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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:effector
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Accession:CHEBI:35224 term browser browse the term
Definition:A small molecule which increases (activator) or decreases (inhibitor) the activity of an (allosteric) enzyme by binding to the enzyme at the regulatory site (which is different from the substrate-binding catalytic site).
Synonyms:related_synonym: enzyme modulator
 xref: Wikipedia:Effector_(biology)


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2-cyclopenten-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO cyclopentenone results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18383863 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO cyclopentenone results in increased expression of CDKN1B CTD PMID:16061222 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO cyclopentenone results in decreased phosphorylation of RB1 protein CTD PMID:16061222 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
4-phenyl-3-furoxancarbonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNA
4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNA		 CTD PMID:22851183 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 4-phenyl-3-furoxancarbonitrile results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-phenyl-3-furoxancarbonitrile results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases abundance ISO ACLY protein results in increased abundance of Acetyl Coenzyme A CTD PMID:28077572 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G App amyloid beta precursor protein affects localization
increases secretion
multiple interactions		 ISO APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]		 CTD PMID:16122837 PMID:22906069 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Crat carnitine O-acetyltransferase decreases activity EXP Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein CTD PMID:8075222 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor decreases abundance
multiple interactions		 ISO ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]		 CTD PMID:25440059 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kat2b lysine acetyltransferase 2B affects binding ISO Acetyl Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Metrnl meteorin-like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] CTD PMID:30213948 NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects binding		 ISO [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein		 CTD PMID:20545351 PMID:22835378 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,680,489...16,683,276 JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cd22 CD22 molecule increases expression ISO bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Il10 interleukin 10 decreases expression ISO bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B decreases expression
increases expression		 ISO bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA		 CTD PMID:15614042 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Itgax integrin subunit alpha X increases expression ISO bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression		 ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein		 CTD PMID:8892972 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions
decreases expression		 ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form		 CTD PMID:8892972 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
decreases expression		 ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein		 CTD PMID:8892972 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
carglumic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of ATG5 mRNA] CTD PMID:31369747 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein] CTD PMID:31369747 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B protein] CTD PMID:31369747 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 protein] CTD PMID:31369747 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
CHIR-98014 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox decreases expression ISO Chir 98014 results in decreased expression of NANOG mRNA CTD PMID:22723015 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression ISO Chir 98014 results in decreased expression of OTX2 mRNA CTD PMID:22723015 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416 		JBrowse link
G Pax6 paired box 6 decreases expression ISO Chir 98014 results in decreased expression of PAX6 mRNA CTD PMID:22723015 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO
EXP		 [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions
affects binding		 EXP
ISO		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
[BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of PTGS2 mRNA] CTD PMID:19667237 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA] CTD PMID:19667237 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion		 ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein		 CTD PMID:16083514 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
ethoxyquin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC2 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA		 CTD PMID:15833929 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC3 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA		 CTD PMID:15833929 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC4 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA		 CTD PMID:15833929 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression		 ISO [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA
Ethoxyquin results in increased expression of ABCC5 mRNA		 CTD PMID:15833929 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC6 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA		 CTD PMID:15833929 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of AKR1B10 mRNA
NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA]		 CTD PMID:21277289 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases activity
increases expression		 EXP Ethoxyquin results in increased activity of AKR7A3 protein
Ethoxyquin results in increased expression of AKR7A3 mRNA; Ethoxyquin results in increased expression of AKR7A3 protein		 CTD PMID:8198522 PMID:8395332 PMID:9328168 PMID:19695238 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO
EXP		 Ethoxyquin results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 PMID:19695238 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Ethoxyquin results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity EXP Ethoxyquin results in decreased activity of ALOX5 protein CTD PMID:3928952 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Ethoxyquin results in increased activity of AR protein]; Ethoxyquin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] CTD PMID:15064155 PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ces2c carboxylesterase 2C increases expression ISO Ethoxyquin results in increased expression of CES2C mRNA CTD PMID:22429928 NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 EXP Ethoxyquin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]
Ethoxyquin results in increased activity of CYP1A1 protein
Ethoxyquin results in increased expression of CYP1A1 mRNA		 CTD PMID:16906435 PMID:19695238 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Ethoxyquin results in increased expression of CYP1A2 mRNA CTD PMID:19695238 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP Ethoxyquin results in increased expression of CYP1B1 mRNA CTD PMID:19695238 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Ethoxyquin results in increased expression of CYP2B10 mRNA CTD PMID:17627975 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP Ethoxyquin results in increased expression of CYP2B15 mRNA CTD PMID:19695238 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP Ethoxyquin results in increased expression of CYP3A18 mRNA CTD PMID:19695238 NCBI chr12:8,880,528...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Ethoxyquin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19695238 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Ethoxyquin results in increased expression of EPHX1 mRNA CTD PMID:19695238 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTA2 protein
Ethoxyquin results in increased expression of GSTA2 mRNA		 CTD PMID:11309284 PMID:19695238 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTA3 protein CTD PMID:8198522 PMID:9794803 PMID:11309284 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Ethoxyquin results in increased expression of GSTA4 mRNA; Ethoxyquin results in increased expression of GSTA4 protein CTD PMID:9794803 PMID:19695238 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression
increases activity		 EXP
ISO		 Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin results in increased expression of and results in increased activity of GSTA5 protein
Ethoxyquin results in increased expression of GSTA1 protein
Ethoxyquin results in increased expression of GSTA5 mRNA; Ethoxyquin results in increased expression of GSTA5 protein
Ethoxyquin results in increased activity of GSTA5 protein		 CTD PMID:1637297 PMID:8198522 PMID:9328168 PMID:9794803 PMID:11309284 More... NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Ethoxyquin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTM1 mRNA; Ethoxyquin results in increased expression of GSTM1 protein CTD PMID:8198522 PMID:11309284 PMID:18723825 PMID:19695238 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP
ISO		 Ethoxyquin results in increased expression of GSTM2 mRNA CTD PMID:18723825 PMID:19695238 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO Ethoxyquin results in increased expression of GSTM4 mRNA CTD PMID:18723825 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTM3 mRNA; Ethoxyquin results in increased expression of GSTM5 protein
Ethoxyquin results in increased expression of GSTM3 protein		 CTD PMID:9794803 PMID:11309284 PMID:18723825 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Ethoxyquin results in increased expression of GSTP1 mRNA; Ethoxyquin results in increased expression of GSTP1 protein CTD PMID:8198522 PMID:9794803 PMID:19695238 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTT1 mRNA
Ethoxyquin results in increased expression of GSTT1 mRNA; Ethoxyquin results in increased expression of GSTT1 protein		 CTD PMID:9794803 PMID:18723825 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Ethoxyquin results in increased expression of HMOX1 mRNA; Ethoxyquin results in increased expression of HMOX1 protein CTD PMID:25690736 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein CTD PMID:16880205 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Ethoxyquin results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression ISO Ethoxyquin results in increased expression of MGST3 mRNA CTD PMID:18723825 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects activity		 ISO NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA]
Ethoxyquin affects the activity of NFE2L2 protein
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; Ethoxyquin binds to and results in increased activity of NFE2L2 protein		 CTD PMID:11309284 PMID:15833929 PMID:15919853 PMID:21277289 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP Ethoxyquin results in increased expression of NOX4 mRNA CTD PMID:19695238 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
increases activity		 ISO
EXP		 Ethoxyquin results in increased expression of NQO1 mRNA; Ethoxyquin results in increased expression of NQO1 protein
Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]		 CTD PMID:11309284 PMID:15919853 PMID:16045903 PMID:16906435 PMID:17627975 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO Ethoxyquin binds to and results in increased activity of NR1I2 protein
Ethoxyquin results in increased activity of NR1I2 protein		 CTD PMID:21115097 PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of PRDX1 protein
[Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein		 CTD PMID:16880205 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO Ethoxyquin results in increased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP
ISO		 Ethoxyquin results in increased expression of UGT1A1 mRNA CTD PMID:19144771 PMID:19695238 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Ethoxyquin results in increased expression of UGT1A5 mRNA CTD PMID:19144771 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
GSK2181236A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP GSK2181236A decreases expression of Acta1 mRNA in rat myocardium RGD PMID:22783192 RGD:25824851 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Nppa natriuretic peptide A decreases expression EXP GSK2181236A decreases expression of Nppa mRNA in rat myocardium RGD PMID:22783192 RGD:25824851 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
riociguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of riociguat CTD PMID:30950278 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 decreases response to substance
increases activity		 ISO KCNK3 protein mutant form results in decreased susceptibility to riociguat
riociguat results in increased activity of KCNK3 protein		 CTD PMID:30365877 NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153 		JBrowse link
sporidesmin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 affects localization ISO sporidesmin affects the localization of CTNNB1 protein CTD PMID:28193462 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO sporidesmin affects the expression of CYP1A2 mRNA CTD PMID:28193462 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression		 ISO MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein		 CTD PMID:28193462 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
multiple interactions		 ISO sporidesmin affects the expression of CYP2C8 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]		 CTD PMID:28193462
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO sporidesmin results in decreased expression of DKK3 mRNA CTD PMID:28193462 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Mir132 microRNA 132 increases expression ISO sporidesmin results in increased expression of MIR132 mRNA CTD PMID:28193462 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796 		JBrowse link
G Mir138-2 microRNA 138-2 increases expression ISO sporidesmin results in increased expression of MIR138-2 mRNA alternative form CTD PMID:28193462 NCBI chr19:10,674,193...10,674,274
Ensembl chr19:10,674,193...10,674,274 		JBrowse link
G Mir139 microRNA 139 increases expression ISO sporidesmin results in increased expression of MIR139 mRNA CTD PMID:28193462 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902 		JBrowse link
G Mir150 microRNA 150 increases expression ISO sporidesmin results in increased expression of MIR150 mRNA CTD PMID:28193462 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108 		JBrowse link
G Mir184 microRNA 184 increases expression ISO sporidesmin results in increased expression of MIR184 mRNA CTD PMID:28193462 NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210 		JBrowse link
G Mir21 microRNA 21 increases expression
multiple interactions		 ISO sporidesmin results in increased expression of MIR21 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]		 CTD PMID:28193462 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir290 microRNA 290 increases expression ISO sporidesmin results in increased expression of MIR371A mRNA CTD PMID:28193462 NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728 		JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO sporidesmin results in increased expression of MIR372 mRNA CTD PMID:28193462 NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646 		JBrowse link
G Mir31 microRNA 31 multiple interactions
increases expression		 ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR31 mRNA		 CTD PMID:28193462 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir375 microRNA 375 increases expression ISO sporidesmin results in increased expression of MIR375 mRNA CTD PMID:28193462 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985 		JBrowse link
G Mir409 microRNA 409 increases expression ISO sporidesmin results in increased expression of MIR409 mRNA CTD PMID:28193462 NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858 		JBrowse link
G Mir487b microRNA 487b increases expression ISO sporidesmin results in increased expression of MIR487B mRNA CTD PMID:28193462 NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 decreases expression
multiple interactions		 ISO sporidesmin results in decreased expression of SFRP1 mRNA
MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]		 CTD PMID:28193462 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions
affects expression		 ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA] CTD PMID:28193462 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360 		JBrowse link
teprenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlg1 discs large MAGUK scaffold protein 1 increases expression
multiple interactions		 ISO geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]		 CTD PMID:21232033 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Edn1 endothelin 1 decreases expression EXP geranylgeranylacetone results in decreased expression of EDN1 protein CTD PMID:16324314 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects response to substance
increases expression		 ISO geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]
HSF1 protein affects the susceptibility to geranylgeranylacetone
geranylgeranylacetone results in increased expression of HSF1 protein		 CTD PMID:17189318 PMID:21232033 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein] CTD PMID:17189318
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein CTD PMID:15340226 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression ISO geranylgeranylacetone results in increased expression of KCNA5 protein CTD PMID:21232033 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          effector 126
            EC 2.7.11.31 \{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase\} activator + 0
            Hsp70 inducer + 9
            UDP-glucuronosyltransferase activator + 43
            VEGF activator + 0
            Wnt signalling activator + 22
            acetyl-CoA + 10
            alpha-secretase activator + 12
            carbamylphosphate synthetase I activator + 4
            differentiation-inducing factor + 0
            gamma-secretase modulator + 24
            histone acetyltransferase activator + 0
            nitric oxide synthase activator + 0
            p53 activator + 0
            soluble guanylate cyclase activator + 11
paths to the root