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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:effector
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Accession:CHEBI:35224 term browser browse the term
Definition:A small molecule which increases (activator) or decreases (inhibitor) the activity of an (allosteric) enzyme by binding to the enzyme at the regulatory site (which is different from the substrate-binding catalytic site).
Synonyms:related_synonym: enzyme modulator
 xref: Wikipedia:Effector_(biology)

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2-cyclopenten-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO cyclopentenone results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18383863 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO cyclopentenone results in increased expression of CDKN1B CTD PMID:16061222 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO cyclopentenone results in decreased phosphorylation of RB1 protein CTD PMID:16061222 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases abundance ISO ACLY protein results in increased abundance of Acetyl Coenzyme A CTD PMID:28077572 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G App amyloid beta precursor protein affects localization
increases secretion
multiple interactions		 ISO APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]		 CTD PMID:16122837 PMID:22906069 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Crat carnitine O-acetyltransferase decreases activity EXP Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein CTD PMID:8075222 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor decreases abundance
multiple interactions		 ISO ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]		 CTD PMID:25440059 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Kat2b lysine acetyltransferase 2B affects binding ISO Acetyl Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Metrnl meteorin-like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] CTD PMID:30213948 NCBI chr10:110,893,261...110,907,256
Ensembl chr10:110,893,232...110,907,243 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects binding		 ISO [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein		 CTD PMID:20545351 PMID:22835378 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Cd22 CD22 molecule increases expression ISO bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr 1:89,313,475...89,329,902
Ensembl chr 1:89,314,558...89,329,418 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Il10 interleukin 10 decreases expression ISO bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12b interleukin 12B decreases expression
increases expression		 ISO bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA		 CTD PMID:15614042 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Itgax integrin subunit alpha X increases expression ISO bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression		 ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein		 CTD PMID:8892972 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions
decreases expression		 ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form		 CTD PMID:8892972 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
decreases expression		 ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein		 CTD PMID:8892972 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636 		JBrowse link
carglumic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of ATG5 mRNA] CTD PMID:31369747 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein] CTD PMID:31369747 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B protein] CTD PMID:31369747 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 protein] CTD PMID:31369747 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
CHIR-98014 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox decreases expression ISO Chir 98014 results in decreased expression of NANOG mRNA CTD PMID:22723015 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268 		JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression ISO Chir 98014 results in decreased expression of OTX2 mRNA CTD PMID:22723015 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
Ensembl chr15:25,502,019...25,505,691 		JBrowse link
G Pax6 paired box 6 decreases expression ISO Chir 98014 results in decreased expression of PAX6 mRNA CTD PMID:22723015 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624 		JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO
EXP		 [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions
affects binding		 EXP
ISO		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
[BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of PTGS2 mRNA] CTD PMID:19667237 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA] CTD PMID:19667237 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion		 ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein		 CTD PMID:16083514 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625 		JBrowse link
ethoxyquin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC2 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA		 CTD PMID:15833929 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC3 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA		 CTD PMID:15833929 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC4 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA		 CTD PMID:15833929 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression		 ISO [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA
Ethoxyquin results in increased expression of ABCC5 mRNA		 CTD PMID:15833929 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of ABCC6 mRNA
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA		 CTD PMID:15833929 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of AKR1B10 mRNA
NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA]		 CTD PMID:21277289 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases activity
increases expression		 EXP Ethoxyquin results in increased activity of AKR7A3 protein
Ethoxyquin results in increased expression of AKR7A3 mRNA; Ethoxyquin results in increased expression of AKR7A3 protein		 CTD PMID:8198522 PMID:8395332 PMID:9328168 PMID:19695238 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO
EXP		 Ethoxyquin results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 PMID:19695238 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Ethoxyquin results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity EXP Ethoxyquin results in decreased activity of ALOX5 protein CTD PMID:3928952 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Ethoxyquin results in increased activity of AR protein]; Ethoxyquin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] CTD PMID:15064155 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Ces2c carboxylesterase 2C increases expression ISO Ethoxyquin results in increased expression of CES2C mRNA CTD PMID:22429928 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 EXP Ethoxyquin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]
Ethoxyquin results in increased activity of CYP1A1 protein
Ethoxyquin results in increased expression of CYP1A1 mRNA		 CTD PMID:16906435 PMID:19695238 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Ethoxyquin results in increased expression of CYP1A2 mRNA CTD PMID:19695238 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP Ethoxyquin results in increased expression of CYP1B1 mRNA CTD PMID:19695238 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Ethoxyquin results in increased expression of CYP2B10 mRNA CTD PMID:17627975 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP Ethoxyquin results in increased expression of CYP2B15 mRNA CTD PMID:19695238 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP Ethoxyquin results in increased expression of CYP3A18 mRNA CTD PMID:19695238 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Ethoxyquin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19695238 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Ethoxyquin results in increased expression of EPHX1 mRNA CTD PMID:19695238 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTA2 protein
Ethoxyquin results in increased expression of GSTA2 mRNA		 CTD PMID:11309284 PMID:19695238 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTA3 protein CTD PMID:8198522 PMID:9794803 PMID:11309284 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Ethoxyquin results in increased expression of GSTA4 mRNA; Ethoxyquin results in increased expression of GSTA4 protein CTD PMID:9794803 PMID:19695238 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression
increases activity		 EXP
ISO		 Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin results in increased expression of and results in increased activity of GSTA5 protein
Ethoxyquin results in increased expression of GSTA1 protein
Ethoxyquin results in increased expression of GSTA5 mRNA; Ethoxyquin results in increased expression of GSTA5 protein
Ethoxyquin results in increased activity of GSTA5 protein		 CTD PMID:1637297 PMID:8198522 PMID:9328168 PMID:9794803 PMID:11309284 PMID:19695238 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Ethoxyquin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTM1 mRNA; Ethoxyquin results in increased expression of GSTM1 protein CTD PMID:8198522 PMID:11309284 PMID:18723825 PMID:19695238 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP
ISO		 Ethoxyquin results in increased expression of GSTM2 mRNA CTD PMID:18723825 PMID:19695238 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO Ethoxyquin results in increased expression of GSTM4 mRNA CTD PMID:18723825 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTM3 mRNA; Ethoxyquin results in increased expression of GSTM5 protein
Ethoxyquin results in increased expression of GSTM3 protein		 CTD PMID:9794803 PMID:11309284 PMID:18723825 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Ethoxyquin results in increased expression of GSTP1 mRNA; Ethoxyquin results in increased expression of GSTP1 protein CTD PMID:8198522 PMID:9794803 PMID:19695238 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO
EXP		 Ethoxyquin results in increased expression of GSTT1 mRNA
Ethoxyquin results in increased expression of GSTT1 mRNA; Ethoxyquin results in increased expression of GSTT1 protein		 CTD PMID:9794803 PMID:18723825 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Ethoxyquin results in increased expression of HMOX1 mRNA; Ethoxyquin results in increased expression of HMOX1 protein CTD PMID:25690736 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein CTD PMID:16880205 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Ethoxyquin results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression ISO Ethoxyquin results in increased expression of MGST3 mRNA CTD PMID:18723825 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects activity		 ISO NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA]
Ethoxyquin affects the activity of NFE2L2 protein
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; Ethoxyquin binds to and results in increased activity of NFE2L2 protein		 CTD PMID:11309284 PMID:15833929 PMID:15919853 PMID:21277289 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP Ethoxyquin results in increased expression of NOX4 mRNA CTD PMID:19695238 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
increases activity		 ISO
EXP		 Ethoxyquin results in increased expression of NQO1 mRNA; Ethoxyquin results in increased expression of NQO1 protein
Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]		 CTD PMID:11309284 PMID:15919853 PMID:16045903 PMID:16906435 PMID:17627975 PMID:19144771 PMID:19695238 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO Ethoxyquin binds to and results in increased activity of NR1I2 protein
Ethoxyquin results in increased activity of NR1I2 protein		 CTD PMID:21115097 PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression
multiple interactions		 ISO Ethoxyquin results in increased expression of PRDX1 protein
[Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein		 CTD PMID:16880205 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO Ethoxyquin results in increased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP
ISO		 Ethoxyquin results in increased expression of UGT1A1 mRNA CTD PMID:19144771 PMID:19695238 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
GSK2181236A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP GSK2181236A decreases expression of Acta1 mRNA in rat myocardium RGD PMID:22783192 RGD:25824851 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084 		JBrowse link
G Nppa natriuretic peptide A decreases expression EXP GSK2181236A decreases expression of Nppa mRNA in rat myocardium RGD PMID:22783192 RGD:25824851 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
riociguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of riociguat CTD PMID:30950278 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 decreases response to substance
increases activity		 ISO KCNK3 protein mutant form results in decreased susceptibility to riociguat
riociguat results in increased activity of KCNK3 protein		 CTD PMID:30365877 NCBI chr 6:27,154,274...27,190,209
Ensembl chr 6:27,151,612...27,190,132 		JBrowse link
teprenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlg1 discs large MAGUK scaffold protein 1 increases expression
multiple interactions		 ISO geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]		 CTD PMID:21232033 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895 		JBrowse link
G Edn1 endothelin 1 decreases expression EXP geranylgeranylacetone results in decreased expression of EDN1 protein CTD PMID:16324314 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects response to substance
increases expression		 ISO geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]
HSF1 protein affects the susceptibility to geranylgeranylacetone
geranylgeranylacetone results in increased expression of HSF1 protein		 CTD PMID:17189318 PMID:21232033 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein] CTD PMID:17189318 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein CTD PMID:15340226 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression ISO geranylgeranylacetone results in increased expression of KCNA5 protein CTD PMID:21232033 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        biochemical role 19323
          effector 106
            EC 2.7.11.31 \{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase\} activator + 0
            Hsp70 inducer + 9
            UDP-glucuronosyltransferase activator + 42
            VEGF activator + 0
            Wnt signalling activator + 3
            acetyl-CoA + 10
            alpha-secretase activator + 12
            carbamylphosphate synthetase I activator + 4
            differentiation-inducing factor + 0
            gamma-secretase modulator + 24
            histone acetyltransferase activator + 0
            nitric oxide synthase activator + 0
            p53 activator + 0
            soluble guanylate cyclase activator + 8
paths to the root