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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefuroxime
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Accession:CHEBI:3515 term browser browse the term
Definition:A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.
Synonyms:exact_synonym: 3-[(carbamoyloxy)methyl]-7beta-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Cefuroxim;   Cephuroxime;   Formula=C16H16N4O8S;   InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1;   InChIKey=JFPVXVDWJQMJEE-IZRZKJBUSA-N;   SMILES=[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1ccco1)C(O)=O;   Sharox;   Zinacef Danmark;   cefuroximo;   cefuroximum
 xref: CAS:55268-75-2;   DrugBank:DB01112;   Drug_Central:565;   KEGG:C06894;   KEGG:D00262
 xref_mesh: MESH:D002444
 xref: MetaCyc:CPD0-2069;   PMID:11168076;   PMID:11322179;   PMID:11581233;   PMID:12141712;   PMID:12235459;   PMID:12833570;   PMID:12898829;   PMID:14658923;   PMID:15052582;   PMID:15828440;   PMID:16341950;   PMID:17111749;   PMID:17113884;   PMID:17261579;   PMID:17366015;   PMID:17676080;   PMID:18208759;   PMID:18611587;   PMID:18795089;   PMID:18931469;   PMID:19069618;   PMID:19142482;   PMID:19411164;   PMID:21425867;   PMID:29017833;   Patent:DE2439880;   Patent:DE2706413;   Patent:US3974153;   Patent:US4267320;   Reaxys:5783190;   Wikipedia:Cefuroxime


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cefuroxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Cefuroxime results in decreased activity of CAT protein CTD PMID:30797828 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Cefuroxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases activity ISO Cefuroxime results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity ISO Cefuroxime results in decreased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases activity ISO Cefuroxime results in decreased activity of PPARA protein CTD PMID:30203046 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Cefuroxime affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Cefuroxime affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link

Term paths to the root
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  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            drug allergen 9926
              cefuroxime 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          3-(carbamoyloxymethyl)cephalosporin 7
                                                            cefuroxime 7
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