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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloroform
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Accession:CHEBI:35255 term browser browse the term
Definition:A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
Synonyms:related_synonym: 1,1,1-trichloromethane;   CHCl3;   Formula=CHCl3;   InChI=1S/CHCl3/c2-1(3)4/h1H;   InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Cl;   Trichlormethan;   chloroforme;   chloroformium pro narcosi;   trichloromethane
 alt_id: CHEBI:23143;   CHEBI:34628
 xref: Beilstein:1731042;   CAS:67-66-3;   Drug_Central:4363;   Gmelin:1837;   HMDB:HMDB0029596;   KEGG:C13827;   LINCS:LSM-37229
 xref_mesh: MESH:D002725
 xref: MetaCyc:CPD-843;   PDBeChem:MCH;   PMID:10379014;   PMID:15583552;   PMID:20051454;   PMID:21850127;   PMID:23093177;   PMID:8476536;   PMID:8625290;   Reaxys:1731042;   UM-BBD_compID:c0595;   Wikipedia:Chloroform


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chloroform term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases expression ISO Chloroform results in decreased expression of ABCB11 mRNA CTD PMID:17522070 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO Chloroform results in increased expression of ABCB1 mRNA CTD PMID:15120965 PMID:17522070 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression ISO Chloroform results in increased expression of ABCB1B mRNA CTD PMID:15120965 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression ISO Chloroform results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain decreases expression ISO Chloroform results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Chloroform results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression ISO Chloroform results in increased expression of ALDH1A1 mRNA CTD PMID:21813463 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 decreases expression ISO Chloroform results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290 		JBrowse link
G Anxa2 annexin A2 increases expression ISO Chloroform results in increased expression of ANXA2 mRNA CTD PMID:21813463 NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases expression ISO Chloroform results in increased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596 		JBrowse link
G Asl argininosuccinate lyase increases expression ISO Chloroform results in increased expression of ASL mRNA CTD PMID:17522070 NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP
ISO		 Chloroform results in increased expression of BTG2 mRNA CTD PMID:9397189 PMID:17522070 PMID:21813463 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858 		JBrowse link
G Calu calumenin increases expression ISO Chloroform results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109 		JBrowse link
G Cat catalase decreases expression ISO Chloroform results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Chloroform results in increased expression of CCL2 mRNA CTD PMID:21907259 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO Chloroform results in increased expression of CCNG1 mRNA CTD PMID:17522070 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Chloroform results in increased expression of CDKN1A mRNA CTD PMID:21813463 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Ces2h carboxylesterase 2H increases expression ISO Chloroform results in increased expression of CES2 mRNA CTD PMID:21813463 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810 		JBrowse link
G Chil3 chitinase-like 3 increases expression EXP Chloroform results in increased expression of CHIL3 mRNA CTD PMID:21977998 NCBI chr 3:106,054,870...106,074,852
Ensembl chr 3:106,054,870...106,074,880 		JBrowse link
G Clu clusterin increases expression ISO Chloroform results in increased expression of CLU mRNA CTD PMID:17522070 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Ctsl cathepsin L increases expression ISO Chloroform results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Chloroform results in increased expression of CXCL8 protein CTD PMID:11306435 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
increases response to substance		 ISO CYP2E1 protein results in increased metabolism of Chloroform
CYP2E1 protein results in increased oxidation of Chloroform
CYP2E1 gene SNP results in increased susceptibility to Chloroform		 CTD PMID:1664256 PMID:15289170 PMID:18350910 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp4f15 cytochrome P450, family 4, subfamily f, polypeptide 15 decreases expression EXP Chloroform results in decreased expression of CYP4F15 mRNA CTD PMID:9397189 NCBI chr17:32,904,605...32,922,329
Ensembl chr17:32,904,601...32,922,326 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Chloroform results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver decreases expression ISO Chloroform results in decreased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Chloroform results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241 		JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Chloroform results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression ISO Chloroform results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:55,776,569...55,838,704
Ensembl chr  X:55,777,147...55,838,706 		JBrowse link
G Fmo1 flavin containing monooxygenase 1 decreases expression ISO Chloroform results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP Chloroform results in increased expression of FOS mRNA CTD PMID:8625290 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Chloroform results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gck glucokinase increases expression ISO Chloroform results in increased expression of GCK mRNA CTD PMID:17522070 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Chloroform results in decreased expression of GJB1 mRNA CTD PMID:17522070 NCBI chr  X:100,419,982...100,429,235
Ensembl chr  X:100,419,984...100,429,235 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases activity		 EXP
ISO		 Anethole Trithione promotes the reaction [Chloroform results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Chloroform results in increased activity of GPT protein] CTD PMID:3795300 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Chloroform results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsr glutathione reductase increases expression EXP Chloroform results in increased expression of GSR mRNA CTD PMID:15914208 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Chloroform results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Chloroform results in increased expression of HAVCR1 mRNA CTD PMID:21907259 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hcn2 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 decreases activity ISO Chloroform results in decreased activity of HCN2 protein CTD PMID:22024336 NCBI chr10:79,552,468...79,571,942
Ensembl chr10:79,552,468...79,571,942 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression ISO Chloroform results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 6:52,523,215...52,617,285
Ensembl chr 6:52,523,213...52,617,374 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Chloroform results in increased expression of HMOX1 mRNA CTD PMID:15914208 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa1a heat shock protein 1A increases expression ISO Chloroform results in increased expression of HSPA1A mRNA CTD PMID:17522070 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Chloroform results in increased expression of ICAM1 mRNA CTD PMID:17522070 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma decreases expression EXP Chloroform results in decreased expression of IFNG protein CTD PMID:16879906 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il13 interleukin 13 increases expression EXP Chloroform results in increased expression of IL13 protein CTD PMID:16879906 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions		 EXP Chloroform results in decreased expression of IL4 protein
Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA]		 CTD PMID:16879906 PMID:21977998 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 increases expression EXP Chloroform results in increased expression of IL5 protein CTD PMID:16879906 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Chloroform results in decreased activity of KCNH2 protein CTD PMID:22024336 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Krt18 keratin 18 increases expression ISO Chloroform results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462 		JBrowse link
G Krt8 keratin 8 increases expression ISO Chloroform results in increased expression of KRT8 mRNA CTD PMID:17522070 NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression ISO Chloroform results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 increases expression ISO Chloroform results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Lipc lipase, hepatic decreases expression ISO Chloroform results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression ISO Chloroform results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 6:112,250,747...112,307,384
Ensembl chr 6:112,250,719...112,307,386 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO Chloroform results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Maob monoamine oxidase B decreases expression ISO Chloroform results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Chloroform results in increased expression of MGMT mRNA CTD PMID:21813463 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mir100 microRNA 100 decreases expression EXP Chloroform results in decreased expression of MIR100 mRNA CTD PMID:32105654 NCBI chr 9:41,442,721...41,442,800
Ensembl chr 9:41,442,721...41,442,800 		JBrowse link
G Mir125b-1 microRNA 125b-1 increases expression EXP Chloroform results in increased expression of MIR125B-1 mRNA CTD PMID:32105654 NCBI chr 9:41,493,222...41,493,298
Ensembl chr 9:41,493,222...41,493,298 		JBrowse link
G Mir1298 microRNA 1298 increases expression EXP Chloroform results in increased expression of MIR1298 mRNA CTD PMID:32105654 NCBI chr  X:145,847,901...145,847,998
Ensembl chr  X:145,847,901...145,847,998 		JBrowse link
G Mir132 microRNA 132 decreases expression EXP Chloroform results in decreased expression of MIR132 mRNA CTD PMID:32105654 NCBI chr11:75,064,508...75,064,573
Ensembl chr11:75,064,508...75,064,573 		JBrowse link
G Mir141 microRNA 141 increases expression EXP Chloroform results in increased expression of MIR141 mRNA CTD PMID:32105654 NCBI chr 6:124,694,877...124,694,948
Ensembl chr 6:124,694,877...124,694,948 		JBrowse link
G Mir144 microRNA 144 decreases expression EXP Chloroform results in decreased expression of MIR144 mRNA CTD PMID:32105654 NCBI chr11:77,963,831...77,963,896
Ensembl chr11:77,963,831...77,963,896 		JBrowse link
G Mir16-2 microRNA 16-2 increases expression ISO Chloroform results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 3:68,917,235...68,917,329
Ensembl chr 3:68,917,235...68,917,329 		JBrowse link
G Mir182 microRNA 182 increases expression EXP Chloroform results in increased expression of MIR182 mRNA CTD PMID:32105654 NCBI chr 6:30,165,917...30,165,991
Ensembl chr 6:30,165,917...30,165,991 		JBrowse link
G Mir1843a microRNA 1843a decreases expression EXP Chloroform results in decreased expression of MIR1843A mRNA CTD PMID:32105654 NCBI chr12:80,438,387...80,438,451
Ensembl chr12:80,438,387...80,438,451 		JBrowse link
G Mir186 microRNA 186 increases expression EXP Chloroform results in increased expression of MIR186 mRNA CTD PMID:32105654 NCBI chr 3:157,249,916...157,249,986
Ensembl chr 3:157,249,916...157,249,986 		JBrowse link
G Mir196a-1 microRNA 196a-1 decreases expression EXP Chloroform results in decreased expression of MIR196A-1 mRNA CTD PMID:32105654 NCBI chr11:96,155,990...96,156,091
Ensembl chr11:96,155,990...96,156,091 		JBrowse link
G Mir1981 microRNA 1981 decreases expression EXP Chloroform results in decreased expression of MIR1981 mRNA CTD PMID:32105654 NCBI chr 1:184,554,604...184,554,685
Ensembl chr 1:184,554,604...184,554,685 		JBrowse link
G Mir204 microRNA 204 increases expression EXP Chloroform results in increased expression of MIR204 mRNA CTD PMID:32105654 NCBI chr19:22,727,969...22,728,036
Ensembl chr19:22,727,969...22,728,036 		JBrowse link
G Mir211 microRNA 211 increases expression EXP Chloroform results in increased expression of MIR211 mRNA CTD PMID:32105654 NCBI chr 7:63,855,554...63,855,659
Ensembl chr 7:63,855,554...63,855,659 		JBrowse link
G Mir214 microRNA 214 increases expression EXP Chloroform results in increased expression of MIR214 mRNA CTD PMID:32105654 NCBI chr 1:162,050,937...162,051,046
Ensembl chr 1:162,050,937...162,051,046 		JBrowse link
G Mir218-2 microRNA 218-2 increases expression EXP Chloroform results in increased expression of MIR218-2 mRNA CTD PMID:32105654 NCBI chr11:35,507,643...35,507,752
Ensembl chr11:35,507,643...35,507,752 		JBrowse link
G Mir219a-1 microRNA 219a-1 increases expression EXP Chloroform results in increased expression of MIR219A-1 mRNA CTD PMID:32105654 NCBI chr17:34,243,957...34,244,066
Ensembl chr17:34,243,957...34,244,066 		JBrowse link
G Mir224 microRNA 224 decreases expression EXP Chloroform results in decreased expression of MIR224 mRNA CTD PMID:32105654 NCBI chr  X:71,304,637...71,304,718
Ensembl chr  X:71,304,637...71,304,718 		JBrowse link
G Mir29b-1 microRNA 29b-1 increases expression EXP Chloroform results in increased expression of MIR29B-1 mRNA CTD PMID:32105654 NCBI chr 6:31,039,958...31,040,028
Ensembl chr 6:31,039,958...31,040,028 		JBrowse link
G Mir29c microRNA 29c decreases expression EXP Chloroform results in decreased expression of MIR29C mRNA CTD PMID:32105654 NCBI chr 1:194,719,855...194,719,942
Ensembl chr 1:194,719,855...194,719,942 		JBrowse link
G Mir302a microRNA 302a decreases expression EXP Chloroform results in decreased expression of MIR302A mRNA CTD PMID:32105654 NCBI chr 3:127,339,145...127,339,213
Ensembl chr 3:127,339,145...127,339,213 		JBrowse link
G Mir3068 microRNA 3068 decreases expression EXP Chloroform results in decreased expression of MIR3068 mRNA CTD PMID:32105654 NCBI chr12:87,484,449...87,484,527
Ensembl chr12:87,484,449...87,484,527
Ensembl chr12:87,484,449...87,484,527 		JBrowse link
G Mir3074-1 microRNA 3074-1 decreases expression EXP Chloroform results in decreased expression of MIR3074-1 mRNA CTD PMID:32105654 NCBI chr13:63,449,013...63,449,097
Ensembl chr13:63,449,013...63,449,097 		JBrowse link
G Mir3078 microRNA 3078 increases expression EXP Chloroform results in increased expression of MIR3078 mRNA CTD PMID:32105654 NCBI chr14:64,828,634...64,828,720
Ensembl chr14:64,828,634...64,828,720 		JBrowse link
G Mir3082 microRNA 3082 decreases expression EXP Chloroform results in decreased expression of MIR3082 mRNA CTD PMID:32105654 NCBI chr17:26,050,339...26,050,402
Ensembl chr17:26,050,339...26,050,402 		JBrowse link
G Mir3091 microRNA 3091 decreases expression EXP Chloroform results in decreased expression of MIR3091 mRNA CTD PMID:32105654 NCBI chr 2:179,899,329...179,899,404
Ensembl chr 2:179,899,329...179,899,404 		JBrowse link
G Mir3097 microRNA 3097 increases expression EXP Chloroform results in increased expression of MIR3097 mRNA CTD PMID:32105654 NCBI chr 5:35,178,393...35,178,459
Ensembl chr 5:35,178,393...35,178,459 		JBrowse link
G Mir3102 microRNA 3102 decreases expression EXP Chloroform results in decreased expression of MIR3102 mRNA CTD PMID:32105654 NCBI chr 7:100,531,513...100,531,616
Ensembl chr 7:100,531,513...100,531,616 		JBrowse link
G Mir33 microRNA 33 decreases expression EXP Chloroform results in decreased expression of MIR33 mRNA CTD PMID:32105654 NCBI chr15:82,082,323...82,082,391
Ensembl chr15:82,082,323...82,082,391 		JBrowse link
G Mir331 microRNA 331 increases expression EXP Chloroform results in increased expression of MIR331 mRNA CTD PMID:32105654 NCBI chr10:93,799,630...93,799,725
Ensembl chr10:93,799,630...93,799,725 		JBrowse link
G Mir3475 microRNA 3475 increases expression EXP Chloroform results in increased expression of MIR3475 mRNA CTD PMID:32105654 NCBI chr  X:139,211,697...139,211,761
Ensembl chr  X:139,211,697...139,211,761 		JBrowse link
G Mir350 microRNA 350 decreases expression EXP Chloroform results in decreased expression of MIR350 mRNA CTD PMID:32105654 NCBI chr 1:176,599,891...176,599,989
Ensembl chr 1:176,599,891...176,599,989 		JBrowse link
G Mir367 microRNA 367 decreases expression EXP Chloroform results in decreased expression of MIR367 mRNA CTD PMID:32105654 NCBI chr 3:127,339,382...127,339,456
Ensembl chr 3:127,339,382...127,339,456 		JBrowse link
G Mir376c microRNA 376c increases expression EXP Chloroform results in increased expression of MIR376C mRNA CTD PMID:32105654 NCBI chr12:109,689,152...109,689,237
Ensembl chr12:109,689,152...109,689,237 		JBrowse link
G Mir409 microRNA 409 decreases expression EXP Chloroform results in decreased expression of MIR409 mRNA CTD PMID:32105654 NCBI chr12:109,709,592...109,709,670
Ensembl chr12:109,709,592...109,709,670 		JBrowse link
G Mir410 microRNA 410 increases expression EXP Chloroform results in increased expression of MIR410 mRNA CTD PMID:32105654 NCBI chr12:109,710,149...109,710,229
Ensembl chr12:109,710,149...109,710,229 		JBrowse link
G Mir429 microRNA 429 increases expression EXP Chloroform results in increased expression of MIR429 mRNA CTD PMID:32105654 NCBI chr 4:156,138,362...156,138,444
Ensembl chr 4:156,138,362...156,138,444 		JBrowse link
G Mir451a microRNA 451a increases expression EXP Chloroform results in increased expression of MIR451A mRNA CTD PMID:32105654 NCBI chr11:77,963,996...77,964,067
Ensembl chr11:77,963,996...77,964,067 		JBrowse link
G Mir463 microRNA 463 increases expression EXP Chloroform results in increased expression of MIR463 mRNA CTD PMID:32105654 NCBI chr  X:65,842,829...65,842,903
Ensembl chr  X:65,842,829...65,842,903 		JBrowse link
G Mir471 microRNA 471 decreases expression EXP Chloroform results in decreased expression of MIR471 mRNA CTD PMID:32105654 NCBI chr  X:65,836,201...65,836,267
Ensembl chr  X:65,836,201...65,836,267 		JBrowse link
G Mir491 microRNA 491 increases expression EXP Chloroform results in increased expression of MIR491 mRNA CTD PMID:32105654 NCBI chr 4:88,040,277...88,040,362
Ensembl chr 4:88,040,277...88,040,362 		JBrowse link
G Mir496a microRNA 496a decreases expression EXP Chloroform results in decreased expression of MIR496A mRNA CTD PMID:32105654 NCBI chr12:109,705,553...109,705,631
Ensembl chr12:109,705,553...109,705,631 		JBrowse link
G Mir539 microRNA 539 decreases expression EXP Chloroform results in decreased expression of MIR539 mRNA CTD PMID:32105654 NCBI chr12:109,694,563...109,694,636
Ensembl chr12:109,694,563...109,694,636 		JBrowse link
G Mir541 microRNA 541 increases expression EXP Chloroform results in increased expression of MIR541 mRNA CTD PMID:32105654 NCBI chr12:109,708,843...109,708,932
Ensembl chr12:109,708,843...109,708,932 		JBrowse link
G Mir582 microRNA 582 decreases expression EXP Chloroform results in decreased expression of MIR582 mRNA CTD PMID:32105654 NCBI chr13:109,461,278...109,461,358
Ensembl chr13:109,461,278...109,461,358 		JBrowse link
G Mir669e microRNA 669e increases expression EXP Chloroform results in increased expression of MIR669E mRNA CTD PMID:32105654 NCBI chr 2:10,472,306...10,472,424
Ensembl chr 2:10,472,306...10,472,424 		JBrowse link
G Mir671 microRNA 671 decreases expression EXP Chloroform results in decreased expression of MIR671 mRNA CTD PMID:32105654 NCBI chr 5:24,797,112...24,797,209
Ensembl chr 5:24,797,112...24,797,209 		JBrowse link
G Mir6935 microRNA 6935 increases expression EXP Chloroform results in increased expression of MIR6935 mRNA CTD PMID:32105654 NCBI chr11:120,238,176...120,238,239
Ensembl chr11:120,238,176...120,238,239 		JBrowse link
G Mir6936 microRNA 6936 increases expression EXP Chloroform results in increased expression of MIR6936 mRNA CTD PMID:32105654 NCBI chr11:120,515,649...120,515,702
Ensembl chr11:120,515,649...120,515,702 		JBrowse link
G Mir6944 microRNA 6944 decreases expression EXP Chloroform results in decreased expression of MIR6944 mRNA CTD PMID:32105654 NCBI chr13:55,625,494...55,625,589
Ensembl chr13:55,625,494...55,625,589 		JBrowse link
G Mir6960 microRNA 6960 decreases expression EXP Chloroform results in decreased expression of MIR6960 mRNA CTD PMID:32105654 NCBI chr15:98,978,686...98,978,746
Ensembl chr15:98,978,686...98,978,746 		JBrowse link
G Mir6979 microRNA 6979 increases expression EXP Chloroform results in increased expression of MIR6979 mRNA CTD PMID:32105654 NCBI chr18:37,987,658...37,987,713
Ensembl chr18:37,987,658...37,987,713 		JBrowse link
G Mir7021 microRNA 7021 decreases expression EXP Chloroform results in decreased expression of MIR7021 mRNA CTD PMID:32105654 NCBI chr 4:142,862,670...142,862,732
Ensembl chr 4:142,862,670...142,862,732 		JBrowse link
G Mir7025 microRNA 7025 decreases expression EXP Chloroform results in decreased expression of MIR7025 mRNA CTD PMID:32105654 NCBI chr 5:75,337,492...75,337,565
Ensembl chr 5:75,337,492...75,337,565 		JBrowse link
G Mir7035 microRNA 7035 increases expression EXP Chloroform results in increased expression of MIR7035 mRNA CTD PMID:32105654 NCBI chr 5:136,134,376...136,134,457
Ensembl chr 5:136,134,376...136,134,457 		JBrowse link
G Mir7063 microRNA 7063 increases expression EXP Chloroform results in increased expression of MIR7063 mRNA CTD PMID:32105654 NCBI chr 7:141,200,614...141,200,704
Ensembl chr 7:141,200,614...141,200,704 		JBrowse link
G Mir7082 microRNA 7082 increases expression EXP Chloroform results in increased expression of MIR7082 mRNA CTD PMID:32105654 NCBI chr 9:20,986,793...20,986,884
Ensembl chr 9:20,986,793...20,986,884 		JBrowse link
G Mir8106 microRNA 8106 decreases expression EXP Chloroform results in decreased expression of MIR8106 mRNA CTD PMID:32105654 NCBI chr 9:122,102,956...122,103,094
Ensembl chr 9:122,102,956...122,103,094 		JBrowse link
G Mir98 microRNA 98 decreases expression EXP Chloroform results in decreased expression of MIR98 mRNA CTD PMID:32105654 NCBI chr  X:150,696,210...150,696,317
Ensembl chr  X:150,696,210...150,696,317 		JBrowse link
G Mug1 murinoglobulin 1 decreases expression ISO Chloroform results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 6:121,815,455...121,866,016
Ensembl chr 6:121,815,500...121,866,016 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
increases expression
decreases methylation		 EXP
ISO		 Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased expression of MYC mRNA]; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased methylation of MYC gene]; Chloroform inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC mRNA]; Chloroform promotes the reaction [Dichloroacetic Acid results in decreased methylation of MYC promoter]
Chloroform results in increased expression of MYC mRNA
Chloroform results in decreased methylation of MYC promoter		 CTD PMID:8625290 PMID:11099637 PMID:11532874 PMID:16014735 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Chloroform results in increased localization of and results in increased activity of NFKB1 protein CTD PMID:11306435 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta increases expression ISO Chloroform results in increased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA] CTD PMID:21977998 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 increases expression ISO Chloroform results in increased expression of ODC1 mRNA CTD PMID:17522070 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Otc ornithine transcarbamylase decreases expression ISO Chloroform results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:10,118,584...10,187,275
Ensembl chr  X:10,118,544...10,187,263 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Chloroform results in increased expression of PCNA protein CTD PMID:11099637 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases response to substance
affects response to substance		 EXP POR results in decreased susceptibility to Chloroform
POR protein affects the susceptibility to Chloroform		 CTD PMID:18031782 PMID:23732084 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ptma prothymosin alpha increases expression ISO Chloroform results in increased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434 		JBrowse link
G Pvr poliovirus receptor increases expression ISO Chloroform results in increased expression of PVR mRNA CTD PMID:17522070 NCBI chr 7:19,637,503...19,655,068
Ensembl chr 7:19,637,503...19,655,085 		JBrowse link
G Pygl liver glycogen phosphorylase decreases expression ISO Chloroform results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Chloroform results in increased localization of and results in increased activity of RELA protein CTD PMID:11306435 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression ISO Chloroform results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr15:98,567,086...98,575,342
Ensembl chr15:98,561,302...98,575,342 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Chloroform results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Chloroform results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha decreases activity ISO Chloroform results in decreased activity of SCN5A protein CTD PMID:22024336 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression ISO Chloroform results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression ISO Chloroform results in increased expression of SLC2A1 mRNA CTD PMID:17522070 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) increases expression ISO Chloroform results in increased expression of TAP1 mRNA CTD PMID:21813463 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Chloroform results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO Chloroform results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Chloroform results in increased expression of TIMP1 mRNA CTD PMID:17522070 PMID:23558518 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a increases expression ISO Chloroform results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Trp53 transformation related protein 53 increases expression
increases phosphorylation		 ISO Chloroform results in increased expression of TP53 mRNA
Chloroform results in increased phosphorylation of TP53 protein		 CTD PMID:8076368 PMID:17522070 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ttr transthyretin decreases expression ISO Chloroform results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Chloroform results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Chloroform results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Vnn1 vanin 1 increases expression ISO Chloroform results in increased expression of VNN1 mRNA CTD PMID:21907259 NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241 		JBrowse link
G Zfand5 zinc finger, AN1-type domain 5 increases expression EXP Chloroform results in increased expression of ZFAND5 mRNA CTD PMID:9397189 NCBI chr19:21,249,150...21,264,204
Ensembl chr19:21,249,642...21,264,204 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        refrigerant 19189
          chloroform 147
            trichloromethyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            organic hydride 20308
                              organic fundamental parent 20308
                                hydrocarbon 19888
                                  halohydrocarbon 16232
                                    haloalkane 12946
                                      chloroalkane 10003
                                        chloromethanes 7618
                                          chloroform 147
                                            trichloromethyl group 0
paths to the root