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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfonium betaine
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Accession:CHEBI:35282 term browser browse the term
Definition:Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:related_synonym: sulfonium betaines


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S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRE4P adhesion G protein-coupled receptor E4, pseudogene decreases expression ISO S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA CTD PMID:18098314 NCBI chr19:6,952,500...6,990,846
Ensembl chr19:6,952,500...6,997,872
JBrowse link
G ADGRE5 adhesion G protein-coupled receptor E5 decreases expression ISO S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA CTD PMID:18098314 NCBI chr19:14,381,144...14,408,725
Ensembl chr19:14,380,501...14,408,725
JBrowse link
G AFP alpha fetoprotein multiple interactions
decreases expression
ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA
CTD PMID:18098314 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
decreases abundance
ISO PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALAD aminolevulinate dehydratase increases activity ISO S-Adenosylmethionine results in increased activity of ALAD protein CTD PMID:9559101 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 multiple interactions EXP [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G APP amyloid beta precursor protein increases secretion EXP S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AS3MT arsenite methyltransferase multiple interactions
affects binding
EXP Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] CTD PMID:22955273 PMID:25349987 NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899
JBrowse link
G ATF3 activating transcription factor 3 increases expression ISO S-Adenosylmethionine results in increased expression of ATF3 mRNA CTD PMID:18098314 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions ISO ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] CTD PMID:22945834 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] CTD PMID:18230605 NCBI chr 5:79,069,767...79,090,069
Ensembl chr 5:79,069,767...79,090,069
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) decreases expression ISO S-Adenosylmethionine results in decreased expression of CASP12 mRNA CTD PMID:18098314 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases activity
EXP
ISO
S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein
CTD PMID:17869084 PMID:18571630 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] CTD PMID:22683606 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression
multiple interactions
EXP S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]
CTD PMID:15983038 PMID:16996477 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions
decreases expression
ISO
EXP
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA
CTD PMID:8878782 PMID:15983038 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] CTD PMID:22683606 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity
multiple interactions
EXP
ISO
S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]
CTD PMID:15763544 PMID:15983038 PMID:22683606 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G DDC dopa decarboxylase multiple interactions EXP [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 NCBI chr 7:50,458,436...50,565,460
Ensembl chr 7:50,458,436...50,565,405
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] CTD PMID:22558281 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]
CTD PMID:18098314 PMID:22558281 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] CTD PMID:22558281 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia decreases expression ISO S-Adenosylmethionine results in decreased expression of FCGR1 mRNA CTD PMID:18098314 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,791,675
JBrowse link
G FGF19 fibroblast growth factor 19 increases abundance ISO FGF19 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
JBrowse link
G FGL2 fibrinogen like 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of FGL2 mRNA CTD PMID:18098314 NCBI chr 7:77,193,369...77,199,819
Ensembl chr 7:77,193,369...77,199,848
JBrowse link
G GBP2 guanylate binding protein 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of GBP2 mRNA CTD PMID:18098314 NCBI chr 1:89,106,132...89,126,114
Ensembl chr 1:89,106,132...89,150,456
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GREB1 growth regulating estrogen receptor binding 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] CTD PMID:22558281 NCBI chr 2:11,481,675...11,642,788
Ensembl chr 2:11,482,341...11,642,788
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22683606 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] CTD PMID:20146260 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] CTD PMID:18098314 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 multiple interactions ISO [Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] CTD PMID:30892605 NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229
JBrowse link
G HBB hemoglobin subunit beta multiple interactions EXP [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HDAC9 histone deacetylase 9 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA CTD PMID:18098314 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G HMBS hydroxymethylbilane synthase multiple interactions EXP [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:119,084,864...119,093,549
Ensembl chr11:119,084,866...119,093,549
JBrowse link
G IFI44L interferon induced protein 44 like decreases expression ISO S-Adenosylmethionine results in decreased expression of IFI44L mRNA CTD PMID:18098314 NCBI chr 1:78,620,412...78,646,145
Ensembl chr 1:78,619,902...78,646,145
JBrowse link
G IFNG interferon gamma multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL2RG interleukin 2 receptor subunit gamma decreases expression ISO S-Adenosylmethionine results in decreased expression of IL2RG mRNA CTD PMID:18098314 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108
JBrowse link
G IL36G interleukin 36 gamma decreases expression ISO S-Adenosylmethionine results in decreased expression of IL36G mRNA CTD PMID:18098314 NCBI chr 2:112,978,006...112,985,658
Ensembl chr 2:112,973,203...112,985,658
JBrowse link
G IL6 interleukin 6 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KLF6 Kruppel like factor 6 decreases expression
multiple interactions
ISO S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]
CTD PMID:18098314 NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281
JBrowse link
G LEP leptin multiple interactions EXP S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LTB lymphotoxin beta multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522
JBrowse link
G MAF MAF bZIP transcription factor multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] CTD PMID:20146260 NCBI chr16:79,202,624...79,601,952
Ensembl chr16:79,585,843...79,600,737
JBrowse link
G MAFG MAF bZIP transcription factor G multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] CTD PMID:20146260 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:15983038 PMID:16996477 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAT1A methionine adenosyltransferase 1A affects abundance
increases chemical synthesis
ISO MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine
CTD PMID:8373829 PMID:12060674 NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658
JBrowse link
G MAT2A methionine adenosyltransferase 2A increases chemical synthesis ISO MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine CTD PMID:8373829 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281
JBrowse link
G MBD2 methyl-CpG binding domain protein 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] CTD PMID:22558281 NCBI chr18:54,151,606...54,224,669
Ensembl chr18:54,151,606...54,224,669
JBrowse link
G MIR491 microRNA 491 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MIR491 mRNA] CTD PMID:24680928 NCBI chr 9:20,716,105...20,716,188
Ensembl chr 9:20,716,105...20,716,188
JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 increases abundance ISO MTHFD1 protein results in increased abundance of S-Adenosylmethionine CTD PMID:19033438 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457
JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions
EXP S-Adenosylmethionine binds to MTR protein
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]
CTD PMID:17477549 PMID:26989453 NCBI chr 1:236,794,304...236,903,981
Ensembl chr 1:236,795,260...236,921,278
JBrowse link
G NDRG1 N-myc downstream regulated 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of NDRG1 mRNA CTD PMID:18098314 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] CTD PMID:20146260 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G NLGN3 neuroligin 3 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:71,144,389...71,175,307
Ensembl chr  X:71,144,831...71,171,201
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases abundance ISO NR0B2 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NRXN1 neurexin 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr 2:49,918,503...51,032,132
Ensembl chr 2:49,918,503...51,225,575
JBrowse link
G PDE4B phosphodiesterase 4B multiple interactions ISO [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] CTD PMID:21266552 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr17:17,505,561...17,591,987
Ensembl chr17:17,505,563...17,591,708
JBrowse link
G PFN2 profilin 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of PFN2 mRNA CTD PMID:18098314 NCBI chr 3:149,964,904...149,970,895
Ensembl chr 3:149,964,904...150,050,788
JBrowse link
G PRDM7 PR/SET domain 7 affects binding EXP S-Adenosylmethionine binds to PRDM7 protein CTD PMID:27129774 NCBI chr16:90,056,566...90,077,339
Ensembl chr16:90,056,566...90,092,072
JBrowse link
G PSMB8 proteasome 20S subunit beta 8 increases expression ISO S-Adenosylmethionine results in increased expression of PSMB8 mRNA CTD PMID:18098314 NCBI chr 6:32,840,717...32,844,679
Ensembl chr 6:32,840,717...32,844,679
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of PTGS1 mRNA CTD PMID:18098314 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] CTD PMID:21266552 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RNASEL ribonuclease L decreases expression ISO S-Adenosylmethionine results in decreased expression of RNASEL mRNA CTD PMID:18098314 NCBI chr 1:182,573,634...182,589,285
Ensembl chr 1:182,573,634...182,589,256
JBrowse link
G SLC19A1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylmethionine CTD PMID:15705887 NCBI chr21:45,502,517...45,563,140
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SMYD2 SET and MYND domain containing 2 affects binding EXP S-Adenosylmethionine binds to SMYD2 protein CTD PMID:21782458 NCBI chr 1:214,281,159...214,337,136
Ensembl chr 1:214,281,102...214,337,131
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:22683606 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] CTD PMID:22683606 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]
CTD PMID:15983038 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SYN1 synapsin I multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857
JBrowse link
G TF transferrin multiple interactions
increases expression
ISO [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron CTD PMID:18571630 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TFF1 trefoil factor 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] CTD PMID:22558281 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535
JBrowse link
G TFRC transferrin receptor decreases expression ISO S-Adenosylmethionine results in decreased expression of TFRC mRNA CTD PMID:18571630 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:15983038 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
CTD PMID:19822164 PMID:21266552 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TPMT thiopurine S-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] CTD PMID:20196537 NCBI chr 6:18,128,311...18,155,169
Ensembl chr 6:18,128,311...18,155,077
JBrowse link
G UBD ubiquitin D multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] CTD PMID:18098314 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732
JBrowse link
G VIM vimentin multiple interactions ISO S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] CTD PMID:26745512 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24779
    chemical entity 24749
      atom 24738
        nonmetal atom 24470
          sulfur atom 17592
            sulfur molecular entity 17592
              sulfonium compound 87
                sulfonium betaine 86
                  (dimethylsulfonio)acetate 0
                  S,S-dimethyl-beta-propiothetin 0
                  S-adenosyl-4-methylthio-2-oxobutanoate 0
                  S-adenosyl-L-methioninate 86
                  S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion 0
                  S-methyl-L-methioninate 0
                  phosphatidylsulfocholine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24779
    subatomic particle 24738
      composite particle 24738
        hadron 24738
          baryon 24738
            nucleon 24738
              atomic nucleus 24738
                atom 24738
                  main group element atom 24603
                    p-block element atom 24603
                      carbon group element atom 24396
                        carbon atom 24360
                          organic molecular entity 24360
                            organic molecule 24243
                              dipolar compound 1062
                                zwitterion 1061
                                  onium betaine 417
                                    sulfonium betaine 86
                                      (dimethylsulfonio)acetate 0
                                      S,S-dimethyl-beta-propiothetin 0
                                      S-adenosyl-4-methylthio-2-oxobutanoate 0
                                      S-adenosyl-L-methioninate 86
                                      S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion 0
                                      S-methyl-L-methioninate 0
                                      phosphatidylsulfocholine + 0
paths to the root