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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfonium betaine
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Accession:CHEBI:35282 term browser browse the term
Definition:Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:related_synonym: sulfonium betaines


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S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgre4 adhesion G protein-coupled receptor E4 decreases expression EXP S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA CTD PMID:18098314 NCBI chr17:55,749,984...55,853,662
Ensembl chr17:55,749,984...55,853,662
JBrowse link
G Adgre5 adhesion G protein-coupled receptor E5 decreases expression EXP S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA CTD PMID:18098314 NCBI chr 8:83,723,245...83,741,311
Ensembl chr 8:83,723,251...83,741,326
JBrowse link
G Afp alpha fetoprotein multiple interactions
decreases expression
EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA
CTD PMID:18098314 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
decreases abundance
EXP PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alad aminolevulinate, delta-, dehydratase increases activity EXP S-Adenosylmethionine results in increased activity of ALAD protein CTD PMID:9559101 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:150,547,417...150,570,622
Ensembl chr  X:150,547,375...150,570,638
JBrowse link
G App amyloid beta (A4) precursor protein increases secretion ISO S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
affects binding
ISO Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] CTD PMID:22955273 PMID:25349987 NCBI chr19:46,707,157...46,741,099
Ensembl chr19:46,707,458...46,741,099
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP S-Adenosylmethionine results in increased expression of ATF3 mRNA CTD PMID:18098314 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions EXP ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] CTD PMID:22945834 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Bhmt2 betaine-homocysteine methyltransferase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] CTD PMID:18230605 NCBI chr13:93,656,097...93,674,302
Ensembl chr13:93,655,720...93,674,302
JBrowse link
G Casp12 caspase 12 decreases expression EXP S-Adenosylmethionine results in decreased expression of CASP12 mRNA CTD PMID:18098314 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein
CTD PMID:17869084 PMID:18571630 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] CTD PMID:22683606 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression
multiple interactions
ISO S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]
CTD PMID:15983038 PMID:16996477 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions
decreases expression
EXP
ISO
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA
CTD PMID:8878782 PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] CTD PMID:22683606 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]
CTD PMID:15763544 PMID:15983038 PMID:22683606 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 NCBI chr11:11,814,101...11,898,144
Ensembl chr11:11,814,101...11,898,144
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 NCBI chr11:70,017,203...70,045,535
Ensembl chr11:70,016,942...70,047,522
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] CTD PMID:22558281 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3a DNA methyltransferase 3A multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]
CTD PMID:18098314 PMID:22558281 NCBI chr12:3,801,559...3,914,443
Ensembl chr12:3,806,007...3,914,443
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] CTD PMID:22558281 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I decreases expression EXP S-Adenosylmethionine results in decreased expression of FCGR1 mRNA CTD PMID:18098314 NCBI chr 3:96,282,909...96,293,969
Ensembl chr 3:96,282,909...96,293,969
JBrowse link
G Fgf15 fibroblast growth factor 15 increases abundance EXP FGF19 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Fgl2 fibrinogen-like protein 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of FGL2 mRNA CTD PMID:18098314 NCBI chr 5:21,372,673...21,378,386
Ensembl chr 5:21,372,642...21,378,374
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of GBP2 mRNA CTD PMID:18098314 NCBI chr 3:142,620,663...142,638,008
Ensembl chr 3:142,620,602...142,638,008
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA] CTD PMID:22558281 NCBI chr12:16,670,615...16,801,394
Ensembl chr12:16,670,615...16,800,886
JBrowse link
G Gsr glutathione reductase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22683606 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gss glutathione synthetase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] CTD PMID:20146260 NCBI chr 2:155,563,181...155,592,810
Ensembl chr 2:155,563,181...155,592,810
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] CTD PMID:18098314 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta decreases expression EXP S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA CTD PMID:18098314 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 multiple interactions EXP [Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] CTD PMID:30892605 NCBI chr 8:57,320,983...57,324,517
Ensembl chr 8:57,320,983...57,324,633
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029
G Hdac9 histone deacetylase 9 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 NCBI chr12:34,047,580...34,917,095
Ensembl chr12:34,047,580...34,917,095
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 9:44,336,348...44,344,228
Ensembl chr 9:44,336,339...44,344,228
JBrowse link
G Ifi44l interferon-induced protein 44 like decreases expression EXP S-Adenosylmethionine results in decreased expression of IFI44L mRNA CTD PMID:18098314 NCBI chr 3:151,758,737...151,762,891
Ensembl chr 3:151,758,737...151,762,892
JBrowse link
G Ifng interferon gamma multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il2rg interleukin 2 receptor, gamma chain decreases expression EXP S-Adenosylmethionine results in decreased expression of IL2RG mRNA CTD PMID:18098314 NCBI chr  X:101,264,385...101,268,255
Ensembl chr  X:101,264,378...101,268,255
JBrowse link
G Il36g interleukin 36G decreases expression EXP S-Adenosylmethionine results in decreased expression of IL36G mRNA CTD PMID:18098314 NCBI chr 2:24,186,476...24,193,567
Ensembl chr 2:24,186,476...24,193,568
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Klf6 Kruppel-like factor 6 decreases expression
multiple interactions
EXP S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]
CTD PMID:18098314 NCBI chr13:5,861,489...5,870,393
Ensembl chr13:5,861,482...5,870,394
JBrowse link
G Lep leptin multiple interactions ISO S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Ltb lymphotoxin B multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr17:35,194,507...35,196,305
Ensembl chr17:35,194,439...35,196,320
JBrowse link
G Maf avian musculoaponeurotic fibrosarcoma oncogene homolog multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] CTD PMID:20146260 NCBI chr 8:115,703,253...115,706,894
Ensembl chr 8:115,682,942...115,707,794
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] CTD PMID:20146260 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mat1a methionine adenosyltransferase I, alpha affects abundance
increases chemical synthesis
EXP MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine
CTD PMID:8373829 PMID:12060674 NCBI chr14:41,105,012...41,124,428
Ensembl chr14:41,105,035...41,124,412
JBrowse link
G Mat2a methionine adenosyltransferase II, alpha increases chemical synthesis EXP MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine CTD PMID:8373829 NCBI chr 6:72,432,796...72,439,556
Ensembl chr 6:72,432,799...72,439,558
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] CTD PMID:22558281 NCBI chr18:70,568,225...70,629,134
Ensembl chr18:70,568,189...70,626,131
JBrowse link
G Mir491 microRNA 491 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of MIR491 mRNA] CTD PMID:24680928 NCBI chr 4:88,122,040...88,122,125
Ensembl chr 4:88,122,040...88,122,125
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase increases abundance EXP MTHFD1 protein results in increased abundance of S-Adenosylmethionine CTD PMID:19033438 NCBI chr12:76,254,406...76,319,820
Ensembl chr12:76,255,298...76,319,803
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions
ISO S-Adenosylmethionine binds to MTR protein
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]
CTD PMID:17477549 PMID:26989453 NCBI chr13:12,181,331...12,258,199
Ensembl chr13:12,182,712...12,258,113
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 decreases expression EXP S-Adenosylmethionine results in decreased expression of NDRG1 mRNA CTD PMID:18098314 NCBI chr15:66,929,318...66,969,641
Ensembl chr15:66,929,318...66,969,640
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] CTD PMID:20146260 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nlgn3 neuroligin 3 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:101,299,179...101,321,350
Ensembl chr  X:101,299,168...101,325,963
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases abundance EXP NR0B2 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nrxn1 neurexin I multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr17:90,033,644...91,093,159
Ensembl chr17:90,033,631...91,093,071
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific multiple interactions EXP [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] CTD PMID:21266552 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr11:59,970,614...60,046,561
Ensembl chr11:59,970,614...60,046,489
JBrowse link
G Pfn2 profilin 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of PFN2 mRNA CTD PMID:18098314 NCBI chr 3:57,841,895...57,847,757
Ensembl chr 3:57,841,895...57,848,079
JBrowse link
G Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) increases expression EXP S-Adenosylmethionine results in increased expression of PSMB8 mRNA CTD PMID:18098314 NCBI chr17:34,198,195...34,201,454
Ensembl chr17:34,197,721...34,201,454
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP S-Adenosylmethionine results in decreased expression of PTGS1 mRNA CTD PMID:18098314 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] CTD PMID:21266552 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) decreases expression EXP S-Adenosylmethionine results in decreased expression of RNASEL mRNA CTD PMID:18098314 NCBI chr 1:153,749,344...153,768,690
Ensembl chr 1:153,749,426...153,764,221
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 affects abundance EXP SLC19A1 protein affects the abundance of S-Adenosylmethionine CTD PMID:15705887 NCBI chr10:77,032,269...77,050,432
Ensembl chr10:77,032,241...77,061,002
JBrowse link
G Smyd2 SET and MYND domain containing 2 affects binding ISO S-Adenosylmethionine binds to SMYD2 protein CTD PMID:21782458 NCBI chr 1:189,880,492...189,922,495
Ensembl chr 1:189,880,492...189,922,363
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:22683606 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] CTD PMID:22683606 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]
CTD PMID:15983038 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404
JBrowse link
G Syn1 synapsin I multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276 NCBI chr  X:20,860,511...20,920,918
Ensembl chr  X:20,860,511...20,921,004
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] CTD PMID:22558281 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Tfrc transferrin receptor decreases expression ISO S-Adenosylmethionine results in decreased expression of TFRC mRNA CTD PMID:18571630 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:15983038 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
CTD PMID:19822164 PMID:21266552 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tpmt thiopurine methyltransferase multiple interactions ISO [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] CTD PMID:20196537 NCBI chr13:47,021,987...47,043,338
Ensembl chr13:47,022,482...47,044,737
JBrowse link
G Trf transferrin multiple interactions
increases expression
ISO [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron CTD PMID:18571630 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444
JBrowse link
G Ubd ubiquitin D multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] CTD PMID:18098314 NCBI chr17:37,193,892...37,196,101
Ensembl chr17:37,193,892...37,196,095
JBrowse link
G Vim vimentin multiple interactions EXP S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] CTD PMID:26745512 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21746
    chemical entity 21744
      atom 21732
        nonmetal atom 21625
          sulfur atom 16935
            sulfur molecular entity 16935
              sulfonium compound 86
                sulfonium betaine 85
                  (dimethylsulfonio)acetate 0
                  S,S-dimethyl-beta-propiothetin 0
                  S-adenosyl-4-methylthio-2-oxobutanoate 0
                  S-adenosyl-L-methioninate 85
                  S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion 0
                  S-methyl-L-methioninate 0
                  phosphatidylsulfocholine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21746
    subatomic particle 21732
      composite particle 21732
        hadron 21732
          baryon 21732
            nucleon 21732
              atomic nucleus 21732
                atom 21732
                  main group element atom 21647
                    p-block element atom 21647
                      carbon group element atom 21454
                        carbon atom 21353
                          organic molecular entity 21353
                            organic molecule 21249
                              dipolar compound 1099
                                zwitterion 1098
                                  onium betaine 423
                                    sulfonium betaine 85
                                      (dimethylsulfonio)acetate 0
                                      S,S-dimethyl-beta-propiothetin 0
                                      S-adenosyl-4-methylthio-2-oxobutanoate 0
                                      S-adenosyl-L-methioninate 85
                                      S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion 0
                                      S-methyl-L-methioninate 0
                                      phosphatidylsulfocholine + 0
paths to the root