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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:buffer
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Accession:CHEBI:35225 term browser browse the term
Definition:Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
Synonyms:related_synonym: buffer compound;   buffer compounds


show annotations for term's descendants           Sort by:
ammonium acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase increases activity EXP ammonium acetate results in increased activity of ADA protein CTD PMID:19900420 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adra1a adrenoceptor alpha 1A decreases expression EXP ammonium acetate results in decreased expression of ADRA1A mRNA CTD PMID:33404927 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 increases activity EXP ammonium acetate results in increased activity of AMPD2 protein CTD PMID:19900420 NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity EXP ammonium acetate results in increased activity of AMPD3 protein CTD PMID:19900420 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G Asl argininosuccinate lyase increases activity EXP ammonium acetate results in increased activity of ASL protein CTD PMID:16009439 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Ass1 argininosuccinate synthase 1 increases activity EXP ammonium acetate results in increased activity of ASS1 protein CTD PMID:16009439 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression EXP ammonium acetate results in decreased expression of ATP1A1 protein CTD PMID:33404927 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression EXP ammonium acetate results in decreased expression of ATP1A2 protein CTD PMID:33404927 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP ammonium acetate results in decreased expression of ATP1A3 protein CTD PMID:33404927 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP ammonium acetate results in decreased expression of ATP2A2 protein CTD PMID:33404927 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP ammonium acetate results in decreased expression of ATP2B2 protein CTD PMID:33404927 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 decreases expression EXP ammonium acetate results in decreased expression of ATP2B3 protein CTD PMID:33404927 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 decreases expression EXP ammonium acetate results in decreased expression of ATP2B4 protein CTD PMID:33404927 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Calr calreticulin increases expression
decreases expression		 EXP ammonium acetate results in increased expression of CALR protein
ammonium acetate results in decreased expression of CALR mRNA		 CTD PMID:33404927 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity		 EXP ammonium acetate results in increased activity of CAT protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein]		 CTD PMID:12885441 PMID:15945352 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd74 CD74 molecule increases expression EXP ammonium acetate results in increased expression of CD74 mRNA; ammonium acetate results in increased expression of CD74 protein CTD PMID:33404927 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd8a CD8 subunit alpha increases expression EXP ammonium acetate results in increased expression of CD8A mRNA CTD PMID:33404927 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit increases expression EXP ammonium acetate results in increased expression of CHRNE mRNA CTD PMID:33404927 NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Cldn10 claudin 10 decreases expression EXP ammonium acetate results in decreased expression of CLDN10 mRNA; ammonium acetate results in decreased expression of CLDN10 protein CTD PMID:33404927 NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression EXP ammonium acetate results in increased expression of CRHR2 mRNA CTD PMID:33404927 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP ammonium acetate results in increased expression of GPR83 mRNA CTD PMID:33404927 NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP ammonium acetate results in decreased expression of GRIA4 mRNA; ammonium acetate results in decreased expression of GRIA4 protein CTD PMID:33404927 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
decreases expression		 EXP Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP ammonium acetate results in decreased expression of GRIN2B protein CTD PMID:20084674 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grm6 glutamate metabotropic receptor 6 increases expression EXP ammonium acetate results in increased expression of GRM6 mRNA CTD PMID:33404927 NCBI chr10:35,167,985...35,182,717
Ensembl chr10:35,167,985...35,182,717 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP ammonium acetate results in increased expression of HMOX1 protein CTD PMID:12420312 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP ammonium acetate results in increased expression of ICAM1 mRNA CTD PMID:33404927 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP [Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA] CTD PMID:36346500 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP ammonium acetate results in increased expression of IL6 mRNA
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]		 CTD PMID:36346500 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP ammonium acetate results in decreased expression of ITPR1 CTD PMID:33404927 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP ammonium acetate results in increased expression of LHB mRNA CTD PMID:33404927 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mag myelin-associated glycoprotein increases expression EXP ammonium acetate results in increased expression of MAG mRNA CTD PMID:33404927 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656 		JBrowse link
G Maoa monoamine oxidase A increases activity
multiple interactions		 EXP ammonium acetate results in increased activity of MAOA protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]		 CTD PMID:12885441 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression EXP ammonium acetate results in decreased expression of NPY1R mRNA CTD PMID:33404927 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions		 EXP ammonium acetate results in increased expression of PARP1 protein
Cycloheximide inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]		 CTD PMID:15147502 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma increases expression EXP ammonium acetate results in increased expression of PPP1CC protein CTD PMID:33404927 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553 		JBrowse link
G RT1-A1 RT1 class Ia, locus A1 decreases expression EXP ammonium acetate results in decreased expression of RT1-A1 mRNA CTD PMID:33404927 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 decreases expression EXP ammonium acetate results in decreased expression of RT1-A2 mRNA CTD PMID:33404927 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE10 RT1 class I, locus CE10 decreases expression EXP ammonium acetate results in decreased expression of RT1-CE10 mRNA CTD PMID:33404927 NCBI chr20:3,377,284...3,380,301 JBrowse link
G Slc8a2 solute carrier family 8 member A2 decreases expression EXP ammonium acetate results in decreased expression of SLC8A2 protein CTD PMID:33404927 NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
multiple interactions		 EXP ammonium acetate results in decreased activity of SOD2 protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein]		 CTD PMID:12885441 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Xdh xanthine dehydrogenase affects activity
multiple interactions		 EXP ammonium acetate affects the activity of XDH protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein]		 CTD PMID:12885441 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
ketorolac tromethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase multiple interactions EXP Ketorolac Tromethamine results in decreased localization of and results in decreased activity of AANAT protein CTD PMID:37348669 NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein] CTD PMID:37348669 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ereg epiregulin increases expression ISO Ketorolac Tromethamine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP Ketorolac Tromethamine results in decreased activity of GPX1 protein CTD PMID:37348669 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Ketorolac Tromethamine results in increased activity of GSR protein CTD PMID:37348669 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il24 interleukin 24 increases expression ISO Ketorolac Tromethamine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Maoa monoamine oxidase A multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein] CTD PMID:37348669 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mtnr1a melatonin receptor 1A increases localization EXP Ketorolac Tromethamine results in increased localization of MTNR1A protein CTD PMID:37348669 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Ketorolac Tromethamine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Ketorolac Tromethamine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Ketorolac Tromethamine results in decreased activity of SOD1 protein CTD PMID:37348669 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Ketorolac Tromethamine results in decreased activity of SOD2 protein CTD PMID:37348669 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
triethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO [triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO triethanolamine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      chemical role 19422
        buffer 54
          Good's buffer substance + 0
          Htris + 12
          ammonium acetate 42
          ammonium formate 0
          bis-tris 0
          bis-tris propane 0
          diammonium citrate 0
          diisopropanolamine 0
          dipotassium hydrogen phosphate 0
          disodium PIPES 0
          disodium tetraborate decahydrate 0
          monosodium PIPES 0
          potassium formate 0
          potassium hydrogencarbonate 0
          potassium metaphosphate 0
          sodium dimethylarsinate 0
          sodium formate 0
          triammonium citrate 0
          triethanolamine 3
          triethanolammonium + 0
          tris + 0
          tris acetate 0
          tris maleate 0
          tris phosphate 0
paths to the root