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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefuroxime
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Accession:CHEBI:3515 term browser browse the term
Definition:A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.
Synonyms:exact_synonym: 3-[(carbamoyloxy)methyl]-7beta-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Cefuroxim;   Cephuroxime;   Formula=C16H16N4O8S;   InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1;   InChIKey=JFPVXVDWJQMJEE-IZRZKJBUSA-N;   SMILES=[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1ccco1)C(O)=O;   Sharox;   Zinacef Danmark;   cefuroximo;   cefuroximum
 xref: CAS:55268-75-2;   DrugBank:DB01112;   Drug_Central:565;   KEGG:C06894;   KEGG:D00262
 xref_mesh: MESH:D002444
 xref: MetaCyc:CPD0-2069;   PMID:11168076;   PMID:11322179;   PMID:11581233;   PMID:12141712;   PMID:12235459;   PMID:12833570;   PMID:12898829;   PMID:14658923;   PMID:15052582;   PMID:15828440;   PMID:16341950;   PMID:17111749;   PMID:17113884;   PMID:17261579;   PMID:17366015;   PMID:17676080;   PMID:18208759;   PMID:18611587;   PMID:18795089;   PMID:18931469;   PMID:19069618;   PMID:19142482;   PMID:19411164;   PMID:21425867;   PMID:29017833;   Patent:DE2439880;   Patent:DE2706413;   Patent:US3974153;   Patent:US4267320;   Reaxys:5783190;   Wikipedia:Cefuroxime



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cefuroxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Cefuroxime results in decreased activity of CAT protein CTD PMID:30797828 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Cefuroxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases activity ISO Cefuroxime results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity ISO Cefuroxime results in decreased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases activity ISO Cefuroxime results in decreased activity of PPARA protein CTD PMID:30203046 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Cefuroxime affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Cefuroxime affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            drug allergen 10073
              cefuroxime 7
Path 2
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                lactam 8311
                                                  beta-lactam 796
                                                    beta-lactam antibiotic 781
                                                      cephem 546
                                                        cephalosporin 545
                                                          3-(carbamoyloxymethyl)cephalosporin 7
                                                            cefuroxime 7
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