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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefuroxime
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Accession:CHEBI:3515 term browser browse the term
Definition:A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.
Synonyms:exact_synonym: 3-[(carbamoyloxy)methyl]-7beta-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Cefuroxim;   Cephuroxime;   Formula=C16H16N4O8S;   InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1;   InChIKey=JFPVXVDWJQMJEE-IZRZKJBUSA-N;   SMILES=[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1ccco1)C(O)=O;   Sharox;   Zinacef Danmark;   cefuroximo;   cefuroximum
 xref: CAS:55268-75-2;   DrugBank:DB01112;   Drug_Central:565;   KEGG:C06894;   KEGG:D00262
 xref_mesh: MESH:D002444
 xref: MetaCyc:CPD0-2069;   PMID:11168076;   PMID:11322179;   PMID:11581233;   PMID:12141712;   PMID:12235459;   PMID:12833570;   PMID:12898829;   PMID:14658923;   PMID:15052582;   PMID:15828440;   PMID:16341950;   PMID:17111749;   PMID:17113884;   PMID:17261579;   PMID:17366015;   PMID:17676080;   PMID:18208759;   PMID:18611587;   PMID:18795089;   PMID:18931469;   PMID:19069618;   PMID:19142482;   PMID:19411164;   PMID:21425867;   PMID:29017833;   Patent:DE2439880;   Patent:DE2706413;   Patent:US3974153;   Patent:US4267320;   Reaxys:5783190;   Wikipedia:Cefuroxime


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cefuroxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Cefuroxime results in decreased activity of CAT protein CTD PMID:30797828 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Cefuroxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases activity ISO Cefuroxime results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity ISO Cefuroxime results in decreased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases activity ISO Cefuroxime results in decreased activity of PPARA protein CTD PMID:30203046 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Cefuroxime affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Cefuroxime affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        pharmaceutical 19503
          drug 19471
            drug allergen 11740
              cefuroxime 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              lactam 8380
                                                beta-lactam 826
                                                  beta-lactam antibiotic 811
                                                    cephem 548
                                                      cephalosporin 547
                                                        3-(carbamoyloxymethyl)cephalosporin 7
                                                          cefuroxime 7
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