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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:onium betaine
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Accession:CHEBI:35281 term browser browse the term
Definition:Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:exact_synonym: betaines
 related_synonym: onium betaines


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(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Carnitine results in increased expression of ADIPOQ protein CTD PMID:30256492 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
ISO Carnitine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]
CTD PMID:29186614 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] CTD PMID:33290254 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions
ISO Carnitine results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]
CTD PMID:29186614 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) multiple interactions
increases chemical synthesis
ISO Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]; Ketoglutaric Acids inhibits the reaction [Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] CTD PMID:21439360 NCBI chr 2:110,264,056...110,314,813
Ensembl chr 2:110,262,697...110,314,560
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA] CTD PMID:23213347 PMID:29186614 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein] CTD PMID:19491382 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]
CTD PMID:19491382 PMID:23213347 PMID:26562095 PMID:32478940 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]
Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]
CTD PMID:23213347 PMID:32478940 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO Carnitine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA] CTD PMID:16889571 PMID:19294768 PMID:23213347 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Carnitine inhibits the reaction [Sunitinib results in increased expression of CCN2 mRNA] CTD PMID:26581635 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein] CTD PMID:28973641 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of COL1A1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of COL1A1 mRNA] CTD PMID:26581635 PMID:28973641 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] affects the abundance of Carnitine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine] CTD PMID:24709313 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Carnitine]
[Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNA; [Genistein co-treated with Carnitine] results in increased expression of CPT1A protein; Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]
CTD PMID:16283381 PMID:16362726 PMID:19854160 PMID:32478940 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions ISO Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] CTD PMID:21816645 NCBI chr 4:107,903,982...107,923,589
Ensembl chr 4:107,903,981...107,923,610
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of NOX2 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of NOX2 protein] CTD PMID:26581635 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA] CTD PMID:29710542 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:8130774 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart multiple interactions ISO Carnitine inhibits the reaction [Doxorubicin results in decreased expression of FABP3 mRNA] CTD PMID:20470772 NCBI chr 4:130,308,738...130,315,463
Ensembl chr 4:130,308,595...130,315,463
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA] CTD PMID:23213347 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein] CTD PMID:32478940 NCBI chr 5:30,119,423...30,154,980
Ensembl chr 5:30,118,304...30,155,162
JBrowse link
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) multiple interactions EXP Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein] CTD PMID:16239342 NCBI chr 5:118,169,764...118,189,478
Ensembl chr 5:118,164,648...118,189,478
JBrowse link
G Hspa2 heat shock protein 2 multiple interactions ISO Carnitine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA2 protein] CTD PMID:22359436 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in decreased expression of IL10 mRNA] CTD PMID:26581635 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Carnitine inhibits the reaction [sunitinib results in increased expression of IL1B mRNA] CTD PMID:26562095 PMID:26581635 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of IL6 mRNA] CTD PMID:26581635 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I decreases uptake EXP INS1 protein results in decreased uptake of Carnitine CTD PMID:28298333 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of Carnitine CTD PMID:20567778 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in decreased expression of MMP9 mRNA] CTD PMID:26581635 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
ISO [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased activity of MPO protein] CTD PMID:18597074 PMID:18852009 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions EXP Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] CTD PMID:21419151 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial multiple interactions EXP Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA] CTD PMID:21419151 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] CTD PMID:18299183 NCBI chr 3:138,089,855...138,143,418
Ensembl chr 3:138,089,854...138,144,968
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA] CTD PMID:23213347 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Carnitine results in increased expression of NOS3 CTD PMID:20123095 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
ISO [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine]; PPARA protein promotes the reaction [Carnitine results in decreased susceptibility to Gentamicins]
Carnitine results in increased activity of PPARA protein
CTD PMID:19491382 PMID:19735737 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO Carnitine results in increased expression of PPARG protein
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]
CTD PMID:30256492 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase increases expression
increases response to substance
multiple interactions
ISO Carnitine results in increased expression of PTGIS mRNA
PTGIS protein results in increased susceptibility to Carnitine
[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
CTD PMID:19491382 NCBI chr 2:167,203,194...167,252,150
Ensembl chr 2:167,191,805...167,240,604
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions
increases uptake
EXP Acetylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Carnitine analog inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Choline inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Cimetidine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Corticosterone inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Cyclic AMP inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; estrone sulfate inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; octanoylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Salicylic Acid inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; tetramethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,864,388...7,966,517
Ensembl chr19:7,864,388...7,966,027
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 increases uptake ISO SLC22A4 protein results in increased uptake of Carnitine CTD PMID:21256917 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions
decreases expression
increases transport
increases uptake
increases expression
affects uptake
affects binding
ISO
EXP
[Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA; Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine results in decreased expression of SLC22A5 mRNA; Carnitine results in decreased expression of SLC22A5 protein
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine deficiency results in increased expression of SLC22A5 mRNA
SLC22A5 protein results in increased uptake of Carnitine; SLC22A5 protein results in increased uptake of Carnitine analog
SLC22A5 protein affects the uptake of Carnitine
Carnitine binds to SLC22A5 protein
CTD PMID:12644265 PMID:15486076 PMID:16283381 PMID:16928358 PMID:18762717 PMID:18981167 PMID:19041296 PMID:19539806 PMID:19735737 PMID:20303936 PMID:20470772 PMID:21256917 PMID:21641380 PMID:22701146 PMID:30465787 PMID:31437515 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases transport EXP SLC22A8 protein results in increased transport of Carnitine CTD PMID:15100168 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions
increases transport
ISO Ampicillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Carnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cefonicid inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Piperacillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 PMID:23402788 NCBI chr 9:108,662,136...108,684,642
Ensembl chr 9:108,662,088...108,684,641
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions
increases expression
ISO Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Carnitine results in increased expression of SLC2A4 protein
CTD PMID:30256492 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein] CTD PMID:28973641 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA] CTD PMID:18299183 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TGFB1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of TGFB1 mRNA] CTD PMID:26562095 PMID:26581635 PMID:28973641 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA] CTD PMID:26581635 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein] CTD PMID:28973641 NCBI chr 7:65,296,165...65,527,850
Ensembl chr 7:65,296,165...65,527,781
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression
ISO Carnitine deficiency results in increased expression of TNF mRNA
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased expression of TNF mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]
Carnitine results in decreased expression of TNF protein
CTD PMID:18597074 PMID:18629605 PMID:18852009 PMID:26562095 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vim vimentin multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of VIM protein] CTD PMID:28973641 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein] CTD PMID:19041333 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein] CTD PMID:19041333 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Prnp prion protein multiple interactions
affects folding
ISO Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 NCBI chr 2:131,909,928...131,938,436
Ensembl chr 2:131,909,928...131,938,429
JBrowse link
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine CTD PMID:29906468 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
1-O-oleoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 NCBI chr 1:136,842,562...136,960,448
Ensembl chr 1:136,842,571...136,960,448
JBrowse link
G Smad3 SMAD family member 3 decreases abundance EXP SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA CTD PMID:16386258 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Cd68 CD68 antigen increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CD68 mRNA CTD PMID:16386258 NCBI chr11:69,664,213...69,666,170
Ensembl chr11:69,664,213...69,666,153
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CXCL8 mRNA CTD PMID:16386258 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]; resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein] CTD PMID:24079413 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1B mRNA CTD PMID:16386258 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 multiple interactions ISO [KCNAB2 protein co-treated with NADP] results in increased reduction of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine CTD PMID:21296056 NCBI chr 4:152,390,744...152,477,549
Ensembl chr 4:152,390,742...152,477,910
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein
resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein]
CTD PMID:24079413 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK3 protein] CTD PMID:24079413 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 6:129,479,150...129,507,350
Ensembl chr 6:129,485,244...129,507,165
JBrowse link
G Ptafr platelet-activating factor receptor affects binding
multiple interactions
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine binds to PTAFR protein
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
CTD PMID:16386258 NCBI chr 4:132,564,067...132,582,683
Ensembl chr 4:132,564,067...132,582,683
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Sele selectin, endothelial cell increases expression
increases secretion
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of SELE mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of SELE protein
CTD PMID:16386258 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Src Rous sarcoma oncogene multiple interactions
increases phosphorylation
ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein] CTD PMID:24079413 NCBI chr 2:157,423,906...157,471,838
Ensembl chr 2:157,418,444...157,471,862
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 6:115,244,444...115,252,205
Ensembl chr 6:115,241,892...115,252,205
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TNF mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of TNF protein
CTD PMID:16386258 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase, endothelial increases hydrolysis ISO LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Alox12 arachidonate 12-lipoxygenase increases expression ISO Platelet Activating Factor results in increased expression of ALOX12 mRNA CTD PMID:16386258 NCBI chr11:70,241,457...70,255,380
Ensembl chr11:70,241,457...70,255,353
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]
Platelet Activating Factor results in increased expression of ALOX5 mRNA
CTD PMID:8387780 PMID:10779545 PMID:16386258 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
increases secretion
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CCL2 protein] CTD PMID:15149885 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 increases expression ISO Platelet Activating Factor results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Platelet Activating Factor results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cx3cr1 chemokine (C-X3-C motif) receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 NCBI chr 9:120,048,683...120,068,296
Ensembl chr 9:119,901,616...120,069,879
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases secretion
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CXCL8 protein] CTD PMID:15149885 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance
ISO Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
G Egr1 early growth response 1 increases expression ISO Platelet Activating Factor results in increased expression of EGR1 mRNA CTD PMID:16386258 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Platelet Activating Factor results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
ISO Platelet Activating Factor results in increased expression of IL1B mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]
CTD PMID:16386258 PMID:32830409 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein] CTD PMID:32830409 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itgam integrin alpha M multiple interactions
increases expression
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein] CTD PMID:9762784 PMID:11116075 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Ltb4r1 leukotriene B4 receptor 1 affects response to substance EXP LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 NCBI chr14:55,765,962...55,768,492
Ensembl chr14:55,765,962...55,768,494
JBrowse link
G Mir149 microRNA 149 decreases expression
multiple interactions
ISO Platelet Activating Factor results in decreased expression of MIR149 mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; [Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA
CTD PMID:32830409 NCBI chr 1:92,850,378...92,850,443
Ensembl chr 1:92,850,378...92,850,443
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Platelet Activating Factor results in increased expression of MMP13 mRNA CTD PMID:16386258 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions
increases expression
ISO PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein] CTD PMID:32830409 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 multiple interactions EXP NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 3:27,183,004...27,245,266
Ensembl chr 3:27,182,965...27,284,608
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases degradation
EXP Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Genistein inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 6:129,479,150...129,507,350
Ensembl chr 6:129,485,244...129,507,165
JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) multiple interactions
increases expression
ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA; bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA] CTD PMID:21432021 NCBI chr17:43,567,994...43,612,202
Ensembl chr17:43,568,098...43,612,201
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Platelet Activating Factor results in decreased expression of PPARA mRNA CTD PMID:16386258 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions
increases expression
increases phosphorylation
affects binding
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
Platelet Activating Factor results in increased expression of PTAFR mRNA
Platelet Activating Factor results in increased phosphorylation of PTAFR protein
bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
CTD PMID:9065783 PMID:10447766 PMID:11297424 PMID:11529688 PMID:16386258 PMID:18205269 NCBI chr 4:132,564,067...132,582,683
Ensembl chr 4:132,564,067...132,582,683
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Platelet Activating Factor results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Platelet Activating Factor results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pvt1 Pvt1 oncogene increases expression
multiple interactions
ISO Platelet Activating Factor results in increased expression of PVT1 mRNA
[Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
CTD PMID:32830409 NCBI chr15:62,037,986...62,260,215
Ensembl chr15:62,037,986...62,378,096
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein] CTD PMID:11297424 NCBI chr 1:169,741,477...169,747,642
Ensembl chr 1:169,741,477...169,747,642
JBrowse link
G Sele selectin, endothelial cell increases expression ISO Platelet Activating Factor results in increased expression of SELE mRNA CTD PMID:16386258 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Sell selectin, lymphocyte multiple interactions
increases secretion
ISO Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein] CTD PMID:9762784 NCBI chr 1:164,061,987...164,082,930
Ensembl chr 1:164,061,982...164,084,181
JBrowse link
G Selp selectin, platelet multiple interactions
increases expression
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO Platelet Activating Factor results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 6:115,244,444...115,252,205
Ensembl chr 6:115,241,892...115,252,205
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression
ISO
EXP
Platelet Activating Factor results in increased secretion of TNF protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
Platelet Activating Factor results in increased expression of TNF mRNA
Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]
CTD PMID:9065783 PMID:10921504 PMID:16386258 PMID:32830409 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression ISO platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
3-dehydrocarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
4-(trimethylammonio)butanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) multiple interactions ISO [BBOX1 protein co-treated with Ketoglutaric Acids] results in increased metabolism of gamma-butyrobetaine CTD PMID:21439360 NCBI chr 2:110,264,056...110,314,813
Ensembl chr 2:110,262,697...110,314,560
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
CAR(3:0(Me2)) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases transport
multiple interactions
affects binding
increases uptake
ISO SLC22A5 protein results in increased transport of pivaloylcarnitine
Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]
pivaloylcarnitine binds to SLC22A5 protein
SLC22A5 protein results in increased uptake of pivaloylcarnitine
CTD PMID:18762717 PMID:19539806 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660
JBrowse link
ergothioneine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Ergothioneine inhibits the reaction [Cisplatin results in decreased activity of ACHE protein] CTD PMID:20932872 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3bp ABI family member 3 binding protein increases expression ISO Betaine results in increased expression of ABI3BP mRNA CTD PMID:26391144 NCBI chr16:56,477,801...56,690,135
Ensembl chr16:56,477,878...56,690,135
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA CTD PMID:22648174 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Adss adenylosuccinate synthetase, non muscle decreases expression ISO Betaine results in decreased expression of ADSS mRNA CTD PMID:26391144 NCBI chr 1:177,763,176...177,796,695
Ensembl chr 1:177,762,962...177,796,511
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression EXP
ISO
Betaine results in decreased expression of AHCY mRNA CTD PMID:22945834 PMID:26391144 NCBI chr 2:155,059,310...155,074,497
Ensembl chr 2:155,059,310...155,074,497
JBrowse link
G Akip1 A kinase (PRKA) interacting protein 1 increases expression ISO Betaine results in increased expression of AKIP1 mRNA CTD PMID:26391144 NCBI chr 7:109,703,678...109,712,186
Ensembl chr 7:109,703,690...109,712,189
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) decreases expression ISO Betaine results in decreased expression of AKR1B1 mRNA CTD PMID:26391144 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein CTD PMID:20118189 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 decreases expression ISO Betaine results in decreased expression of APEX1 mRNA CTD PMID:26391144 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions EXP Betaine inhibits the reaction [Azacitidine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [Azacitidine results in increased expression of and results in increased cleavage of APP protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein] CTD PMID:19635394 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions EXP ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine]; Betaine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Betaine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA] CTD PMID:22945834 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Axin1 axin 1 multiple interactions EXP [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene CTD PMID:16868943 NCBI chr17:26,131,217...26,195,811
Ensembl chr17:26,138,688...26,195,811
JBrowse link
G Bax BCL2-associated X protein decreases expression ISO Betaine results in decreased expression of BAX protein CTD PMID:25080425 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects binding
increases expression
ISO Betaine analog binds to BCL2 protein
Betaine results in increased expression of BCL2 protein
CTD PMID:25080425 PMID:25765238 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Betaine results in increased expression of BHLHE40 mRNA CTD PMID:26391144 NCBI chr 6:108,660,629...108,666,925
Ensembl chr 6:108,660,629...108,666,925
JBrowse link
G Bhmt betaine-homocysteine methyltransferase increases metabolic processing ISO BHMT protein results in increased metabolism of Betaine CTD PMID:18230605 NCBI chr13:93,616,891...93,637,758
Ensembl chr13:93,616,675...93,637,961
JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit multiple interactions ISO Betaine inhibits the reaction [Ethanol results in increased expression of BRF1 mRNA]; Betaine inhibits the reaction [Ethanol results in increased expression of BRF1 protein] CTD PMID:32418914 NCBI chr12:112,955,631...113,000,706
Ensembl chr12:112,960,085...113,000,704
JBrowse link
G Cab39l calcium binding protein 39-like decreases expression ISO Betaine results in decreased expression of CAB39L mRNA CTD PMID:26391144 NCBI chr14:59,440,934...59,548,904
Ensembl chr14:59,440,972...59,585,764
JBrowse link
G Casp1 caspase 1 increases expression ISO Betaine results in increased expression of CASP1 mRNA CTD PMID:26391144 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Betaine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:24632105 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein
Betaine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Betaine inhibits the reaction [Carbon Tetrachloride results in increased activity of CAT protein]
CTD PMID:12893363 PMID:20118189 PMID:24632105 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccdc113 coiled-coil domain containing 113 increases expression ISO Betaine results in increased expression of CCDC113 mRNA CTD PMID:26391144 NCBI chr 8:95,534,060...95,558,888
Ensembl chr 8:95,534,085...95,558,890
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA CTD PMID:22648174 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 increases expression ISO Betaine results in increased expression of CCL5 mRNA CTD PMID:26391144 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression ISO Betaine results in increased expression of CCL6 mRNA CTD PMID:26391144 NCBI chr11:83,587,886...83,593,087
Ensembl chr11:83,587,882...83,593,087
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Betaine results in decreased expression of CCNB2 mRNA CTD PMID:26391144 NCBI chr 9:70,407,689...70,421,554
Ensembl chr 9:70,407,692...70,421,547
JBrowse link
G Cd44 CD44 antigen decreases expression ISO Betaine results in decreased expression of CD44 mRNA CTD PMID:26391144 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cdc42ep2 CDC42 effector protein (Rho GTPase binding) 2 decreases expression ISO Betaine results in decreased expression of CDC42EP2 mRNA CTD PMID:26391144 NCBI chr19:5,917,556...5,924,816
Ensembl chr19:5,915,636...5,924,816
JBrowse link
G Cdh13 cadherin 13 decreases expression ISO Betaine results in decreased expression of CDH13 mRNA CTD PMID:26391144 NCBI chr 8:118,140,017...119,324,929
Ensembl chr 8:118,283,733...119,324,921
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO Betaine promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA] CTD PMID:19642983 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Ces3b carboxylesterase 3B increases expression ISO Betaine results in increased expression of CES3 mRNA CTD PMID:26391144 NCBI chr 8:105,083,733...105,093,929
Ensembl chr 8:105,083,753...105,093,929
JBrowse link
G Ckb creatine kinase, brain increases expression ISO Betaine results in increased expression of CKB mRNA CTD PMID:26391144 NCBI chr12:111,669,355...111,672,338
Ensembl chr12:111,669,361...111,672,338
JBrowse link
G Cks1b CDC28 protein kinase 1b decreases expression ISO Betaine results in decreased expression of CKS1B mRNA CTD PMID:26391144 NCBI chr 3:89,415,472...89,418,291
Ensembl chr 3:89,415,472...89,418,383
JBrowse link
G Cotl1 coactosin-like 1 (Dictyostelium) decreases expression ISO Betaine results in decreased expression of COTL1 mRNA CTD PMID:26391144 NCBI chr 8:119,809,214...119,840,579
Ensembl chr 8:119,809,222...119,840,544
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions
decreases expression
EXP Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]
Betaine results in decreased expression of CPT1A mRNA
CTD PMID:22945834 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Cxcl16 chemokine (C-X-C motif) ligand 16 decreases expression ISO Betaine results in decreased expression of CXCL16 mRNA CTD PMID:26391144 NCBI chr11:70,454,389...70,459,984
Ensembl chr11:70,453,983...70,459,984
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]
Betaine promotes the reaction [Ethanol results in increased expression of CYP2E1]
CTD PMID:20118189 PMID:21352821 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of CYP4A10 protein CTD PMID:20118189 NCBI chr 4:115,518,287...115,533,649
Ensembl chr 4:115,518,264...115,533,649
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 increases expression ISO Betaine results in increased expression of CYSLTR1 mRNA CTD PMID:26391144 NCBI chr  X:106,576,509...106,603,679
Ensembl chr  X:106,574,346...106,603,679
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression ISO Betaine results in decreased expression of DAPK1 mRNA CTD PMID:26391144 NCBI chr13:60,601,723...60,763,191
Ensembl chr13:60,601,947...60,763,191
JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO Betaine results in increased expression of DLX2 mRNA CTD PMID:26391144 NCBI chr 2:71,543,408...71,546,754
Ensembl chr 2:71,543,408...71,546,754
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions
increases expression
EXP Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]
Betaine results in increased expression of DNMT1 mRNA
CTD PMID:22945834 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression EXP Betaine results in decreased expression of DNMT3B mRNA CTD PMID:22945834 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Ect2 ect2 oncogene decreases expression ISO Betaine results in decreased expression of ECT2 mRNA CTD PMID:26391144 NCBI chr 3:27,097,222...27,154,253
Ensembl chr 3:27,097,222...27,153,878
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase increases expression ISO Betaine results in increased expression of EEF2K mRNA CTD PMID:26391144 NCBI chr 7:120,842,642...120,907,219
Ensembl chr 7:120,842,831...120,907,450
JBrowse link
G Egr1 early growth response 1 increases expression ISO Betaine results in increased expression of EGR1 mRNA CTD PMID:26391144 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Elf3 E74-like factor 3 decreases expression ISO Betaine results in decreased expression of ELF3 mRNA CTD PMID:26391144 NCBI chr 1:135,253,574...135,258,472
Ensembl chr 1:135,253,575...135,258,568
JBrowse link
G Emc9 ER membrane protein complex subunit 9 increases expression ISO Betaine results in increased expression of EMC9 mRNA CTD PMID:26391144 NCBI chr14:55,581,519...55,585,375
Ensembl chr14:55,581,516...55,585,302
JBrowse link
G Ephb6 Eph receptor B6 increases expression ISO Betaine results in increased expression of EPHB6 mRNA CTD PMID:26391144 NCBI chr 6:41,603,834...41,620,509
Ensembl chr 6:41,605,482...41,620,509
JBrowse link
G F8 coagulation factor VIII multiple interactions
increases secretion
ISO Betaine affects the localization of and results in increased secretion of F8 protein; Betaine affects the localization of and results in increased secretion of F8 protein mutant form
Betaine results in increased secretion of F8 protein; Betaine results in increased secretion of F8 protein mutant form
CTD PMID:22973456 NCBI chr  X:75,170,344...75,382,738
Ensembl chr  X:75,172,715...75,382,615
JBrowse link
G F9 coagulation factor IX increases secretion ISO Betaine results in increased secretion of F9 protein CTD PMID:22973456 NCBI chr  X:59,999,329...60,030,760
Ensembl chr  X:59,999,464...60,030,759
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] CTD PMID:22648174 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression ISO Betaine results in increased expression of FLRT3 mRNA CTD PMID:26391144 NCBI chr 2:140,658,198...140,671,476
Ensembl chr 2:140,650,914...140,671,469
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 decreases expression ISO Betaine results in decreased expression of FXYD2 mRNA; Betaine results in decreased expression of FXYD2 mRNA alternative form CTD PMID:26391144 NCBI chr 9:45,399,709...45,410,278
Ensembl chr 9:45,399,669...45,410,278
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions ISO Betaine inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:19294532 NCBI chr19:3,409,915...3,414,544
Ensembl chr19:3,409,915...3,414,544
JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression ISO Betaine results in increased expression of GPCPD1 mRNA CTD PMID:26391144 NCBI chr 2:132,529,082...132,578,248
Ensembl chr 2:132,529,082...132,587,729
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Betaine inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:19294532 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049
JBrowse link
G H2az1 H2A.Z variant histone 1 decreases expression ISO Betaine results in decreased expression of H2AZ1 mRNA CTD PMID:26391144 NCBI chr 3:137,864,487...137,866,922
Ensembl chr 3:137,864,487...137,866,922
JBrowse link
G Hip1 huntingtin interacting protein 1 decreases expression ISO Betaine results in decreased expression of HIP1 mRNA CTD PMID:26391144 NCBI chr 5:135,406,496...135,545,323
Ensembl chr 5:135,406,531...135,545,120
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Betaine results in decreased expression of HMGB2 mRNA CTD PMID:26391144 NCBI chr 8:57,511,843...57,515,999
Ensembl chr 8:57,511,907...57,515,999
JBrowse link
G Hspa5 heat shock protein 5 decreases expression EXP Betaine results in decreased expression of HSPA5 mRNA CTD PMID:22945834 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Betaine results in increased expression of ID2 mRNA CTD PMID:26391144 NCBI chr12:25,093,799...25,096,092
Ensembl chr12:25,093,799...25,097,140
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Betaine] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Irx4 Iroquois homeobox 4 decreases expression ISO Betaine results in decreased expression of IRX4 mRNA CTD PMID:26391144 NCBI chr13:73,259,589...73,269,622
Ensembl chr13:73,260,479...73,269,608
JBrowse link
G Jun jun proto-oncogene increases expression ISO Betaine results in increased expression of JUN mRNA CTD PMID:26391144 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Khdrbs3 KH domain containing, RNA binding, signal transduction associated 3 decreases expression ISO Betaine results in decreased expression of KHDRBS3 mRNA CTD PMID:26391144 NCBI chr15:68,928,392...69,101,794
Ensembl chr15:68,928,420...69,101,211
JBrowse link
G Kif1b kinesin family member 1B increases expression ISO Betaine results in increased expression of KIF1B mRNA CTD PMID:26391144 NCBI chr 4:149,176,319...149,307,773
Ensembl chr 4:149,176,319...149,307,693
JBrowse link
G Kif22 kinesin family member 22 decreases expression ISO Betaine results in decreased expression of KIF22 mRNA CTD PMID:26391144 NCBI chr 7:127,027,729...127,042,467
Ensembl chr 7:127,027,729...127,042,471
JBrowse link
G Klf10 Kruppel-like factor 10 increases expression ISO Betaine results in increased expression of KLF10 mRNA CTD PMID:26391144 NCBI chr15:38,291,464...38,300,711
Ensembl chr15:38,291,463...38,300,706
JBrowse link
G Krt2 keratin 2 increases expression ISO Betaine results in increased expression of KRT2 mRNA; Betaine results in increased expression of KRT2 protein CTD PMID:26391144 NCBI chr15:101,810,689...101,818,956
Ensembl chr15:101,810,689...101,818,169
JBrowse link
G Lars leucyl-tRNA synthetase decreases expression ISO Betaine results in decreased expression of LARS mRNA CTD PMID:26391144 NCBI chr18:42,202,298...42,262,237
Ensembl chr18:42,202,298...42,262,194
JBrowse link
G Lin9 lin-9 homolog (C. elegans) decreases expression ISO Betaine results in decreased expression of LIN9 mRNA CTD PMID:26391144 NCBI chr 1:180,641,150...180,690,687
Ensembl chr 1:180,641,150...180,690,694
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 decreases stability
multiple interactions
ISO Betaine results in decreased stability of MARCHF6 protein
Cholesterol inhibits the reaction [Betaine results in decreased stability of MARCHF6 protein]
CTD PMID:30545937 NCBI chr15:31,455,899...31,531,082
Ensembl chr15:31,455,891...31,531,053
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Betaine results in decreased expression of MCM3 mRNA CTD PMID:26391144 NCBI chr 1:20,802,966...20,820,312
Ensembl chr 1:20,802,968...20,820,312
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Betaine results in decreased expression of MCM4 mRNA CTD PMID:26391144 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Betaine results in decreased expression of MCM7 mRNA CTD PMID:26391144 NCBI chr 5:138,164,583...138,172,111
Ensembl chr 5:138,164,583...138,172,422
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like decreases expression ISO Betaine results in decreased expression of MTHFD1L mRNA CTD PMID:26391144 NCBI chr10:3,972,892...4,167,081
Ensembl chr10:3,973,118...4,167,081
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases expression ISO Betaine results in decreased expression of MTHFD2 mRNA CTD PMID:26391144 NCBI chr 6:83,305,704...83,326,011
Ensembl chr 6:83,305,691...83,325,908
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Betaine inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA] CTD PMID:19642983 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist increases expression ISO Betaine results in increased expression of NBL1 mRNA CTD PMID:26391144 NCBI chr 4:139,082,291...139,093,126
Ensembl chr 4:139,082,284...139,092,993
JBrowse link
G Nckipsd NCK interacting protein with SH3 domain decreases expression ISO Betaine results in decreased expression of NCKIPSD mRNA CTD PMID:26391144 NCBI chr 9:108,808,346...108,818,839
Ensembl chr 9:108,808,368...108,818,844
JBrowse link
G Ndrg4 N-myc downstream regulated gene 4 decreases expression ISO Betaine results in decreased expression of NDRG4 mRNA CTD PMID:26391144 NCBI chr 8:95,676,974...95,714,956
Ensembl chr 8:95,676,980...95,715,119
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 decreases expression ISO Betaine results in decreased expression of NUPR1 mRNA CTD PMID:26391144 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter] CTD PMID:22064374 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
G Pcp4 Purkinje cell protein 4 increases expression ISO Betaine results in increased expression of PCP4 mRNA CTD PMID:26391144 NCBI chr16:96,467,606...96,525,793
Ensembl chr16:96,467,606...96,525,793
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Betaine results in decreased expression of PCTP mRNA CTD PMID:26391144 NCBI chr11:89,982,544...90,002,894
Ensembl chr11:89,982,665...90,002,894
JBrowse link
G Pola2 polymerase (DNA directed), alpha 2 decreases expression ISO Betaine results in decreased expression of POLA2 mRNA CTD PMID:26391144 NCBI chr19:5,940,543...5,964,238
Ensembl chr19:5,940,542...5,964,202
JBrowse link
G Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) decreases expression ISO Betaine results in decreased expression of POLE2 mRNA CTD PMID:26391144 NCBI chr12:69,201,773...69,228,205
Ensembl chr12:69,201,773...69,228,195
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein
Betaine results in decreased expression of PPARA mRNA
CTD PMID:20118189 PMID:22945834 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Prss23 protease, serine 23 increases expression ISO Betaine results in increased expression of PRSS23 mRNA CTD PMID:26391144 NCBI chr 7:89,507,783...89,527,187
Ensembl chr 7:89,507,783...89,527,187
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP Betaine inhibits the reaction [Azacitidine results in decreased methylation of PSEN1 promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter] CTD PMID:19635394 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Betaine results in decreased expression of PTGS1 mRNA CTD PMID:26391144 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ranbp3l RAN binding protein 3-like decreases expression ISO Betaine results in decreased expression of RANBP3L mRNA CTD PMID:26391144 NCBI chr15:8,967,949...9,067,335
Ensembl chr15:8,967,949...9,067,335
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein] CTD PMID:25559852 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Betaine results in increased expression of RGS2 mRNA CTD PMID:26391144 NCBI chr 1:143,999,338...144,004,149
Ensembl chr 1:143,999,338...144,004,161
JBrowse link
G Rrm2 ribonucleotide reductase M2 decreases expression ISO Betaine results in decreased expression of RRM2 mRNA CTD PMID:26391144 NCBI chr12:24,708,254...24,714,146
Ensembl chr12:24,708,241...24,714,146
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO Betaine results in decreased expression of SCD1 mRNA CTD PMID:26391144 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Sectm1a secreted and transmembrane 1A increases expression ISO Betaine results in increased expression of SECTM1A mRNA CTD PMID:26391144 NCBI chr11:121,067,395...121,097,153
Ensembl chr11:121,067,407...121,081,220
JBrowse link
G Serinc2 serine incorporator 2 decreases expression ISO Betaine results in decreased expression of SERINC2 mRNA CTD PMID:26391144 NCBI chr 4:130,253,495...130,279,218
Ensembl chr 4:130,253,495...130,279,205
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression ISO Betaine results in decreased expression of SERPINA3N mRNA CTD PMID:26391144 NCBI chr12:104,406,646...104,414,334
Ensembl chr12:104,406,729...104,414,329
JBrowse link
G Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 increases expression ISO Betaine results in increased expression of SLC16A6 mRNA CTD PMID:26391144 NCBI chr11:109,450,855...109,473,598
Ensembl chr11:109,450,855...109,473,598
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP Betaine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,864,388...7,966,517
Ensembl chr19:7,864,388...7,966,027
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions ISO Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660
JBrowse link
G Slc36a1 solute carrier family 36 (proton/amino acid symporter), member 1 increases uptake EXP SLC36A1 protein results in increased uptake of Betaine CTD PMID:18845132 NCBI chr11:55,204,322...55,236,330
Ensembl chr11:55,204,350...55,236,330
JBrowse link
G Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 multiple interactions EXP Betaine inhibits the reaction [Lipopolysaccharides results in increased expression of SLC6A12 mRNA] CTD PMID:22053950 NCBI chr 6:121,342,574...121,365,773
Ensembl chr 6:121,343,076...121,365,775
JBrowse link
G Slc6a20b solute carrier family 6 (neurotransmitter transporter), member 20B increases uptake EXP SLC6A20B protein results in increased uptake of Betaine CTD PMID:18845132 NCBI chr 9:123,593,823...123,632,538
Ensembl chr 9:123,590,800...123,632,565
JBrowse link
G Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 decreases expression ISO Betaine results in decreased expression of SLC6A9 mRNA CTD PMID:26391144 NCBI chr 4:117,835,258...117,869,305
Ensembl chr 4:117,834,506...117,875,198
JBrowse link
G Snx10 sorting nexin 10 decreases expression ISO Betaine results in decreased expression of SNX10 mRNA CTD PMID:26391144 NCBI chr 6:51,523,900...51,590,679
Ensembl chr 6:51,523,901...51,590,679
JBrowse link
G Sostdc1 sclerostin domain containing 1 increases expression ISO Betaine results in increased expression of SOSTDC1 mRNA CTD PMID:26391144 NCBI chr12:36,314,169...36,318,452
Ensembl chr12:36,314,139...36,318,452
JBrowse link
G Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) decreases expression ISO Betaine results in decreased expression of SPC25 mRNA CTD PMID:26391144 NCBI chr 2:69,193,895...69,206,213
Ensembl chr 2:69,193,895...69,206,194
JBrowse link
G Ssr4 signal sequence receptor, delta decreases expression ISO Betaine results in decreased expression of SSR4 mRNA CTD PMID:26391144 NCBI chr  X:73,787,023...73,790,828
Ensembl chr  X:73,787,028...73,790,830
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Betaine promotes the reaction [Isoproterenol results in increased phosphorylation of STAT3 protein] CTD PMID:25080425 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO Betaine results in decreased expression of STMN1 mRNA CTD PMID:26391144 NCBI chr 4:134,468,320...134,473,843
Ensembl chr 4:134,468,320...134,473,843
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Betaine results in decreased expression of STXBP1 mRNA CTD PMID:26391144 NCBI chr 2:32,787,607...32,847,237
Ensembl chr 2:32,787,602...32,847,245
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Betaine results in increased expression of TGFB2 mRNA CTD PMID:26391144 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Betaine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA] CTD PMID:22945834 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Betaine results in decreased expression of TRIB2 mRNA CTD PMID:26391144 NCBI chr12:15,791,725...15,816,962
Ensembl chr12:15,791,727...15,816,922
JBrowse link
G Upk3bl uroplakin 3B-like decreases expression ISO Betaine results in decreased expression of UPK3BL1 mRNA CTD PMID:26391144 NCBI chr 5:136,057,259...136,076,695
Ensembl chr 5:136,054,492...136,064,326
JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 decreases expression ISO Betaine results in decreased expression of WNK4 mRNA CTD PMID:26391144 NCBI chr11:101,260,537...101,277,409
Ensembl chr11:101,260,567...101,277,409
JBrowse link
G Ybx2 Y box protein 2 decreases expression ISO Betaine results in decreased expression of YBX2 mRNA CTD PMID:26391144 NCBI chr11:69,935,805...69,941,604
Ensembl chr11:69,935,796...69,941,605
JBrowse link
L-proline betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein] CTD PMID:32417162 NCBI chr 1:171,250,129...171,262,267
Ensembl chr 1:171,250,421...171,260,637
JBrowse link
G Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein] CTD PMID:32417162 NCBI chr16:85,858,157...85,901,125
Ensembl chr16:85,856,173...85,901,828
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:32417162 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein] CTD PMID:32417162 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:32417162 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein] CTD PMID:32417162 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:32417162 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:32417162 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein] CTD PMID:32417162 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
meldonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadl acyl-Coenzyme A dehydrogenase, long-chain increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of ACADL mRNA CTD PMID:32389661 NCBI chr 1:66,830,839...66,863,309
Ensembl chr 1:66,830,839...66,863,277
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of ACADM mRNA CTD PMID:32389661 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACADVL mRNA CTD PMID:32389661 NCBI chr11:70,010,183...70,015,428
Ensembl chr11:70,010,183...70,015,411
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACOX1 mRNA CTD PMID:32389661 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1B mRNA CTD PMID:32389661 NCBI chr15:89,416,405...89,425,862
Ensembl chr15:89,416,405...89,425,863
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1C mRNA CTD PMID:32389661 NCBI chr 7:44,958,483...44,974,880
Ensembl chr 7:44,959,372...44,974,851
JBrowse link
G Hk1 hexokinase 1 increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of HK1 mRNA CTD PMID:32389661 NCBI chr10:62,268,855...62,379,920
Ensembl chr10:62,268,855...62,379,908
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of PDK1 mRNA CTD PMID:32389661 NCBI chr 2:71,873,215...71,903,858
Ensembl chr 2:71,873,224...71,903,858
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARA mRNA CTD PMID:32389661 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression ISO
EXP
3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of PPARGC1A mRNA CTD PMID:27559315 PMID:32389661 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARGC1B mRNA CTD PMID:27559315 NCBI chr18:61,291,445...61,400,756
Ensembl chr18:61,298,136...61,400,431
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases uptake ISO SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate CTD PMID:18981167 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of SLC2A4 mRNA CTD PMID:32389661 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of SLC5A2 mRNA CTD PMID:32389661 NCBI chr 7:128,265,683...128,272,430
Ensembl chr 7:128,265,657...128,272,430
JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of TFAM mRNA CTD PMID:27559315 NCBI chr10:71,225,468...71,238,328
Ensembl chr10:71,225,464...71,238,280
JBrowse link
N-methylnicotinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 multiple interactions EXP
ISO
trigonelline inhibits the reaction [Palmitic Acid results in decreased expression of ATG7 protein]
ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]]; ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; trigonelline inhibits the reaction [Palmitic Acid results in decreased expression of ATG7 protein]
CTD PMID:30208301 NCBI chr 6:114,643,127...114,860,604
Ensembl chr 6:114,643,097...114,860,614
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein] CTD PMID:31935362 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of BCL2 protein] CTD PMID:31935362 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP
ISO
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in decreased expression of BECN1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in decreased expression of BECN1 protein] CTD PMID:30208301 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP
ISO
trigonelline results in increased activity of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]
CTD PMID:26593444 PMID:31935362 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of CD36 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of CD36 protein] CTD PMID:30208301 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA CTD PMID:29959986 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:30208301 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA CTD PMID:29959986 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098
JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA CTD PMID:29959986 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein] CTD PMID:30208301 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein] CTD PMID:31935362 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL6 protein] CTD PMID:31935362 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I multiple interactions EXP trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of INS1 protein] CTD PMID:30208301 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of trigonelline CTD PMID:20567778 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased phosphorylation of MTOR protein] CTD PMID:30208301 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Myc myelocytomatosis oncogene decreases expression EXP trigonelline results in decreased expression of MYC mRNA CTD PMID:26593444 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein] CTD PMID:24015256 PMID:29959986 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA] CTD PMID:24015256 PMID:29959986 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased cleavage of PARP1 protein] CTD PMID:30208301 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Plin1 perilipin 1 multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PLIN1 protein] CTD PMID:30208301 NCBI chr 7:79,721,164...79,732,904
Ensembl chr 7:79,720,218...79,732,903
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP
ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of PPARG protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]
CTD PMID:30208301 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects abundance EXP SLCO1A1 protein affects the abundance of trigonelline CTD PMID:21561886 NCBI chr 6:141,907,281...141,946,962
Ensembl chr 6:141,907,282...141,946,962
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO
EXP
trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of SQSTM1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]
CTD PMID:30208301 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP
ISO
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]
ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]
CTD PMID:30208301 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein] CTD PMID:31935362 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases expression ISO Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Atp6v1f ATPase, H+ transporting, lysosomal V1 subunit F increases expression ISO Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 6:29,467,783...29,470,509
Ensembl chr 6:29,467,718...29,470,512
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C4b complement component 4B (Chido blood group) decreases expression EXP Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr17:34,728,139...34,743,902
Ensembl chr17:34,728,380...34,743,882
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Csprs component of Sp100-rs decreases expression EXP Acetylcarnitine results in decreased expression of CSPRS mRNA CTD PMID:19555370
G Ctss cathepsin S decreases expression EXP Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,526,786...95,556,405
Ensembl chr 3:95,526,786...95,556,403
JBrowse link
G Cxcl14 chemokine (C-X-C motif) ligand 14 decreases expression EXP Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr13:56,288,643...56,296,811
Ensembl chr13:56,288,643...56,296,551
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gsr glutathione reductase multiple interactions EXP Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr16:4,726,361...4,766,742
Ensembl chr16:4,726,361...4,766,742
JBrowse link
G Hspb1 heat shock protein 1 decreases expression ISO Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions
EXP IDH2 protein mutant form results in increased abundance of Acetylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]
CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Acetylcarnitine results in decreased expression of LYZ1 mRNA CTD PMID:19555370 NCBI chr10:117,287,795...117,292,868
Ensembl chr10:117,287,797...117,292,868
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr10:87,521,795...87,584,137
Ensembl chr10:87,521,795...87,584,136
JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 4:138,313,409...138,326,296
Ensembl chr 4:138,313,409...138,326,307
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions
ISO Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
CTD PMID:20414966 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr17:10,840,359...12,063,370
Ensembl chr17:10,840,384...12,063,361
JBrowse link
G Psmb6 proteasome (prosome, macropain) subunit, beta type 6 increases expression ISO Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr11:70,525,324...70,527,858
Ensembl chr11:70,525,367...70,527,858
JBrowse link
G Ptma prothymosin alpha increases expression ISO Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 1:86,526,557...86,530,712
Ensembl chr 1:86,526,726...86,530,712
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rps17 ribosomal protein S17 increases expression ISO Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr 7:81,342,733...81,345,234
Ensembl chr 7:81,342,732...81,345,254
JBrowse link
G Skap2 src family associated phosphoprotein 2 decreases expression EXP Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 6:51,859,165...52,012,549
Ensembl chr 6:51,857,422...52,012,549
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP Acetylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,864,388...7,966,517
Ensembl chr19:7,864,388...7,966,027
JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions ISO Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 9:108,662,136...108,684,642
Ensembl chr 9:108,662,088...108,684,641
JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 7:4,518,305...4,522,718
Ensembl chr 7:4,518,305...4,524,229
JBrowse link
O-butanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions
EXP IDH2 protein mutant form results in increased abundance of butyrylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine]
CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
O-octanoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crot carnitine O-octanoyltransferase increases chemical synthesis EXP CROT protein results in increased chemical synthesis of octanoylcarnitine CTD PMID:6838215 NCBI chr 5:8,966,033...8,997,146
Ensembl chr 5:8,966,033...8,997,324
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP octanoylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,864,388...7,966,517
Ensembl chr19:7,864,388...7,966,027
JBrowse link
O-palmitoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Palmitoylcarnitine CTD PMID:24709313 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Gls glutaminase increases chemical synthesis ISO GLS protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr 1:52,163,449...52,235,009
Ensembl chr 1:52,163,448...52,233,232
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) decreases metabolic processing EXP PPP3R1 gene mutant form results in decreased metabolism of Palmitoylcarnitine CTD PMID:19700627 NCBI chr11:17,159,298...17,200,380
Ensembl chr11:17,159,263...17,200,375
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases chemical synthesis ISO PRKAA1 protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO
EXP
[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658 PMID:21267448 PMID:30265530 PMID:31445927 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658 PMID:25416439 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein CTD PMID:15781658 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Egf epidermal growth factor multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) affects response to substance ISO perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO
EXP
[perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA
perifosine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of FOXO1 protein]
CTD PMID:30265530 PMID:33078829 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions
decreases response to substance
decreases expression
ISO ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 NCBI chr 5:134,600,103...134,619,783
Ensembl chr 5:134,600,022...134,615,025
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:15781658 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
phosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 increases secretion EXP ABCB11 protein results in increased secretion of Phosphatidylcholines CTD PMID:14570929 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects export
affects transport
ISO ABCB1 protein affects the export of Phosphatidylcholines
ABCB1 protein affects the transport of Phosphatidylcholines
CTD PMID:11147995 PMID:11745043 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 affects transport
affects export
EXP
ISO
ABCB4 protein affects the transport of Phosphatidylcholines
ABCB4 protein affects the export of Phosphatidylcholines
CTD PMID:11745043 PMID:15696852 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 decreases activity ISO Phosphatidylcholines results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr 9:53,580,522...53,610,350
Ensembl chr 9:53,580,522...53,610,382
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP Phosphatidylcholines results in decreased expression of ADIPOQ mRNA CTD PMID:23911798 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance
EXP
ISO
PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of AIFM1 protein CTD PMID:21695227 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases abundance EXP ARNTL gene mutant form results in increased abundance of Phosphatidylcholines CTD PMID:27056296 NCBI chr 7:113,178,471...113,314,126
Ensembl chr 7:113,207,465...113,314,126
JBrowse link
G As3mt arsenite methyltransferase affects metabolic processing EXP AS3MT gene mutant form affects the metabolism of Phosphatidylcholines CTD PMID:27591999 NCBI chr19:46,707,157...46,741,099
Ensembl chr19:46,707,458...46,741,099
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of BAX protein CTD PMID:21695227 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of BCL2 protein CTD PMID:21695227 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP3 protein CTD PMID:21695227 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP9 protein CTD PMID:21695227 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression EXP Phosphatidylcholines results in increased expression of CCL2 mRNA CTD PMID:23911798 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CCND1 protein CTD PMID:21695227 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Phosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein] CTD PMID:21695227 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CDK2 protein CTD PMID:21695227 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1A protein CTD PMID:21695227 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein CTD PMID:21695227 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP Phosphatidylcholines results in decreased expression of CES1D mRNA CTD PMID:23911798 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Crp C-reactive protein, pentraxin-related affects binding
decreases activity
ISO CRP protein binds to Phosphatidylcholines
Phosphatidylcholines results in decreased activity of CRP protein
CTD PMID:16962105 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects activity ISO Phosphatidylcholines affects the activity of CYP1A2 protein CTD PMID:15966743 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases activity ISO Phosphatidylcholines results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Phosphatidylcholines CTD PMID:12885774 NCBI chr11:118,988,181...118,993,221
Ensembl chr11:118,988,188...118,993,221
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines CTD PMID:18723500 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fgf15 fibroblast growth factor 15 decreases abundance EXP FGF19 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases activity ISO Phosphatidylcholines results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Igf1 insulin-like growth factor 1 increases degradation EXP IGF1 protein results in increased degradation of Phosphatidylcholines CTD PMID:2120207 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Il10 interleukin 10 increases expression EXP Phosphatidylcholines results in increased expression of IL10 mRNA CTD PMID:23911798 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Phosphatidylcholines results in increased expression of IL1B mRNA
Phosphatidylcholines results in increased expression of and results in increased secretion of IL1B protein
CTD PMID:23911798 PMID:30958839 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 increases expression EXP Phosphatidylcholines results in increased expression of IL6 mRNA CTD PMID:23911798 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lep leptin decreases expression EXP Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lipc lipase, hepatic multiple interactions
increases abundance
EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPC gene mutant form results in increased abundance of Phosphatidylcholines
CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipe lipase, hormone sensitive increases expression EXP Phosphatidylcholines results in increased expression of LIPE mRNA CTD PMID:23911798 NCBI chr 7:25,379,527...25,398,486
Ensembl chr 7:25,379,527...25,398,710
JBrowse link
G Lipg lipase, endothelial multiple interactions
increases abundance
EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPG gene mutant form results in increased abundance of Phosphatidylcholines
CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
G Ltf lactotransferrin multiple interactions EXP [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 9:111,019,292...111,042,766
Ensembl chr 9:111,019,271...111,042,767
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA] CTD PMID:16169303 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance EXP NR0B2 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Phosphatidylcholines CTD PMID:29515023 NCBI chr 1:136,842,562...136,960,448
Ensembl chr 1:136,842,571...136,960,448
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 multiple interactions
increases secretion
ISO PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines]; PAFAH1B1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Phosphatidylcholines]
PAFAH1B1 protein results in increased secretion of Phosphatidylcholines
CTD PMID:12013527 NCBI chr11:74,673,949...74,724,384
Ensembl chr11:74,673,949...74,724,670
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 multiple interactions ISO PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 4:134,396,320...134,427,412
Ensembl chr 4:134,396,320...134,427,413
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform multiple interactions ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr16:32,430,921...32,475,065
Ensembl chr16:32,430,921...32,475,070
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO
EXP
PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr11:59,970,614...60,046,561
Ensembl chr11:59,970,614...60,046,489
JBrowse link
G Plin1 perilipin 1 increases expression EXP Phosphatidylcholines results in increased expression of PLIN1 mRNA CTD PMID:23911798 NCBI chr 7:79,721,164...79,732,904
Ensembl chr 7:79,720,218...79,732,903
JBrowse link
G Plpp6 phospholipid phosphatase 6 multiple interactions
increases chemical synthesis
ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr19:28,963,920...28,966,801
Ensembl chr19:28,963,953...28,966,811
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression EXP Phosphatidylcholines results in decreased expression of PNPLA2 mRNA CTD PMID:23911798 NCBI chr 7:141,455,188...141,460,743
Ensembl chr 7:141,455,198...141,460,743
JBrowse link
G Pon2 paraoxonase 2 increases activity
increases expression
EXP Phosphatidylcholines results in increased activity of PON2 protein
Phosphatidylcholines results in increased expression of PON2 mRNA
CTD PMID:12615656 NCBI chr 6:5,264,620...5,298,345
Ensembl chr 6:5,264,147...5,298,455
JBrowse link
G Pon3 paraoxonase 3 multiple interactions EXP Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin] CTD PMID:12615656 NCBI chr 6:5,216,256...5,256,285
Ensembl chr 6:5,220,852...5,256,286
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression EXP Phosphatidylcholines results in increased expression of PPARG mRNA CTD PMID:23911798 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases abundance EXP PPARGC1B results in increased abundance of Phosphatidylcholines CTD PMID:17932310 NCBI chr18:61,291,445...61,400,756
Ensembl chr18:61,298,136...61,400,431
JBrowse link
G Pten phosphatase and tensin homolog affects binding
multiple interactions
ISO PTEN protein binds to Phosphatidylcholines
[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]
CTD PMID:15313215 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Retn resistin decreases expression EXP Phosphatidylcholines results in decreased expression of RETN mRNA CTD PMID:23911798 NCBI chr 8:3,655,770...3,659,818
Ensembl chr 8:3,655,770...3,660,110
JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr14:41,131,788...41,136,373
Ensembl chr14:41,131,782...41,136,452
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases abundance
ISO
EXP
GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]
Phosphatidylcholines results in increased expression of TNF mRNA
[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Phosphatidylcholines results in increased expression of and results in increased secretion of TNF protein
CTD PMID:16141546 PMID:22433871 PMID:23911798 PMID:30958839 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Phosphatidylcholines inhibits the reaction [rubitecan results in increased expression of TP53 protein] CTD PMID:21695227 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor increases expression EXP Pyocyanine results in increased expression of AHR mRNA CTD PMID:31078726 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Atf6 activating transcription factor 6 increases activity ISO Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 decreases expression EXP Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 increases expression EXP Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression EXP Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913
JBrowse link
G Il10 interleukin 10 increases expression EXP Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13 interleukin 13 decreases expression EXP Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il6 interleukin 6 increases expression EXP Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr10:81,105,913...81,124,697
Ensembl chr10:81,105,915...81,133,975
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256 PMID:24316274 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256 PMID:24316274 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256 PMID:27613716 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression EXP Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgre4 adhesion G protein-coupled receptor E4 decreases expression EXP S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA CTD PMID:18098314 NCBI chr17:55,749,984...55,853,662
Ensembl chr17:55,749,984...55,853,662
JBrowse link
G Adgre5 adhesion G protein-coupled receptor E5 decreases expression EXP S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA CTD PMID:18098314 NCBI chr 8:83,723,245...83,741,311
Ensembl chr 8:83,723,251...83,741,326
JBrowse link
G Afp alpha fetoprotein multiple interactions
decreases expression
EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA
CTD PMID:18098314 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
decreases abundance
EXP PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alad aminolevulinate, delta-, dehydratase increases activity EXP S-Adenosylmethionine results in increased activity of ALAD protein CTD PMID:9559101 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:150,547,417...150,570,622
Ensembl chr  X:150,547,375...150,570,638
JBrowse link
G App amyloid beta (A4) precursor protein increases secretion ISO S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
affects binding
ISO Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] CTD PMID:22955273 PMID:25349987 NCBI chr19:46,707,157...46,741,099
Ensembl chr19:46,707,458...46,741,099
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP S-Adenosylmethionine results in increased expression of ATF3 mRNA CTD PMID:18098314 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions EXP ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] CTD PMID:22945834 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Bhmt2 betaine-homocysteine methyltransferase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] CTD PMID:18230605 NCBI chr13:93,656,097...93,674,302
Ensembl chr13:93,655,720...93,674,302
JBrowse link
G Casp12 caspase 12 decreases expression EXP S-Adenosylmethionine results in decreased expression of CASP12 mRNA CTD PMID:18098314 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein
CTD PMID:17869084 PMID:18571630 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] CTD PMID:22683606 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression
multiple interactions
ISO S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]
CTD PMID:15983038 PMID:16996477 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions
decreases expression
EXP
ISO
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA
CTD PMID:8878782 PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] CTD PMID:22683606 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]
CTD PMID:15763544 PMID:15983038 PMID:22683606 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 NCBI chr11:11,814,101...11,898,144
Ensembl chr11:11,814,101...11,898,144
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 NCBI chr11:70,017,203...70,045,535
Ensembl chr11:70,016,942...70,047,522
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] CTD PMID:22558281 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3a DNA methyltransferase 3A multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]
CTD PMID:18098314 PMID:22558281 NCBI chr12:3,801,559...3,914,443
Ensembl chr12:3,806,007...3,914,443
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] CTD PMID:22558281 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I decreases expression EXP S-Adenosylmethionine results in decreased expression of FCGR1 mRNA CTD PMID:18098314 NCBI chr 3:96,282,909...96,293,969
Ensembl chr 3:96,282,909...96,293,969
JBrowse link
G Fgf15 fibroblast growth factor 15 increases abundance EXP FGF19 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Fgl2 fibrinogen-like protein 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of FGL2 mRNA CTD PMID:18098314 NCBI chr 5:21,372,673...21,378,386
Ensembl chr 5:21,372,642...21,378,374
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of GBP2 mRNA CTD PMID:18098314 NCBI chr 3:142,620,663...142,638,008
Ensembl chr 3:142,620,602...142,638,008
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA] CTD PMID:22558281 NCBI chr12:16,670,615...16,801,394
Ensembl chr12:16,670,615...16,800,886
JBrowse link
G Gsr glutathione reductase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22683606 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gss glutathione synthetase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] CTD PMID:20146260 NCBI chr 2:155,563,181...155,592,810
Ensembl chr 2:155,563,181...155,592,810
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] CTD PMID:18098314 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta decreases expression EXP S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA CTD PMID:18098314 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 multiple interactions EXP [Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] CTD PMID:30892605 NCBI chr 8:57,320,983...57,324,517
Ensembl chr 8:57,320,983...57,324,633
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029
G Hdac9 histone deacetylase 9 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 NCBI chr12:34,047,580...34,917,095
Ensembl chr12:34,047,580...34,917,095
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 9:44,336,348...44,344,228
Ensembl chr 9:44,336,339...44,344,228
JBrowse link
G Ifi44l interferon-induced protein 44 like decreases expression EXP S-Adenosylmethionine results in decreased expression of IFI44L mRNA CTD PMID:18098314 NCBI chr 3:151,758,737...151,762,891
Ensembl chr 3:151,758,737...151,762,892
JBrowse link
G Ifng interferon gamma multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il2rg interleukin 2 receptor, gamma chain decreases expression EXP S-Adenosylmethionine results in decreased expression of IL2RG mRNA CTD PMID:18098314 NCBI chr  X:101,264,385...101,268,255
Ensembl chr  X:101,264,378...101,268,255
JBrowse link
G Il36g interleukin 36G decreases expression EXP S-Adenosylmethionine results in decreased expression of IL36G mRNA CTD PMID:18098314 NCBI chr 2:24,186,476...24,193,567
Ensembl chr 2:24,186,476...24,193,568
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Klf6 Kruppel-like factor 6 decreases expression
multiple interactions
EXP S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]
CTD PMID:18098314 NCBI chr13:5,861,489...5,870,393
Ensembl chr13:5,861,482...5,870,394
JBrowse link
G Lep leptin multiple interactions ISO S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Ltb lymphotoxin B multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr17:35,194,507...35,196,305
Ensembl chr17:35,194,439...35,196,320
JBrowse link
G Maf avian musculoaponeurotic fibrosarcoma oncogene homolog multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] CTD PMID:20146260 NCBI chr 8:115,703,253...115,706,894
Ensembl chr 8:115,682,942...115,707,794
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] CTD PMID:20146260 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mat1a methionine adenosyltransferase I, alpha affects abundance
increases chemical synthesis
EXP MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine
CTD PMID:8373829 PMID:12060674 NCBI chr14:41,105,012...41,124,428
Ensembl chr14:41,105,035...41,124,412
JBrowse link
G Mat2a methionine adenosyltransferase II, alpha increases chemical synthesis EXP MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine CTD PMID:8373829 NCBI chr 6:72,432,796...72,439,556
Ensembl chr 6:72,432,799...72,439,558
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] CTD PMID:22558281 NCBI chr18:70,568,225...70,629,134
Ensembl chr18:70,568,189...70,626,131
JBrowse link
G Mir491 microRNA 491 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of MIR491 mRNA] CTD PMID:24680928 NCBI chr 4:88,122,040...88,122,125
Ensembl chr 4:88,122,040...88,122,125
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase increases abundance EXP MTHFD1 protein results in increased abundance of S-Adenosylmethionine CTD PMID:19033438 NCBI chr12:76,254,406...76,319,820
Ensembl chr12:76,255,298...76,319,803
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions
ISO S-Adenosylmethionine binds to MTR protein
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]
CTD PMID:17477549 PMID:26989453 NCBI chr13:12,181,331...12,258,199
Ensembl chr13:12,182,712...12,258,113
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 decreases expression EXP S-Adenosylmethionine results in decreased expression of NDRG1 mRNA CTD PMID:18098314 NCBI chr15:66,929,318...66,969,641
Ensembl chr15:66,929,318...66,969,640
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] CTD PMID:20146260 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nlgn3 neuroligin 3 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:101,299,179...101,321,350
Ensembl chr  X:101,299,168...101,325,963
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases abundance EXP NR0B2 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nrxn1 neurexin I multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr17:90,033,644...91,093,159
Ensembl chr17:90,033,631...91,093,071
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific multiple interactions EXP [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] CTD PMID:21266552 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr11:59,970,614...60,046,561
Ensembl chr11:59,970,614...60,046,489
JBrowse link
G Pfn2 profilin 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of PFN2 mRNA CTD PMID:18098314 NCBI chr 3:57,841,895...57,847,757
Ensembl chr 3:57,841,895...57,848,079
JBrowse link
G Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) increases expression EXP S-Adenosylmethionine results in increased expression of PSMB8 mRNA CTD PMID:18098314 NCBI chr17:34,198,195...34,201,454
Ensembl chr17:34,197,721...34,201,454
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP S-Adenosylmethionine results in decreased expression of PTGS1 mRNA CTD PMID:18098314 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] CTD PMID:21266552 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) decreases expression EXP S-Adenosylmethionine results in decreased expression of RNASEL mRNA CTD PMID:18098314 NCBI chr 1:153,749,344...153,768,690
Ensembl chr 1:153,749,426...153,764,221
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 affects abundance EXP SLC19A1 protein affects the abundance of S-Adenosylmethionine CTD PMID:15705887 NCBI chr10:77,032,269...77,050,432
Ensembl chr10:77,032,241...77,061,002
JBrowse link
G Smyd2 SET and MYND domain containing 2 affects binding ISO S-Adenosylmethionine binds to SMYD2 protein CTD PMID:21782458 NCBI chr 1:189,880,492...189,922,495
Ensembl chr 1:189,880,492...189,922,363
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:22683606 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] CTD PMID:22683606 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]
CTD PMID:15983038 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404
JBrowse link
G Syn1 synapsin I multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276 NCBI chr  X:20,860,511...20,920,918
Ensembl chr  X:20,860,511...20,921,004
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] CTD PMID:22558281 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Tfrc transferrin receptor decreases expression ISO S-Adenosylmethionine results in decreased expression of TFRC mRNA CTD PMID:18571630 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:15983038 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
CTD PMID:19822164 PMID:21266552 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tpmt thiopurine methyltransferase multiple interactions ISO [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] CTD PMID:20196537 NCBI chr13:47,021,987...47,043,338
Ensembl chr13:47,022,482...47,044,737
JBrowse link
G Trf transferrin multiple interactions
increases expression
ISO [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron CTD PMID:18571630 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444
JBrowse link
G Ubd ubiquitin D multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] CTD PMID:18098314 NCBI chr17:37,193,892...37,196,101
Ensembl chr17:37,193,892...37,196,095
JBrowse link
G Vim vimentin multiple interactions EXP S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] CTD PMID:26745512 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
serpentine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases activity
ISO serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
serpentine (alkaloid) results in decreased activity of CYP2D6 protein
CTD PMID:15930738 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21727
    chemical entity 21725
      molecular entity 21712
        polyatomic entity 21602
          molecule 21239
            organic molecule 21229
              dipolar compound 1062
                zwitterion 1061
                  onium betaine 376
                    ammonium betaine + 295
                    diazonium betaine + 0
                    iminium betaine + 44
                    nitrilium betaine + 0
                    oxonium betaine + 0
                    sulfonium betaine + 85
Path 2
Term Annotations click to browse term
  CHEBI ontology 21727
    subatomic particle 21713
      composite particle 21713
        hadron 21713
          baryon 21713
            nucleon 21713
              atomic nucleus 21713
                atom 21713
                  main group element atom 21630
                    p-block element atom 21630
                      carbon group element atom 21435
                        carbon atom 21332
                          organic molecular entity 21332
                            organic molecule 21229
                              dipolar compound 1062
                                zwitterion 1061
                                  onium betaine 376
                                    ammonium betaine + 295
                                    diazonium betaine + 0
                                    iminium betaine + 44
                                    nitrilium betaine + 0
                                    oxonium betaine + 0
                                    sulfonium betaine + 85
paths to the root