Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-nitrotoluene
go back to main search page
Accession:CHEBI:35227 term browser browse the term
Definition:A mononitrotoluene that consists of toluene bearing a nitro substituent at the 4-position.
Synonyms:related_synonym: 1-Methyl-4-nitrobenzene;   4-Nitrotoluol;   4-methylnitrobenzene;   Formula=C7H7NO2;   InChI=1S/C7H7NO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3;   InChIKey=ZPTVNYMJQHSSEA-UHFFFAOYSA-N;   PNT;   SMILES=Cc1ccc(cc1)[N+]([O-])=O;   p-methylnitrobenzene;   p-nitrotoluene;   para-Nitrotoluol
 alt_id: CHEBI:20461;   CHEBI:33097;   CHEBI:34431
 xref: Beilstein:1906911;   CAS:99-99-0;   Gmelin:26926;   KEGG:C14394
 xref_mesh: MESH:C017572
 xref: PMID:21895789;   PMID:23389716;   PMID:9139924;   Reaxys:1906911


show annotations for term's descendants           Sort by:
4-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cish cytokine inducible SH2-containing protein decreases expression ISO 4-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 4-nitrotoluene results in decreased expression of EGFR protein CTD PMID:15618236 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression ISO 4-nitrotoluene results in increased expression of EGR1 mRNA CTD PMID:15618236 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO 4-nitrotoluene binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO 4-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO 4-nitrotoluene results in increased expression of JUNB mRNA CTD PMID:15618236 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 4-nitrotoluene promotes the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression EXP 4-nitrotoluene results in decreased expression of SLC6A3 mRNA CTD PMID:15265578 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        polyatomic entity 19787
          molecule 19692
            organic molecule 19677
              C-nitro compound 10861
                nitrotoluene 3877
                  mononitrotoluene 68
                    4-nitrotoluene 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                carbocyclic compound 18582
                                  benzenoid aromatic compound 18000
                                    benzenes 17863
                                      toluenes 7251
                                        nitrotoluene 3877
                                          mononitrotoluene 68
                                            4-nitrotoluene 8
paths to the root