Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloroform
go back to main search page
Accession:CHEBI:35255 term browser browse the term
Definition:A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
Synonyms:related_synonym: 1,1,1-trichloromethane;   CHCl3;   Formula=CHCl3;   InChI=1S/CHCl3/c2-1(3)4/h1H;   InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Cl;   Trichlormethan;   chloroforme;   chloroformium pro narcosi;   trichloromethane
 alt_id: CHEBI:23143;   CHEBI:34628
 xref: Beilstein:1731042;   CAS:67-66-3;   Drug_Central:4363;   Gmelin:1837;   HMDB:HMDB0029596;   KEGG:C13827;   LINCS:LSM-37229
 xref_mesh: MESH:D002725
 xref: MetaCyc:CPD-843;   PDBeChem:MCH;   PMID:10379014;   PMID:15583552;   PMID:20051454;   PMID:21850127;   PMID:23093177;   PMID:8476536;   PMID:8625290;   Reaxys:1731042;   UM-BBD_compID:c0595;   Wikipedia:Chloroform



show annotations for term's descendants           Sort by:
 
chloroform term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Chloroform results in decreased expression of ABCB11 mRNA CTD PMID:17522070 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO
EXP
Chloroform results in increased expression of ABCB1 mRNA CTD PMID:15120965 PMID:17522070 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Chloroform results in increased expression of ABCB1B mRNA CTD PMID:15120965 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Chloroform results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Chloroform results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Chloroform results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Chloroform results in increased expression of AKR7A3 mRNA CTD PMID:21813463 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Chloroform results in increased expression of ALDH1A1 mRNA CTD PMID:21813463 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Chloroform results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Chloroform results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Anxa2 annexin A2 increases expression EXP Chloroform results in increased expression of ANXA2 mRNA CTD PMID:21813463 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Chloroform results in increased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Chloroform results in increased expression of ASL mRNA CTD PMID:17522070 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO
EXP
Chloroform results in increased expression of BTG2 mRNA CTD PMID:9397189 PMID:17522070 PMID:21813463 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Calu calumenin increases expression EXP Chloroform results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
JBrowse link
G Cat catalase decreases expression EXP Chloroform results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Chloroform results in increased expression of CCL2 mRNA CTD PMID:21907259 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Chloroform results in increased expression of CCNG1 mRNA CTD PMID:17522070 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Chloroform results in increased expression of CDKN1A mRNA CTD PMID:21813463 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Chloroform results in increased expression of CES2 mRNA CTD PMID:21813463 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Clu clusterin increases expression EXP Chloroform results in increased expression of CLU mRNA CTD PMID:17522070 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Ctsl cathepsin L increases expression EXP Chloroform results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Chloroform results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
increases response to substance
ISO CYP2E1 protein results in increased metabolism of Chloroform
CYP2E1 protein results in increased oxidation of Chloroform
CYP2E1 gene SNP results in increased susceptibility to Chloroform
CTD PMID:1664256 PMID:15289170 PMID:18350910 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Chloroform results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:15120965 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Chloroform results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression EXP Chloroform results in decreased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Chloroform results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Chloroform results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Chloroform results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Chloroform results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Chloroform results in increased expression of FOS mRNA CTD PMID:8625290 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Chloroform results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gck glucokinase increases expression EXP Chloroform results in increased expression of GCK mRNA CTD PMID:17522070 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Chloroform results in decreased expression of GJB1 mRNA CTD PMID:17522070 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO
EXP
Anethole Trithione promotes the reaction [Chloroform results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Chloroform results in increased activity of GPT protein] CTD PMID:3795300 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Chloroform results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Chloroform results in increased expression of GSR mRNA CTD PMID:15914208 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Chloroform results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Chloroform results in increased expression of HAVCR1 mRNA CTD PMID:21907259 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases activity ISO Chloroform results in decreased activity of HCN2 protein CTD PMID:22024336 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Chloroform results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Chloroform results in increased expression of HMOX1 mRNA CTD PMID:15914208 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Chloroform results in increased expression of HSPA1A mRNA CTD PMID:17522070
G Icam1 intercellular adhesion molecule 1 increases expression EXP Chloroform results in increased expression of ICAM1 mRNA CTD PMID:17522070 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma decreases expression ISO Chloroform results in decreased expression of IFNG protein CTD PMID:16879906 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il13 interleukin 13 increases expression ISO Chloroform results in increased expression of IL13 protein CTD PMID:16879906 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Chloroform results in decreased expression of IL4 protein
Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA]
CTD PMID:16879906 PMID:21977998 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 increases expression ISO Chloroform results in increased expression of IL5 protein CTD PMID:16879906 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chloroform results in decreased activity of KCNH2 protein CTD PMID:22024336 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Krt18 keratin 18 increases expression EXP Chloroform results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt8 keratin 8 increases expression EXP Chloroform results in increased expression of KRT8 mRNA CTD PMID:17522070 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Chloroform results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lgals3 galectin 3 increases expression EXP Chloroform results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Chloroform results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Chloroform results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Chloroform results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Chloroform results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Chloroform results in increased expression of MGMT mRNA CTD PMID:21813463 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mir100 microRNA 100 decreases expression ISO Chloroform results in decreased expression of MIR100 mRNA CTD PMID:32105654 NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304
JBrowse link
G Mir125b1 microRNA 125b-1 increases expression ISO Chloroform results in increased expression of MIR125B-1 mRNA CTD PMID:32105654 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052
JBrowse link
G Mir132 microRNA 132 decreases expression ISO Chloroform results in decreased expression of MIR132 mRNA CTD PMID:32105654 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir141 microRNA 141 increases expression ISO Chloroform results in increased expression of MIR141 mRNA CTD PMID:32105654 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Mir144 microRNA 144 decreases expression ISO Chloroform results in decreased expression of MIR144 mRNA CTD PMID:32105654 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
JBrowse link
G Mir16 microRNA 16 increases expression EXP Chloroform results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mir186 microRNA 186 increases expression ISO Chloroform results in increased expression of MIR186 mRNA CTD PMID:32105654 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891
JBrowse link
G Mir196c microRNA 196c decreases expression ISO Chloroform results in decreased expression of MIR196A-1 mRNA CTD PMID:32105654 NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085
JBrowse link
G Mir204 microRNA 204 increases expression ISO Chloroform results in increased expression of MIR204 mRNA CTD PMID:32105654 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
JBrowse link
G Mir211 microRNA 211 increases expression ISO Chloroform results in increased expression of MIR211 mRNA CTD PMID:32105654 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644
JBrowse link
G Mir214 microRNA 214 increases expression ISO Chloroform results in increased expression of MIR214 mRNA CTD PMID:32105654 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G Mir218-2 microRNA 218-2 increases expression ISO Chloroform results in increased expression of MIR218-2 mRNA CTD PMID:32105654 NCBI chr10:20,068,451...20,068,560
Ensembl chr10:20,068,451...20,068,560
JBrowse link
G Mir219a1 microRNA 219a-1 increases expression ISO Chloroform results in increased expression of MIR219A-1 mRNA CTD PMID:32105654 NCBI chr20:4,829,687...4,829,796
Ensembl chr20:4,829,687...4,829,796
JBrowse link
G Mir224 microRNA 224 decreases expression ISO Chloroform results in decreased expression of MIR224 mRNA CTD PMID:32105654 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169
JBrowse link
G Mir29b1 microRNA 29b-1 increases expression ISO Chloroform results in increased expression of MIR29B-1 mRNA CTD PMID:32105654 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mir33 microRNA 33 decreases expression ISO Chloroform results in decreased expression of MIR33 mRNA CTD PMID:32105654 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
JBrowse link
G Mir331 microRNA 331 increases expression ISO Chloroform results in increased expression of MIR331 mRNA CTD PMID:32105654 NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485
JBrowse link
G Mir409 microRNA 409 decreases expression ISO Chloroform results in decreased expression of MIR409 mRNA CTD PMID:32105654 NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858
JBrowse link
G Mir410 microRNA 410 increases expression ISO Chloroform results in increased expression of MIR410 mRNA CTD PMID:32105654 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
JBrowse link
G Mir429 microRNA 429 increases expression ISO Chloroform results in increased expression of MIR429 mRNA CTD PMID:32105654 NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543
JBrowse link
G Mir451a microRNA 451a increases expression ISO Chloroform results in increased expression of MIR451A mRNA CTD PMID:32105654 NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591
JBrowse link
G Mir496 microRNA 496 decreases expression ISO Chloroform results in decreased expression of MIR496A mRNA CTD PMID:32105654 NCBI chr 6:128,753,644...128,753,722
Ensembl chr 6:128,753,644...128,753,722
JBrowse link
G Mir541 microRNA 541 increases expression ISO Chloroform results in increased expression of MIR541 mRNA CTD PMID:32105654 NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:128,757,016...128,757,105
JBrowse link
G Mir582 microRNA 582 decreases expression ISO Chloroform results in decreased expression of MIR582 mRNA CTD PMID:32105654 NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651
JBrowse link
G Mir671 microRNA 671 decreases expression ISO Chloroform results in decreased expression of MIR671 mRNA CTD PMID:32105654 NCBI chr 4:10,580,747...10,580,827
Ensembl chr 4:10,580,738...10,580,835
JBrowse link
G Mir98 microRNA 98 decreases expression ISO Chloroform results in decreased expression of MIR98 mRNA CTD PMID:32105654 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Chloroform results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases methylation
ISO
EXP
Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased expression of MYC mRNA]; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased methylation of MYC gene]; Chloroform inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC mRNA]; Chloroform promotes the reaction [Dichloroacetic Acid results in decreased methylation of MYC promoter]
Chloroform results in increased expression of MYC mRNA
Chloroform results in decreased methylation of MYC promoter
CTD PMID:8625290 PMID:11099637 PMID:11532874 PMID:16014735 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Chloroform results in increased localization of and results in increased activity of NFKB1 protein CTD PMID:11306435 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbib NFKB inhibitor beta increases expression EXP Chloroform results in increased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA] CTD PMID:21977998 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Chloroform results in increased expression of ODC1 mRNA CTD PMID:17522070 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Chloroform results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Chloroform results in increased expression of PCNA protein CTD PMID:11099637 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Por cytochrome p450 oxidoreductase decreases response to substance
affects response to substance
ISO POR results in decreased susceptibility to Chloroform
POR protein affects the susceptibility to Chloroform
CTD PMID:18031782 PMID:23732084 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ptma prothymosin alpha increases expression EXP Chloroform results in increased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Chloroform results in increased expression of PVR mRNA CTD PMID:17522070 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Chloroform results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chloroform results in increased localization of and results in increased activity of RELA protein CTD PMID:11306435 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Chloroform results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Chloroform results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Chloroform results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Chloroform results in decreased activity of SCN5A protein CTD PMID:22024336 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Chloroform results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Chloroform results in increased expression of SLC2A1 mRNA CTD PMID:17522070 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Snora58 small nucleolar RNA, H/ACA box 58 decreases expression ISO Chloroform results in decreased expression of MIR3068 mRNA CTD PMID:32105654 NCBI chr 6:107,080,945...107,081,020
Ensembl chr 6:107,080,945...107,081,020
JBrowse link
G Spin2b spindlin family member 2B decreases expression EXP Chloroform results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,371...17,192,351
Ensembl chr  X:17,180,474...17,192,351
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression EXP Chloroform results in increased expression of TAP1 mRNA CTD PMID:21813463 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Chloroform results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Chloroform results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Chloroform results in increased expression of TIMP1 mRNA CTD PMID:17522070 PMID:23558518 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Chloroform results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
EXP
ISO
Chloroform results in increased expression of TP53 mRNA
Chloroform results in increased phosphorylation of TP53 protein
CTD PMID:8076368 PMID:17522070 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ttr transthyretin decreases expression EXP Chloroform results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Chloroform results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Chloroform results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Vnn1 vanin 1 increases expression ISO Chloroform results in increased expression of VNN1 mRNA CTD PMID:21907259 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
JBrowse link
G Zfand5 zinc finger AN1-type containing 5 increases expression ISO Chloroform results in increased expression of ZFAND5 mRNA CTD PMID:9397189 NCBI chr 1:218,765,735...218,776,118
Ensembl chr 1:218,766,614...218,775,843
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      application 19773
        refrigerant 18117
          chloroform 117
            trichloromethyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    main group molecular entity 19974
                      s-block molecular entity 19774
                        hydrogen molecular entity 19766
                          hydrides 19135
                            organic hydride 18677
                              organic fundamental parent 18677
                                hydrocarbon 18414
                                  halohydrocarbon 15431
                                    haloalkane 12114
                                      chloroalkane 9335
                                        chloromethanes 7496
                                          chloroform 117
                                            trichloromethyl group 0
paths to the root