfate 0
                                            hercynylcysteine sulfoxide 0
                                            hercynylselenocysteine 0
                                            homostachydrine 0
                                            lauramidopropyl betaine + 0
                                            lauryl sulfobetaine 0
                                            meldonium 15
                                            perifosine 18
                                            phosphatidylcholine + 83
                                            phosphonocholine + 0
                                            sphinganine-1-phosphocholine 0
                                            sphingomyelin + 0
                                            sphingosine-1-phosphocholine + 0
                                            thiaminium carboxylate betaine 0
paths to the root