CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | plant growth retardant |
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Accession: | CHEBI:35219
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browse the term
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Synonyms: | related_synonym: | plant growth inhibitor; plant growth inhibitors; plant growth retardants |
| alt_id: | CHEBI:26154; CHEBI:26156 |
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Abca7 |
ATP binding cassette subfamily A member 7 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Abcb4 |
ATP binding cassette subfamily B member 4 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA |
CTD |
PMID:9210621 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 protein Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA] |
CTD |
PMID:10377250 PMID:16426233 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Acap3 |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACAP3 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 5:166,500,781...166,515,477
Ensembl chr 5:166,500,781...166,515,481
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Acer2 |
alkaline ceramidase 2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACER2 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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Adgrb2 |
adhesion G protein-coupled receptor B2 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADGRB2 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540
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Adh4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Alpi |
alkaline phosphatase, intestinal |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ALPI mRNA |
CTD |
PMID:18579281 |
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NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
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Ar |
androgen receptor |
affects binding |
EXP |
2,4,5-Trichlorophenoxyacetic Acid binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arhgap32 |
Rho GTPase activating protein 32 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARHGAP32 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 8:30,421,269...30,681,653
Ensembl chr 8:30,421,515...30,678,454
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Arsg |
arylsulfatase G |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA |
CTD |
PMID:18579281 |
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NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941
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Basp1 |
brain abundant, membrane attached signal protein 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of BASP1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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C1qtnf4 |
C1q and TNF related 4 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of C1QTNF4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139
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Cacnb3 |
calcium voltage-gated channel auxiliary subunit beta 3 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CACNB3 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
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Camk1d |
calcium/calmodulin-dependent protein kinase ID |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CAMK1D mRNA |
CTD |
PMID:18579281 |
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NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
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Capn6 |
calpain 6 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CAPN6 mRNA |
CTD |
PMID:18579281 |
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NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489
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Cdh1 |
cadherin 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cirbp |
cold inducible RNA binding protein |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CIRBP mRNA |
CTD |
PMID:18579281 |
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NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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Ckm |
creatine kinase, M-type |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Clca4 |
chloride channel accessory 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CLCA4A mRNA |
CTD |
PMID:18579281 |
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NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
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Col15a1 |
collagen type XV alpha 1 chain |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP7B1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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Ddc |
dopa decarboxylase |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA |
CTD |
PMID:18579281 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Eepd1 |
endonuclease/exonuclease/phosphatase family domain containing 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of EEPD1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340
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Ephx1 |
epoxide hydrolase 1 |
increases activity |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein |
CTD |
PMID:3032197 |
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NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein |
CTD |
PMID:3032197 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:16626760 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Far1 |
fatty acyl CoA reductase 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FAR1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730
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Fkbp5 |
FKBP prolyl isomerase 5 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA |
CTD |
PMID:18579281 |
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NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fmo2 |
flavin containing dimethylaniline monoxygenase 2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FMO2 mRNA |
CTD |
PMID:18579281 |
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NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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G0s2 |
G0/G1switch 2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of G0S2 mRNA |
CTD |
PMID:18579281 |
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NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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Gbf1 |
golgi brefeldin A resistant guanine nucleotide exchange factor 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBF1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042
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Gbp6 |
guanylate binding protein family member 6 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBP9 mRNA |
CTD |
PMID:18579281 |
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NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
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Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA |
CTD |
PMID:10377250 PMID:16426233 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gde1 |
glycerophosphodiester phosphodiesterase 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GDE1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429
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Gfra1 |
GDNF family receptor alpha 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Git2 |
GIT ArfGAP 2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA |
CTD |
PMID:18579281 |
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NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
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Gmppb |
GDP-mannose pyrophosphorylase B |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GMPPB mRNA |
CTD |
PMID:18579281 |
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NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286
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Got1 |
glutamic-oxaloacetic transaminase 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GOT1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpm6a |
glycoprotein m6a |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPM6A mRNA |
CTD |
PMID:18579281 |
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NCBI chr16:36,641,282...36,973,477
Ensembl chr16:36,641,284...36,973,475
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Gpr12 |
G protein-coupled receptor 12 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA |
CTD |
PMID:18579281 |
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NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973
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Gpr85 |
G protein-coupled receptor 85 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPR85 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566
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Hapln1 |
hyaluronan and proteoglycan link protein 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HAPLN1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777
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Hmox1 |
heme oxygenase 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HMOX1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa8 |
heat shock protein family A (Hsp70) member 8 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPA8 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Hspb1 |
heat shock protein family B (small) member 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Hsph1 |
heat shock protein family H (Hsp110) member 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Ido2 |
indoleamine 2,3-dioxygenase 2 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IDO2 mRNA |
CTD |
PMID:18579281 |
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NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
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Ihh |
Indian hedgehog signaling molecule |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA |
CTD |
PMID:18579281 |
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NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA |
CTD |
PMID:18579281 |
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NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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Il1r1 |
interleukin 1 receptor type 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Insc |
INSC, spindle orientation adaptor protein |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of INSC mRNA |
CTD |
PMID:18579281 |
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NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433
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Klf5 |
KLF transcription factor 5 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA |
CTD |
PMID:18579281 |
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NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
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Limch1 |
LIM and calponin homology domains 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr14:41,112,579...41,425,185
Ensembl chr14:41,114,803...41,425,191
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Lmcd1 |
LIM and cysteine-rich domains 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LMCD1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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Lpar4 |
lysophosphatidic acid receptor 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPAR4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977
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Lpin1 |
lipin 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPIN1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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Lrtm1 |
leucine-rich repeats and transmembrane domains 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA |
CTD |
PMID:18579281 |
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NCBI chr16:4,210,343...4,217,843
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Matk |
megakaryocyte-associated tyrosine kinase |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MATK mRNA |
CTD |
PMID:18579281 |
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NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022
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Mpdz |
multiple PDZ domain crumbs cell polarity complex component |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MPDZ mRNA |
CTD |
PMID:18579281 |
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NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499
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Mt4 |
metallothionein 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909
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Mvd |
mevalonate diphosphate decarboxylase |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA |
CTD |
PMID:18579281 |
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NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
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Mybph |
myosin binding protein H |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MYBPH mRNA |
CTD |
PMID:18579281 |
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NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
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Ndrg4 |
NDRG family member 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914
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Nherf4 |
NHERF family PDZ scaffold protein 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NHERF4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 8:44,584,390...44,588,838
Ensembl chr 8:44,584,390...44,588,860
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Nip7 |
nucleolar pre-rRNA processing protein NIP7 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NIP7 mRNA |
CTD |
PMID:18579281 |
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NCBI chr19:34,962,557...34,964,700
Ensembl chr19:34,962,557...34,964,711
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Nrg4 |
neuregulin 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA |
CTD |
PMID:18579281 |
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NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483
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Ogn |
osteoglycin |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of OGN mRNA |
CTD |
PMID:18579281 |
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NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
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Or5b99 |
olfactory receptor family 5 subfamily B member 99 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of OR5B99 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 1:210,136,841...210,137,767
Ensembl chr 1:210,132,946...210,138,365
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G |
Pfkp |
phosphofructokinase, platelet |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA |
CTD |
PMID:18579281 |
|
NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
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|
G |
Plin4 |
perilipin 4 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PLIN4 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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G |
Por |
cytochrome p450 oxidoreductase |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA |
CTD |
PMID:18579281 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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|
G |
Ppfibp1 |
PPFIA binding protein 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPFIBP1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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|
G |
Ppp1r3a |
protein phosphatase 1, regulatory subunit 3A |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638
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G |
Ppp1r3g |
protein phosphatase 1, regulatory subunit 3G |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3G mRNA |
CTD |
PMID:18579281 |
|
NCBI chr17:28,874,956...28,878,288
Ensembl chr17:28,876,482...28,877,525
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G |
Prok1 |
prokineticin 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:194,853,991...194,859,250
Ensembl chr 2:194,853,991...194,859,250
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|
G |
Prr9 |
proline rich 9 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PRR9 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:177,599,483...177,600,849
Ensembl chr 2:177,599,483...177,600,849
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|
G |
Ptp4a1 |
protein tyrosine phosphatase 4A1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PTP4A1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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|
G |
Retreg1 |
reticulophagy regulator 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898
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|
G |
Rprd1a |
regulation of nuclear pre-mRNA domain containing 1A |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RPRD1A mRNA |
CTD |
PMID:18579281 |
|
NCBI chr18:15,791,418...15,839,338
Ensembl chr18:15,791,418...15,839,338
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|
G |
Selenop |
selenoprotein P |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SELENOP mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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|
G |
Sema3c |
semaphorin 3C |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
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G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
|
|
G |
Slc24a2 |
solute carrier family 24 member 2 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 5:101,499,536...101,739,337
Ensembl chr 5:101,502,278...101,739,337
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G |
Slc25a32 |
solute carrier family 25 member 32 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770
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G |
Slc66a1 |
solute carrier family 66 member 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC66A1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 5:151,537,870...151,552,338
Ensembl chr 5:151,542,376...151,552,259
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|
G |
Slc6a15 |
solute carrier family 6 member 15 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC6A15 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
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G |
Snx7 |
sorting nexin 7 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SNX7 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:205,843,164...205,927,737
Ensembl chr 2:205,842,837...205,927,763
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G |
Spon2 |
spondin 2 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SPON2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Svil |
supervillin |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA |
CTD |
PMID:18579281 |
|
NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404
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G |
Tacc2 |
transforming, acidic coiled-coil containing protein 2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TACC2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 1:185,139,223...185,327,881
Ensembl chr 1:185,116,111...185,327,881
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G |
Tbc1d8 |
TBC1 domain family, member 8 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
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G |
Tcea2 |
transcription elongation factor A2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TCEA2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
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G |
Thra |
thyroid hormone receptor alpha |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of THRA mRNA |
CTD |
PMID:18579281 |
|
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
affects binding |
ISO |
2,4,5-Trichlorophenoxyacetic Acid binds to THRB protein |
CTD |
PMID:27410513 |
|
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Tom1l2 |
target of myb1 like 2 membrane trafficking protein |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TOM1L2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr10:45,036,034...45,158,168
Ensembl chr10:45,036,035...45,158,032
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Tril |
TLR4 interactor with leucine-rich repeats |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TRIL mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172
|
|
G |
Tsc22d1 |
TSC22 domain family, member 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TSC22D1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
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|
G |
Ugt2a3 |
UDP glucuronosyltransferase family 2 member A3 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of UGT2A3 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr14:20,572,825...20,590,295
Ensembl chr14:20,572,808...20,590,729
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G |
Usp2 |
ubiquitin specific peptidase 2 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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G |
Vamp1 |
vesicle-associated membrane protein 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VAMP1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VCAM1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Veph1 |
ventricular zone expressed PH domain-containing 1 |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of VEPH1 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:150,291,379...150,537,491
Ensembl chr 2:150,296,573...150,537,266
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|
G |
Wars2 |
tryptophanyl tRNA synthetase 2 (mitochondrial) |
increases expression |
ISO |
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of WARS2 mRNA |
CTD |
PMID:18579281 |
|
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
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G |
Ces1d |
carboxylesterase 1D |
increases hydrolysis |
ISO |
CES1 protein results in increased hydrolysis of 2-nitrophenylacetic acid |
CTD |
PMID:23123248 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces2h |
carboxylesterase 2H |
increases hydrolysis |
ISO |
CES2 protein results in increased hydrolysis of 2-nitrophenylacetic acid |
CTD |
PMID:23123248 |
|
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Actb |
actin, beta |
affects binding multiple interactions |
EXP |
3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein Catechin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]; epicatechin gallate inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]; Quercetin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein] |
CTD |
PMID:19743802 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
EXP |
[3,4-Dihydroxyphenylacetic Acid co-treated with Glucose] results in increased phosphorylation of AKT1 protein 3,4-Dihydroxyphenylacetic Acid results in increased phosphorylation of AKT1 protein |
CTD |
PMID:29981789 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Cartpt |
CART prepropeptide |
increases abundance |
EXP |
CARTPT protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:15659233 |
|
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid] |
CTD |
PMID:11435997 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Comt |
catechol-O-methyltransferase |
increases methylation multiple interactions |
ISO EXP |
COMT protein results in increased methylation of 3,4-Dihydroxyphenylacetic Acid [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:11160877 PMID:11793163 PMID:15190105 PMID:16012872 |
|
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
3,4-Dihydroxyphenylacetic Acid results in increased expression of GSTP1 mRNA |
CTD |
PMID:19743802 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gys1 |
glycogen synthase 1 |
multiple interactions decreases phosphorylation |
EXP |
3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein] 3,4-Dihydroxyphenylacetic Acid results in decreased phosphorylation of GYS1 protein |
CTD |
PMID:29981789 |
|
NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
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G |
Insr |
insulin receptor |
multiple interactions |
EXP |
3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; 3,4-Dihydroxyphenylacetic Acid results in increased expression of and results in increased phosphorylation of INSR protein |
CTD |
PMID:29981789 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Maob |
monoamine oxidase B |
multiple interactions |
EXP |
[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:16012872 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
ISO |
NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid] |
CTD |
PMID:11085313 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
|
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
3,4-Dihydroxyphenylacetic Acid results in increased expression of NQO1 mRNA |
CTD |
PMID:19743802 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases abundance |
ISO |
NR3C1 protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:11226678 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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|
G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
EXP |
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid] |
CTD |
PMID:8884884 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:10318960 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
EXP |
3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:10224140 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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|
G |
Snca |
synuclein alpha |
decreases abundance |
ISO |
SNCA protein mutant form results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:18622040 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
|
|
G |
Tfam |
transcription factor A, mitochondrial |
decreases abundance |
ISO |
TFAM gene mutant form results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid |
CTD |
PMID:28595911 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
|
|
|
G |
Clcnka |
chloride voltage-gated channel Ka |
decreases activity |
EXP |
2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKA protein |
CTD |
PMID:15167890 |
|
NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148
|
|
G |
Clcnkb |
chloride voltage-gated channel Kb |
decreases activity |
EXP |
2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKB protein |
CTD |
PMID:15167890 |
|
NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153
|
|
G |
Slc1a2 |
solute carrier family 1 member 2 |
affects expression |
EXP |
2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 protein |
CTD |
PMID:16019039 |
|
NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
2-Methyl-4-chlorophenoxyacetic Acid results in increased expression of TNF protein |
CTD |
PMID:10883730 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Ces1d |
carboxylesterase 1D |
increases hydrolysis |
ISO |
CES1 protein results in increased hydrolysis of 4-nitrophenylacetic acid |
CTD |
PMID:11950785 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Ces2h |
carboxylesterase 2H |
increases hydrolysis |
ISO |
CES2 protein results in increased hydrolysis of 4-nitrophenylacetic acid |
CTD |
PMID:11950785 |
|
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
|
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|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA |
CTD |
PMID:9210621 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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|
G |
Alb |
albumin |
affects binding |
ISO |
2,4-Dichlorophenoxyacetic Acid binds to ALB protein |
CTD |
PMID:9877224 PMID:11451446 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions decreases expression |
ISO |
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 protein 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 protein |
CTD |
PMID:33865415 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
|
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein] |
CTD |
PMID:16107550 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Axin2 |
axin 2 |
multiple interactions increases expression |
ISO |
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of AXIN2 mRNA 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 protein |
CTD |
PMID:34463001 |
|
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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G |
Becn1 |
beclin 1 |
decreases expression multiple interactions |
EXP ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein] |
CTD |
PMID:34464015 PMID:35099110 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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|
G |
Casp1 |
caspase 1 |
decreases cleavage multiple interactions increases cleavage |
EXP ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased cleavage of CASP1 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased cleavage of CASP1 protein] |
CTD |
PMID:34464015 PMID:35099110 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Ccdc120 |
coiled-coil domain containing 120 |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CCDC120 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein |
CTD |
PMID:19467290 |
|
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL2 protein |
CTD |
PMID:19467290 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein |
CTD |
PMID:19467290 |
|
NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
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|
G |
Cdk6 |
cyclin-dependent kinase 6 |
increases expression multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 protein [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 protein |
CTD |
PMID:33865415 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cldn1 |
claudin 1 |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 protein |
CTD |
PMID:28699141 |
|
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Clk1 |
CDC-like kinase 1 |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLK1 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
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G |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein |
CTD |
PMID:18460445 |
|
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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G |
Crat |
carnitine O-acetyltransferase |
increases activity |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased activity of CRAT protein |
CTD |
PMID:1755024 |
|
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions increases expression |
ISO |
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA] 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 protein |
CTD |
PMID:29633193 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
affects expression |
ISO |
2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA |
CTD |
PMID:26838045 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A1 mRNA |
CTD |
PMID:10910964 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A2 mRNA |
CTD |
PMID:10910964 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1B1 mRNA |
CTD |
PMID:10910964 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Dbh |
dopamine beta-hydroxylase |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein |
CTD |
PMID:16931444 |
|
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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|
G |
Dclre1c |
DNA cross-link repair 1C |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNA |
CTD |
PMID:15878651 |
|
NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186
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G |
Ddb2 |
damage specific DNA binding protein 2 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of DDIT3 mRNA |
CTD |
PMID:34626751 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ephx1 |
epoxide hydrolase 1 |
increases activity |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein |
CTD |
PMID:3032197 |
|
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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G |
Ephx2 |
epoxide hydrolase 2 |
increases activity |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein |
CTD |
PMID:1755024 PMID:3032197 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Foxo1 |
forkhead box O1 |
increases expression multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 protein PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA] |
CTD |
PMID:29633193 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of FTH1 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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|
G |
Gfap |
glial fibrillary acidic protein |
increases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of GFAP mRNA |
CTD |
PMID:22954530 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases activity |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased activity of GPX1 protein |
CTD |
PMID:35099110 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR |
CTD |
PMID:26838045 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCS1 |
CTD |
PMID:26838045 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Ifng |
interferon gamma |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IFNG |
CTD |
PMID:20728597 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il18 |
interleukin 18 |
increases expression multiple interactions |
EXP ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein] |
CTD |
PMID:34464015 PMID:35099110 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein] |
CTD |
PMID:34464015 PMID:35099110 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il1rl1 |
interleukin 1 receptor-like 1 |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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|
G |
Il2 |
interleukin 2 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2 |
CTD |
PMID:20728597 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA |
CTD |
PMID:20728597 |
|
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il4 |
interleukin 4 |
increases expression increases secretion |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein 2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein |
CTD |
PMID:19467290 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL5 protein |
CTD |
PMID:19467290 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein] |
CTD |
PMID:19467290 PMID:34464015 PMID:35099110 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Itgb1 |
integrin subunit beta 1 |
increases expression multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 protein [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 protein |
CTD |
PMID:33865415 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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|
G |
Ldha |
lactate dehydrogenase A |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA protein |
CTD |
PMID:23538319 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions decreases expression affects localization |
EXP ISO |
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA] lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid affects the localization of MAP1LC3B protein]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA] |
CTD |
PMID:34464015 PMID:35099110 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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|
G |
Mbp |
myelin basic protein |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of MBP protein |
CTD |
PMID:18460445 |
|
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases methylation |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased methylation of MYC promoter |
CTD |
PMID:11857776 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases expression |
ISO |
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 protein |
CTD |
PMID:33865415 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions increases expression |
EXP ISO |
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein] 2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein] |
CTD |
PMID:34464015 PMID:35099110 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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|
G |
Ocln |
occludin |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of OCLN mRNA |
CTD |
PMID:28699141 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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|
G |
Oxt |
oxytocin/neurophysin I prepropeptide |
decreases secretion |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein |
CTD |
PMID:20122984 |
|
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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|
G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of PCNA mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Pfkm |
phosphofructokinase, muscle |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM protein |
CTD |
PMID:23538319 |
|
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases response to substance |
ISO |
PPARA protein results in increased susceptibility to 2,4-Dichlorophenoxyacetic Acid |
CTD |
PMID:26838045 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions increases expression |
ISO |
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]; PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA] 2,4-Dichlorophenoxyacetic Acid results in increased expression of PPARB mRNA |
CTD |
PMID:29633193 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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|
G |
Prl |
prolactin |
decreases secretion |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased secretion of PRL protein |
CTD |
PMID:20122984 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
|
|
G |
Ptger3 |
prostaglandin E receptor 3 |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
|
|
G |
Pycard |
PYD and CARD domain containing |
multiple interactions increases expression |
EXP |
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein] |
CTD |
PMID:34464015 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
|
|
G |
Slc16a3 |
solute carrier family 16 member 3 |
decreases expression increases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC16A3 mRNA 2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC16A3 mRNA |
CTD |
PMID:23538319 |
|
NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562
|
|
G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid] |
CTD |
PMID:15284287 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
|
|
G |
Slc22a20 |
solute carrier family 22 member 20 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:16478971 |
|
NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822
|
|
G |
Slc22a25 |
solute carrier family 22, member 25 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A] |
CTD |
PMID:15068970 |
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NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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G |
Slc22a6 |
solute carrier family 22 member 6 |
increases uptake multiple interactions |
EXP ISO |
SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid] |
CTD |
PMID:16857889 PMID:17255469 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc2a3 |
solute carrier family 2 member 3 |
increases expression decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein |
CTD |
PMID:23538319 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Sod1 |
superoxide dismutase 1 |
decreases activity |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased activity of SOD1 protein |
CTD |
PMID:35099110 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions increases expression |
EXP ISO |
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein] 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; NLRP3 protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein] |
CTD |
PMID:34464015 PMID:35099110 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of SRXN1 mRNA |
CTD |
PMID:34626751 |
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NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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G |
Th |
tyrosine hydroxylase |
increases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein |
CTD |
PMID:16931444 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Thrb |
thyroid hormone receptor beta |
affects binding |
ISO |
2,4-Dichlorophenoxyacetic Acid binds to THRB protein |
CTD |
PMID:27410513 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Tjp1 |
tight junction protein 1 |
decreases expression |
EXP |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 protein |
CTD |
PMID:28699141 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO EXP |
2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF; 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein] |
CTD |
PMID:20728597 PMID:34464015 PMID:35099110 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 protein |
CTD |
PMID:33865415 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Usp19 |
ubiquitin specific peptidase 19 |
increases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in increased expression of USP19 mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
2,4-Dichlorophenoxyacetic Acid results in decreased expression of VEGFA mRNA |
CTD |
PMID:15878651 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
2,6-diisopropylnaphthalene binds to and results in increased activity of ESR1 protein |
CTD |
PMID:27633901 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
2,6-diisopropylnaphthalene binds to and results in increased activity of ESR2 protein |
CTD |
PMID:27633901 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
2,6-diisopropylnaphthalene binds to and results in increased activity of PPARG protein |
CTD |
PMID:27633901 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions |
ISO |
2,6-diisopropylnaphthalene binds to and results in increased activity of THRB protein |
CTD |
PMID:27633901 |
|
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
EXP |
4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] |
CTD |
PMID:25641191 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] |
CTD |
PMID:25641191 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
4-hydroxyphenylethanol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] |
CTD |
PMID:18081942 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
4'-hydroxydiclofenac binds to and affects the activity of AR protein |
CTD |
PMID:29777833 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
4'-hydroxydiclofenac results in increased expression of CCL2 mRNA |
CTD |
PMID:24104198 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Esr1 |
estrogen receptor 1 |
affects activity |
ISO |
4'-hydroxydiclofenac affects the activity of ESR1 protein |
CTD |
PMID:29777833 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases glutathionylation multiple interactions |
ISO |
GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:24246759 PMID:24552538 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] |
CTD |
PMID:29777833 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] |
CTD |
PMID:29777833 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] |
CTD |
PMID:29777833 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] |
CTD |
PMID:29777833 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac |
CTD |
PMID:28754375 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] |
CTD |
PMID:24552538 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone reductase 2 |
multiple interactions |
ISO |
NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac |
CTD |
PMID:29281794 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein |
CTD |
PMID:29777833 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Tnf |
tumor necrosis factor |
increases response to substance multiple interactions |
EXP ISO |
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein] |
CTD |
PMID:23939143 PMID:29777833 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c24 |
cytochrome P450, family 2, subfamily c, polypeptide 24 |
multiple interactions |
ISO |
[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
ISO |
[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac |
CTD |
PMID:28754375 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
increases response to substance |
ISO |
ADAM17 results in increased susceptibility to aceclofenac |
CTD |
PMID:12147693 |
|
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
aceclofenac results in increased expression of GDF15 protein aceclofenac results in increased expression of GDF15 mRNA |
CTD |
PMID:15555568 PMID:18076062 |
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NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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G |
Sell |
selectin L |
decreases expression |
ISO |
aceclofenac results in decreased expression of SELL protein |
CTD |
PMID:12147693 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein |
CTD |
PMID:17328244 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
ISO |
acteoside results in decreased expression of ACTA2 protein |
CTD |
PMID:33522686 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Ager |
advanced glycosylation end product-specific receptor |
decreases expression |
ISO |
acteoside results in decreased expression of AGER protein |
CTD |
PMID:33522686 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions decreases localization |
ISO |
acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein] acteoside results in decreased localization of AHR protein |
CTD |
PMID:21756928 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
increases localization |
ISO |
acteoside results in increased localization of ARNT protein |
CTD |
PMID:21756928 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression multiple interactions decreases secretion |
ISO |
acteoside results in decreased expression of CCL2 mRNA acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA] acteoside results in decreased secretion of CCL2 protein |
CTD |
PMID:21756928 PMID:21967610 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
acteoside results in decreased expression of CCND1 protein |
CTD |
PMID:17634406 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
decreases expression |
ISO |
acteoside results in decreased expression of CCND2 protein |
CTD |
PMID:17634406 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
acteoside results in decreased expression of CCND3 protein |
CTD |
PMID:17634406 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
acteoside results in decreased expression of CCNE1 protein |
CTD |
PMID:17634406 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
acteoside results in increased expression of CDH1 protein |
CTD |
PMID:33522686 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
acteoside results in decreased expression of and results in decreased activity of CDK2 protein |
CTD |
PMID:17634406 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases activity |
ISO |
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein] acteoside results in decreased activity of CDK4 protein |
CTD |
PMID:17634406 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
multiple interactions |
ISO |
acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein |
CTD |
PMID:17634406 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein] |
CTD |
PMID:17634406 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions increases expression |
ISO |
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein] acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein |
CTD |
PMID:17634406 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases secretion decreases expression multiple interactions |
ISO |
acteoside results in decreased secretion of CXCL10 protein acteoside results in decreased expression of CXCL10 mRNA acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein] |
CTD |
PMID:21756928 PMID:21967610 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
acteoside results in increased expression of CYP1A1 mRNA |
CTD |
PMID:21756928 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] |
CTD |
PMID:14672760 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
ISO |
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] |
CTD |
PMID:17634406 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation multiple interactions |
ISO |
acteoside results in decreased phosphorylation of EGFR protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] |
CTD |
PMID:21756928 PMID:21967610 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Hmgb1 |
high mobility group box 1 |
decreases expression |
ISO |
acteoside results in decreased expression of HMGB1 protein |
CTD |
PMID:33522686 |
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NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
acteoside results in decreased expression of ICAM1 mRNA |
CTD |
PMID:21371465 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
decreases expression multiple interactions |
ISO |
acteoside results in decreased expression of IFNG mRNA acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] |
CTD |
PMID:21371465 PMID:21756928 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO |
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] acteoside results in decreased expression of IL6 mRNA |
CTD |
PMID:21756928 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb2 |
integrin subunit beta 2 |
multiple interactions |
ISO |
acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] |
CTD |
PMID:16393473 |
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NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation increases phosphorylation |
ISO |
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] acteoside results in decreased phosphorylation of MAPK1 protein acteoside results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:21756928 PMID:23527233 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions decreases phosphorylation |
ISO |
acteoside results in increased phosphorylation of MAPK3 protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] acteoside results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:21756928 PMID:23527233 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nox1 |
NADPH oxidase 1 |
decreases activity |
ISO |
acteoside results in decreased activity of NOX1 protein |
CTD |
PMID:16393473 |
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NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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G |
Ptgds |
prostaglandin D2 synthase |
affects binding |
ISO |
acteoside binds to PTGDS protein |
CTD |
PMID:26456343 |
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NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA |
CTD |
PMID:21756928 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rac1 |
Rac family small GTPase 1 |
decreases expression |
ISO |
Verbascoside decreases expression of RAC1 mRNA in colon cancer cells |
RGD |
PMID:29886834 |
RGD:153298971 |
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation multiple interactions |
ISO |
acteoside results in decreased phosphorylation of RB1 protein [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] |
CTD |
PMID:17634406 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases phosphorylation multiple interactions decreases phosphorylation |
ISO |
acteoside results in increased phosphorylation of RELA protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] acteoside results in decreased phosphorylation of RELA protein |
CTD |
PMID:21756928 PMID:23527233 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Smad2 |
SMAD family member 2 |
increases phosphorylation |
ISO |
acteoside results in increased phosphorylation of SMAD2 protein |
CTD |
PMID:17634406 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
increases phosphorylation |
ISO |
acteoside results in increased phosphorylation of SMAD3 protein |
CTD |
PMID:17634406 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Smad7 |
SMAD family member 7 |
increases expression |
ISO |
acteoside results in increased expression of SMAD7 protein |
CTD |
PMID:33522686 |
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NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
acteoside results in decreased expression of SNAI1 protein |
CTD |
PMID:33522686 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
acteoside results in decreased expression of SNAI2 protein |
CTD |
PMID:33522686 |
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NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression |
ISO |
acteoside results in decreased expression of SOD2 mRNA |
CTD |
PMID:21371465 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tgfa |
transforming growth factor alpha |
multiple interactions |
ISO |
[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] |
CTD |
PMID:21756928 PMID:21967610 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
acteoside results in increased expression of TGFB1 mRNA |
CTD |
PMID:17634406 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
decreases expression |
ISO |
acteoside results in decreased expression of TGFBR1 protein |
CTD |
PMID:33522686 |
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NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Tgfbr2 |
transforming growth factor, beta receptor 2 |
decreases expression |
ISO |
acteoside results in decreased expression of TGFBR2 protein |
CTD |
PMID:33522686 |
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NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] |
CTD |
PMID:21756928 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
acteoside results in decreased expression of VCAM1 mRNA |
CTD |
PMID:21371465 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity multiple interactions |
ISO |
Atropine results in decreased activity of ABCB11 protein Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP ISO |
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]] [1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein] |
CTD |
PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 More...
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adcy5 |
adenylate cyclase 5 |
increases response to substance |
ISO |
ADCY5 protein results in increased susceptibility to Atropine |
CTD |
PMID:12869393 |
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NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Aqp5 |
aquaporin 5 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] |
CTD |
PMID:26208470 |
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NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] |
CTD |
PMID:21971501 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcar1 |
BCAR1 scaffold protein, Cas family member |
multiple interactions |
ISO |
Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] |
CTD |
PMID:10537051 |
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NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
EXP ISO |
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein [BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX |
CTD |
PMID:17963125 PMID:22981459 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bdkrb2 |
bradykinin receptor B2 |
multiple interactions |
ISO |
BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] |
CTD |
PMID:10614985 |
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NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] |
CTD |
PMID:18472332 |
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NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
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G |
Cacna1e |
calcium voltage-gated channel subunit alpha1 E |
multiple interactions |
EXP |
Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] |
CTD |
PMID:12663092 |
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NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
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G |
Calca |
calcitonin-related polypeptide alpha |
affects activity |
EXP |
Atropine affects the activity of CALCA protein |
CTD |
PMID:7906887 PMID:10075105 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Casp3 |
caspase 3 |
increases expression |
EXP |
Atropine results in increased expression of CASP3 mRNA |
CTD |
PMID:19815060 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] |
CTD |
PMID:22245128 |
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NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Ccna1 |
cyclin A1 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CCNA1 mRNA [Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccnd3 |
cyclin D3 |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CCNE1 mRNA [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccne2 |
cyclin E2 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA Atropine results in increased expression of CCNE2 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] |
CTD |
PMID:16879495 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cdc20 |
cell division cycle 20 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA Atropine results in increased expression of CDC20 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc6 |
cell division cycle 6 |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA |
CTD |
PMID:17390078 |
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NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA Atropine results in increased expression of CDK1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] |
CTD |
PMID:9311626 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions decreases activity |
ISO |
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] Atropine results in decreased activity of CHRM1 protein Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein] |
CTD |
PMID:16439611 PMID:18316702 PMID:31830555 |
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NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
ISO |
Atropine binds to and results in decreased activity of CHRM2 protein |
CTD |
PMID:15140916 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions decreases activity |
ISO |
Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein] Atropine results in decreased activity of CHRM3 protein |
CTD |
PMID:15140916 PMID:20708676 PMID:31830555 |
|
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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|
G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
multiple interactions affects binding |
ISO |
[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] |
CTD |
PMID:16709648 |
|
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
|
|
G |
Chrm5 |
cholinergic receptor, muscarinic 5 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] |
CTD |
PMID:31323226 |
|
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
|
|
G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions affects binding |
ISO EXP |
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]] Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:15733544 PMID:21791372 |
|
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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|
G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
affects binding multiple interactions |
ISO EXP |
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]] Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] |
CTD |
PMID:15733544 PMID:21791372 |
|
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] |
CTD |
PMID:21971501 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
|
|
G |
Crh |
corticotropin releasing hormone |
multiple interactions |
ISO EXP |
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein] |
CTD |
PMID:12039681 PMID:12906840 |
|
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] |
CTD |
PMID:17390078 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] |
CTD |
PMID:22245128 |
|
NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Dvl2 |
dishevelled segment polarity protein 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] |
CTD |
PMID:17390078 |
|
NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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|
G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] |
CTD |
PMID:12906840 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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|
G |
Eef2 |
eukaryotic translation elongation factor 2 |
multiple interactions |
ISO |
atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells] |
RGD |
PMID:31227218 |
RGD:153298919 |
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] |
CTD |
PMID:17390078 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Egr1 |
early growth response 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] |
CTD |
PMID:7968354 |
|
NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
|
|
G |
Egr2 |
early growth response 2 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] |
CTD |
PMID:7968354 |
|
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
|
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G |
Ezr |
ezrin |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] |
CTD |
PMID:17390078 |
|
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
|
|
G |
F2 |
coagulation factor II |
multiple interactions |
ISO |
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein |
CTD |
PMID:30515700 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
|
|
G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein |
CTD |
PMID:30515700 |
|
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Atropine results in increased expression of FOS protein Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA] [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] |
CTD |
PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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|
G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
EXP |
Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] |
CTD |
PMID:16959836 |
|
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
|
|
G |
Glra1 |
glycine receptor, alpha 1 |
multiple interactions |
ISO |
Atropine binds to and results in decreased activity of GLRA1 protein |
CTD |
PMID:15081878 |
|
NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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|
G |
Grm4 |
glutamate metabotropic receptor 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
|
NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] |
CTD |
PMID:22245128 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] |
CTD |
PMID:22245128 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] |
CTD |
PMID:22245128 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] |
CTD |
PMID:21971501 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] |
CTD |
PMID:7968354 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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|
G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
multiple interactions |
ISO |
Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
|
NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
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|
G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] |
CTD |
PMID:17390078 |
|
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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|
G |
Ltf |
lactotransferrin |
multiple interactions |
ISO |
Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] |
CTD |
PMID:11112886 |
|
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21971501 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:21971501 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21971501 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:21971501 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mcm4 |
minichromosome maintenance complex component 4 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA Atropine results in increased expression of MCM4 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
|
|
G |
Mcm6 |
minichromosome maintenance complex component 6 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of MCM6 mRNA [Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
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G |
Nefh |
neurofilament heavy chain |
affects expression |
EXP |
Atropine affects the expression of NEFH mRNA |
CTD |
PMID:22954530 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
|
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Atropine results in increased expression of NLRP3 mRNA |
CTD |
PMID:28138970 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] |
CTD |
PMID:15610444 PMID:16944022 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Notch4 |
notch receptor 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] |
CTD |
PMID:17390078 |
|
NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
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G |
Nppa |
natriuretic peptide A |
affects activity |
EXP |
Atropine affects the activity of NPPA protein modified form |
CTD |
PMID:1363893 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
G |
Oprl1 |
opioid related nociceptin receptor 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] |
CTD |
PMID:12007927 |
|
NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] |
CTD |
PMID:12762645 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Pnoc |
prepronociceptin |
multiple interactions |
EXP |
Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] |
CTD |
PMID:12007927 |
|
NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867
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|
G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] |
CTD |
PMID:7588217 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] |
CTD |
PMID:18812576 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] |
CTD |
PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] |
CTD |
PMID:10537051 |
|
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
|
|
G |
Pxn |
paxillin |
multiple interactions |
ISO |
Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] |
CTD |
PMID:10537051 |
|
NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931
|
|
G |
Rac3 |
Rac family small GTPase 3 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] |
CTD |
PMID:17390078 |
|
NCBI chr10:106,002,808...106,005,244
Ensembl chr10:105,993,087...106,005,260
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] |
CTD |
PMID:21971501 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] |
CTD |
PMID:17390078 |
|
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
|
|
G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:16263091 PMID:21641380 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:16263091 PMID:21599003 PMID:23770354 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
G |
Slc22a3 |
solute carrier family 22 member 3 |
increases uptake multiple interactions |
ISO |
SLC22A3 protein results in increased uptake of Atropine Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:16263091 |
|
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
|
|
G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
|
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
|
|
G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
|
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
|
|
G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
|
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
|
|
G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Atropine results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
|
|
G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] |
CTD |
PMID:22245128 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
|
|
G |
Spn |
sialophorin |
increases response to substance |
ISO |
SPN protein results in increased susceptibility to Atropine |
CTD |
PMID:18711009 |
|
NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
|
|
G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] |
CTD |
PMID:7761789 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] |
CTD |
PMID:18472332 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] |
CTD |
PMID:22245128 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] |
CTD |
PMID:12762645 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trio |
trio Rho guanine nucleotide exchange factor |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] |
CTD |
PMID:17390078 |
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NCBI chr 2:78,505,069...78,801,384
Ensembl chr 2:78,505,070...78,803,135
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
decreases response to substance |
ISO |
TRPA1 gene mutant form results in decreased susceptibility to Atropine |
CTD |
PMID:29627347 |
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NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
EXP |
[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] |
CTD |
PMID:15891268 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Tspo |
translocator protein |
multiple interactions |
EXP |
[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein |
CTD |
PMID:33823148 |
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NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] |
CTD |
PMID:22245128 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Ache |
acetylcholinesterase |
decreases activity multiple interactions |
EXP ISO |
Carbaryl results in decreased activity of ACHE protein [Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein [Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein] |
CTD |
PMID:4859365 PMID:7713347 PMID:14644616 PMID:16256972 PMID:19934164 PMID:21251949 PMID:23418109 PMID:23962483 PMID:25707986 PMID:33844597 More...
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Agxt |
alanine--glyoxylate aminotransferase |
decreases activity |
EXP |
Carbaryl results in decreased activity of AGXT protein |
CTD |
PMID:2119399 |
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NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO EXP |
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein] |
CTD |
PMID:9169082 PMID:9853009 PMID:17553063 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Alb |
albumin |
multiple interactions increases hydrolysis |
EXP ISO |
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl] |
CTD |
PMID:27665777 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Ar |
androgen receptor |
affects binding |
EXP |
Carbaryl binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bche |
butyrylcholinesterase |
decreases activity multiple interactions |
EXP |
Carbaryl results in decreased activity of BCHE protein [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein |
CTD |
PMID:20708061 PMID:22649187 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bcl2l11 |
Bcl2-like 11 |
decreases expression |
ISO |
Carbaryl results in decreased expression of BCL2L11 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Casp3 |
caspase 3 |
increases expression |
EXP |
Carbaryl results in increased expression of CASP3 |
CTD |
PMID:27296064 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
Carbaryl results in decreased expression of CEBPA mRNA |
CTD |
PMID:27829164 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
multiple interactions |
EXP |
Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] |
CTD |
PMID:14644616 |
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NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions |
EXP |
Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] |
CTD |
PMID:14644616 |
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NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions |
EXP |
Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:14644616 |
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NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
multiple interactions |
EXP |
Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] |
CTD |
PMID:14644616 |
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NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity increases expression multiple interactions |
ISO EXP |
Carbaryl results in increased activity of CYP1A1 protein Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:9169082 PMID:9858662 PMID:11226373 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression decreases activity |
ISO EXP |
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol] Carbaryl results in increased expression of CYP1A2 protein Carbaryl results in decreased activity of CYP1A2 protein |
CTD |
PMID:9858662 PMID:16790556 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases activity increases expression |
ISO |
Carbaryl results in increased activity of CYP2B6 protein Carbaryl results in increased expression of CYP2B6 mRNA |
CTD |
PMID:22310298 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity multiple interactions |
ISO |
Carbaryl results in decreased activity of CYP2E1 protein Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] |
CTD |
PMID:22634058 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
Carbaryl results in increased expression of CYP3A4 mRNA |
CTD |
PMID:22310298 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Carbaryl results in increased expression of DDIT3 mRNA |
CTD |
PMID:11226373 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
Carbaryl results in increased expression of DNAJB4 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Carbaryl results in increased expression of DNAJB9 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnajc3 |
DnaJ heat shock protein family (Hsp40) member C3 |
increases expression |
ISO |
Carbaryl results in increased expression of DNAJC3 mRNA |
CTD |
PMID:27829164 |
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NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
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G |
E2f5 |
E2F transcription factor 5 |
decreases expression |
ISO |
Carbaryl results in decreased expression of E2F5 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
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G |
Enc1 |
ectodermal-neural cortex 1 |
decreases expression |
ISO |
Carbaryl results in decreased expression of ENC1 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] |
CTD |
PMID:9126867 PMID:16626760 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions decreases expression |
ISO |
Carbaryl binds to and results in decreased activity of ESR2 protein Carbaryl results in decreased expression of ESR2 mRNA |
CTD |
PMID:16626760 PMID:27829164 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression decreases expression |
ISO |
Carbaryl results in increased expression of FOS mRNA Carbaryl results in decreased expression of FOS mRNA |
CTD |
PMID:11226373 PMID:27829164 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxo1 |
forkhead box O1 |
decreases expression |
ISO |
Carbaryl results in decreased expression of FOXO1 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone] |
CTD |
PMID:16413094 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity multiple interactions |
EXP |
Carbaryl results in increased activity of G6PD protein [Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein] |
CTD |
PMID:27214522 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
decreases expression |
ISO |
Carbaryl results in decreased expression of GADD45B mRNA |
CTD |
PMID:27829164 |
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NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Carbaryl results in increased expression of GCLM mRNA |
CTD |
PMID:27829164 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gpx5 |
glutathione peroxidase 5 |
increases expression |
ISO |
Carbaryl results in increased expression of GPX5 mRNA |
CTD |
PMID:27829164 |
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NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
increases expression |
EXP |
Carbaryl results in increased expression of GRIN2B protein |
CTD |
PMID:28975519 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
ISO |
Carbaryl results in increased expression of HERPUD1 mRNA |
CTD |
PMID:27829164 |
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NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Carbaryl results in increased expression of HMOX1 mRNA |
CTD |
PMID:27829164 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Carbaryl results in increased expression of HSPA5 mRNA |
CTD |
PMID:11226373 PMID:27829164 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
decreases expression |
ISO |
Carbaryl results in decreased expression of HSPA6 mRNA |
CTD |
PMID:27829164 |
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NCBI chr13:83,271,340...83,275,267
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G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] |
CTD |
PMID:15907790 PMID:18177342 |
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NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
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G |
Il2 |
interleukin 2 |
decreases response to substance |
ISO |
Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein |
CTD |
PMID:8349949 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Kyat1 |
kynurenine aminotransferase 1 |
decreases activity |
EXP |
Carbaryl results in decreased activity of KYAT1 protein |
CTD |
PMID:2119399 |
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NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
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G |
Map2 |
microtubule-associated protein 2 |
multiple interactions |
ISO |
Carbaryl promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] |
CTD |
PMID:32949729 |
|
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Mitf |
melanocyte inducing transcription factor |
decreases expression |
ISO |
Carbaryl results in decreased expression of MITF mRNA |
CTD |
PMID:27829164 |
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NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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G |
Mtnr1a |
melatonin receptor 1A |
affects binding multiple interactions |
ISO |
Carbaryl binds to MTNR1A protein Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein] |
CTD |
PMID:28027439 |
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NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
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G |
Mtnr1b |
melatonin receptor 1B |
affects binding multiple interactions |
ISO |
Carbaryl binds to MTNR1B protein Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]] |
CTD |
PMID:28027439 |
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NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
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G |
Nefh |
neurofilament heavy chain |
increases phosphorylation |
ISO |
Carbaryl results in increased phosphorylation of NEFH protein |
CTD |
PMID:16256972 |
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NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] |
CTD |
PMID:15907790 PMID:17015962 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] |
CTD |
PMID:15907790 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases expression increases activity |
ISO EXP |
Carbaryl results in increased expression of NR1I2 mRNA Carbaryl results in increased activity of NR1I2 protein |
CTD |
PMID:22310298 PMID:27665777 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
EXP |
Carbaryl results in increased activity of NR1I3 protein |
CTD |
PMID:27665777 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Otx2 |
orthodenticle homeobox 2 |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA] |
CTD |
PMID:32949729 |
|
NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416
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G |
Pax6 |
paired box 6 |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] |
CTD |
PMID:32949729 |
|
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein] |
CTD |
PMID:9126867 |
|
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases activity |
EXP |
Carbaryl results in decreased activity of PNPLA6 protein |
CTD |
PMID:7713347 |
|
NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
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G |
Pou5f1 |
POU class 5 homeobox 1 |
multiple interactions |
ISO |
Carbaryl promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] |
CTD |
PMID:32949729 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases activity |
EXP |
Carbaryl results in increased activity of PPARA protein |
CTD |
PMID:27665777 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] |
CTD |
PMID:15907790 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions decreases expression |
ISO |
Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] Carbaryl results in decreased expression of STAR mRNA |
CTD |
PMID:16413094 |
|
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Tdo2 |
tryptophan 2,3-dioxygenase |
decreases activity |
ISO EXP |
Carbaryl results in decreased activity of TDO2 protein |
CTD |
PMID:2119399 PMID:2547861 |
|
NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
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G |
Tgfb2 |
transforming growth factor, beta 2 |
increases expression |
ISO |
Carbaryl results in increased expression of TGFB2 mRNA |
CTD |
PMID:27829164 |
|
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions affects binding |
ISO |
Carbaryl binds to and results in decreased activity of THRB protein Carbaryl binds to THRB protein |
CTD |
PMID:18584933 PMID:28973306 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Tpo |
thyroid peroxidase |
increases activity |
ISO |
Carbaryl results in increased activity of TPO protein |
CTD |
PMID:21809831 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Wnt6 |
Wnt family member 6 |
decreases expression |
ISO |
Carbaryl results in decreased expression of WNT6 mRNA |
CTD |
PMID:27829164 |
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NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523
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G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
Carbaryl results in increased expression of XBP1 mRNA |
CTD |
PMID:27829164 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Abcd1 |
ATP binding cassette subfamily D member 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ABCD1 protein |
CTD |
PMID:34958886 |
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NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115
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G |
Adarb1 |
adenosine deaminase, RNA-specific, B1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of ADARB1 protein |
CTD |
PMID:34958886 |
|
NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
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G |
Agtrap |
angiotensin II receptor-associated protein |
increases expression |
EXP |
Chlormequat results in increased expression of AGTRAP protein |
CTD |
PMID:34958886 |
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NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Chlormequat promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:25684042 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Alg12 |
ALG12, alpha-1,6-mannosyltransferase |
decreases expression |
EXP |
Chlormequat results in decreased expression of ALG12 protein |
CTD |
PMID:34958886 |
|
NCBI chr 7:119,895,112...119,909,488
Ensembl chr 7:119,895,120...119,909,458
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G |
Alg14 |
ALG14, UDP-N-acetylglucosaminyltransferase subunit |
decreases expression |
EXP |
Chlormequat results in decreased expression of ALG14 protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:209,368,285...209,445,425
Ensembl chr 2:209,368,312...209,445,431
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G |
Apol9a |
apolipoprotein L 9a |
increases expression |
EXP |
Chlormequat results in increased expression of APOL9A protein |
CTD |
PMID:34958886 |
|
NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649
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G |
Arhgap20 |
Rho GTPase activating protein 20 |
increases expression |
EXP |
Chlormequat results in increased expression of ARHGAP20 protein |
CTD |
PMID:34958886 |
|
NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739
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G |
Atl1 |
atlastin GTPase 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ATL1 protein |
CTD |
PMID:34958886 |
|
NCBI chr 6:88,377,168...88,475,242
Ensembl chr 6:88,377,239...88,475,204
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G |
Atp10b |
ATPase phospholipid transporting 10B (putative) |
increases expression |
EXP |
Chlormequat results in increased expression of ATP10B protein |
CTD |
PMID:34958886 |
|
NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
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G |
B9d2 |
B9 domain containing 2 |
increases expression |
EXP |
Chlormequat results in increased expression of B9D2 protein |
CTD |
PMID:34958886 |
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NCBI chr 1:81,189,395...81,195,383
Ensembl chr 1:81,189,405...81,195,356
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G |
Bet1l |
Bet1 golgi vesicular membrane trafficking protein-like |
increases expression |
EXP |
Chlormequat results in increased expression of BET1L protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:195,930,165...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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G |
Bglap |
bone gamma-carboxyglutamate protein |
decreases expression |
EXP |
Chlormequat results in decreased expression of BGLAP protein |
CTD |
PMID:28214531 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
C1qc |
complement C1q C chain |
increases expression |
EXP |
Chlormequat results in increased expression of C1QC protein |
CTD |
PMID:34958886 |
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NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
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G |
Caap1 |
caspase activity and apoptosis inhibitor 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of CAAP1 protein |
CTD |
PMID:34958886 |
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NCBI chr 5:109,313,253...109,414,323
Ensembl chr 5:109,361,912...109,414,314
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G |
Cbx1 |
chromobox 1 |
increases expression |
EXP |
Chlormequat results in increased expression of CBX1 protein |
CTD |
PMID:34958886 |
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NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
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G |
Ccdc32 |
coiled-coil domain containing 32 |
increases expression |
EXP |
Chlormequat results in increased expression of CCDC32 protein |
CTD |
PMID:34958886 |
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NCBI chr 3:105,998,429...106,010,930
Ensembl chr 3:105,998,430...106,010,975
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G |
Ccnyl1 |
cyclin Y-like 1 |
increases expression |
EXP |
Chlormequat results in increased expression of CCNYL1 protein |
CTD |
PMID:34958886 |
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NCBI chr 9:66,071,721...66,121,742
Ensembl chr 9:66,071,543...66,107,999
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G |
Ccs |
copper chaperone for superoxide dismutase |
increases expression |
EXP |
Chlormequat results in increased expression of CCS protein |
CTD |
PMID:34958886 |
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NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
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G |
Cd151 |
CD151 molecule (Raph blood group) |
decreases expression |
EXP |
Chlormequat results in decreased expression of CD151 protein |
CTD |
PMID:34958886 |
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NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
increases expression |
EXP |
Chlormequat results in increased expression of CD55 protein |
CTD |
PMID:34958886 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cfap298 |
cilia and flagella associated protein 298 |
increases expression |
EXP |
Chlormequat results in increased expression of CFAP298 protein |
CTD |
PMID:34958886 |
|
NCBI chr11:30,181,916...30,191,302
Ensembl chr11:30,181,905...30,191,346
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G |
Chmp7 |
charged multivesicular body protein 7 |
increases expression |
EXP |
Chlormequat results in increased expression of CHMP7 protein |
CTD |
PMID:34958886 |
|
NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216
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G |
Coprs |
coordinator of PRMT5 and differentiation stimulator |
increases expression |
EXP |
Chlormequat results in increased expression of COPRS protein |
CTD |
PMID:34958886 |
|
NCBI chr16:75,721,264...75,726,375
Ensembl chr16:75,720,061...75,726,375
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G |
Coq4 |
coenzyme Q4 |
increases expression |
EXP |
Chlormequat results in increased expression of COQ4 protein |
CTD |
PMID:34958886 |
|
NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799
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G |
Csnk1a1 |
casein kinase 1, alpha 1 |
increases expression |
EXP |
Chlormequat results in increased expression of CSNK1A1 protein |
CTD |
PMID:34958886 |
|
NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
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G |
Ctss |
cathepsin S |
decreases expression |
EXP |
Chlormequat results in decreased expression of CTSS protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of CYP11A1 protein |
CTD |
PMID:29447956 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases expression |
ISO |
Chlormequat results in increased expression of CYP7A1 protein |
CTD |
PMID:32194361 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Dap |
death-associated protein |
decreases expression |
EXP |
Chlormequat results in decreased expression of DAP protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Dcaf13 |
DDB1 and CUL4 associated factor 13 |
increases expression |
EXP |
Chlormequat results in increased expression of DCAF13 protein |
CTD |
PMID:34958886 |
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NCBI chr 7:70,160,983...70,196,142
Ensembl chr 7:70,160,941...70,196,142
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G |
Dctn6 |
dynactin subunit 6 |
increases expression |
EXP |
Chlormequat results in increased expression of DCTN6 protein |
CTD |
PMID:34958886 |
|
NCBI chr16:58,077,595...58,096,604
Ensembl chr16:58,077,585...58,096,968
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
EXP |
Chlormequat results in increased expression of DDIT3 protein 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of DDIT3 protein] |
CTD |
PMID:34958886 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Degs1 |
delta(4)-desaturase, sphingolipid 1 |
increases expression |
EXP |
Chlormequat results in increased expression of DEGS1 protein |
CTD |
PMID:34958886 |
|
NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664
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G |
Dnajc14 |
DnaJ heat shock protein family (Hsp40) member C14 |
increases expression |
EXP |
Chlormequat results in increased expression of DNAJC14 protein |
CTD |
PMID:34958886 |
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NCBI chr 7:1,233,856...1,247,349
Ensembl chr 7:1,235,162...1,248,645
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G |
Dnmbp |
dynamin binding protein |
increases expression |
EXP |
Chlormequat results in increased expression of DNMBP protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:242,736,189...242,829,498
Ensembl chr 1:242,736,189...242,802,604
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G |
Dynlt3 |
dynein light chain Tctex-type 3 |
increases expression |
EXP |
Chlormequat results in increased expression of DYNLT3 protein |
CTD |
PMID:34958886 |
|
NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139
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G |
Ears2 |
glutamyl-tRNA synthetase 2, mitochondrial |
increases expression |
EXP |
Chlormequat results in increased expression of EARS2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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G |
Eef1a2 |
eukaryotic translation elongation factor 1 alpha 2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of EEF1A2 protein |
CTD |
PMID:34958886 |
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NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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G |
Elovl1 |
ELOVL fatty acid elongase 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ELOVL1 protein |
CTD |
PMID:34958886 |
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NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958
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G |
Elovl5 |
ELOVL fatty acid elongase 5 |
increases expression |
EXP |
Chlormequat results in increased expression of ELOVL5 protein |
CTD |
PMID:34958886 |
|
NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
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G |
Eno3 |
enolase 3 |
decreases expression |
EXP |
Chlormequat results in decreased expression of ENO3 protein |
CTD |
PMID:34958886 |
|
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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G |
Evc |
EvC ciliary complex subunit 1 |
increases expression |
EXP |
Chlormequat results in increased expression of EVC protein |
CTD |
PMID:34958886 |
|
NCBI chr14:73,456,181...73,498,955
Ensembl chr14:73,456,222...73,498,099
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
EXP |
Chlormequat results in decreased expression of FABP4 protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
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G |
Fancd2 |
FA complementation group D2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of FANCD2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fbln1 |
fibulin 1 |
increases expression |
EXP |
Chlormequat results in increased expression of FBLN1 protein |
CTD |
PMID:34958886 |
|
NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Chlormequat results in decreased expression of FOS protein |
CTD |
PMID:34958886 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxk2 |
forkhead box K2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of FOXK2 protein |
CTD |
PMID:34958886 |
|
NCBI chr10:106,542,643...106,592,569
Ensembl chr10:106,542,566...106,592,563
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G |
Gabarap |
GABA type A receptor-associated protein |
increases expression |
EXP |
Chlormequat results in increased expression of GABARAP protein |
CTD |
PMID:34958886 |
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NCBI chr10:54,714,834...54,717,769
Ensembl chr10:54,714,198...54,717,765
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G |
Gh1 |
growth hormone 1 |
increases expression |
EXP |
Chlormequat results in increased expression of GH1 protein |
CTD |
PMID:31704167 PMID:32622971 |
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NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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G |
Ghr |
growth hormone receptor |
decreases expression |
EXP |
Chlormequat results in decreased expression of GHR mRNA |
CTD |
PMID:28214531 |
|
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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G |
Ghrh |
growth hormone releasing hormone |
increases expression |
EXP |
Chlormequat results in increased expression of GHRH protein |
CTD |
PMID:32622971 |
|
NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
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G |
Gnai1 |
G protein subunit alpha i1 |
increases expression |
EXP |
Chlormequat results in increased expression of GNAI1 protein |
CTD |
PMID:34958886 |
|
NCBI chr 4:16,813,941...16,898,111
Ensembl chr 4:16,814,001...16,896,417
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G |
Gng5 |
G protein subunit gamma 5 |
decreases expression |
EXP |
Chlormequat results in decreased expression of GNG5 protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:235,394,680...235,403,177
Ensembl chr 1:77,292,043...77,292,513
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
increases expression |
EXP |
Chlormequat results in increased expression of GNRH1 protein |
CTD |
PMID:29447956 |
|
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
Chlormequat results in increased expression of GSTA2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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|
G |
Gtf2h5 |
general transcription factor IIH subunit 5 |
increases expression |
EXP |
Chlormequat results in increased expression of GTF2H5 protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
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|
G |
H1f0 |
H1.0 linker histone |
increases expression |
EXP |
Chlormequat results in increased expression of H1-0 protein |
CTD |
PMID:34958886 |
|
NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694
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|
G |
H1f5 |
H1.5 linker histone, cluster member |
increases expression |
EXP |
Chlormequat results in increased expression of H1-5 protein |
CTD |
PMID:34958886 |
|
NCBI chr17:42,726,189...42,726,857
Ensembl chr17:42,726,127...42,769,160
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|
G |
Hebp2 |
heme binding protein 2 |
increases expression |
EXP |
Chlormequat results in increased expression of HEBP2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
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|
G |
Herpud2 |
HERPUD family member 2 |
increases expression |
EXP |
Chlormequat results in increased expression of HERPUD2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 8:23,573,374...23,617,874
Ensembl chr 8:23,573,379...23,617,874
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|
G |
Hnrnpc |
heterogeneous nuclear ribonucleoprotein C |
increases expression |
EXP |
Chlormequat results in increased expression of HNRNPC protein |
CTD |
PMID:34958886 |
|
NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of HSD3B1 protein |
CTD |
PMID:29447956 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
EXP |
Chlormequat results in increased expression of HSPA5 protein 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of HSPA5 protein] |
CTD |
PMID:34958886 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Igf1 |
insulin-like growth factor 1 |
affects expression increases expression |
EXP |
Chlormequat affects the expression of IGF1 protein Chlormequat results in increased expression of IGF1 protein |
CTD |
PMID:28214531 PMID:31704167 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Ina |
internexin neuronal intermediate filament protein, alpha |
decreases expression |
EXP |
Chlormequat results in decreased expression of INA protein |
CTD |
PMID:34958886 |
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NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
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G |
Isoc2b |
isochorismatase domain containing 2b |
increases expression |
EXP |
Chlormequat results in increased expression of ISOC2 protein |
CTD |
PMID:34958886 |
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NCBI chr 1:68,972,960...68,993,760
Ensembl chr 1:68,972,960...68,993,757
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G |
Itgb1bp1 |
integrin subunit beta 1 binding protein 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ITGB1BP1 protein |
CTD |
PMID:34958886 |
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NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
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G |
Kazn |
kazrin, periplakin interacting protein |
increases expression |
EXP |
Chlormequat results in increased expression of KAZN protein |
CTD |
PMID:34958886 |
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NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074
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G |
Klhl26 |
kelch-like family member 26 |
decreases expression |
EXP |
Chlormequat results in decreased expression of KLHL26 protein |
CTD |
PMID:34958886 |
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NCBI chr16:18,952,123...18,977,328
Ensembl chr16:18,952,234...18,977,328
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G |
Klhl7 |
kelch-like family member 7 |
decreases expression |
EXP |
Chlormequat results in decreased expression of KLHL7 protein |
CTD |
PMID:34958886 |
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NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
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G |
Ldb1 |
LIM domain binding 1 |
increases expression |
EXP |
Chlormequat results in increased expression of LDB1 protein |
CTD |
PMID:34958886 |
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NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013
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G |
Lhb |
luteinizing hormone subunit beta |
increases expression |
EXP |
Chlormequat results in increased expression of LHB protein |
CTD |
PMID:29447956 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lrrc7 |
leucine rich repeat containing 7 |
increases expression |
EXP |
Chlormequat results in increased expression of LRRC7 protein |
CTD |
PMID:34958886 |
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NCBI chr 2:247,147,752...247,533,332
Ensembl chr 2:247,147,752...247,634,547
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G |
Macroh2a1 |
macroH2A.1 histone |
increases expression |
EXP |
Chlormequat results in increased expression of MACROH2A1 protein |
CTD |
PMID:34958886 |
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NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
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G |
Macroh2a2 |
macroH2A.2 histone |
increases expression |
EXP |
Chlormequat results in increased expression of MACROH2A2 protein |
CTD |
PMID:34958886 |
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NCBI chr20:29,678,194...29,727,867
Ensembl chr20:29,678,222...29,727,891
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G |
Map4 |
microtubule-associated protein 4 |
decreases expression |
EXP |
Chlormequat results in decreased expression of MAP4 protein |
CTD |
PMID:34958886 |
|
NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
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G |
Mgat4b |
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
increases expression |
EXP |
Chlormequat results in increased expression of MGAT4B protein |
CTD |
PMID:34958886 |
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NCBI chr10:34,548,918...34,559,229
Ensembl chr10:34,549,433...34,559,229
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G |
Mospd3 |
motile sperm domain containing 3 |
decreases expression |
EXP |
Chlormequat results in decreased expression of MOSPD3 protein |
CTD |
PMID:34958886 |
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NCBI chr12:19,095,203...19,100,303
Ensembl chr12:19,095,242...19,099,477
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G |
Mov10 |
Mov10 RISC complex RNA helicase |
increases expression |
EXP |
Chlormequat results in increased expression of MOV10 protein |
CTD |
PMID:34958886 |
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NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
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G |
Mpp2 |
MAGUK p55 scaffold protein 2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of MPP2 protein |
CTD |
PMID:34958886 |
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NCBI chr10:87,011,434...87,043,883
Ensembl chr10:87,011,434...87,043,896
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G |
Mpv17l2 |
MPV17 mitochondrial inner membrane protein like 2 |
increases expression |
EXP |
Chlormequat results in increased expression of MPV17L2 protein |
CTD |
PMID:34958886 |
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NCBI chr16:18,680,106...18,684,212
Ensembl chr16:18,681,826...18,684,212
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G |
Mrpl51 |
mitochondrial ribosomal protein L51 |
increases expression |
EXP |
Chlormequat results in increased expression of MRPL51 protein |
CTD |
PMID:34958886 |
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NCBI chr 4:157,991,756...157,994,715
Ensembl chr 4:157,992,408...157,995,414
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G |
Mrpl54 |
mitochondrial ribosomal protein L54 |
increases expression |
EXP |
Chlormequat results in increased expression of MRPL54 protein |
CTD |
PMID:34958886 |
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NCBI chr 7:8,452,801...8,455,321
Ensembl chr 7:8,452,716...8,455,321
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G |
Mrps14 |
mitochondrial ribosomal protein S14 |
increases expression |
EXP |
Chlormequat results in increased expression of MRPS14 protein |
CTD |
PMID:34958886 |
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NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915
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G |
Mtrfr |
mitochondrial translation release factor in rescue |
increases expression |
EXP |
Chlormequat results in increased expression of MTRFR protein |
CTD |
PMID:34958886 |
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NCBI chr12:32,261,569...32,275,258
Ensembl chr12:32,258,435...32,275,258
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G |
Ncl |
nucleolin |
increases expression |
EXP |
Chlormequat results in increased expression of NCL protein |
CTD |
PMID:34958886 |
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NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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G |
Nhp2 |
NHP2 ribonucleoprotein |
increases expression |
EXP |
Chlormequat results in increased expression of NHP2 protein |
CTD |
PMID:34958886 |
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NCBI chr10:35,877,015...35,880,409
Ensembl chr10:35,877,054...35,882,545
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G |
Nipa1 |
NIPA magnesium transporter 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of NIPA1 protein |
CTD |
PMID:34958886 |
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NCBI chr 1:106,834,000...106,875,148
Ensembl chr 1:106,834,000...106,874,790
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G |
Npr3 |
natriuretic peptide receptor 3 |
decreases expression |
EXP |
Chlormequat results in decreased expression of NPR3 protein |
CTD |
PMID:34958886 |
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NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
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G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
increases expression |
EXP |
Chlormequat results in increased expression of NR3C2 protein |
CTD |
PMID:34958886 |
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NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
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G |
Orai1 |
ORAI calcium release-activated calcium modulator 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ORAI1 protein |
CTD |
PMID:34958886 |
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NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
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G |
Pabpc1 |
poly(A) binding protein, cytoplasmic 1 |
increases expression |
EXP |
Chlormequat results in increased expression of PABPC1 protein |
CTD |
PMID:34958886 |
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NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
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G |
Pabpc4 |
poly(A) binding protein, cytoplasmic 4 |
increases expression |
EXP |
Chlormequat results in increased expression of PABPC4 protein |
CTD |
PMID:34958886 |
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NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979
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G |
Pccb |
propionyl-CoA carboxylase subunit beta |
increases expression |
EXP |
Chlormequat results in increased expression of PCCB protein |
CTD |
PMID:34958886 |
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NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:101,590,737...101,641,234
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G |
Pex26 |
peroxisomal biogenesis factor 26 |
increases expression |
EXP |
Chlormequat results in increased expression of PEX26 protein |
CTD |
PMID:34958886 |
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NCBI chr 4:154,414,332...154,426,954
Ensembl chr 4:154,414,849...154,426,952
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G |
Pgpep1 |
pyroglutamyl-peptidase I |
increases expression |
EXP |
Chlormequat results in increased expression of PGPEP1 protein |
CTD |
PMID:34958886 |
|
NCBI chr16:18,770,563...18,782,968
Ensembl chr16:18,771,021...18,783,478
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G |
Phldb1 |
pleckstrin homology-like domain, family B, member 1 |
increases expression |
EXP |
Chlormequat results in increased expression of PHLDB1 protein |
CTD |
PMID:34958886 |
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NCBI chr 8:45,003,538...45,051,541
Ensembl chr 8:45,003,538...45,051,522
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G |
Pias3 |
protein inhibitor of activated STAT, 3 |
decreases expression |
EXP |
Chlormequat results in decreased expression of PIAS3 protein |
CTD |
PMID:34958886 |
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NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
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G |
Pik3cd |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
increases expression |
EXP |
Chlormequat results in increased expression of PIK3CD protein |
CTD |
PMID:34958886 |
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NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
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G |
Pitpnm2 |
phosphatidylinositol transfer protein, membrane-associated 2 |
increases expression |
EXP |
Chlormequat results in increased expression of PITPNM2 protein |
CTD |
PMID:34958886 |
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NCBI chr12:32,347,455...32,479,103
Ensembl chr12:32,380,805...32,479,102
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G |
Pole4 |
DNA polymerase epsilon 4, accessory subunit |
increases expression |
EXP |
Chlormequat results in increased expression of POLE4 protein |
CTD |
PMID:34958886 |
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NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097
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G |
Pphln1 |
periphilin 1 |
increases expression |
EXP |
Chlormequat results in increased expression of PPHLN1 protein |
CTD |
PMID:34958886 |
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NCBI chr 7:124,538,594...124,629,985
Ensembl chr 7:124,538,627...124,629,985
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G |
Prkar1b |
protein kinase cAMP-dependent type I regulatory subunit beta |
increases expression |
EXP |
Chlormequat results in increased expression of PRKAR1B protein |
CTD |
PMID:34958886 |
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NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
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G |
Psmb7 |
proteasome 20S subunit beta 7 |
increases expression |
EXP |
Chlormequat results in increased expression of PSMB7 protein |
CTD |
PMID:34958886 |
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NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
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G |
Rab6a |
RAB6A, member RAS oncogene family |
increases expression |
EXP |
Chlormequat results in increased expression of RAB6A protein |
CTD |
PMID:34958886 |
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NCBI chr 1:154,957,870...155,008,922
Ensembl chr 1:154,958,189...154,996,715
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G |
Rad17 |
RAD17 checkpoint clamp loader component |
increases expression |
EXP |
Chlormequat results in increased expression of RAD17 protein |
CTD |
PMID:34958886 |
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NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
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G |
RGD1306195 |
similar to RAN protein |
increases expression |
EXP |
Chlormequat results in increased expression of RGD1306195 protein |
CTD |
PMID:34958886 |
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NCBI chr 5:54,456,005...54,457,381
Ensembl chr 5:54,455,893...54,457,677
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G |
Rhoq |
ras homolog family member Q |
increases expression |
EXP |
Chlormequat results in increased expression of RHOQ protein |
CTD |
PMID:34958886 |
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NCBI chr 6:7,613,632...7,652,047
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G |
Rnf113a1 |
ring finger protein 113A1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of RNF113A1 protein |
CTD |
PMID:34958886 |
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NCBI chr X:116,428,037...116,429,164
Ensembl chr X:116,427,684...116,433,762
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G |
Rnf185 |
ring finger protein 185 |
increases expression multiple interactions |
EXP |
Chlormequat results in increased expression of RNF185 protein 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of RNF185 protein] |
CTD |
PMID:34958886 |
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NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864
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G |
Rspry1 |
ring finger and SPRY domain containing 1 |
increases expression |
EXP |
Chlormequat results in increased expression of RSPRY1 protein |
CTD |
PMID:34958886 |
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NCBI chr19:10,352,449...10,403,015
Ensembl chr19:10,353,821...10,401,102
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G |
Rtn1 |
reticulon 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of RTN1 protein |
CTD |
PMID:34958886 |
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NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436
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G |
S100a1 |
S100 calcium binding protein A1 |
increases expression |
EXP |
Chlormequat results in increased expression of S100A1 protein |
CTD |
PMID:34958886 |
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NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
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G |
Samd8 |
sterile alpha motif domain containing 8 |
increases expression |
EXP |
Chlormequat results in increased expression of SAMD8 protein |
CTD |
PMID:34958886 |
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NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379 Ensembl chr15:2,512,105...2,515,379
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G |
Sar1a |
secretion associated, Ras related GTPase 1A |
increases expression |
EXP |
Chlormequat results in increased expression of SAR1A protein |
CTD |
PMID:34958886 |
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NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935
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G |
Shroom1 |
shroom family member 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of SHROOM1 protein |
CTD |
PMID:34958886 |
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NCBI chr10:37,621,149...37,631,895
Ensembl chr10:37,621,723...37,631,256
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G |
Ski |
Ski proto-oncogene |
increases expression |
EXP |
Chlormequat results in increased expression of SKI protein |
CTD |
PMID:34958886 |
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NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733
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G |
Slc48a1 |
solute carrier family 48 member 1 |
decreases expression |
EXP |
Chlormequat results in decreased expression of SLC48A1 protein |
CTD |
PMID:34958886 |
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NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024
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G |
Slit3 |
slit guidance ligand 3 |
increases expression |
EXP |
Chlormequat results in increased expression of SLIT3 protein |
CTD |
PMID:34958886 |
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NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
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G |
Slu7 |
SLU7 homolog, splicing factor |
increases expression |
EXP |
Chlormequat results in increased expression of SLU7 protein |
CTD |
PMID:34958886 |
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NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349
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G |
Smim26 |
small integral membrane protein 26 |
decreases expression |
EXP |
Chlormequat results in decreased expression of SMIM26 protein |
CTD |
PMID:34958886 |
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NCBI chr 3:131,990,147...131,991,779
Ensembl chr 3:131,990,291...131,992,132
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G |
Spns1 |
sphingolipid transporter 1 |
increases expression |
EXP |
Chlormequat results in increased expression of SPNS1 protein |
CTD |
PMID:34958886 |
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NCBI chr 1:180,942,088...180,949,415
Ensembl chr 1:180,942,088...180,949,370
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G |
Sppl2b |
signal peptide peptidase-like 2B |
increases expression |
EXP |
Chlormequat results in increased expression of SPPL2B protein |
CTD |
PMID:34958886 |
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NCBI chr 7:8,843,918...8,856,642
Ensembl chr 7:8,843,918...8,856,608
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G |
St3gal1 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ST3GAL1 protein |
CTD |
PMID:34958886 |
|
NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236
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G |
St7l |
suppression of tumorigenicity 7-like |
decreases expression |
EXP |
Chlormequat results in decreased expression of ST7L protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:192,364,594...192,434,414
Ensembl chr 2:192,364,594...192,487,190
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G |
Star |
steroidogenic acute regulatory protein |
decreases expression |
EXP |
Chlormequat results in decreased expression of STAR protein |
CTD |
PMID:29447956 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stk26 |
serine/threonine kinase 26 |
increases expression |
EXP |
Chlormequat results in increased expression of STK26 protein |
CTD |
PMID:34958886 |
|
NCBI chr X:130,310,855...130,375,677
Ensembl chr X:130,310,885...130,374,291
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G |
Susd2 |
sushi domain containing 2 |
increases expression |
EXP |
Chlormequat results in increased expression of SUSD2 protein |
CTD |
PMID:34958886 |
|
NCBI chr20:13,017,468...13,024,903
Ensembl chr20:13,017,477...13,024,903
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G |
Taf7 |
TATA-box binding protein associated factor 7 |
increases expression |
EXP |
Chlormequat results in increased expression of TAF7 protein |
CTD |
PMID:34958886 |
|
NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
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G |
Tcaf1 |
TRPM8 channel-associated factor 1 |
increases expression |
EXP |
Chlormequat results in increased expression of TCAF1 protein |
CTD |
PMID:34958886 |
|
NCBI chr 4:71,589,674...71,639,309
Ensembl chr 4:71,591,200...71,613,309
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G |
Tceanc |
transcription elongation factor A N-terminal and central domain containing |
decreases expression |
EXP |
Chlormequat results in decreased expression of TCEANC protein |
CTD |
PMID:34958886 |
|
NCBI chr X:27,952,539...27,961,038
Ensembl chr X:27,952,457...27,960,940
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G |
Tent2 |
terminal nucleotidyltransferase 2 |
increases expression |
EXP |
Chlormequat results in increased expression of TENT2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:24,380,135...24,432,099
Ensembl chr 2:24,380,225...24,432,099
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G |
Them4 |
thioesterase superfamily member 4 |
decreases expression |
EXP |
Chlormequat results in decreased expression of THEM4 protein |
CTD |
PMID:34958886 |
|
NCBI chr 2:181,953,550...181,974,708
Ensembl chr 2:181,953,550...181,974,708
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G |
Thoc6 |
THO complex subunit 6 |
increases expression |
EXP |
Chlormequat results in increased expression of THOC6 protein |
CTD |
PMID:34958886 |
|
NCBI chr10:12,700,051...12,705,411
Ensembl chr10:12,700,051...12,706,925
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G |
Tirap |
TIR domain containing adaptor protein |
increases expression |
EXP |
Chlormequat results in increased expression of TIRAP protein |
CTD |
PMID:34958886 |
|
NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
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G |
Tkt |
transketolase |
increases expression |
EXP |
Chlormequat results in increased expression of TKT protein |
CTD |
PMID:34958886 |
|
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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G |
Tmem106c |
transmembrane protein 106C |
increases expression |
EXP |
Chlormequat results in increased expression of TMEM106C protein |
CTD |
PMID:34958886 |
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NCBI chr 7:129,088,468...129,094,128
Ensembl chr 7:129,088,498...129,094,130
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G |
Tmem184c |
transmembrane protein 184C |
decreases expression |
EXP |
Chlormequat results in decreased expression of TMEM184C protein |
CTD |
PMID:34958886 |
|
NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269
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G |
Tmem208 |
transmembrane protein 208 |
increases expression |
EXP |
Chlormequat results in increased expression of TMEM208 protein |
CTD |
PMID:34958886 |
|
NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183
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G |
Tmem222 |
transmembrane protein 222 |
increases expression |
EXP |
Chlormequat results in increased expression of TMEM222 protein |
CTD |
PMID:34958886 |
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NCBI chr 5:145,465,847...145,477,932
Ensembl chr 5:145,465,847...145,484,491
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G |
Tnfsf11 |
TNF superfamily member 11 |
affects expression |
EXP |
Chlormequat affects the expression of TNFSF11 mRNA |
CTD |
PMID:28214531 |
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NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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G |
Tp53i11 |
tumor protein p53 inducible protein 11 |
increases expression |
EXP |
Chlormequat results in increased expression of TP53I11 protein |
CTD |
PMID:34958886 |
|
NCBI chr 3:79,144,824...79,160,056
Ensembl chr 3:79,144,895...79,160,050
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G |
Tra2a |
transformer 2 alpha |
increases expression |
EXP |
Chlormequat results in increased expression of TRA2A protein |
CTD |
PMID:34958886 |
|
NCBI chr 4:78,220,838...78,239,737
Ensembl chr 4:78,220,883...78,239,712
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G |
Tram2 |
translocation associated membrane protein 2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of TRAM2 protein |
CTD |
PMID:34958886 |
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NCBI chr 9:23,419,204...23,498,745
Ensembl chr 9:23,424,232...23,498,689
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G |
Ttc12 |
tetratricopeptide repeat domain 12 |
increases expression |
EXP |
Chlormequat results in increased expression of TTC12 protein |
CTD |
PMID:34958886 |
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NCBI chr 8:49,799,916...49,847,940
Ensembl chr 8:49,799,920...49,847,087
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G |
Ube2d1 |
ubiquitin-conjugating enzyme E2D 1 |
multiple interactions increases expression |
EXP |
4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of UBE2D1 protein] |
CTD |
PMID:34958886 |
|
NCBI chr20:17,309,315...17,343,770
Ensembl chr20:17,309,315...17,342,295
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G |
Ucp2 |
uncoupling protein 2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of UCP2 protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Wdr74 |
WD repeat domain 74 |
increases expression |
EXP |
Chlormequat results in increased expression of WDR74 protein |
CTD |
PMID:34958886 |
|
NCBI chr 1:205,631,769...205,636,563
Ensembl chr 1:205,631,824...205,636,563
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G |
Wsb2 |
WD repeat and SOCS box-containing 2 |
decreases expression |
EXP |
Chlormequat results in decreased expression of WSB2 protein |
CTD |
PMID:34958886 |
|
NCBI chr12:39,217,645...39,238,667
Ensembl chr12:39,217,648...39,238,640
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G |
Zeb1 |
zinc finger E-box binding homeobox 1 |
increases expression |
EXP |
Chlormequat results in increased expression of ZEB1 protein |
CTD |
PMID:34958886 |
|
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases response to substance |
ISO |
ABCC1 protein results in decreased susceptibility to Chlorpropham |
CTD |
PMID:12765240 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Chlorpropham binds to and results in increased activity of AHR protein |
CTD |
PMID:18835618 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ar |
androgen receptor |
increases expression multiple interactions |
ISO |
Chlorpropham results in increased expression of AR mRNA Chlorpropham inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] |
CTD |
PMID:21310686 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25028461 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
[Maleic Hydrazide co-treated with Chlorpropham] results in increased activity of NR1I2 protein; Chlorpropham binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 PMID:25028461 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Chlorpropham binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 |
CTD |
PMID:26359731 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
A2m |
alpha-2-macroglobulin |
increases expression |
ISO |
Diclofenac results in increased expression of A2M mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
A2ml1 |
alpha-2-macroglobulin-like 1 |
increases expression |
ISO |
Diclofenac results in increased expression of A2ML1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:161,815,111...161,857,286
Ensembl chr 4:161,814,708...161,857,343
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G |
Aacs |
acetoacetyl-CoA synthetase |
decreases expression |
ISO |
Diclofenac results in decreased expression of AACS mRNA |
CTD |
PMID:26934552 |
|
NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AARS mRNA |
CTD |
PMID:35537566 |
|
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Diclofenac results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 PMID:28437613 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases response to substance decreases activity increases expression |
ISO |
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac Diclofenac results in decreased activity of ABCB1A protein Diclofenac results in increased expression of ABCB1B mRNA |
CTD |
PMID:15458769 PMID:19022234 PMID:28193520 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, subfamily B (MDR/TAP), member 1B |
decreases expression |
EXP |
Diclofenac results in decreased expression of ABCB1B mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression decreases activity |
ISO |
Diclofenac results in decreased expression of ABCB4 mRNA Diclofenac results in decreased activity of ABCB4 protein |
CTD |
PMID:19022234 PMID:28437613 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions increases expression |
ISO EXP |
Diclofenac results in decreased activity of ABCC2 protein ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac Diclofenac results in increased expression of ABCC2 mRNA |
CTD |
PMID:19022234 PMID:22646477 PMID:25450747 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
affects expression |
ISO |
Diclofenac affects the expression of ABCC4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abl2 |
ABL proto-oncogene 2, non-receptor tyrosine kinase |
affects expression |
ISO |
Diclofenac affects the expression of ABL2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr13:68,673,702...68,839,742
Ensembl chr13:68,673,722...68,839,742
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G |
Ace2 |
angiotensin I converting enzyme 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acin1 |
apoptotic chromatin condensation inducer 1 |
affects expression |
ISO |
Diclofenac affects the expression of ACIN1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
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G |
Ackr3 |
atypical chemokine receptor 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ACKR3 mRNA |
CTD |
PMID:19192274 |
|
NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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G |
Acot2 |
acyl-CoA thioesterase 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ACOT2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
Diclofenac results in increased expression of ACOX1 mRNA |
CTD |
PMID:19022234 |
|
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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G |
Acp3 |
acid phosphatase 3 |
increases expression |
ISO |
Diclofenac results in increased expression of ACPP mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
affects expression |
ISO |
Diclofenac affects the expression of ACTA1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
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G |
Actn1 |
actinin, alpha 1 |
affects expression |
EXP |
Diclofenac affects the expression of ACTN1 mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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G |
Acvr1 |
activin A receptor type 1 |
affects expression |
ISO |
Diclofenac affects the expression of ACVR1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
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G |
Acvr1b |
activin A receptor type 1B |
affects expression |
ISO |
Diclofenac affects the expression of ACVR1B mRNA |
CTD |
PMID:24752500 |
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NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673
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G |
Acvr2b |
activin A receptor type 2B |
affects expression |
ISO |
Diclofenac affects the expression of ACVR2B mRNA |
CTD |
PMID:24752500 |
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NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
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G |
Adamdec1 |
ADAM-like, decysin 1 |
increases expression |
ISO |
Diclofenac results in increased expression of ADAMDEC1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr15:42,900,629...42,923,136
Ensembl chr15:42,900,636...42,921,712
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G |
Adcy6 |
adenylate cyclase 6 |
affects expression |
ISO |
Diclofenac affects the expression of ADCY6 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
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G |
Adcy9 |
adenylate cyclase 9 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of ADCY9 mRNA Diclofenac results in decreased expression of ADCY9 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
|
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Adh1 |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
increases expression |
EXP |
Diclofenac results in increased expression of ADH1 protein |
CTD |
PMID:25772430 |
|
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Adh7 |
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
decreases expression |
ISO |
Diclofenac results in decreased expression of ADH7 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
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G |
Adk |
adenosine kinase |
increases expression decreases expression |
ISO EXP |
Diclofenac results in increased expression of ADK mRNA Diclofenac results in decreased expression of ADK mRNA |
CTD |
PMID:19022234 |
|
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
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G |
Adora2a |
adenosine A2a receptor |
increases expression |
ISO |
Diclofenac results in increased expression of ADORA2A mRNA |
CTD |
PMID:26934552 |
|
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adora2b |
adenosine A2B receptor |
increases expression |
ISO |
Diclofenac results in increased expression of ADORA2B mRNA |
CTD |
PMID:26934552 |
|
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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G |
Adrb2 |
adrenoceptor beta 2 |
increases expression |
ISO |
Diclofenac results in increased expression of ADRB2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
Diclofenac results in increased expression of AEN mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Ager |
advanced glycosylation end product-specific receptor |
increases expression |
ISO |
Diclofenac results in increased expression of AGER mRNA |
CTD |
PMID:24747151 PMID:28138970 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Aggf1 |
angiogenic factor with G patch and FHA domains 1 |
affects expression |
ISO |
Diclofenac affects the expression of AGGF1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:26,619,336...26,646,050
Ensembl chr 2:26,619,339...26,645,952
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G |
Ago2 |
argonaute RISC catalytic component 2 |
affects expression |
ISO |
Diclofenac affects the expression of AGO2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
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G |
Ago3 |
argonaute RISC catalytic component 3 |
affects expression |
ISO |
Diclofenac affects the expression of AGO3 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
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G |
Ago4 |
argonaute RISC component 4 |
affects expression |
ISO |
Diclofenac affects the expression of AGO4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:138,780,450...138,825,889
Ensembl chr 5:138,783,069...138,825,632
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G |
Agrp |
agouti related neuropeptide |
increases expression |
EXP |
Diclofenac results in increased expression of AGRP mRNA |
CTD |
PMID:30723492 |
|
NCBI chr19:33,447,992...33,523,068
Ensembl chr19:33,447,992...33,449,584
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
Diclofenac results in increased expression of AHR mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ahsg |
alpha-2-HS-glycoprotein |
multiple interactions |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein |
CTD |
PMID:25772430 |
|
NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects expression |
ISO |
Diclofenac affects the expression of AIFM1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Aim2 |
absent in melanoma 2 |
increases expression |
ISO |
Diclofenac results in increased expression of AIM2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
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G |
Akna |
AT-hook transcription factor |
decreases expression |
ISO |
Diclofenac results in decreased expression of AKNA mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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G |
Akt1 |
AKT serine/threonine kinase 1 |
affects expression |
ISO |
Diclofenac affects the expression of AKT1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
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G |
Akt2 |
AKT serine/threonine kinase 2 |
affects expression |
ISO |
Diclofenac affects the expression of AKT2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
|
|
G |
Alas1 |
5'-aminolevulinate synthase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ALAS1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
|
|
G |
Alas2 |
5'-aminolevulinate synthase 2 |
affects expression |
ISO |
Diclofenac affects the expression of ALAS2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
|
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G |
Alb |
albumin |
affects binding multiple interactions decreases expression increases expression |
ISO EXP |
Diclofenac binds to ALB protein [Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein] Diclofenac results in decreased expression of ALB protein Diclofenac results in increased expression of ALB mRNA |
CTD |
PMID:9353694 PMID:19022234 PMID:28400101 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression decreases expression |
ISO |
Diclofenac results in increased expression of ALDH18A1 mRNA Diclofenac results in decreased expression of ALDH18A1 mRNA |
CTD |
PMID:26934552 PMID:35537566 |
|
NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
|
|
G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
increases expression |
ISO |
Diclofenac results in increased expression of ALDH1B1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
|
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G |
Aldh1l2 |
aldehyde dehydrogenase 1 family, member L2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ALDH1L2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ALDH3A2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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Aldoc |
aldolase, fructose-bisphosphate C |
increases expression |
EXP |
Diclofenac results in increased expression of ALDOC mRNA |
CTD |
PMID:30723492 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alox15 |
arachidonate 15-lipoxygenase |
increases expression |
EXP |
Diclofenac results in increased expression of ALOX15 mRNA |
CTD |
PMID:23939143 |
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NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Amh |
anti-Mullerian hormone |
increases expression |
ISO |
Diclofenac results in increased expression of AMH mRNA |
CTD |
PMID:35537566 |
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NCBI chr 7:8,906,776...8,909,184
Ensembl chr 7:8,906,836...8,909,282
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G |
Amotl2 |
angiomotin like 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AMOTL2 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
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G |
Ang |
angiogenin |
increases expression |
ISO |
Diclofenac results in increased expression of ANG mRNA |
CTD |
PMID:26934552 |
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NCBI chr15:24,317,733...24,323,361
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G |
Aoc3 |
amine oxidase, copper containing 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AOC3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:86,272,757...86,280,702
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
affects expression |
ISO |
Diclofenac affects the expression of APAF1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apcs |
amyloid P component, serum |
multiple interactions increases expression |
EXP ISO |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein |
CTD |
PMID:25772430 PMID:26934552 |
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NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
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G |
Apoa4 |
apolipoprotein A4 |
affects expression |
ISO |
Diclofenac affects the expression of APOA4 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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G |
Aqp2 |
aquaporin 2 |
decreases expression |
EXP |
Diclofenac results in decreased expression of AQP2 protein |
CTD |
PMID:15579502 |
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NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
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G |
Aqp9 |
aquaporin 9 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AQP9 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
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