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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:plant growth retardant
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Accession:CHEBI:35219 term browser browse the term
Synonyms:related_synonym: plant growth inhibitor;   plant growth inhibitors;   plant growth retardants
 alt_id: CHEBI:26154;   CHEBI:26156


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(2,4,5-trichlorophenoxy)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA CTD PMID:18579281 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA CTD PMID:9210621 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 protein
Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA]
CTD PMID:10377250, PMID:16426233 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACAP3 mRNA CTD PMID:18579281 NCBI chr 5:173,340,060...173,354,756
Ensembl chr 5:173,340,060...173,354,755
JBrowse link
G Acer2 alkaline ceramidase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACER2 mRNA CTD PMID:18579281 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Adgrb2 adhesion G protein-coupled receptor B2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADGRB2 mRNA CTD PMID:18579281 NCBI chr 5:148,168,530...148,231,587
Ensembl chr 5:148,193,710...148,231,587
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA CTD PMID:18579281 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Alpi alkaline phosphatase, intestinal decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ALPI mRNA CTD PMID:18579281 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Ar androgen receptor affects binding EXP 2,4,5-Trichlorophenoxyacetic Acid binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgap32 Rho GTPase activating protein 32 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARHGAP32 mRNA CTD PMID:18579281 NCBI chr 8:33,131,874...33,392,198
Ensembl chr 8:33,239,139...33,392,305
JBrowse link
G Arsg arylsulfatase G increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA CTD PMID:18579281 NCBI chr10:97,722,550...97,859,975
Ensembl chr10:97,771,264...97,863,311
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of BASP1 mRNA CTD PMID:18579281 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G C1qtnf4 C1q and TNF related 4 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of C1QTNF4 mRNA CTD PMID:18579281 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CACNB3 mRNA CTD PMID:18579281 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CAMK1D mRNA CTD PMID:18579281 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Capn6 calpain 6 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CAPN6 mRNA CTD PMID:18579281 NCBI chr  X:115,049,113...115,073,824
Ensembl chr  X:115,049,154...115,073,890
JBrowse link
G Cdh1 cadherin 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA CTD PMID:18579281 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CIRBP mRNA CTD PMID:18579281 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Ckm creatine kinase, M-type increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA CTD PMID:18579281 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA CTD PMID:18579281 NCBI chr 5:62,840,360...62,950,240 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP7B1 mRNA CTD PMID:18579281 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Ddc dopa decarboxylase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA CTD PMID:18579281 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of EEPD1 mRNA CTD PMID:18579281 NCBI chr 8:26,651,241...26,758,330
Ensembl chr 8:26,652,121...26,758,325
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein CTD PMID:3032197 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein CTD PMID:3032197 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Far1 fatty acyl CoA reductase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FAR1 mRNA CTD PMID:18579281 NCBI chr 1:178,351,674...178,412,838
Ensembl chr 1:178,351,680...178,431,395
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA CTD PMID:18579281 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FMO2 mRNA CTD PMID:18579281 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of G0S2 mRNA CTD PMID:18579281 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBF1 mRNA CTD PMID:18579281 NCBI chr 1:265,904,616...266,033,107
Ensembl chr 1:265,904,566...266,033,156
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
CTD PMID:10377250, PMID:16426233 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GDE1 mRNA CTD PMID:18579281 NCBI chr 1:188,367,550...188,407,125
Ensembl chr 1:188,394,814...188,407,132
JBrowse link
G Gfra1 GDNF family receptor alpha 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA CTD PMID:18579281 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Git2 GIT ArfGAP 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA CTD PMID:18579281 NCBI chr12:47,590,110...47,630,991
Ensembl chr12:47,590,154...47,631,119
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GMPPB mRNA CTD PMID:18579281 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GOT1 mRNA CTD PMID:18579281 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpm6a glycoprotein m6a decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPM6A mRNA CTD PMID:18579281 NCBI chr16:39,367,697...39,719,292
Ensembl chr16:39,367,692...39,719,187
JBrowse link
G Gpr12 G protein-coupled receptor 12 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA CTD PMID:18579281 NCBI chr12:10,253,710...10,257,135
Ensembl chr12:10,254,951...10,257,130
JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPR85 mRNA CTD PMID:18579281 NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349
JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HAPLN1 mRNA CTD PMID:18579281 NCBI chr 2:18,354,542...18,419,077
Ensembl chr 2:18,354,542...18,419,071
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HMOX1 mRNA CTD PMID:18579281 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPA8 mRNA CTD PMID:18579281 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA CTD PMID:18579281 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA CTD PMID:18579281 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IDO2 mRNA CTD PMID:18579281 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA CTD PMID:18579281 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA CTD PMID:18579281 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA CTD PMID:18579281 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Insc INSC, spindle orientation adaptor protein increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of INSC mRNA CTD PMID:18579281 NCBI chr 1:184,299,200...184,407,487
Ensembl chr 1:184,299,250...184,407,480
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA CTD PMID:18579281 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Limch1 LIM and calponin homology domains 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA CTD PMID:18579281 NCBI chr14:42,760,363...43,072,976
Ensembl chr14:42,762,587...43,072,843
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LMCD1 mRNA CTD PMID:18579281 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G LOC102547963 leucine-rich repeat and transmembrane domain-containing protein 1-like increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:5,078,506...5,089,888
Ensembl chr16:5,082,239...5,087,844
JBrowse link
G LOC103690086 uncharacterized LOC103690086 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBP9 mRNA CTD PMID:18579281 NCBI chr14:5,642,357...5,646,406 JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPAR4 mRNA CTD PMID:18579281 NCBI chr  X:78,042,859...78,056,347
Ensembl chr  X:78,042,859...78,056,347
JBrowse link
G Lpin1 lipin 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPIN1 mRNA CTD PMID:18579281 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lrtm1 leucine-rich repeats and transmembrane domains 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:4,993,728...5,005,110
Ensembl chr16:4,997,461...5,003,066
JBrowse link
G Matk megakaryocyte-associated tyrosine kinase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MATK mRNA CTD PMID:18579281 NCBI chr 7:11,325,246...11,334,311
Ensembl chr 7:11,325,254...11,330,278
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MPDZ mRNA CTD PMID:18579281 NCBI chr 5:99,413,184...99,566,356
Ensembl chr 5:99,413,187...99,566,318
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT1 mRNA CTD PMID:18579281 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt4 metallothionein 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT4 mRNA CTD PMID:18579281 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA CTD PMID:18579281 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mybph myosin binding protein H increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MYBPH mRNA CTD PMID:18579281 NCBI chr13:51,034,228...51,041,903
Ensembl chr13:51,034,256...51,041,902
JBrowse link
G Ndrg4 NDRG family member 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA CTD PMID:18579281 NCBI chr19:9,766,439...9,802,396
Ensembl chr19:9,766,439...9,801,942
JBrowse link
G Nip7 nucleolar pre-rRNA processing protein NIP7 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NIP7 mRNA CTD PMID:18579281 NCBI chr19:39,257,586...39,259,728
Ensembl chr19:39,257,586...39,259,728
JBrowse link
G Nrg4 neuregulin 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA CTD PMID:18579281 NCBI chr 8:59,782,789...59,849,433
Ensembl chr 8:59,782,974...59,849,490
JBrowse link
G Ogn osteoglycin decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of OGN mRNA CTD PMID:18579281 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Olr346 olfactory receptor 346 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of OLFR1451 mRNA CTD PMID:18579281 NCBI chr 1:229,849,892...229,850,818
Ensembl chr 1:229,849,892...229,850,818
JBrowse link
G Pdzd3 PDZ domain containing 3 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PDZD3 mRNA CTD PMID:18579281 NCBI chr 8:48,577,905...48,582,353
Ensembl chr 8:48,577,952...48,582,353
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA CTD PMID:18579281 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Plin4 perilipin 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PLIN4 mRNA CTD PMID:18579281 NCBI chr 9:10,963,494...10,972,360
Ensembl chr 9:10,963,723...10,971,277
JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA CTD PMID:18579281 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppfibp1 PPFIA binding protein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPFIBP1 mRNA CTD PMID:18579281 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA CTD PMID:18579281 NCBI chr 4:41,171,486...41,212,116
Ensembl chr 4:41,171,486...41,212,072
JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3G mRNA CTD PMID:18579281 NCBI chr17:29,566,032...29,570,294
Ensembl chr17:29,567,404...29,568,447
JBrowse link
G Prok1 prokineticin 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA CTD PMID:18579281 NCBI chr 2:209,986,503...209,994,438
Ensembl chr 2:209,987,992...209,993,250
JBrowse link
G Prr9 proline rich 9 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PRR9 mRNA CTD PMID:18579281 NCBI chr 2:192,025,457...192,036,073
Ensembl chr 2:192,025,875...192,027,225
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PTP4A1 mRNA CTD PMID:18579281 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Retreg1 reticulophagy regulator 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA CTD PMID:18579281 NCBI chr 2:78,391,921...78,401,569
Ensembl chr 2:78,391,921...78,399,987
JBrowse link
G Rprd1a regulation of nuclear pre-mRNA domain containing 1A decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RPRD1A mRNA CTD PMID:18579281 NCBI chr18:16,450,160...16,497,913
Ensembl chr18:16,453,369...16,497,886
JBrowse link
G Selenop selenoprotein P decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SELENOP mRNA CTD PMID:18579281 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Sema3c semaphorin 3C decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA CTD PMID:18579281 NCBI chr 4:14,318,276...14,490,438
Ensembl chr 4:14,318,274...14,490,446
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA CTD PMID:18579281 NCBI chr 3:159,361,313...159,385,843
Ensembl chr 3:159,368,273...159,384,775
JBrowse link
G Slc24a2 solute carrier family 24 member 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA CTD PMID:18579281 NCBI chr 5:105,336,287...105,579,959
Ensembl chr 5:105,336,262...105,582,375
JBrowse link
G Slc25a32 solute carrier family 25 member 32 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA CTD PMID:18579281 NCBI chr 7:77,983,885...78,005,058
Ensembl chr 7:77,987,212...78,004,975
JBrowse link
G Slc66a1 solute carrier family 66 member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC66A1 mRNA CTD PMID:18579281 NCBI chr 5:157,744,945...157,759,370
Ensembl chr 5:157,745,490...157,759,322
JBrowse link
G Slc6a15 solute carrier family 6 member 15 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC6A15 mRNA CTD PMID:18579281 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Snx7 sorting nexin 7 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SNX7 mRNA CTD PMID:18579281 NCBI chr 2:221,015,302...221,099,810
Ensembl chr 2:221,015,310...221,099,738
JBrowse link
G Spon2 spondin 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SPON2 mRNA CTD PMID:18579281 NCBI chr14:82,815,158...82,824,529
Ensembl chr14:82,818,663...82,824,599
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA CTD PMID:18579281 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Svil supervillin increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA CTD PMID:18579281 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Tacc2 transforming, acidic coiled-coil containing protein 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TACC2 mRNA CTD PMID:18579281 NCBI chr 1:201,140,264...201,329,612
Ensembl chr 1:201,055,644...201,329,622
JBrowse link
G Tbc1d8 TBC1 domain family, member 8 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA CTD PMID:18579281 NCBI chr 9:46,090,613...46,206,672
Ensembl chr 9:46,090,019...46,206,605
JBrowse link
G Tcea2 transcription elongation factor A2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TCEA2 mRNA CTD PMID:18579281 NCBI chr 3:177,187,686...177,195,898
Ensembl chr 3:177,188,044...177,195,894
JBrowse link
G Thra thyroid hormone receptor alpha increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of THRA mRNA CTD PMID:18579281 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2,4,5-Trichlorophenoxyacetic Acid binds to THRB protein CTD PMID:27410513 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tom1l2 target of myb1 like 2 membrane trafficking protein decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TOM1L2 mRNA CTD PMID:18579281 NCBI chr10:46,599,392...46,720,921
Ensembl chr10:46,602,231...46,720,910
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA CTD PMID:18579281 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tril TLR4 interactor with leucine-rich repeats decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TRIL mRNA CTD PMID:18579281 NCBI chr 4:83,967,695...83,972,540
Ensembl chr 4:83,967,696...83,972,540
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TSC22D1 mRNA CTD PMID:18579281 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of UGT2A3 mRNA CTD PMID:18579281 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA CTD PMID:18579281 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VCAM1 mRNA CTD PMID:18579281 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Veph1 ventricular zone expressed PH domain-containing 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of VEPH1 mRNA CTD PMID:18579281 NCBI chr 2:157,869,383...158,156,266
Ensembl chr 2:157,869,392...158,156,444
JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of WARS2 mRNA CTD PMID:18579281 NCBI chr 2:201,170,363...201,256,115
Ensembl chr 2:201,172,312...201,255,703
JBrowse link
(3,4-dihydroxyphenyl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta affects binding
multiple interactions
EXP 3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein
Catechin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]; epicatechin gallate inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]; Quercetin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]
CTD PMID:19743802 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP [3,4-Dihydroxyphenylacetic Acid co-treated with Glucose] results in increased phosphorylation of AKT1 protein
3,4-Dihydroxyphenylacetic Acid results in increased phosphorylation of AKT1 protein
CTD PMID:29981789 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cartpt CART prepropeptide increases abundance EXP CARTPT protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acid CTD PMID:15659233 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid] CTD PMID:11435997 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Comt catechol-O-methyltransferase increases methylation
multiple interactions
ISO
EXP
COMT protein results in increased methylation of 3,4-Dihydroxyphenylacetic Acid
[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid
CTD PMID:11160877, PMID:11793163, PMID:15190105, PMID:16012872 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP 3,4-Dihydroxyphenylacetic Acid results in increased expression of GSTP1 mRNA CTD PMID:19743802 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gys1 glycogen synthase 1 multiple interactions
decreases phosphorylation
EXP 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein]
3,4-Dihydroxyphenylacetic Acid results in decreased phosphorylation of GYS1 protein
CTD PMID:29981789 NCBI chr 1:101,427,195...101,447,092
Ensembl chr 1:101,427,195...101,447,092
JBrowse link
G Insr insulin receptor multiple interactions EXP 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; 3,4-Dihydroxyphenylacetic Acid results in increased expression of and results in increased phosphorylation of INSR protein CTD PMID:29981789 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid CTD PMID:16012872 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid] CTD PMID:11085313 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 3,4-Dihydroxyphenylacetic Acid results in increased expression of NQO1 mRNA CTD PMID:19743802 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases abundance ISO NR3C1 protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acid CTD PMID:11226678 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid] CTD PMID:8884884 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid CTD PMID:10318960 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Snca synuclein alpha decreases abundance ISO SNCA protein mutant form results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid CTD PMID:18622040 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Tfam transcription factor A, mitochondrial decreases abundance ISO TFAM gene mutant form results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid CTD PMID:28595911 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
(4-chloro-2-methylphenoxy)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcnka chloride voltage-gated channel Ka decreases activity EXP 2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKA protein CTD PMID:15167890 NCBI chr 5:159,931,497...159,946,483
Ensembl chr 5:159,931,511...159,946,446
JBrowse link
G Clcnkb chloride voltage-gated channel Kb decreases activity EXP 2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKB protein CTD PMID:15167890 NCBI chr 5:159,950,384...159,973,576
Ensembl chr 5:159,950,392...159,962,676
JBrowse link
G Slc1a2 solute carrier family 1 member 2 affects expression EXP 2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 protein CTD PMID:16019039 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Tnf tumor necrosis factor increases expression ISO 2-Methyl-4-chlorophenoxyacetic Acid results in increased expression of TNF protein CTD PMID:10883730 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
(4-nitrophenyl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of 4-nitrophenylacetic acid CTD PMID:11950785 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-nitrophenylacetic acid CTD PMID:11950785 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
(S)-atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
2,4-D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA CTD PMID:9210621 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Alb albumin affects binding ISO 2,4-Dichlorophenoxyacetic Acid binds to ALB protein CTD PMID:9877224, PMID:11451446 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein] CTD PMID:16107550 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccdc120 coiled-coil domain containing 120 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CCDC120 mRNA CTD PMID:15878651 NCBI chr  X:15,610,230...15,616,727
Ensembl chr  X:15,598,652...15,617,665
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein CTD PMID:19467290 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL2 protein CTD PMID:19467290 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein CTD PMID:19467290 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cldn1 claudin 1 decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 protein CTD PMID:28699141 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Clk1 CDC-like kinase 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLK1 mRNA CTD PMID:15878651 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein CTD PMID:18460445 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Crat carnitine O-acetyltransferase increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of CRAT protein CTD PMID:1755024 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 protein
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]
CTD PMID:29633193 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression ISO 2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA CTD PMID:26838045 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A1 mRNA CTD PMID:10910964 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A2 mRNA CTD PMID:10910964 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1B1 mRNA CTD PMID:10910964 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Dbh dopamine beta-hydroxylase decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein CTD PMID:16931444 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Dclre1c DNA cross-link repair 1C increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNA CTD PMID:15878651 NCBI chr17:78,782,512...78,812,140
Ensembl chr17:78,783,437...78,812,111
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA CTD PMID:15878651 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein CTD PMID:3032197 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein CTD PMID:1755024, PMID:3032197 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
ISO PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA]
2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 protein
CTD PMID:29633193 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of FTH1 mRNA CTD PMID:15878651 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA CTD PMID:15878651 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR CTD PMID:26838045 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCS1 CTD PMID:26838045 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Ifng interferon gamma increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IFNG CTD PMID:20728597 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNA CTD PMID:15878651 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il2 interleukin 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2 CTD PMID:20728597 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA CTD PMID:20728597 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein
2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein
CTD PMID:19467290 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL5 protein CTD PMID:19467290 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein CTD PMID:19467290 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ldha lactate dehydrogenase A decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA protein CTD PMID:23538319 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Mbp myelin basic protein decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of MBP protein CTD PMID:18460445 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO 2,4-Dichlorophenoxyacetic Acid results in decreased methylation of MYC promoter CTD PMID:11857776 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ocln occludin decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of OCLN mRNA CTD PMID:28699141 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases secretion EXP 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein CTD PMID:20122984 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of PCNA mRNA CTD PMID:15878651 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM protein CTD PMID:23538319 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases response to substance ISO PPARA protein results in increased susceptibility to 2,4-Dichlorophenoxyacetic Acid CTD PMID:26838045 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
increases expression
ISO PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]; PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA]
2,4-Dichlorophenoxyacetic Acid results in increased expression of PPARB mRNA
CTD PMID:29633193 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Prl prolactin decreases secretion EXP 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of PRL protein CTD PMID:20122984 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA CTD PMID:15878651 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Slc16a3 solute carrier family 16 member 3 decreases expression
increases expression
EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC16A3 mRNA
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC16A3 mRNA
CTD PMID:23538319 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid] CTD PMID:15284287 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:221,327,608...221,344,367
Ensembl chr 1:221,328,711...221,343,889
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
multiple interactions
EXP
ISO
SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid
p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]
CTD PMID:16857889, PMID:17255469 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression
increases expression
EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA
CTD PMID:23538319 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Th tyrosine hydroxylase increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein CTD PMID:16931444 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2,4-Dichlorophenoxyacetic Acid binds to THRB protein CTD PMID:27410513 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 protein CTD PMID:28699141 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF CTD PMID:20728597 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Usp19 ubiquitin specific peptidase 19 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of USP19 mRNA CTD PMID:15878651 NCBI chr 8:117,280,690...117,291,729
Ensembl chr 8:117,280,705...117,291,351
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of VEGFA mRNA CTD PMID:15878651 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
2,6-diisopropylnaphthalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO 2,6-diisopropylnaphthalene binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 2,6-diisopropylnaphthalene binds to and results in increased activity of ESR2 protein CTD PMID:27633901 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 2,6-diisopropylnaphthalene binds to and results in increased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 2,6-diisopropylnaphthalene binds to and results in increased activity of THRB protein CTD PMID:27633901 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
2-(4-hydroxyphenyl)ethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC protein] CTD PMID:25641191 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-hydroxyphenylethanol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] CTD PMID:18081942 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
4'-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4'-hydroxydiclofenac results in increased expression of CCL2 mRNA CTD PMID:24104198 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO 4'-hydroxydiclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation
multiple interactions
ISO GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:24246759, PMID:24552538 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] CTD PMID:29777833 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] CTD PMID:29777833 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] CTD PMID:29777833 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] CTD PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac CTD PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein CTD PMID:29777833 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions
EXP
ISO
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
CTD PMID:23939143, PMID:29777833 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
5-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
aceclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to aceclofenac CTD PMID:12147693 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA
CTD PMID:15555568, PMID:18076062 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Sell selectin L decreases expression ISO aceclofenac results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
acteoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases localization
ISO acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein
CTD PMID:21756928 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO acteoside results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
decreases secretion
ISO acteoside results in decreased expression of CCL2 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased secretion of CCL2 protein
CTD PMID:21756928, PMID:21967610 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO acteoside results in decreased expression of CCND1 protein CTD PMID:17634406 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO acteoside results in decreased expression of CCND2 protein CTD PMID:17634406 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO acteoside results in decreased expression of CCND3 protein CTD PMID:17634406 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acteoside results in decreased expression of CCNE1 protein CTD PMID:17634406 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO acteoside results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:17634406 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity
multiple interactions
ISO acteoside results in decreased activity of CDK4 protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
CTD PMID:17634406 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein CTD PMID:17634406 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
decreases expression
multiple interactions
ISO acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21756928, PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO acteoside results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:14672760 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
CTD PMID:21756928, PMID:21967610 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of ICAM1 mRNA CTD PMID:21371465 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
CTD PMID:21371465, PMID:21756928 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA
CTD PMID:21756928 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein
CTD PMID:21756928, PMID:23527233 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein
CTD PMID:21756928, PMID:23527233 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nox1 NADPH oxidase 1 decreases activity ISO acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO acteoside binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA CTD PMID:21756928 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]
CTD PMID:17634406 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein
CTD PMID:21756928, PMID:23527233 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO acteoside results in decreased expression of SOD2 mRNA CTD PMID:21371465 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928, PMID:21967610 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO acteoside results in increased expression of TGFB1 mRNA CTD PMID:17634406 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of VCAM1 mRNA CTD PMID:21371465 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428, PMID:10421444, PMID:17963125, PMID:20105433, PMID:21600273, PMID:21787676, PMID:22783142, PMID:23047022, PMID:24881594, PMID:26751814, PMID:31794810 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP
ISO
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125, PMID:22981459 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions EXP Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity EXP Atropine affects the activity of CALCA protein CTD PMID:7906887, PMID:10075105 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 increases expression EXP Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna1 cyclin A1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611, PMID:18316702, PMID:31830555 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916, PMID:20708676, PMID:31830555 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] CTD PMID:16709648 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
ISO
EXP
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544, PMID:21791372 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO
EXP
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544, PMID:21791372 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP
ISO
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
CTD PMID:12039681, PMID:12906840 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr10:56,609,810...56,619,269
Ensembl chr10:56,610,051...56,619,269
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Ezr ezrin multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7968354, PMID:8281324, PMID:21787676, PMID:21971501 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression
multiple interactions
ISO Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Nefh neurofilament heavy affects expression EXP Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444, PMID:16944022 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch4 notch receptor 4 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Nppa natriuretic peptide A affects activity EXP Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions EXP Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pnoc prepronociceptin multiple interactions EXP Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355, PMID:15610444, PMID:16259740, PMID:16804302 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rac3 Rac family small GTPase 3 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr10:109,903,920...109,906,596
Ensembl chr10:109,904,259...109,906,232
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091, PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091, PMID:21599003, PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Spn sialophorin increases response to substance ISO SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] CTD PMID:12762645 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trio trio Rho guanine nucleotide exchange factor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] CTD PMID:17390078 NCBI chr 2:80,471,398...80,769,313
Ensembl chr 2:80,473,202...80,667,481
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atropine CTD PMID:29627347 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] CTD PMID:22245128 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
carbaryl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]
[Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein
CTD PMID:4859365, PMID:7713347, PMID:14644616, PMID:16256972, PMID:19934164, PMID:21251949, PMID:23418109, PMID:23962483, PMID:25707986 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases activity EXP Carbaryl results in decreased activity of AGXT protein CTD PMID:2119399 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein] CTD PMID:9169082, PMID:9853009, PMID:17553063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
EXP
ISO
ALB protein results in increased hydrolysis of Carbaryl
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl]
CTD PMID:27665777 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor affects binding EXP Carbaryl binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP Carbaryl results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein
CTD PMID:20708061, PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO Carbaryl results in decreased expression of BCL2L11 mRNA CTD PMID:27829164 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Casp3 caspase 3 increases expression EXP Carbaryl results in increased expression of CASP3 CTD PMID:27296064 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Carbaryl results in decreased expression of CEBPA mRNA CTD PMID:27829164 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
increases expression
ISO
EXP
Carbaryl results in increased activity of CYP1A1 protein
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein
CTD PMID:9169082, PMID:9858662, PMID:11226373 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases expression
ISO
EXP
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]
Carbaryl results in decreased activity of CYP1A2 protein
Carbaryl results in increased expression of CYP1A2 protein
CTD PMID:9858662, PMID:16790556 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO Carbaryl results in increased activity of CYP2B6 protein
Carbaryl results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Carbaryl results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Carbaryl results in increased expression of DDIT3 mRNA CTD PMID:11226373 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Carbaryl results in increased expression of DNAJB4 mRNA CTD PMID:27829164 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Carbaryl results in increased expression of DNAJB9 mRNA CTD PMID:27829164 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Carbaryl results in increased expression of DNAJC3 mRNA CTD PMID:27829164 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Carbaryl results in decreased expression of E2F5 mRNA CTD PMID:27829164 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Carbaryl results in decreased expression of ENC1 mRNA CTD PMID:27829164 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867, PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Carbaryl binds to and results in decreased activity of ESR2 protein
Carbaryl results in decreased expression of ESR2 mRNA
CTD PMID:16626760, PMID:27829164 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Carbaryl results in increased expression of FOS mRNA
Carbaryl results in decreased expression of FOS mRNA
CTD PMID:11226373, PMID:27829164 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Carbaryl results in decreased expression of FOXO1 mRNA CTD PMID:27829164 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone] CTD PMID:16413094 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP Carbaryl results in increased activity of G6PD protein
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
CTD PMID:27214522 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Carbaryl results in decreased expression of GADD45B mRNA CTD PMID:27829164 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Carbaryl results in increased expression of GCLM mRNA CTD PMID:27829164 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Carbaryl results in increased expression of GPX5 mRNA CTD PMID:27829164 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Carbaryl results in increased expression of HERPUD1 mRNA CTD PMID:27829164 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbaryl results in increased expression of HMOX1 mRNA CTD PMID:27829164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Carbaryl results in increased expression of HSPA5 mRNA CTD PMID:11226373, PMID:27829164 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:15907790, PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Carbaryl results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Carbaryl results in decreased expression of MITF mRNA CTD PMID:27829164 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions
ISO Carbaryl binds to MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]
CTD PMID:28027439 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions
ISO Carbaryl binds to MTNR1B protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]
CTD PMID:28027439 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nefh neurofilament heavy increases phosphorylation ISO Carbaryl results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:15907790, PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity
ISO
EXP
Carbaryl results in increased expression of NR1I2 mRNA
Carbaryl results in increased activity of NR1I2 protein
CTD PMID:22310298, PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP Carbaryl results in increased activity of NR1I3 protein CTD PMID:27665777 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity EXP Carbaryl results in decreased activity of PNPLA6 protein CTD PMID:7713347 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Carbaryl results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15907790 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
Carbaryl results in decreased expression of STAR mRNA
CTD PMID:16413094 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO
EXP
Carbaryl results in decreased activity of TDO2 protein CTD PMID:2119399, PMID:2547861 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Carbaryl results in increased expression of TGFB2 mRNA CTD PMID:27829164 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
ISO Carbaryl binds to and results in decreased activity of THRB protein
Carbaryl binds to THRB protein
CTD PMID:18584933, PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tpo thyroid peroxidase increases activity ISO Carbaryl results in increased activity of TPO protein CTD PMID:21809831 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Wnt6 Wnt family member 6 decreases expression ISO Carbaryl results in decreased expression of WNT6 mRNA CTD PMID:27829164 NCBI chr 9:82,033,543...82,047,172
Ensembl chr 9:82,033,543...82,047,166
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Carbaryl results in increased expression of XBP1 mRNA CTD PMID:27829164 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
chlormequat chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Chlormequat promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Chlormequat results in decreased expression of BGLAP protein CTD PMID:28214531 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Chlormequat results in decreased expression of CYP11A1 protein CTD PMID:29447956 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Chlormequat results in increased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Gh1 growth hormone 1 increases expression EXP Chlormequat results in increased expression of GH1 protein CTD PMID:31704167, PMID:32622971 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Ghr growth hormone receptor decreases expression EXP Chlormequat results in decreased expression of GHR mRNA CTD PMID:28214531 NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638
JBrowse link
G Ghrh growth hormone releasing hormone increases expression EXP Chlormequat results in increased expression of GHRH protein CTD PMID:32622971 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression EXP Chlormequat results in increased expression of GNRH1 protein CTD PMID:29447956 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Chlormequat results in decreased expression of HSD3B1 protein CTD PMID:29447956
G Igf1 insulin-like growth factor 1 affects expression
increases expression
EXP Chlormequat affects the expression of IGF1 protein
Chlormequat results in increased expression of IGF1 protein
CTD PMID:28214531, PMID:31704167 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Chlormequat results in increased expression of LHB protein CTD PMID:29447956 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Chlormequat results in decreased expression of STAR protein CTD PMID:29447956 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tnfsf11 TNF superfamily member 11 affects expression EXP Chlormequat affects the expression of TNFSF11 mRNA CTD PMID:28214531 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
chlorpropham term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Chlorpropham CTD PMID:12765240 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Chlorpropham binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor increases expression
multiple interactions
ISO Chlorpropham results in increased expression of AR mRNA
Chlorpropham inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Maleic Hydrazide co-treated with Chlorpropham] results in increased activity of NR1I2 protein; Chlorpropham binds to and results in increased activity of NR1I2 protein CTD PMID:21115097, PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Chlorpropham binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA CTD PMID:26934552 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Aacs acetoacetyl-CoA synthetase decreases expression ISO Diclofenac results in decreased expression of AACS mRNA CTD PMID:26934552 NCBI chr12:36,512,393...36,555,694
Ensembl chr12:36,512,393...36,555,694
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Diclofenac results in decreased activity of ABCB11 protein
CTD PMID:24014644, PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases response to substance
decreases activity
ISO Diclofenac results in increased expression of ABCB1B mRNA
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in decreased activity of ABCB1A protein
CTD PMID:15458769, PMID:19022234, PMID:28193520 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression EXP Diclofenac results in decreased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity
ISO Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein
CTD PMID:19022234, PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac
CTD PMID:19022234, PMID:22646477, PMID:25450747 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Diclofenac affects the expression of ABCC4 mRNA CTD PMID:24752500 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of ABL2 mRNA CTD PMID:24752500 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO Diclofenac affects the expression of ACIN1 mRNA CTD PMID:24752500 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Diclofenac results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression ISO Diclofenac results in decreased expression of ACOT2 mRNA CTD PMID:26934552 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Diclofenac results in increased expression of ACOX1 mRNA CTD PMID:19022234 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Diclofenac results in increased expression of ACPP mRNA CTD PMID:26934552 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects expression ISO Diclofenac affects the expression of ACTA1 mRNA CTD PMID:24752500 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Actn1 actinin, alpha 1 affects expression EXP Diclofenac affects the expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Acvr1 activin A receptor type 1 affects expression ISO Diclofenac affects the expression of ACVR1 mRNA CTD PMID:24752500 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Acvr1b activin A receptor type 1B affects expression ISO Diclofenac affects the expression of ACVR1B mRNA CTD PMID:24752500 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr2b activin A receptor type 2B affects expression ISO Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO Diclofenac results in increased expression of ADAMDEC1 mRNA CTD PMID:26934552 NCBI chr15:49,485,604...49,521,638
Ensembl chr15:49,485,611...49,505,553
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression ISO Diclofenac affects the expression of ADCY6 mRNA CTD PMID:24752500 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy9 adenylate cyclase 9 affects expression
decreases expression
ISO Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression EXP Diclofenac results in increased expression of ADH1 protein CTD PMID:25772430 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adk adenosine kinase increases expression
decreases expression
ISO
EXP
Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA
CTD PMID:19022234 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO Diclofenac results in increased expression of ADORA2A mRNA CTD PMID:26934552 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diclofenac results in increased expression of ADORA2B mRNA CTD PMID:26934552 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Diclofenac results in increased expression of ADRB2 mRNA CTD PMID:26934552 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Diclofenac results in increased expression of AGER mRNA CTD PMID:24747151, PMID:28138970 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Aggf1 angiogenic factor with G patch and FHA domains 1 affects expression ISO Diclofenac affects the expression of AGGF1 mRNA CTD PMID:24752500 NCBI chr 2:25,068,804...25,095,429
Ensembl chr 2:25,069,620...25,095,106
JBrowse link
G Ago2 argonaute RISC catalytic component 2 affects expression ISO Diclofenac affects the expression of AGO2 mRNA CTD PMID:24752500 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ago3 argonaute RISC catalytic component 3 affects expression ISO Diclofenac affects the expression of AGO3 mRNA CTD PMID:24752500 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Ago4 argonaute RISC component 4 affects expression ISO Diclofenac affects the expression of AGO4 mRNA CTD PMID:24752500 NCBI chr 5:144,501,875...144,557,165
Ensembl chr 5:144,504,938...144,556,889
JBrowse link
G Agrp agouti related neuropeptide increases expression EXP Diclofenac results in increased expression of AGRP mRNA CTD PMID:30723492 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Diclofenac results in increased expression of AHR mRNA CTD PMID:26934552 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahsg alpha-2-HS-glycoprotein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein CTD PMID:25772430 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression ISO Diclofenac affects the expression of AIFM1 mRNA CTD PMID:24752500 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Diclofenac results in increased expression of AIM2 mRNA CTD PMID:26934552 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Diclofenac affects the expression of AKT1 mRNA CTD PMID:24752500 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of AKT2 mRNA CTD PMID:24752500 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ALAS1 mRNA CTD PMID:26934552 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 affects expression ISO Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin affects binding
multiple interactions
decreases expression
increases expression
ISO
EXP
Diclofenac binds to ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased expression of ALB protein
Diclofenac results in increased expression of ALB mRNA
CTD PMID:9353694, PMID:19022234, PMID:28400101 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Diclofenac results in increased expression of ALDH18A1 mRNA CTD PMID:26934552 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Diclofenac results in increased expression of ALDH1B1 mRNA CTD PMID:26934552 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO Diclofenac results in decreased expression of ALDH1L2 mRNA CTD PMID:26934552 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Diclofenac results in decreased expression of ALDH3A2 mRNA CTD PMID:26934552 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Diclofenac results in increased expression of ALDOC mRNA CTD PMID:30723492 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP Diclofenac results in increased expression of ALOX15 mRNA CTD PMID:23939143 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Ang angiogenin increases expression ISO Diclofenac results in increased expression of ANG mRNA CTD PMID:26934552 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Aoc3 amine oxidase, copper containing 3 decreases expression ISO Diclofenac results in decreased expression of AOC3 mRNA CTD PMID:26934552 NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression ISO Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apcs amyloid P component, serum multiple interactions
increases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein
CTD PMID:25772430, PMID:26934552 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apoa4 apolipoprotein A4 affects expression ISO Diclofenac affects the expression of APOA4 mRNA CTD PMID:26934552 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Diclofenac results in decreased expression of AQP2 protein CTD PMID:15579502 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor affects expression ISO Diclofenac affects the expression of AQR mRNA CTD PMID:24752500 NCBI chr 3:105,570,399...105,640,431
Ensembl chr 3:105,570,292...105,640,463
JBrowse link
G Ar androgen receptor affects activity ISO Diclofenac affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of ARAF mRNA CTD PMID:24752500 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Arhgap20 Rho GTPase activating protein 20 increases expression EXP Diclofenac results in increased expression of ARHGAP20 mRNA CTD PMID:30723492 NCBI chr 8:56,179,581...56,264,343
Ensembl chr 8:56,179,637...56,264,263
JBrowse link
G Arhgap26 Rho GTPase activating protein 26 affects expression ISO Diclofenac affects the expression of ARHGAP26 mRNA CTD PMID:24752500 NCBI chr18:31,807,052...32,557,176
Ensembl chr18:31,812,109...32,207,801
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of ARHGEF2 mRNA CTD PMID:24752500 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 affects expression ISO Diclofenac affects the expression of ARHGEF3 mRNA CTD PMID:24752500 NCBI chr16:2,743,714...3,026,768
Ensembl chr16:2,743,823...3,026,760
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 affects expression ISO Diclofenac affects the expression of ARHGEF7 mRNA CTD PMID:24752500 NCBI chr16:83,006,732...83,117,065
Ensembl chr16:83,006,718...83,132,785
JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO Diclofenac results in decreased expression of ARID5B mRNA CTD PMID:26934552 NCBI chr20:21,713,900...21,881,193
Ensembl chr20:21,564,975...21,880,715
JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression EXP Diclofenac results in increased expression of ARMCX1 mRNA CTD PMID:30723492 NCBI chr  X:105,535,670...105,539,575
Ensembl chr  X:105,537,602...105,539,375
Ensembl chr  X:105,537,602...105,539,375
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects expression ISO Diclofenac affects the expression of ARNT mRNA CTD PMID:24752500 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 affects expression ISO Diclofenac affects the expression of ASAP1 mRNA CTD PMID:24752500 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
JBrowse link
G Ash2l ASH2 like histone lysine methyltransferase complex subunit affects expression ISO Diclofenac affects the expression of ASH2L mRNA CTD PMID:24752500 NCBI chr16:71,011,315...71,033,171
Ensembl chr16:71,011,332...71,032,790
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Diclofenac results in decreased expression of ASIC1 mRNA CTD PMID:11588175 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Diclofenac results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression
decreases activity
EXP Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein
CTD PMID:11588175 NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
JBrowse link
G Asl argininosuccinate lyase affects expression ISO Diclofenac affects the expression of ASL mRNA CTD PMID:24752500 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression
ISO Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA
CTD PMID:19192274, PMID:26934552 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ASS1 mRNA CTD PMID:26934552 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Diclofenac affects the expression of ATF2 mRNA CTD PMID:24752500 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf4 activating transcription factor 4 affects expression
increases expression
ISO Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA
CTD PMID:24752500, PMID:27313093 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO Diclofenac results in increased expression of ATP11A mRNA CTD PMID:26934552 NCBI chr16:81,990,340...82,100,222
Ensembl chr16:81,990,340...82,100,222
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein
CTD PMID:25772430 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein
CTD PMID:25772430 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein
CTD PMID:25772430 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Azin1 antizyme inhibitor 1 affects expression ISO Diclofenac affects the expression of AZIN1 mRNA CTD PMID:24752500 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Diclofenac results in increased expression of B3GALT1 mRNA CTD PMID:26934552 NCBI chr 3:53,699,409...54,269,612
Ensembl chr 3:54,253,949...54,267,292
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects expression ISO Diclofenac affects the expression of BACH1 mRNA CTD PMID:24752500 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO Diclofenac results in increased activity of BAK1 protein CTD PMID:18191430 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Diclofenac affects the expression of BARD1 mRNA CTD PMID:24752500 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
increases expression
affects localization
ISO
EXP
Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein
CTD PMID:18191430, PMID:29027214 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO
EXP
Diclofenac results in increased expression of BCL2 mRNA CTD PMID:29027214 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Diclofenac results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
affects expression
ISO Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA
CTD PMID:14609740, PMID:24752500 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 affects expression ISO Diclofenac affects the expression of BCL2L11 mRNA CTD PMID:24752500 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Diclofenac results in increased expression of BCL3 mRNA CTD PMID:26934552 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Diclofenac results in decreased expression of BCL6 mRNA CTD PMID:26934552 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Diclofenac results in decreased expression of BDH1 mRNA CTD PMID:26934552 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA
CTD PMID:18191430, PMID:24752500 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bmp4 bone morphogenetic protein 4 affects expression ISO Diclofenac affects the expression of BMP4 mRNA CTD PMID:24752500 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Diclofenac results in decreased expression of BMP6 mRNA CTD PMID:26934552 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of BRAF mRNA CTD PMID:24752500 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 affects expression ISO Diclofenac affects the expression of BRIP1 mRNA CTD PMID:24752500 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Diclofenac results in decreased expression of BTG1 mRNA CTD PMID:26934552 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G C1qa complement C1q A chain increases expression ISO Diclofenac results in increased expression of C1QA mRNA CTD PMID:26934552 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qb complement C1q B chain increases expression ISO Diclofenac results in increased expression of C1QB mRNA CTD PMID:26934552 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C1qc complement C1q C chain increases expression ISO Diclofenac results in increased expression of C1QC mRNA CTD PMID:26934552 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C2 complement C2 increases expression ISO Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C4b complement C4B (Chido blood group) increases expression ISO Diclofenac results in increased expression of C4B mRNA CTD PMID:26934552 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Ca13 carbonic anhydrase 13 decreases expression ISO Diclofenac results in decreased expression of CAR13 mRNA CTD PMID:26934552 NCBI chr 2:88,282,961...88,314,254
Ensembl chr 2:88,282,961...88,314,254
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression
increases secretion
ISO
EXP
Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein
CTD PMID:24038040, PMID:26934552 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression ISO Diclofenac results in decreased expression of CACNA1B mRNA CTD PMID:26934552 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Diclofenac results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calm1 calmodulin 1 affects expression ISO Diclofenac affects the expression of CALM1 mRNA CTD PMID:24752500 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calml3 calmodulin-like 3 increases expression EXP Diclofenac results in increased expression of CALML3 mRNA CTD PMID:30723492 NCBI chr17:70,070,458...70,073,697
Ensembl chr17:70,072,156...70,073,530
JBrowse link
G Calr calreticulin affects expression
decreases expression
EXP Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA
CTD PMID:18246545 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Diclofenac results in increased expression of CAMK1D mRNA CTD PMID:26934552 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Diclofenac results in increased expression of CAMP mRNA CTD PMID:26934552 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Capn10 calpain 10 affects expression ISO Diclofenac affects the expression of CAPN10 mRNA CTD PMID:24752500 NCBI chr 9:100,104,000...100,112,833
Ensembl chr 9:100,104,000...100,112,832
JBrowse link
G Car1 carbonic anhydrase 1 decreases expression ISO Diclofenac results in decreased expression of CAR1 mRNA CTD PMID:26934552 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 multiple interactions
affects expression
ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA
CTD PMID:16388830, PMID:24752500 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
CTD PMID:12826271, PMID:14599462, PMID:14609740, PMID:16388830, PMID:24770551, PMID:26609140, PMID:27313093, PMID:31042592 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 affects expression ISO Diclofenac affects the expression of CASP6 mRNA CTD PMID:24752500 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases activity
affects expression
multiple interactions
EXP
ISO
Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]
CTD PMID:14609740, PMID:20237495, PMID:24752500, PMID:27313093 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO
EXP
[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA
CTD PMID:14609740, PMID:16388830, PMID:25014874, PMID:27313093, PMID:29027214 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity
EXP
ISO
Diclofenac results in increased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]
CTD PMID:17274466, PMID:23994749, PMID:31042592, PMID:31332906 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbl Cbl proto-oncogene affects expression ISO Diclofenac affects the expression of CBL mRNA CTD PMID:24752500 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Diclofenac affects the expression of CBR1 mRNA CTD PMID:24752500 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbs cystathionine beta synthase affects expression ISO Diclofenac affects the expression of CBS mRNA CTD PMID:24752500 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
affects expression
EXP
ISO
[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA
CTD PMID:22285467, PMID:23939143, PMID:24104198, PMID:25051504, PMID:27671914, PMID:31042592 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA] CTD PMID:23939143 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression ISO Diclofenac results in increased expression of CCL6 mRNA CTD PMID:26934552 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccn1 cellular communication network factor 1 affects expression
increases expression
ISO Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA
CTD PMID:19192274, PMID:24752500 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
affects expression
decreases expression
increases expression
ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein
CTD PMID:15188006, PMID:15489888, PMID:19022234, PMID:26934552 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 affects expression ISO Diclofenac affects the expression of CCND3 mRNA CTD PMID:24752500 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 affects expression ISO Diclofenac affects the expression of CCNE1 mRNA CTD PMID:24752500 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 affects expression ISO Diclofenac affects the expression of CCNE2 mRNA CTD PMID:24752500 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnf cyclin F affects expression ISO Diclofenac affects the expression of CCNF mRNA CTD PMID:24752500 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Diclofenac results in increased expression of CCNG1 mRNA CTD PMID:19022234 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccnh cyclin H affects expression ISO Diclofenac affects the expression of CCNH mRNA CTD PMID:24752500 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Diclofenac results in increased expression of CCR1 mRNA CTD PMID:26934552 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd14 CD14 molecule increases expression ISO Diclofenac results in increased expression of CD14 mRNA CTD PMID:26934552 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd163 CD163 molecule increases expression ISO Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd28 Cd28 molecule increases expression ISO Diclofenac results in increased expression of CD28 mRNA CTD PMID:26934552 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Diclofenac results in increased expression of CD44 mRNA CTD PMID:26934552 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Diclofenac results in increased expression of CD55 mRNA CTD PMID:26934552 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd5l Cd5 molecule-like increases expression ISO Diclofenac results in increased expression of CD5L mRNA CTD PMID:26934552 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cd9 CD9 molecule increases expression ISO Diclofenac results in increased expression of CD9 mRNA CTD PMID:26934552 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Diclofenac results in decreased expression of CDC42EP5 mRNA CTD PMID:26934552 NCBI chr 1:73,717,207...73,719,600
Ensembl chr 1:73,719,005...73,719,529
JBrowse link
G Cdc6 cell division cycle 6 affects expression ISO Diclofenac affects the expression of CDC6 mRNA CTD PMID:24752500 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 affects expression ISO Diclofenac affects the expression of CDC7 mRNA CTD PMID:24752500 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Diclofenac results in increased expression of CDCA5 mRNA CTD PMID:26934552 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
decreases expression
ISO
EXP
Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA
CTD PMID:19022234, PMID:19628293, PMID:24752500 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Diclofenac affects the expression of CDK2 mRNA CTD PMID:24752500 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression ISO Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression EXP Diclofenac results in increased expression of CDK5R1 mRNA CTD PMID:30723492 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Diclofenac affects the expression of CDK6 mRNA CTD PMID:24752500 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects expression ISO Diclofenac affects the expression of CDK7 mRNA CTD PMID:24752500 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP
Diclofenac results in increased expression of CDKN1A mRNA CTD PMID:19022234, PMID:26934552 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Diclofenac affects the expression of CDKN1B mRNA CTD PMID:24752500 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 affects expression ISO Diclofenac affects the expression of CDT1 mRNA CTD PMID:24752500 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
affects expression
ISO
EXP
Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA
CTD PMID:19022234, PMID:24752500 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO Diclofenac results in increased expression of CERS6 mRNA CTD PMID:26934552 NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO Diclofenac results in decreased expression of CES1D mRNA CTD PMID:26934552 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cfh complement factor H increases expression ISO Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
affects expression
ISO [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA
CTD PMID:20237495, PMID:24752500 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression ISO Diclofenac results in decreased expression of CGREF1 mRNA CTD PMID:26934552 NCBI chr 6:26,797,126...26,809,132
Ensembl chr 6:26,797,126...26,809,129
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Diclofenac results in increased expression of CHAC1 mRNA CTD PMID:26934552 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Chdh choline dehydrogenase affects expression ISO Diclofenac affects the expression of CHDH mRNA CTD PMID:24752500 NCBI chr16:6,078,083...6,109,386
Ensembl chr16:6,078,122...6,109,382
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chka choline kinase alpha affects expression ISO Diclofenac affects the expression of CHKA mRNA CTD PMID:24752500 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chkb choline kinase beta affects expression ISO Diclofenac affects the expression of CHKB mRNA CTD PMID:24752500 NCBI chr 7:130,404,818...130,408,813
Ensembl chr 7:130,404,832...130,408,187
JBrowse link
G Chl1 cell adhesion molecule L1-like increases expression ISO Diclofenac results in increased expression of CHL1 mRNA CTD PMID:26934552 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
JBrowse link
G Chst4 carbohydrate sulfotransferase 4 decreases expression ISO Diclofenac results in decreased expression of CHST4 mRNA CTD PMID:26934552 NCBI chr19:41,630,060...41,642,373
Ensembl chr19:41,631,715...41,640,367
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]
CTD PMID:15489888, PMID:25935278 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clu clusterin increases expression
multiple interactions
ISO
EXP
Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein
CTD PMID:23506792, PMID:25772430 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 affects expression ISO Diclofenac affects the expression of CMPK2 mRNA CTD PMID:24752500 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]
CTD PMID:26934552, PMID:31042592 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 increases expression ISO Diclofenac results in increased expression of COTL1 mRNA CTD PMID:26934552 NCBI chr19:52,465,074...52,499,433
Ensembl chr19:52,465,087...52,499,433
JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Diclofenac results in increased expression of CPB2 mRNA CTD PMID:26934552 NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760
JBrowse link
G Cplx1 complexin 1 increases expression EXP Diclofenac results in increased expression of CPLX1 mRNA CTD PMID:30723492 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598
JBrowse link
G Cplx4 complexin 4 increases expression EXP Diclofenac results in increased expression of CPLX4 mRNA CTD PMID:30723492 NCBI chr18:61,657,216...61,672,641
Ensembl chr18:61,656,758...61,672,663
JBrowse link
G Cpne8 copine 8 increases expression ISO Diclofenac results in increased expression of CPNE8 mRNA CTD PMID:26934552 NCBI chr 7:131,623,180...131,798,236
Ensembl chr 7:131,623,181...131,798,236
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 affects expression ISO Diclofenac affects the expression of CPSF6 mRNA CTD PMID:24752500 NCBI chr 7:60,385,688...60,417,661
Ensembl chr 7:60,385,688...60,416,925
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO
EXP
Diclofenac results in increased expression of CPT1A mRNA CTD PMID:19022234 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr13:113,824,886...113,872,097
Ensembl chr13:113,824,892...113,872,097
JBrowse link
G Cr2 complement C3d receptor 2 affects expression ISO Diclofenac affects the expression of CR2 mRNA CTD PMID:26934552 NCBI chr13:113,890,274...113,927,824
Ensembl chr13:113,890,272...113,927,877
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 increases expression ISO Diclofenac results in increased expression of CREB3L2 mRNA CTD PMID:26934552 NCBI chr 4:64,869,285...64,981,519
Ensembl chr 4:64,869,026...64,981,384
JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 affects expression ISO Diclofenac affects the expression of CREB3L4 mRNA CTD PMID:24752500 NCBI chr 2:189,596,657...189,602,243
Ensembl chr 2:189,595,415...189,602,143
JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]
CTD PMID:25772430, PMID:27313093 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Diclofenac results in decreased expression of CRY1 mRNA CTD PMID:26934552 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO Diclofenac results in decreased expression of CSF1 mRNA CTD PMID:26934552 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression
increases secretion
ISO Diclofenac results in increased expression of CSF1R mRNA
Diclofenac results in increased secretion of CSF1R protein
CTD PMID:26934552 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA CTD PMID:26934552 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 affects expression ISO Diclofenac affects the expression of CSNK2A1 mRNA CTD PMID:24752500 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Diclofenac affects the expression of CSNK2A2 mRNA CTD PMID:24752500 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Csrnp3 cysteine and serine rich nuclear protein 3 increases expression EXP Diclofenac results in increased expression of CSRNP3 mRNA CTD PMID:30723492 NCBI chr 3:51,883,559...52,120,290
Ensembl chr 3:51,883,559...52,120,290
JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 affects expression ISO Diclofenac affects the expression of CSTF2 mRNA CTD PMID:24752500 NCBI chr  X:104,882,726...104,909,746
Ensembl chr  X:104,882,704...104,909,739
JBrowse link
G Cstf3 cleavage stimulation factor subunit 3 affects expression ISO Diclofenac affects the expression of CSTF3 mRNA CTD PMID:24752500 NCBI chr 3:94,530,586...94,603,378
Ensembl chr 3:94,530,586...94,607,588
JBrowse link
G Ctbp2 C-terminal binding protein 2 affects expression ISO Diclofenac affects the expression of CTBP2 mRNA CTD PMID:24752500 NCBI chr 1:205,001,354...205,030,565
Ensembl chr 1:205,001,396...205,040,755
JBrowse link
G Cth cystathionine gamma-lyase affects expression ISO Diclofenac affects the expression of CTH mRNA CTD PMID:24752500 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Diclofenac results in increased expression of CTLA4 protein CTD PMID:26934552 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO Diclofenac affects the expression of CTNNB1 mRNA CTD PMID:24752500 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctps1 CTP synthase 1 affects expression ISO Diclofenac affects the expression of CTPS mRNA CTD PMID:24752500 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 affects expression ISO Diclofenac affects the expression of CTPS2 mRNA CTD PMID:24752500 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
G Ctsc cathepsin C increases expression ISO Diclofenac results in increased expression of CTSC mRNA CTD PMID:26934552 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Ctss cathepsin S increases expression ISO Diclofenac results in increased expression of CTSS mRNA CTD PMID:26934552 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cul3 cullin 3 affects expression ISO Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Cul7 cullin 7 decreases expression ISO Diclofenac results in decreased expression of CUL7 mRNA CTD PMID:26934552 NCBI chr 9:16,629,491...16,643,527
Ensembl chr 9:16,629,401...16,643,182
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] CTD PMID:23939143 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO Diclofenac results in increased expression of CXCL13 mRNA CTD PMID:26934552 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Diclofenac results in increased expression of CXCL14 mRNA CTD PMID:26934552 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein
CTD PMID:22285467, PMID:23939143, PMID:24747151, PMID:26934552, PMID:27671914 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
decreases expression
ISO Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
Diclofenac results in decreased expression of CXCL1 mRNA
CTD PMID:26934552, PMID:27671914 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Diclofenac results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Diclofenac results in increased expression of CYB561 mRNA CTD PMID:26934552 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression ISO Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Diclofenac results in increased expression of CYBB mRNA CTD PMID:26934552 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Diclofenac affects the expression of CYCS mRNA CTD PMID:24752500 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP17A1 mRNA CTD PMID:26934552 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
ISO Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein
CTD PMID:18420780, PMID:21784029 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac
CTD PMID:21784029, PMID:23397584, PMID:28960974 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Diclofenac results in decreased expression of CYP26A1 mRNA CTD PMID:26934552 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
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G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 affects expression ISO Diclofenac affects the expression of CYP2A5 mRNA CTD PMID:26934552 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
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G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Diclofenac results in increased expression of CYP2B9 mRNA CTD PMID:26934552 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO Diclofenac results in decreased expression of CYP2C55 mRNA CTD PMID:26934552 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
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G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation
increases response to substance
multiple interactions
EXP
ISO
CYP2C6V1 protein results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased susceptibility to Diclofenac
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac
CTD PMID:11911841, PMID:15486075, PMID:18511451, PMID:23397584, PMID:28762043 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540 NCBI chr 1:147,422,999...148,119,979
Ensembl chr 1:148,053,687...148,119,857
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G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Diclofenac results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CTD PMID:23397584, PMID:24246759 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Diclofenac metabolite results in decreased activity of CYP2E1 protein CTD PMID:28960974 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP39A1 mRNA CTD PMID:26934552 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diclofenac results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19022234, PMID:29027214 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases expression
ISO Diclofenac metabolite results in decreased activity of CYP3A13 protein
Diclofenac results in increased expression of CYP3A13 mRNA
CTD PMID:26934552, PMID:28960974 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Diclofenac CTD PMID:14640697 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Diclofenac results in decreased expression of CYP4V3 mRNA CTD PMID:26934552 NCBI chr16:50,111,803...50,136,741
Ensembl chr16:50,111,306...50,136,727
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression
ISO Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA
CTD PMID:26934552, PMID:28960974 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP7A1 mRNA CTD PMID:26934552 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Diclofenac results in decreased expression of CYP8B1 mRNA CTD PMID:26934552 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link