Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-proline betaine
go back to main search page
Accession:CHEBI:35280 term browser browse the term
Definition:An amino acid betaine that is L-proline zwitterion in which both of the hydrogens attached to the nitrogen are replaced by methyl groups.
Synonyms:exact_synonym: (2S)-1,1-dimethylpyrrolidinium-2-carboxylate
 related_synonym: (S)-2-carboxylato-1,1-dimethylpyrrolidinium;   Formula=C7H13NO2;   InChI=1S/C7H13NO2/c1-8(2)5-3-4-6(8)7(9)10/h6H,3-5H2,1-2H3/t6-/m0/s1;   InChIKey=CMUNUTVVOOHQPW-LURJTMIESA-N;   N,N-dimethyl-L-proline;   SMILES=C[N+]1(C)CCC[C@H]1C([O-])=O;   Stachydrine;   proline betaine
 alt_id: CHEBI:26272;   CHEBI:26748;   CHEBI:9247
 xref: Beilstein:3542403;   CAS:471-87-4;   DrugBank:DB04284;   HMDB:HMDB0004827;   KEGG:C10172;   KNApSAcK:C00002074
 xref_mesh: MESH:C003342
 xref: PDBeChem:PBE;   PMID:22770225;   PMID:24704554;   PMID:25012968;   Reaxys:3542403
 cyclic_relationship: is_conjugate_base_of CHEBI:44813;   is_enantiomer_of CHEBI:134398


show annotations for term's descendants           Sort by:
 
L-proline betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein] CTD PMID:32417162 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein] CTD PMID:32417162 NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:32417162 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein] CTD PMID:32417162 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:32417162 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein] CTD PMID:32417162 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:32417162 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:32417162 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein] CTD PMID:32417162 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19772
    role 19717
      biological role 19716
        physiological role 19709
          food component 19709
            L-proline betaine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19772
    subatomic particle 19767
      composite particle 19767
        hadron 19767
          baryon 19767
            nucleon 19767
              atomic nucleus 19767
                atom 19767
                  main group element atom 19654
                    p-block element atom 19654
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18058
                                        amino acid 14069
                                          alpha-amino acid 11535
                                            L-alpha-amino acid 11369
                                              non-proteinogenic L-alpha-amino acid 594
                                                N-methyl-L-alpha-amino acid 11
                                                  L-proline betaine 11
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.