CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4-nitrotoluene
Accession: CHEBI:35227
browse the term
Definition: A mononitrotoluene that consists of toluene bearing a nitro substituent at the 4-position.
Synonyms: related_synonym: 1-Methyl-4-nitrobenzene; 4-Nitrotoluol; 4-methylnitrobenzene; Formula=C7H7NO2; InChI=1S/C7H7NO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3; InChIKey=ZPTVNYMJQHSSEA-UHFFFAOYSA-N; PNT; SMILES=Cc1ccc(cc1)[N+]([O-])=O; p-methylnitrobenzene; p-nitrotoluene; para-Nitrotoluol
alt_id: CHEBI:20461; CHEBI:33097; CHEBI:34431
xref: Beilstein:1906911; CAS:99-99-0; Gmelin:26926; KEGG:C14394
xref_mesh: MESH:C017572
xref: PMID:21895789; PMID:23389716; PMID:9139924; Reaxys:1906911
G
Cish
cytokine inducible SH2-containing protein
decreases expression
ISO
4-nitrotoluene results in decreased expression of CISH mRNA
CTD
PMID:15618236
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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Egfr
epidermal growth factor receptor
decreases expression
ISO
4-nitrotoluene results in decreased expression of EGFR protein
CTD
PMID:15618236
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
increases expression
ISO
4-nitrotoluene results in increased expression of EGR1 mRNA
CTD
PMID:15618236
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Esr2
estrogen receptor 2
affects binding
ISO
4-nitrotoluene binds to ESR2 protein
CTD
PMID:12224631
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Inhba
inhibin subunit beta A
decreases expression
ISO
4-nitrotoluene results in decreased expression of INHBA mRNA
CTD
PMID:15618236
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
4-nitrotoluene results in increased expression of JUNB mRNA
CTD
PMID:15618236
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
4-nitrotoluene promotes the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]
CTD
PMID:17015962
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Slc6a3
solute carrier family 6 member 3
decreases expression
EXP
4-nitrotoluene results in decreased expression of SLC6A3 mRNA
CTD
PMID:15265578
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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