elemental mercury - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	elemental mercury	go back to main search page
Accession:	CHEBI:35113	browse the term

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Genes (572)

mercury(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

affects expression

Mercury affects the expression of A1BG protein

NCBI chr15:60,789,438...60,793,119
Ensembl chr15:60,768,708...60,794,861

G

alpha-2-macroglobulin

decreases expression

Mercury results in decreased expression of A2M mRNA

NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186

G

ATP-binding cassette, sub-family A member 1

affects expression

Mercury affects the expression of ABCA1 mRNA

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 1A

multiple interactions

[ABCB1 gene SNP affects the susceptibility to Mercury] which affects the abundance of Mercury; ABCB1 gene SNP affects the susceptibility to and affects the abundance of Mercury

PMID:27262785 PMID:32946573

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 1B

increases expression

Mercury results in increased expression of ABCB1B mRNA

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

ATP-binding cassette, sub-family C member 1

increases expression
multiple interactions

Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein
ABCC1 gene SNP affects the susceptibility to and affects the abundance of Mercury

PMID:12730625 PMID:27262785

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family member 2

multiple interactions
affects response to substance
increases export
increases transport
affects transport

ABCC2 gene SNP affects the susceptibility to and affects the abundance of Mercury; ABCC2 protein affects the transport of [Mercury co-treated with Cysteine]; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]
ABCC2 gene mutant form affects the susceptibility to Mercury
ABCC2 protein results in increased export of Mercury
ABCC2 protein affects the transport of Mercury
EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of ABCC2 protein]; Mercury results in increased expression of and affects the localization of ABCC2 protein

PMID:21134393 PMID:23052037 PMID:23059061 PMID:24039982 PMID:25145654 More...

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP binding cassette subfamily G member 1

increases expression

Mercury results in increased expression of ABCG1 mRNA

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

ATP binding cassette subfamily G member 2 (Junior blood group)

increases expression

Mercury results in increased expression of ABCG2 mRNA

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

c-abl oncogene 1, non-receptor tyrosine kinase

increases expression

Mercury results in increased expression of ABL1 mRNA

NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239

G

acetylcholinesterase

increases activity
multiple interactions

Mercury results in increased activity of ACHE protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein

PMID:10798623 PMID:37415728

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

acid phosphatase 2, lysosomal

decreases expression

Mercury results in decreased expression of ACP2 mRNA

NCBI chr 2:91,033,157...91,044,443
Ensembl chr 2:91,033,230...91,044,443

G

acyl-CoA synthetase long-chain family member 1

decreases expression

Mercury results in decreased expression of ACSL1 mRNA

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

actin, beta

increases expression

Mercury results in increased expression of ACTB mRNA

NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509

G

aarF domain containing kinase 5

decreases expression

Mercury analog results in decreased expression of ADCK5 mRNA

NCBI chr15:76,460,559...76,480,012
Ensembl chr15:76,460,558...76,480,016

G

adrenomedullin

increases expression

Mercury results in increased expression of ADM mRNA

NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027

G

aryl-hydrocarbon receptor

multiple interactions

Mercury results in increased activity of [AHR protein binds to ARNT protein]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

aldo-keto reductase family 1 member B

decreases expression

Mercury results in decreased expression of AKR1B1 mRNA

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

AKT1 substrate 1

decreases expression

Mercury results in decreased expression of AKT1S1 mRNA

NCBI chr 7:44,498,648...44,504,845
Ensembl chr 7:44,498,415...44,504,845

G

thymoma viral proto-oncogene 2

decreases expression

Mercury results in decreased expression of AKT2 mRNA

NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251

G

aminolevulinate, delta-, dehydratase

multiple interactions
decreases activity
affects abundance

[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury; Sodium Selenite inhibits the reaction [Mercury results in decreased activity of ALAD protein]
ALAD gene polymorphism affects the abundance of Mercury

PMID:12499120 PMID:14615064 PMID:25728017

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

albumin

multiple interactions
increases export

[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; [Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of ALB protein; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]
Mercury results in increased export of ALB protein

PMID:30090589 PMID:37137463 PMID:37676925

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

aldhehyde dehydrogenase family 5, subfamily A1

decreases expression

Mercury analog results in decreased expression of ALDH5A1 mRNA

NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644
Ensembl chr13:25,091,562...25,121,644

G

aldehyde dehydrogenase family 6, subfamily A1

decreases expression

Mercury results in decreased expression of ALDH6A1 mRNA

NCBI chr12:84,477,491...84,497,798
Ensembl chr12:84,477,491...84,497,778

G

ALG3 alpha-1,3- mannosyltransferase

increases expression

Mercury results in increased expression of ALG3 mRNA

NCBI chr16:20,424,208...20,429,515
Ensembl chr16:20,424,124...20,430,485

G

alsin Rho guanine nucleotide exchange factor

increases expression

Mercury results in increased expression of ALS2 mRNA

NCBI chr 1:59,201,915...59,276,390
Ensembl chr 1:59,202,085...59,276,390

G

ankyrin 1, erythroid

decreases expression

Mercury results in decreased expression of ANK1 mRNA

NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513

G

ankyrin repeat and KH domain containing 1

increases expression

Mercury results in increased expression of ANKHD1 mRNA

NCBI chr18:36,693,656...36,791,961
Ensembl chr18:36,693,040...36,791,966

G

annexin A2

increases expression

Mercury results in increased expression of ANXA2 mRNA

NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077

G

adaptor-related protein complex 2, alpha 2 subunit

decreases expression

Mercury results in decreased expression of AP2A2 mRNA

NCBI chr 7:141,142,093...141,212,924
Ensembl chr 7:141,142,086...141,212,924

G

apolipoprotein A-II

affects expression

Mercury affects the expression of APOA2 protein

NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948

G

apolipoprotein E

affects response to substance

APOE gene polymorphism affects the susceptibility to Mercury; APOE polymorphism affects the susceptibility to Mercury

PMID:12897404 PMID:23603214

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

amyloid beta precursor protein

multiple interactions
increases secretion

Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form]
Mercury results in increased secretion of APP protein alternative form; Mercury results in increased secretion of APP protein modified form

PMID:12182891 PMID:25673500

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

aquaporin 1

multiple interactions
decreases activity

Mercury inhibits the reaction [AQP1 protein results in increased transport of Water]
Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein]

PMID:21259319 PMID:24028651

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

aquaporin 10, pseudogene

decreases activity
affects activity

Mercury results in decreased activity of AQP10 protein
Mercury affects the activity of AQP10 protein

PMID:11573934 PMID:12084581

NCBI chr 3:89,870,751...89,877,041
Ensembl chr 3:89,872,016...89,875,998

G

aquaporin 8

multiple interactions

Mercury affects the reaction [AQP8 protein affects the transport of Water]

NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227

G

aquaporin 9

multiple interactions

Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]

NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964

G

ARF GTPase 4

decreases expression

Mercury results in decreased expression of ARF4 mRNA

NCBI chr14:26,359,289...26,377,997
Ensembl chr14:26,359,229...26,386,239

G

arginase, liver

decreases activity

Mercury results in decreased activity of ARG1 protein

NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382

G

arginase type II

decreases activity

Mercury results in decreased activity of ARG2 protein

NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075

G

Rho guanine nucleotide exchange factor 28

decreases expression

Mercury results in decreased expression of ARHGEF28 mRNA

NCBI chr13:98,035,105...98,343,183
Ensembl chr13:98,035,977...98,342,947

G

AT-rich interaction domain 1A

increases expression

Mercury results in increased expression of ARID1A mRNA

NCBI chr 4:133,406,319...133,484,682
Ensembl chr 4:133,406,319...133,484,080

G

AT-rich interaction domain 4A

affects expression

Mercury affects the expression of ARID4A mRNA

NCBI chr12:71,061,314...71,146,125
Ensembl chr12:71,062,764...71,145,366

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

Mercury results in increased activity of [AHR protein binds to ARNT protein]

NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551

G

ATPase, Na+/K+ transporting, beta 3 polypeptide

increases expression

Mercury results in increased expression of ATP1B3 mRNA

NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495

G

ATPase, H+ transporting, lysosomal V1 subunit A

decreases expression

Mercury results in decreased expression of ATP6V1A mRNA

NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068

G

ataxin 3

decreases expression

Mercury analog results in decreased expression of ATXN3 mRNA

NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505

G

ataxin 7-like 3

decreases expression

Mercury analog results in decreased expression of ATXN7L3 mRNA

NCBI chr11:102,180,126...102,187,615
Ensembl chr11:102,180,126...102,187,457

G

alpha-2-glycoprotein 1, zinc

decreases expression

Mercury results in decreased expression of AZGP1 mRNA

NCBI chr 5:137,979,783...137,988,495
Ensembl chr 5:137,979,782...137,988,495

G

beta-2 microglobulin

multiple interactions

[Metals, Heavy results in increased abundance of Mercury] which results in increased secretion of B2M protein

NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564

G

BCL2-associated agonist of cell death

decreases expression

Mercury results in decreased expression of BAD mRNA

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated athanogene 6

decreases expression

Mercury results in decreased expression of BAG6 mRNA

NCBI chr17:35,354,132...35,366,297
Ensembl chr17:35,354,154...35,366,298

G

B cell scaffold protein with ankyrin repeats 1

increases expression

Mercury results in increased expression of BANK1 mRNA

NCBI chr 3:135,759,124...136,031,902
Ensembl chr 3:135,759,124...136,031,827

G

BCL2-associated X protein

increases expression
multiple interactions

Mercury results in increased expression of BAX protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]

PMID:21186712 PMID:29115570

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

Mercury results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2 like 11

decreases expression

Mercury results in decreased expression of BCL2L11 mRNA

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

BCL6 interacting corepressor

increases expression

Mercury results in increased expression of BCOR mRNA

NCBI chr X:11,902,976...12,026,769
Ensembl chr X:11,902,979...12,026,594

G

brain derived neurotrophic factor

decreases expression
affects response to substance

Mercury results in decreased expression of BDNF mRNA
BDNF polymorphism affects the susceptibility to Mercury

PMID:16301096 PMID:19937285

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

basic helix-loop-helix family, member e40

increases expression

Mercury results in increased expression of BHLHE40 mRNA

PMID:17547211 PMID:19937285

NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886

G

baculoviral IAP repeat-containing 3

increases expression

Mercury results in increased expression of BIRC3 mRNA

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

bone morphogenetic protein receptor type 2

increases expression

Mercury results in increased expression of BMPR2 mRNA

NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173

G

Braf transforming gene

increases expression

Mercury results in increased expression of BRAF mRNA

NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397

G

BUB1, mitotic checkpoint serine/threonine kinase

increases expression

Mercury results in increased expression of BUB1 mRNA

NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785

G

BUB3 mitotic checkpoint protein

decreases expression

Mercury results in decreased expression of BUB3 mRNA

NCBI chr 7:131,162,081...131,173,625
Ensembl chr 7:131,161,951...131,173,624

G

complement component 3

affects expression

Mercury affects the expression of C3 protein

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

complement component 6

affects expression

Mercury affects the expression of C6 protein

NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449

G

cell adhesion molecule 1

decreases expression

Mercury results in decreased expression of CADM1 mRNA

NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413

G

cell adhesion molecule 2

decreases expression

Mercury analog results in decreased expression of CADM2 mRNA

NCBI chr16:66,452,302...67,417,825
Ensembl chr16:66,452,307...67,417,796

G

calmodulin 3

decreases expression

Mercury results in decreased expression of CALM3 mRNA

NCBI chr 7:16,649,304...16,657,957
Ensembl chr 7:16,649,304...16,658,039

G

calpain, small subunit 1

decreases expression

Mercury analog results in decreased expression of CAPNS1 mRNA

NCBI chr 7:29,886,359...29,898,308
Ensembl chr 7:29,886,361...29,898,236

G

capping actin protein of muscle Z-line subunit beta

increases expression

Mercury results in increased expression of CAPZB mRNA

NCBI chr 4:138,920,210...139,019,131
Ensembl chr 4:138,920,210...139,019,129

G

carbonic anhydrase 1

decreases activity

Mercury results in decreased activity of CA1 protein

NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428

G

carbonic anhydrase 2

decreases activity

Mercury results in decreased activity of CA2 protein

NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830

G

carbonic anhydrase 3

increases expression

Mercury results in increased expression of CA3 mRNA

NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583

G

carnosine synthase 1

decreases expression

Mercury analog results in decreased expression of CARNS1 mRNA

NCBI chr19:4,214,323...4,227,390
Ensembl chr19:4,214,323...4,225,478

G

caspase 1

multiple interactions

CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

increases activity
increases expression
multiple interactions

Mercury results in increased activity of CASP3 protein
Mercury results in increased expression of CASP3 protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein]

PMID:16823075 PMID:21186712 PMID:29115570 PMID:37415728 PMID:37676925

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

increases expression
multiple interactions

Mercury results in increased expression of CASP9 protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein]

PMID:21186712 PMID:29115570

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

decreases activity
multiple interactions

Mercury results in decreased activity of CAT protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; Selenium affects the reaction [Mercury results in decreased activity of CAT protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]

PMID:17176674 PMID:20143455 PMID:37415728 PMID:37676925

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cation channel, sperm associated 2

decreases expression

Mercury results in decreased expression of CATSPER2 mRNA

NCBI chr 2:121,222,109...121,245,082
Ensembl chr 2:121,223,112...121,244,273

G

caveolae associated 2

decreases expression

Mercury analog results in decreased expression of CAVIN2 mRNA

NCBI chr 1:51,328,285...51,342,119
Ensembl chr 1:51,328,285...51,342,119

G

chromobox 7

decreases expression

Mercury analog results in decreased expression of CBX7 mRNA

NCBI chr15:79,800,005...79,855,344
Ensembl chr15:79,800,008...79,855,320

G

C-C motif chemokine ligand 12

increases expression

Mercury results in increased expression of CCL12 mRNA

NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226

G

C-C motif chemokine ligand 3

increases expression
multiple interactions

Mercury results in increased expression of CCL3 mRNA
MT3 protein affects the reaction [Mercury results in increased expression of CCL3 mRNA]

PMID:12730625 PMID:30103553

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine ligand 7

multiple interactions

[MT3 protein affects the susceptibility to Mercury] which affects the expression of CCL7 mRNA

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

cyclin B2

increases expression

Mercury results in increased expression of CCNB2 mRNA

NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829

G

C-C motif chemokine receptor 2

decreases expression

Mercury results in decreased expression of CCR2 mRNA

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

CD226 antigen

increases expression

Mercury results in increased expression of CD226 mRNA

NCBI chr18:89,195,078...89,290,356
Ensembl chr18:89,195,091...89,290,353

G

CD40 antigen

increases expression

Mercury results in increased expression of CD40 mRNA

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD84 antigen

decreases expression

Mercury results in decreased expression of CD84 mRNA

NCBI chr 1:171,667,261...171,718,288
Ensembl chr 1:171,667,265...171,718,285

G

cadherin 1

decreases expression

Mercury results in decreased expression of CDH1 mRNA

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cyclin dependent kinase 5, regulatory subunit 1

increases expression

Mercury results in increased expression of CDK5R1 mRNA

NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010

G

cyclin dependent kinase like 2

decreases expression

Mercury analog results in decreased expression of CDKL2 mRNA

NCBI chr 5:92,153,933...92,198,479
Ensembl chr 5:92,153,933...92,191,742

G

cyclin dependent kinase inhibitor 3

increases expression

Mercury results in increased expression of CDKN3 mRNA

NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126

G

CCAAT/enhancer binding protein delta

decreases expression

Mercury results in decreased expression of CEBPD mRNA

NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895

G

complement factor B

decreases expression
affects expression

Mercury results in decreased expression of CFB mRNA
Mercury affects the expression of CFB protein

PMID:17547211 PMID:22030286

NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494

G

complement factor D

increases expression

Mercury results in increased expression of CFD mRNA

NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489

G

ChaC, cation transport regulator 1

decreases expression

Mercury analog results in decreased expression of CHAC1 mRNA

NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862

G

choline O-acetyltransferase

decreases expression

Mercury results in decreased expression of CHAT mRNA

NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946

G

cell death-inducing DNA fragmentation factor, alpha subunit-like effector B

decreases expression

Mercury results in decreased expression of CIDEB mRNA

NCBI chr14:55,991,509...55,995,881
Ensembl chr14:55,991,507...55,995,915

G

CDC28 protein kinase regulatory subunit 2

increases expression

Mercury results in increased expression of CKS2 mRNA

NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696

G

CLIP associating protein 2

increases expression

Mercury results in increased expression of CLASP2 mRNA

NCBI chr 9:113,567,776...113,748,765
Ensembl chr 9:113,570,541...113,748,750

G

calmegin

decreases expression

Mercury results in decreased expression of CLGN mRNA

NCBI chr 8:84,116,454...84,155,181
Ensembl chr 8:84,116,496...84,155,181

G

CDC-like kinase 1

affects expression

Mercury affects the expression of CLK1 mRNA

NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225

G

cleft lip and palate associated transmembrane protein 1

decreases expression
increases expression

Mercury results in decreased expression of CLPTM1 mRNA
Mercury results in increased expression of CLPTM1 mRNA

PMID:16823088 PMID:17547211

NCBI chr 7:19,365,505...19,398,955
Ensembl chr 7:19,365,496...19,398,958

G

clathrin heavy chain

decreases expression

Mercury results in decreased expression of CLTC mRNA

NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391

G

carboxymethylenebutenolidase homolog

decreases expression

Mercury analog results in decreased expression of CMBL mRNA

NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265

G

CCR4-NOT transcription complex, subunit 3

increases expression

Mercury results in increased expression of CNOT3 mRNA

NCBI chr 7:3,646,717...3,664,108
Ensembl chr 7:3,648,267...3,664,108

G

collagen, type XXVI, alpha 1

decreases methylation

Mercury results in decreased methylation of COL26A1 gene

NCBI chr 5:136,770,613...136,912,230
Ensembl chr 5:136,770,613...136,912,063

G

collagen, type IV, alpha 3

increases expression

Mercury results in increased expression of COL4A3 mRNA

NCBI chr 1:82,564,647...82,699,778
Ensembl chr 1:82,564,642...82,699,780

G

catechol-O-methyltransferase

affects response to substance

COMT gene polymorphism affects the susceptibility to Mercury; COMT gene SNP affects the susceptibility to Mercury

PMID:19296409 PMID:24593143

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

ceruloplasmin

affects expression

Mercury affects the expression of CP protein

NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309

G

carboxypeptidase N, polypeptide 2

affects expression

Mercury affects the expression of CPN2 protein

NCBI chr16:30,075,196...30,086,350
Ensembl chr16:30,075,196...30,086,317

G

coproporphyrinogen oxidase

affects response to substance
multiple interactions
decreases activity

CPOX polymorphism affects the susceptibility to Mercury; CPOX protein affects the susceptibility to Mercury; CPOX protein polymorphism affects the susceptibility to Mercury
[Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins; Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]; Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]

PMID:16214298 PMID:16343843 PMID:19339664

NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999

G

carboxypeptidase Z

increases expression

Mercury results in increased expression of CPZ mRNA

NCBI chr 5:35,659,562...35,682,970
Ensembl chr 5:35,659,562...35,683,042

G

cysteine-rich protein 1

decreases expression

Mercury analog results in decreased expression of CRIP1 mRNA

NCBI chr12:113,115,632...113,117,499
Ensembl chr12:113,109,936...113,117,499

G

crystallin, alpha A

decreases expression

Mercury results in decreased expression of CRYAA mRNA

NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707

G

crystallin, alpha B

multiple interactions
decreases response to substance
increases expression

[arsenite co-treated with Cadmium] promotes the reaction [Mercury results in increased expression of CRYAB protein]; [arsenite co-treated with Mercury] promotes the reaction [Cadmium results in increased expression of CRYAB protein]; [Mercury co-treated with Cadmium] promotes the reaction [arsenite results in increased expression of CRYAB protein]
CRYAB protein results in decreased susceptibility to Mercury

NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936

G

crystallin, zeta

multiple interactions
increases activity

Mercury promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]
Mercury results in increased activity of CRYZ protein

NCBI chr 3:154,302,348...154,328,819
Ensembl chr 3:154,302,348...154,328,819

G

chondroitin sulfate proteoglycan 5

increases expression

Mercury results in increased expression of CSPG5 mRNA

NCBI chr 9:110,072,851...110,091,644
Ensembl chr 9:110,072,851...110,091,644

G

cysteine-serine-rich nuclear protein 2

increases expression

Mercury results in increased expression of CSRNP2 mRNA

NCBI chr15:100,377,451...100,393,120
Ensembl chr15:100,377,451...100,393,369

G

cystatin C

multiple interactions

[Metals, Heavy results in increased abundance of Mercury] which results in increased secretion of CST3 protein

NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612

G

C-terminal binding protein 1

increases expression

Mercury results in increased expression of CTBP1 mRNA

NCBI chr 5:33,405,067...33,432,348
Ensembl chr 5:33,405,067...33,432,338

G

cathepsin B

increases activity

Mercury results in increased activity of CTSB protein

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cullin 4B

decreases expression

Mercury analog results in decreased expression of CUL4B mRNA

NCBI chr X:37,620,493...37,665,073
Ensembl chr X:37,622,151...37,665,073

G

C-X-C motif chemokine ligand 15

increases expression

Mercury results in increased expression of CXCL8 protein

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome b-561

decreases expression

Mercury results in decreased expression of CYB561 mRNA

NCBI chr11:105,824,528...105,844,157
Ensembl chr11:105,824,528...105,844,162

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases stability
increases activity
increases expression

[Mercury co-treated with methylmercuric chloride] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Cycloheximide promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; pyrazolanthrone promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 inhibits the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]
Mercury results in increased stability of CYP1A1 protein
Mercury results in increased activity of CYP1A1 protein

PMID:15297030 PMID:16093525 PMID:18078826 PMID:22579925 PMID:23231920 More...

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases activity

[Mercury co-treated with methylmercuric chloride] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A2 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
Mercury results in increased activity of CYP1A2 protein

PMID:22579925 PMID:23231920 PMID:36245390

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Mercury results in increased expression of CYP1B1 protein

PMID:22579925 PMID:23231920

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily u, polypeptide 1

increases expression

Mercury results in increased expression of CYP2U1 mRNA

NCBI chr 3:131,084,140...131,097,806
Ensembl chr 3:131,082,090...131,096,876

G

cytochrome P450, family 7, subfamily a, polypeptide 1

decreases activity

Mercury results in decreased activity of CYP7A1 protein

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

disabled 1

increases expression

Mercury results in increased expression of DAB1 mRNA

NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041

G

doublecortin

multiple interactions

[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of DCX mRNA

NCBI chr X:142,638,838...142,716,392
Ensembl chr X:142,638,838...142,716,307

G

differentially expressed in FDCP 8

decreases expression

Mercury results in decreased expression of DEF8 mRNA

NCBI chr 8:124,169,725...124,190,009
Ensembl chr 8:124,150,266...124,190,009

G

DIRAS family, GTP-binding RAS-like 1

decreases expression

Mercury results in decreased expression of DIRAS1 mRNA

NCBI chr10:80,855,423...80,862,038
Ensembl chr10:80,855,423...80,861,496

G

dynein, axonemal, heavy chain 1

decreases expression

Mercury results in decreased expression of DNAH1 mRNA

NCBI chr14:30,982,332...31,045,926
Ensembl chr14:30,982,332...31,045,853

G

DnaJ heat shock protein family (Hsp40) member A2

increases expression

Mercury results in increased expression of DNAJA2 mRNA

NCBI chr 8:86,264,262...86,281,990
Ensembl chr 8:86,264,262...86,281,973

G

dedicator of cytokinesis 10

increases expression

Mercury results in increased expression of DOCK10 mRNA

NCBI chr 1:80,478,785...80,736,482
Ensembl chr 1:80,478,790...80,736,244

G

dihydropyrimidinase-like 4

increases expression

Mercury results in increased expression of DPYSL4 mRNA

NCBI chr 7:138,665,917...138,681,711
Ensembl chr 7:138,665,917...138,682,620

G

dopamine receptor D3

multiple interactions

Mercury inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295

G

dopamine receptor D4

multiple interactions

Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377

G

dystrobrevin alpha

increases expression

Mercury results in increased expression of DTNA mRNA

NCBI chr18:23,443,063...23,792,776
Ensembl chr18:23,548,192...23,792,772

G

early endosome antigen 1

increases expression

Mercury results in increased expression of EEA1 mRNA

NCBI chr10:95,776,525...95,881,380
Ensembl chr10:95,776,512...95,881,380

G

ephrin B1

increases expression

Mercury results in increased expression of EFNB1 mRNA

NCBI chr X:98,179,667...98,192,628
Ensembl chr X:98,179,736...98,192,597

G

eukaryotic translation initiation factor 2 alpha kinase 1

decreases activity
multiple interactions

Mercury results in decreased activity of EIF2AK1 protein
Nitric Oxide inhibits the reaction [Mercury results in decreased activity of EIF2AK1 protein]

NCBI chr 5:143,803,586...143,839,535
Ensembl chr 5:143,803,543...143,841,069

G

eukaryotic translation initiation factor 3, subunit F

decreases expression

Mercury results in decreased expression of EIF3F mRNA

NCBI chr 7:108,533,622...108,541,149
Ensembl chr 7:108,533,624...108,542,158

G

eukaryotic translation initiation factor 4, gamma 1

decreases expression

Mercury analog results in decreased expression of EIF4G1 mRNA

NCBI chr16:20,491,457...20,511,633
Ensembl chr16:20,487,063...20,511,634

G

elongator complex protein 1

decreases expression

Mercury results in decreased expression of ELP1 mRNA

NCBI chr 4:56,746,547...56,802,565
Ensembl chr 4:56,749,680...56,802,331

G

empty spiracles homeobox 2

increases expression

Mercury results in increased expression of EMX2 mRNA

NCBI chr19:59,447,122...59,453,789
Ensembl chr19:59,446,804...59,453,789

G

engrailed 1

increases expression

Mercury results in increased expression of EN1 mRNA

NCBI chr 1:120,530,246...120,535,719
Ensembl chr 1:120,530,147...120,535,721

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

increases expression

Mercury results in increased expression of ENPP1 mRNA

NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057

G

erythropoietin

multiple interactions

EPO protein affects the reaction [Mercury affects the localization of SLC22A8 protein]; EPO protein inhibits the reaction [Mercury results in increased expression of SLC22A19 protein]; EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of ABCC2 protein]; EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of SLC22A6 protein]; EPO protein promotes the reaction [Mercury results in increased expression of SLC22A8 protein]

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

estrogen receptor 2 (beta)

increases expression

Mercury results in increased expression of ESR2 mRNA

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

electron transferring flavoprotein, beta polypeptide

increases expression

Mercury results in increased expression of ETFB mRNA

NCBI chr 7:43,093,496...43,107,224
Ensembl chr 7:43,093,507...43,107,224

G

E26 avian leukemia oncogene 2, 3' domain

increases expression

Mercury results in increased expression of ETS2 mRNA

NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

increases expression

Mercury results in increased expression of EZH1 mRNA

NCBI chr11:101,081,941...101,117,268
Ensembl chr11:101,081,941...101,117,289

G

coagulation factor X

decreases expression

Mercury results in decreased expression of F10 mRNA

NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676

G

coagulation factor V

decreases expression

Mercury results in decreased expression of F5 mRNA

NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846

G

fatty acid binding protein 5, epidermal

increases expression

Mercury results in increased expression of FABP5 mRNA

NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667

G

fatty acid binding protein 7, brain

increases expression

Mercury results in increased expression of FABP7 mRNA

NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546

G

family with sequence similarity 184, member B

decreases expression

Mercury analog results in decreased expression of FAM184B mRNA

NCBI chr 5:45,687,047...45,796,843
Ensembl chr 5:45,687,047...45,796,956

G

Fas cell surface death receptor

multiple interactions

Mercury inhibits the reaction [FAS protein binds to FAS protein]

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fc receptor, IgE, high affinity I, gamma polypeptide

affects response to substance

FCER1G protein affects the susceptibility to Mercury

NCBI chr 1:171,057,141...171,061,918
Ensembl chr 1:171,057,141...171,061,934

G

Fc receptor, IgG, high affinity I

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]

NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285

G

Fc receptor, IgG, low affinity IV

decreases expression

Mercury results in decreased expression of FCGR3A mRNA

NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330

G

Fc receptor-like A

decreases expression

Mercury results in decreased expression of FCRLA mRNA

NCBI chr 1:170,745,163...170,755,169
Ensembl chr 1:170,745,145...170,755,152

G

ferrochelatase

decreases activity

Mercury results in decreased activity of FECH protein

NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322

G

Fer3 like bHLH transcription factor

decreases expression

Mercury results in decreased expression of FERD3L mRNA

NCBI chr12:33,978,424...33,979,309
Ensembl chr12:33,978,424...33,979,309

G

fibroblast growth factor 2

increases expression

Mercury results in increased expression of FGF2 mRNA

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

filamin, beta

increases expression

Mercury results in increased expression of FLNB mRNA

NCBI chr14:14,518,185...14,651,852
Ensembl chr14:14,518,185...14,651,816

G

fibronectin 1

decreases expression

Mercury results in decreased expression of FN1 mRNA

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FBJ osteosarcoma oncogene

multiple interactions

Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

fos-like antigen 1

increases expression

Mercury results in increased expression of FOSL1 mRNA

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

G

forkhead box I1

decreases expression

Mercury results in decreased expression of FOXI1 mRNA

NCBI chr11:34,154,341...34,158,089
Ensembl chr11:34,154,338...34,158,089

G

forkhead box K1

increases expression

Mercury results in increased expression of FOXK1 mRNA

NCBI chr 5:142,387,252...142,447,770
Ensembl chr 5:142,387,252...142,447,766

G

FERM domain containing 6

decreases expression

Mercury analog results in decreased expression of FRMD6 mRNA

NCBI chr12:70,872,235...70,949,009
Ensembl chr12:70,872,288...70,949,008

G

furin, paired basic amino acid cleaving enzyme

decreases expression

Mercury results in decreased expression of FURIN mRNA

NCBI chr 7:80,038,942...80,055,188
Ensembl chr 7:80,038,333...80,055,184

G

glucose-6-phosphate dehydrogenase X-linked

decreases activity

Mercury results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

gamma-aminobutyric acid type A receptor subunit alpha 6

increases expression

Mercury results in increased expression of GABRA6 mRNA

NCBI chr11:42,197,264...42,211,977
Ensembl chr11:42,197,264...42,211,899

G

growth arrest specific 7

increases expression

Mercury results in increased expression of GAS7 mRNA

NCBI chr11:67,344,083...67,579,818
Ensembl chr11:67,345,917...67,575,800

G

GATA zinc finger domain containing 2B

decreases expression

Mercury analog results in decreased expression of GATAD2B mRNA

NCBI chr 3:90,200,488...90,270,712
Ensembl chr 3:90,200,485...90,270,714

G

glutamate-cysteine ligase, catalytic subunit

increases expression
affects response to substance
multiple interactions

Mercury results in increased expression of GCLC mRNA
GCLC gene SNP affects the susceptibility to Mercury
[Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein; GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]

PMID:17547211 PMID:19515364 PMID:22236634 PMID:27837179 PMID:30359721

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

decreases expression
affects abundance
affects metabolic processing

Mercury results in decreased expression of GCLM mRNA
GCLM gene polymorphism affects the abundance of Mercury; GCLM protein affects the abundance of Mercury
GCLM polymorphism affects the metabolism of Mercury

PMID:16961004 PMID:18560528 PMID:19937285 PMID:21925580

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

gamma-glutamyl carboxylase

decreases expression

Mercury results in decreased expression of GGCX mRNA

NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695

G

gamma-glutamyltransferase 1

decreases expression
multiple interactions

Mercury results in decreased expression of GGT1 mRNA
[Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of GGT1 protein

PMID:19937285 PMID:30090589

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

galactosidase, alpha

increases expression

Mercury results in increased expression of GLA mRNA

NCBI chr X:133,488,912...133,501,707
Ensembl chr X:133,488,898...133,501,874

G

glycine receptor, alpha 3 subunit

increases expression

Mercury results in increased expression of GLRA3 mRNA

NCBI chr 8:56,393,454...56,583,111
Ensembl chr 8:56,393,495...56,583,105

G

predicted gene 4924

increases expression

Mercury results in increased expression of ZNF80 mRNA

NCBI chr10:82,190,087...82,215,477
Ensembl chr10:82,190,089...82,258,716

G

predicted gene 9920

increases expression

Mercury results in increased expression of FAM106A mRNA

NCBI chr15:54,963,313...54,976,978
Ensembl chr15:54,963,313...54,977,100

G

GDP-mannose pyrophosphorylase B

decreases expression

Mercury analog results in decreased expression of GMPPB mRNA

NCBI chr 9:107,926,490...107,929,119
Ensembl chr 9:107,926,441...107,930,000

G

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

increases expression

Mercury results in increased expression of GNGT1 mRNA

NCBI chr 6:3,989,082...3,997,441
Ensembl chr 6:3,993,792...3,997,436

G

gonadotropin releasing hormone 1

increases expression

Mercury results in increased expression of GNRH1 mRNA

NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888

G

golgin A1

decreases expression

Mercury analog results in decreased expression of GOLGA1 mRNA

NCBI chr 2:38,906,167...38,955,568
Ensembl chr 2:38,906,167...38,955,553

G

golgin A3

decreases expression

Mercury analog results in decreased expression of GOLGA3 mRNA

NCBI chr 5:110,324,723...110,374,336
Ensembl chr 5:110,324,567...110,374,336

G

golgi reassembly stacking protein 1

decreases expression

Mercury analog results in decreased expression of GORASP1 mRNA

NCBI chr 9:119,754,739...119,766,624
Ensembl chr 9:119,754,323...119,766,631

G

G protein-coupled estrogen receptor 1

decreases expression

Mercury results in decreased expression of GPER1 mRNA

NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555

G

glutamic pyruvic transaminase, soluble

multiple interactions

[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

affects response to substance
increases expression

GPX1 gene SNP affects the susceptibility to Mercury
Mercury results in increased expression of GPX1 protein

PMID:16451871 PMID:22236634

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

gelsolin

decreases expression
affects expression

Mercury results in decreased expression of GSN mRNA
Mercury affects the expression of GSN protein

PMID:17547211 PMID:22030286

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

glutathione reductase

decreases activity
multiple interactions

Mercury results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein

PMID:10798623 PMID:17176674

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione synthetase

affects abundance

GSS gene polymorphism affects the abundance of Mercury

NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730

G

glutathione S-transferase, alpha 2 (Yc2)

increases expression

Mercury results in increased expression of GSTA2 mRNA

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

glutathione S-transferase, alpha 3

increases expression
affects activity
multiple interactions

Mercury results in increased expression of GSTA1 mRNA
Mercury affects the activity of GSTA2 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]]; Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]; Mercury inhibits the reaction [Benzo(a)pyrene results in increased activity of GSTA2 protein]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of GSTA2 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction and results in increased expression of Tetrachlorodibenzodioxin promotes the reaction and results in increased expression of GSTA1 mRNA; Mercury results in increased expression of and results in increased activity of GSTA1 protein; NFE2L2 protein affects the reaction [Mercury results in increased expression of GSTA1 mRNA]

PMID:15297030 PMID:16243960 PMID:22579925

NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885

G

glutathione S-transferase, mu 1

affects response to substance
multiple interactions
affects abundance

GSTM1 gene polymorphism affects the susceptibility to Mercury; GSTM1 polymorphism affects the susceptibility to Mercury
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; [GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GSTM1 protein
GSTM1 gene polymorphism affects the abundance of Mercury

PMID:17716707 PMID:19515364 PMID:20194072 PMID:24319713 PMID:25728017 More...

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, pi 1

affects abundance
multiple interactions
increases expression

GSTP1 gene affects the abundance of Mercury; GSTP1 gene polymorphism affects the abundance of Mercury
[GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]; GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]
Mercury results in increased expression of GSTP1 mRNA; Mercury results in increased expression of GSTP1 protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 protein

PMID:12167210 PMID:12730625 PMID:18560528 PMID:19515364 PMID:21967774 More...

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

glutathione S-transferase, theta 1

affects abundance
multiple interactions
affects response to substance

GSTT1 gene polymorphism affects the abundance of Mercury
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]
GSTT1 gene polymorphism affects the susceptibility to Mercury; GSTT1 polymorphism affects the susceptibility to Mercury

PMID:17716707 PMID:19515364 PMID:20194072 PMID:21967774 PMID:24319713

NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418

G

GTP-binding protein 8 (putative)

decreases expression

Mercury analog results in decreased expression of GTPBP8 mRNA

NCBI chr16:44,559,242...44,566,726
Ensembl chr16:44,557,131...44,566,726

G

glucoside xylosyltransferase 2

decreases expression

Mercury analog results in decreased expression of GXYLT2 mRNA

NCBI chr 6:100,681,638...100,787,738
Ensembl chr 6:100,681,695...100,787,874

G

histocompatibility 2, class II antigen A, alpha

decreases expression

Mercury results in decreased expression of HLA-DQA1 mRNA

PMID:16823088 PMID:19937285

NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797

G

histocompatibility 2, class II antigen A, beta 1

increases expression
decreases expression

Mercury results in increased expression of HLA-DQB1 mRNA
Mercury results in decreased expression of HLA-DQB1 mRNA
Mercury results in increased expression of RT1-BB mRNA

PMID:16823088 PMID:19937285 PMID:22688007

NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393

G

H2A clustered histone 22

increases expression

Mercury results in increased expression of H2AC11 mRNA

NCBI chr13:21,970,944...21,971,418
Ensembl chr13:21,970,996...21,971,388

G

H2B clustered histone 27

decreases expression

Mercury analog results in decreased expression of H2BC27 mRNA

NCBI chr11:58,839,737...58,840,198
Ensembl chr11:58,839,746...58,840,359

G

H4 clustered histone 14

increases expression

Mercury results in increased expression of H4C3 mRNA

NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627

G

hyaluronic acid binding protein 4

increases expression

Mercury results in increased expression of HABP4 mRNA

NCBI chr13:64,309,680...64,334,351
Ensembl chr13:64,309,638...64,334,351

G

hepcidin antimicrobial peptide

multiple interactions

[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

hepatitis A virus cellular receptor 1

increases expression

Mercury results in increased expression of HAVCR1 mRNA; Mercury results in increased expression of HAVCR1 protein

PMID:17934191 PMID:25145654

NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405

G

hephaestin

increases expression

Mercury results in increased expression of HEPH mRNA

NCBI chr X:95,499,042...95,618,091
Ensembl chr X:95,498,965...95,618,091

G

hypoxia inducible factor 3, alpha subunit

decreases expression

Mercury results in decreased expression of HIF3A mRNA

NCBI chr 7:16,764,918...16,796,352
Ensembl chr 7:16,765,432...16,796,352

G

histidine triad nucleotide binding protein 3

decreases expression

Mercury analog results in decreased expression of HINT3 mRNA

NCBI chr10:30,479,191...30,499,526
Ensembl chr10:30,484,137...30,505,628

G

high mobility group nucleosomal binding domain 2

increases expression

Mercury results in increased expression of HMGN2 mRNA

NCBI chr 4:133,692,050...133,695,302
Ensembl chr 4:133,692,049...133,695,961

G

heme oxygenase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]
[Benzo(a)pyrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [beta-Naphthoflavone co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Mercury co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 protein; [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Tetrachlorodibenzodioxin co-treated with Mercury] results in increased expression of HMOX1 mRNA; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA]; Mercury results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Mercury results in increased expression of HMOX mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]

PMID:12730625 PMID:15297030 PMID:16093525 PMID:17244614 PMID:17547211 More...

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

HNF1 homeobox A

increases expression

Mercury results in increased expression of HNF1A mRNA

NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153

G

heterogeneous nuclear ribonucleoprotein H3

increases expression

Mercury results in increased expression of HNRNPH3 mRNA

NCBI chr10:62,850,443...62,859,764
Ensembl chr10:62,850,443...62,859,996

G

homeobox B4

increases expression

Mercury results in increased expression of HOXB4 mRNA

NCBI chr11:96,209,093...96,212,464
Ensembl chr11:96,209,093...96,212,464

G

homeobox B6

increases expression

Mercury results in increased expression of HOXB6 mRNA

NCBI chr11:96,183,647...96,192,395
Ensembl chr11:96,183,302...96,192,395

G

hemopexin

affects expression

Mercury affects the expression of HPX protein

NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344

G

Harvey rat sarcoma virus oncogene

multiple interactions

Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

G

HCLS1 binding protein 3

decreases expression

Mercury results in decreased expression of HS1BP3 mRNA

NCBI chr12:8,363,389...8,393,824
Ensembl chr12:8,363,432...8,393,824

G

heat shock factor 1

multiple interactions
increases activity

Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]; Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Mercury results in increased activity of HSF1 protein

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock factor 2

decreases expression

Mercury results in decreased expression of HSF2 mRNA

NCBI chr10:57,359,862...57,389,239
Ensembl chr10:57,362,481...57,389,231

G

heat shock protein 90, alpha (cytosolic), class A member 1

increases expression

Mercury results in increased expression of HSP90AA1 mRNA

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 1A

multiple interactions
increases expression

Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Mercury results in increased expression of HSPA1A mRNA

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 1B

affects response to substance

HSPA1B gene polymorphism affects the susceptibility to Mercury

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

heat shock protein 1-like

affects response to substance

HSPA1L gene polymorphism affects the susceptibility to Mercury

NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261

G

heat shock protein 5

affects expression
multiple interactions

Mercury affects the expression of HSPA5 mRNA
Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]; Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]; Mercury results in increased expression of and results in increased activity of HSPA5 protein

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 1 (chaperonin)

increases expression

Mercury results in increased expression of HSPD1 mRNA

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

5-hydroxytryptamine (serotonin) receptor 7

increases expression

Mercury results in increased expression of HTR7 mRNA

NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907

G

interferon-induced protein 44

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFI44 mRNA

NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597

G

interferon alpha 4

increases expression

Mercury results in increased expression of IFNA8 mRNA

NCBI chr 4:88,760,032...88,761,009
Ensembl chr 4:88,760,098...88,760,658

G

interferon gamma

affects expression
decreases secretion
increases expression
multiple interactions

Mercury affects the expression of IFNG mRNA; Mercury affects the expression of IFNG protein
Mercury results in decreased secretion of IFNG protein
Mercury results in increased expression of IFNG protein
Mercury results in increased expression of IFNG mRNA
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG protein; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG mRNA]; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IFNG mRNA]

PMID:12928768 PMID:15910788 PMID:20176347 PMID:25237059 PMID:28453771

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interferon gamma receptor 1

affects response to substance

IFNGR1 affects the susceptibility to Mercury

NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977

G

interferon-related developmental regulator 1

decreases expression

Mercury results in decreased expression of IFRD1 mRNA

NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503

G

insulin-like growth factor 1

multiple interactions

Mercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

interleukin 10

increases expression

Mercury results in increased expression of IL10 mRNA

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 13

increases expression

Mercury results in increased expression of IL13 mRNA

NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529

G

interleukin 17 receptor B

decreases expression

Mercury results in decreased expression of IL17RB mRNA

NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853

G

interleukin 1 beta

increases expression
multiple interactions

Mercury results in increased expression of IL1B protein
Mercury promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Mercury results in increased expression of IL1B mRNA; Mercury results in increased expression of IL1B protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL1B mRNA; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IL1B mRNA]

PMID:20176347 PMID:20600710 PMID:25237059 PMID:28453771 PMID:37137463

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

increases expression

Mercury results in increased expression of IL2 mRNA

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 33

decreases expression

Mercury analog results in decreased expression of IL33 mRNA

NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118

G

interleukin 3 receptor, alpha chain

decreases expression

Mercury results in decreased expression of IL3RA mRNA

NCBI chr14:8,114,270...8,123,851
Ensembl chr14:8,113,752...8,123,488

G

interleukin 4

decreases secretion
multiple interactions

Mercury results in decreased secretion of IL4 protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]

PMID:15910788 PMID:28453771

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 6

increases expression
multiple interactions

Mercury results in increased expression of IL6 protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL6 mRNA; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; Salicylic Acid inhibits the reaction [Mercury results in increased expression of IL6]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]

PMID:18393961 PMID:23742082 PMID:28453771 PMID:37415728 PMID:37676925

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interphotoreceptor matrix proteoglycan 1

increases expression

Mercury results in increased expression of IMPG1 mRNA

NCBI chr 9:80,215,467...80,347,707
Ensembl chr 9:80,220,612...80,347,534

G

insulin I

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

interferon regulatory factor 1

affects response to substance
multiple interactions

IRF1 affects the susceptibility to Mercury
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]

PMID:22578563 PMID:28453771

NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200

G

interferon regulatory factor 8

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]

NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433

G

insulin receptor substrate 1

multiple interactions

[Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

ISG15 ubiquitin-like modifier

decreases expression

Mercury analog results in decreased expression of ISG15 mRNA

NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253

G

integrin beta 1 (fibronectin receptor beta)

increases activity

Mercury results in increased activity of ITGB1 protein

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

integrin beta 3 binding protein (beta3-endonexin)

increases expression

Mercury results in increased expression of ITGB3BP mRNA

NCBI chr 4:99,655,643...99,717,403
Ensembl chr 4:99,653,639...99,787,010

G

inter-alpha trypsin inhibitor, heavy chain 1

affects expression

Mercury affects the expression of ITIH1 protein

NCBI chr14:30,651,137...30,665,246
Ensembl chr14:30,651,137...30,665,246

G

inter-alpha trypsin inhibitor, heavy chain 3

decreases expression

Mercury results in decreased expression of ITIH3 mRNA

NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717

G

inter alpha-trypsin inhibitor, heavy chain 4

affects expression

Mercury affects the expression of ITIH4 protein

NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310

G

influenza virus NS1A binding protein

decreases expression

Mercury results in decreased expression of IVNS1ABP mRNA

NCBI chr 1:151,220,237...151,240,196
Ensembl chr 1:151,220,228...151,240,173

G

Janus kinase 2

affects expression

Mercury affects the expression of JAK2 mRNA

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

jun proto-oncogene

decreases expression
multiple interactions

Mercury results in decreased expression of JUN mRNA
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein

PMID:12730625 PMID:28035397

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

increases expression

Mercury results in increased expression of KCNH2 mRNA

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

decreases expression

Mercury analog results in decreased expression of KDELR2 mRNA

NCBI chr 5:143,389,575...143,407,659
Ensembl chr 5:143,389,593...143,407,656

G

Kruppel-like transcription factor 12

decreases expression

Mercury results in decreased expression of KLF12 mRNA

NCBI chr14:100,103,617...100,719,681
Ensembl chr14:100,108,068...100,522,115

G

Kruppel-like transcription factor 2 (lung)

decreases expression

Mercury results in decreased expression of KLF2 mRNA

NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500

G

lysine (K)-specific methyltransferase 2B

increases expression

Mercury results in increased expression of KMT2B mRNA

NCBI chr 7:30,268,280...30,288,371
Ensembl chr 7:30,268,283...30,288,151

G

keratin 1

increases expression

Mercury results in increased expression of KRT1 mRNA

NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229

G

laminin, gamma 1

decreases expression

Mercury analog results in decreased expression of LAMC1 mRNA

NCBI chr 1:153,094,668...153,208,532
Ensembl chr 1:153,094,668...153,208,532

G

LanC (bacterial lantibiotic synthetase component C)-like 1

decreases expression

Mercury results in decreased expression of LANCL1 mRNA

NCBI chr 1:67,039,676...67,078,049
Ensembl chr 1:67,039,676...67,078,031

G

LanC (bacterial lantibiotic synthetase component C)-like 2

decreases expression

Mercury results in decreased expression of LANCL2 mRNA

NCBI chr 6:57,679,440...57,716,434
Ensembl chr 6:57,679,525...57,716,424

G

lipocalin 2

increases expression

Mercury results in increased expression of LCN2 mRNA

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

leukocyte receptor cluster (LRC) member 9

decreases expression

Mercury analog results in decreased expression of LENG9 mRNA

NCBI chr 7:4,151,182...4,152,871
Ensembl chr 7:4,150,914...4,153,373

G

leptin receptor

decreases expression

Mercury results in decreased expression of LEPR mRNA

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

LIM domains containing 1

decreases expression

Mercury analog results in decreased expression of LIMD1 mRNA

NCBI chr 9:123,306,790...123,350,617
Ensembl chr 9:123,307,771...123,350,617

G

LIM and senescent cell antigen like domains 2

decreases expression

Mercury analog results in decreased expression of LIMS2 mRNA

NCBI chr18:32,055,346...32,091,673
Ensembl chr18:32,055,343...32,091,672

G

lysosomal acid lipase A

decreases expression

Mercury results in decreased expression of LIPA mRNA

NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874

G

limb region 1

decreases expression

Mercury analog results in decreased expression of LMBR1 mRNA

NCBI chr 5:29,434,800...29,583,414
Ensembl chr 5:29,481,000...29,485,295
Ensembl chr 5:29,481,000...29,485,295

G

lamin A

decreases expression

Mercury results in decreased expression of LMNA mRNA

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

leucine rich repeat (in FLII) interacting protein 1

increases expression

Mercury results in increased expression of LRRFIP1 mRNA

NCBI chr 1:90,924,652...91,056,666
Ensembl chr 1:90,926,459...91,056,666

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Mercury analog results in decreased expression of LSM5 mRNA

NCBI chr 6:56,678,048...56,681,684
Ensembl chr 6:56,678,048...56,681,695

G

lactotransferrin

increases expression

Mercury results in increased expression of LTF protein

NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

Mercury results in increased phosphorylation of and results in increased activity of LYN protein

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

G

leucine zipper, putative tumor suppressor 2

decreases expression

Mercury analog results in decreased expression of LZTS2 mRNA

NCBI chr19:45,003,615...45,015,554
Ensembl chr19:45,002,853...45,015,550

G

microtubule-actin crosslinking factor 1

increases expression

Mercury results in increased expression of MACF1 mRNA

NCBI chr 4:123,243,386...123,581,594
Ensembl chr 4:123,243,426...123,581,331

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

increases expression

Mercury results in increased expression of MAFF mRNA

NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276

G

mannosidase, alpha, class 1B, member 1

affects expression

Mercury affects the expression of MAN1B1 mRNA

NCBI chr 2:25,222,742...25,242,225
Ensembl chr 2:25,222,350...25,242,224

G

microtubule-associated protein 2

multiple interactions

[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of MAP2 mRNA

NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742

G

mitogen-activated protein kinase kinase 2

increases expression

Mercury results in increased expression of MAP2K2 mRNA

NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809

G

microtubule-associated protein 9

increases expression

Mercury results in increased expression of MAP9 mRNA

NCBI chr 3:82,265,379...82,302,575
Ensembl chr 3:82,265,351...82,302,575

G

mitogen-activated protein kinase 1

increases phosphorylation

Mercury results in increased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation

Mercury results in increased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

minichromosome maintenance complex component 2

increases expression

Mercury results in increased expression of MCM2 mRNA

NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762

G

mediator complex subunit 16

increases expression

Mercury results in increased expression of MED16 mRNA

NCBI chr10:79,730,543...79,744,757
Ensembl chr10:79,730,542...79,744,757

G

mesenchyme homeobox 2

increases expression

Mercury results in increased expression of MEOX2 mRNA

NCBI chr12:37,158,539...37,229,533
Ensembl chr12:37,158,539...37,229,533

G

microfibrillar associated protein 5

increases expression

Mercury results in increased expression of MFAP5 mRNA

NCBI chr 6:122,490,543...122,506,249
Ensembl chr 6:122,482,804...122,506,249

G

mannoside acetylglucosaminyltransferase 2

decreases expression

Mercury results in decreased expression of MGAT2 mRNA

NCBI chr12:69,230,932...69,233,547
Ensembl chr12:69,230,931...69,233,544

G

mannoside acetylglucosaminyltransferase 5

increases expression

Mercury results in increased expression of MGAT5 mRNA

NCBI chr 1:127,132,450...127,413,760
Ensembl chr 1:127,132,752...127,416,073

G

microRNA 10a

decreases expression

Mercury results in decreased expression of MIR10A mRNA

NCBI chr11:96,207,991...96,208,100
Ensembl chr11:96,207,991...96,208,100

G

microRNA 151

decreases expression

Mercury results in decreased expression of MIR151A mRNA

NCBI chr15:73,126,664...73,126,731
Ensembl chr15:73,126,664...73,126,731

G

microRNA 190b

decreases expression

Mercury results in decreased expression of MIR190B mRNA

NCBI chr 3:89,977,327...89,977,406
Ensembl chr 3:89,977,327...89,977,406

G

microRNA 193b

decreases expression

Mercury results in decreased expression of MIR193B mRNA

NCBI chr16:13,267,387...13,267,465
Ensembl chr16:13,267,387...13,267,465

G

microRNA 423

decreases expression

Mercury results in decreased expression of MIR423 mRNA

NCBI chr11:76,968,890...76,968,998
Ensembl chr11:76,968,890...76,968,998

G

microRNA 96

decreases expression

Mercury results in decreased expression of MIR96 mRNA

NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550

G

microRNA let7b

decreases expression

Mercury results in decreased expression of MIRLET7B mRNA

NCBI chr15:85,591,520...85,591,604
Ensembl chr15:85,591,520...85,591,604

G

microRNA let7c-1

decreases expression

Mercury results in decreased expression of MIRLET7C mRNA

NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638

G

microRNA let7d

decreases expression

Mercury results in decreased expression of MIRLET7D mRNA

NCBI chr13:48,689,488...48,689,590
Ensembl chr13:48,689,488...48,689,590

G

microRNA let7g

decreases expression

Mercury results in decreased expression of MIRLET7G mRNA

NCBI chr 9:106,056,039...106,056,126
Ensembl chr 9:106,056,039...106,056,126

G

microRNA let7i

decreases expression

Mercury results in decreased expression of MIRLET7I mRNA

NCBI chr10:122,821,545...122,821,629
Ensembl chr10:122,821,545...122,821,629

G

membrane metallo endopeptidase

increases expression
multiple interactions

Mercury results in increased expression of MME protein
Mercury affects the folding of and results in decreased activity of MME protein

NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451

G

matrix metallopeptidase 2

multiple interactions

Mercury affects the reaction [MMP2 promoter polymorphism results in increased expression of MMP2 protein]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

affects response to substance

MMP9 promoter polymorphism affects the susceptibility to Mercury

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

mortality factor 4 like 2

decreases expression

Mercury results in decreased expression of MORF4L2 mRNA

NCBI chr X:135,633,691...135,644,435
Ensembl chr X:135,633,691...135,644,439

G

myeloperoxidase

decreases activity

Mercury results in decreased activity of MPO protein

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

mitochondrial ribosomal protein S23

decreases expression

Mercury analog results in decreased expression of MRPS23 mRNA

NCBI chr11:88,084,932...88,102,333
Ensembl chr11:88,095,214...88,102,333

G

mutS homolog 6

increases expression

Mercury results in increased expression of MSH6 mRNA

NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320

G

MSL complex subunit 3

decreases expression

Mercury analog results in decreased expression of MSL3 mRNA

NCBI chr X:167,434,263...167,456,868
Ensembl chr X:167,437,113...167,456,894

G

macrophage scavenger receptor 1

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of MSR1 mRNA

NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714

G

metallothionein 1

affects binding
increases expression
increases response to substance
multiple interactions

Mercury binds to MT1 protein
Mercury results in increased expression of MT1 mRNA; Mercury results in increased expression of MT1 protein
MT1 gene mutant form results in increased susceptibility to Mercury
[MT1 co-treated with MT2] affects the susceptibility to Mercury
Mercury results in increased expression of MT1 mRNA; Mercury results in increased expression of MT1 protein; Mercury results in increased expression of MT1A mRNA

PMID:8917669 PMID:9462895 PMID:9587011 PMID:12167210 PMID:12730625 More...

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

metallothionein 2

affects binding
increases expression
increases response to substance
multiple interactions
affects abundance
affects response to substance

Mercury binds to MT2 protein
Mercury results in increased expression of MT2 mRNA; Mercury results in increased expression of MT2 protein
MT2 gene mutant form results in increased susceptibility to Mercury
[MT1 co-treated with MT2] affects the susceptibility to Mercury; [MT3 protein affects the susceptibility to Mercury] which affects the expression of MT2 mRNA
MT2A gene SNP affects the abundance of Mercury
[MT1M gene polymorphism co-treated with MT2A gene polymorphism] affects the susceptibility to Mercury
MT2A gene polymorphism affects the susceptibility to Mercury
Mercury results in increased expression of MT2A mRNA

PMID:2771874 PMID:8917669 PMID:9462895 PMID:9587011 PMID:15138662 More...

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

metallothionein 3

affects binding
increases expression
multiple interactions
affects response to substance

Mercury binds to MT3 protein
Mercury results in increased expression of MT3 mRNA; Mercury results in increased expression of MT3 protein
[MT3 protein affects the susceptibility to Mercury] which affects the expression of CCL7 mRNA; [MT3 protein affects the susceptibility to Mercury] which affects the expression of MT2 mRNA; MT3 protein affects the reaction [Mercury results in increased expression of CCL3 mRNA]

PMID:8917669 PMID:9587011 PMID:15138662 PMID:15782327 PMID:17018868 More...

NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774

G

metallothionein 4

affects abundance

MT4 gene polymorphism affects the abundance of Mercury

NCBI chr 8:94,863,832...94,865,659
Ensembl chr 8:94,863,825...94,865,659

G

metal response element binding transcription factor 1

increases expression

Mercury results in increased expression of MTF1 mRNA

NCBI chr 4:124,696,342...124,743,593
Ensembl chr 4:124,695,897...124,743,593

G

myotubularin related protein 11

decreases expression

Mercury results in decreased expression of MTMR11 mRNA

NCBI chr 3:96,069,287...96,079,034
Ensembl chr 3:96,069,321...96,079,034

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Mercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]

PMID:14745455 PMID:26989453

NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999

G

mitochondrial translational release factor 1

decreases expression

Mercury results in decreased expression of MTRF1 mRNA

NCBI chr14:79,635,205...79,672,626
Ensembl chr14:79,635,212...79,661,027

G

mucin 2

increases expression

Mercury results in increased expression of MUC2 mRNA

NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430

G

multivesicular body subunit 12B

increases expression

Mercury results in increased expression of MVB12B mRNA

NCBI chr 2:33,619,965...33,777,958
Ensembl chr 2:33,619,965...33,777,958

G

myelocytomatosis oncogene

decreases expression
affects expression

Mercury results in decreased expression of MYC mRNA
Mercury affects the expression of MYC mRNA

PMID:12928768 PMID:16823088

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

myosin IB

increases expression
decreases expression

Mercury results in increased expression of MYO1B mRNA
Mercury analog results in decreased expression of MYO1B mRNA

PMID:16823088 PMID:25056781

NCBI chr 1:51,788,915...51,955,143
Ensembl chr 1:51,788,924...51,955,230

G

myeloid zinc finger 1

decreases expression

Mercury analog results in decreased expression of MZF1 mRNA

NCBI chr 7:12,777,074...12,792,244
Ensembl chr 7:12,776,230...12,788,691

G

nucleosome assembly protein 1-like 1

increases expression

Mercury results in increased expression of NAP1L1 mRNA

NCBI chr10:111,308,754...111,334,011
Ensembl chr10:111,309,084...111,334,011

G

N-acetyl transferase 1

multiple interactions

Mercury binds to and results in decreased activity of NAT1 protein

NCBI chr 8:67,943,620...67,945,183
Ensembl chr 8:67,933,573...67,944,756

G

neuron navigator 3

increases expression

Mercury results in increased expression of NAV3 mRNA

NCBI chr10:109,517,121...110,292,148
Ensembl chr10:109,517,120...110,292,065

G

non-SMC condensin II complex, subunit D3

increases expression
decreases expression

Mercury results in increased expression of NCAPD3 mRNA
Mercury analog results in decreased expression of NCAPD3 mRNA

PMID:19937285 PMID:25056781

NCBI chr 9:26,941,455...27,008,667
Ensembl chr 9:26,941,471...27,006,611

G

nuclear receptor coactivator 3

increases expression

Mercury results in increased expression of NCOA3 mRNA

NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,545...165,915,162

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Mercury results in decreased expression of NDUFS2 mRNA

NCBI chr 1:171,062,426...171,078,956
Ensembl chr 1:171,062,422...171,078,957

G

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

increases expression

Mercury results in increased expression of NFATC4 mRNA

NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression
increases activity

NFE2L2 protein affects the reaction [Mercury results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA]
Mercury results in increased expression of NFE2L2 mRNA
Mercury results in increased activity of NFE2L2 promoter
[Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of NFE2L2 protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]

PMID:16243960 PMID:21643505 PMID:27837179 PMID:30359721 PMID:37415728

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of NFKB1 protein]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein; Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]

PMID:11437639 PMID:15282405 PMID:37415728

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nerve growth factor

increases expression
decreases expression

Mercury results in increased expression of NGF mRNA
Mercury results in decreased expression of NGF mRNA

PMID:7781173 PMID:16823088

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nerve growth factor receptor (TNFR superfamily, member 16)

decreases expression

Mercury results in decreased expression of NGFR mRNA

NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561

G

NHERF family PDZ scaffold protein 2

increases expression

Mercury results in increased expression of NHERF2 mRNA

NCBI chr17:24,858,255...24,869,279
Ensembl chr17:24,858,260...24,869,301

G

NLR family, pyrin domain containing 1A

decreases expression

Mercury results in decreased expression of NLRP1 mRNA

NCBI chr11:70,982,023...71,035,780
Ensembl chr11:70,983,062...71,035,530

G

NLR family, pyrin domain containing 3

increases expression
multiple interactions

Mercury results in increased expression of NLRP3 mRNA
N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA]

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

N-myristoyltransferase 2

increases expression

Mercury results in increased expression of NMT2 mRNA

NCBI chr 2:3,285,249...3,329,914
Ensembl chr 2:3,285,249...3,329,914

G

nucleotide-binding oligomerization domain containing 1

decreases expression

Mercury results in decreased expression of NOD1 mRNA

NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597

G

NADPH oxidase 4

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NOX4 protein

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases activity
increases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein]; Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein]; Mercury results in increased expression of and results in increased activity of NQO1 protein; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA]; prolinedithiocarbamate promotes the reaction [Mercury results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 protein]; U 0126 promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of NQO1 protein]
Mercury results in increased activity of NQO1 protein
Mercury results in increased expression of NQO1 mRNA; Mercury results in increased expression of NQO1 protein
Acetylcysteine inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]

PMID:16243960 PMID:18752316 PMID:22579925 PMID:26600472

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Mercury results in decreased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

nuclear speckle regulatory protein 1

decreases expression

Mercury analog results in decreased expression of NSRP1 mRNA

NCBI chr11:76,935,118...76,969,263
Ensembl chr11:76,935,118...76,969,261

G

neurotrophic tyrosine kinase, receptor, type 3

increases expression

Mercury results in increased expression of NTRK3 mRNA

NCBI chr 7:77,825,711...78,228,865
Ensembl chr 7:77,825,707...78,387,760

G

nucleoporin 107

increases expression

Mercury results in increased expression of NUP107 mRNA

NCBI chr10:117,586,526...117,628,607
Ensembl chr10:117,586,526...117,628,610

G

occludin

decreases expression

Mercury results in decreased expression of OCLN mRNA

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

8-oxoguanine DNA-glycosylase 1

decreases expression

Mercury results in decreased expression of OGG1 mRNA

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

opioid receptor, delta 1

multiple interactions

Mercury inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]

NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797

G

opioid receptor, kappa 1

multiple interactions

Mercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]

NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354

G

opioid receptor, mu 1

multiple interactions

Mercury inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]

NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198

G

amplified in osteosarcoma

decreases expression

Mercury results in decreased expression of OS9 mRNA

NCBI chr10:126,928,880...126,957,029
Ensembl chr10:126,931,519...126,957,000

G

purinergic receptor P2X, ligand-gated ion channel, 2

multiple interactions

Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]

NCBI chr 5:110,487,678...110,491,186
Ensembl chr 5:110,487,678...110,491,078

G

purinergic receptor P2X, ligand-gated ion channel 4

multiple interactions

[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

PMID:10737610 PMID:15629187 PMID:19793987

NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801

G

Parkinson disease (autosomal recessive, early onset) 7

increases expression
affects binding

Mercury results in increased expression of PARK7 mRNA
Mercury binds to PARK7 protein

PMID:16823088 PMID:23792957

NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

paired box 6

multiple interactions

[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of PAX6 mRNA

NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709

G

protocadherin beta 5

decreases expression

Mercury results in decreased expression of PCDHB4 mRNA

NCBI chr18:37,453,434...37,456,966
Ensembl chr18:37,453,434...37,456,968

G

phosphodiesterase 1A, calmodulin-dependent

decreases expression

Mercury results in decreased expression of PDE1A mRNA

NCBI chr 2:79,664,797...80,026,862
Ensembl chr 2:79,664,797...79,959,802

G

phosphodiesterase 4D interacting protein (myomegalin)

increases expression

Mercury results in increased expression of PDE4DIP mRNA

NCBI chr 3:97,597,144...97,796,023
Ensembl chr 3:97,597,140...97,796,023

G

protein disulfide isomerase associated 4

decreases expression

Mercury results in decreased expression of PDIA4 mRNA

NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364

G

PDS5 cohesin associated factor B

decreases expression

Mercury results in decreased expression of PDS5B mRNA

NCBI chr 5:150,597,178...150,734,174
Ensembl chr 5:150,597,204...150,734,155

G

peroxisomal biogenesis factor 14

increases expression

Mercury results in increased expression of PEX14 mRNA

NCBI chr 4:149,044,992...149,184,300
Ensembl chr 4:149,044,992...149,184,333

G

prefoldin 4

decreases expression

Mercury analog results in decreased expression of PFDN4 mRNA

NCBI chr 2:170,338,348...170,360,987
Ensembl chr 2:170,338,348...170,361,043

G

progastricsin (pepsinogen C)

decreases expression

Mercury results in decreased expression of PGC mRNA

NCBI chr17:48,037,767...48,045,403
Ensembl chr17:48,037,767...48,045,407

G

paired-like homeobox 2b

increases expression

Mercury results in increased expression of PHOX2B mRNA

NCBI chr 5:67,251,751...67,256,399
Ensembl chr 5:67,251,742...67,256,644

G

protein inhibitor of activated STAT 2

affects expression

Mercury affects the expression of PIAS2 mRNA

NCBI chr18:77,152,883...77,243,406
Ensembl chr18:77,152,904...77,241,496

G

protein inhibitor of activated STAT 4

decreases expression

Mercury results in decreased expression of PIAS4 mRNA

NCBI chr10:80,989,795...81,003,554
Ensembl chr10:80,989,100...81,003,757

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

Mercury results in decreased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

phosphoinositide-3-kinase regulatory subunit 4

increases expression

Mercury results in increased expression of PIK3R4 mRNA

NCBI chr 9:105,520,156...105,564,854
Ensembl chr 9:105,520,177...105,564,856

G

phosphoinositide kinase, FYVE type zinc finger containing

decreases expression

Mercury results in decreased expression of PIKFYVE mRNA

NCBI chr 1:65,225,796...65,317,855
Ensembl chr 1:65,225,842...65,317,854

G

phospholipase D1

increases phosphorylation

Mercury results in increased phosphorylation of PLD1 protein

NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511

G

phospholipid phosphatase related 4

increases expression

Mercury results in increased expression of PLPPR4 mRNA

NCBI chr 3:117,112,794...117,154,525
Ensembl chr 3:117,112,788...117,154,525

G

plexin B3

decreases expression

Mercury analog results in decreased expression of PLXNB3 mRNA

NCBI chr X:72,800,564...72,816,116
Ensembl chr X:72,800,696...72,816,120

G

pro-melanin-concentrating hormone

decreases expression

Mercury results in decreased expression of PMCH mRNA

NCBI chr10:87,926,934...87,928,236
Ensembl chr10:87,926,934...87,928,237

G

PMS1 homolog 1, mismatch repair system component

decreases expression

Mercury analog results in decreased expression of PMS1 mRNA

NCBI chr 1:53,225,794...53,336,190
Ensembl chr 1:53,228,346...53,336,177

G

paraneoplastic antigen MA1

decreases expression

Mercury results in decreased expression of PNMA1 mRNA

NCBI chr12:84,192,905...84,195,263
Ensembl chr12:84,192,905...84,195,263

G

pogo transposable element with KRAB domain

affects expression

Mercury affects the expression of POGK mRNA

NCBI chr 1:166,221,179...166,237,402
Ensembl chr 1:166,212,191...166,237,432

G

polymerase (DNA directed), delta 2, regulatory subunit

affects expression

Mercury affects the expression of POLD2 mRNA

NCBI chr11:5,822,180...5,828,256
Ensembl chr11:5,822,180...5,828,292

G

paraoxonase 1

decreases activity
multiple interactions

Mercury results in decreased activity of PON1 protein
Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein]

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

POU domain, class 2, transcription factor 3

increases expression

Mercury results in increased expression of POU2F3 mRNA

NCBI chr 9:43,035,222...43,117,052
Ensembl chr 9:43,035,234...43,121,666

G

peptidylprolyl isomerase A

increases expression

Mercury results in increased expression of PPIA mRNA

NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817

G

peptidyl prolyl isomerase H

increases expression

Mercury results in increased expression of PPIH mRNA

NCBI chr 4:119,157,207...119,177,720
Ensembl chr 4:119,157,207...119,177,743

G

protein phosphatase 1, regulatory subunit 12A

increases expression

Mercury results in increased expression of PPP1R12A mRNA

NCBI chr10:107,997,913...108,115,846
Ensembl chr10:107,998,054...108,120,336

G

protein phosphatase 1, regulatory subunit 15A

decreases expression

Mercury results in decreased expression of PPP1R15A mRNA

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein phosphatase 3, catalytic subunit, beta isoform

decreases expression

Mercury results in decreased expression of PPP3CB mRNA

NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641

G

peroxisome proliferative activated receptor, gamma, coactivator-related 1

affects response to substance

PPRC1 protein affects the susceptibility to Mercury

NCBI chr19:46,044,955...46,061,348
Ensembl chr19:46,033,325...46,061,354

G

palmitoyl-protein thioesterase 2

decreases expression

Mercury results in decreased expression of PPT2 mRNA

NCBI chr17:34,835,636...34,856,993
Ensembl chr17:34,835,636...34,847,484

G

peroxiredoxin 2

increases expression

Mercury results in increased expression of PRDX2 mRNA

NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463

G

peroxiredoxin 6

decreases expression
increases expression

Mercury results in decreased expression of PRDX6 mRNA
Mercury analog results in increased expression of PRDX6 mRNA

PMID:16823088 PMID:25056781

NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789

G

protein kinase C, alpha

increases expression

Mercury results in increased expression of PRKCA mRNA

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

protein kinase C, gamma

increases expression

Mercury results in increased expression of PRKCG mRNA

NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615

G

protein kinase C, theta

decreases expression

Mercury analog results in decreased expression of PRKCQ mRNA

NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033

G

pre-mRNA processing factor 31

decreases expression

Mercury analog results in decreased expression of PRPF31 mRNA

NCBI chr 7:3,632,984...3,645,484
Ensembl chr 7:3,632,984...3,645,485

G

pre-mRNA processing factor 40A

decreases expression

Mercury analog results in decreased expression of PRPF40A mRNA

NCBI chr 2:53,024,714...53,081,450
Ensembl chr 2:53,024,716...53,081,714

G

phosphoserine phosphatase

decreases expression

Mercury results in decreased expression of PSPH mRNA

NCBI chr 5:129,842,622...129,864,318
Ensembl chr 5:129,842,622...129,864,513

G

polypyrimidine tract binding protein 1

decreases expression

Mercury analog results in decreased expression of PTBP1 mRNA

NCBI chr10:79,690,502...79,700,269
Ensembl chr10:79,690,261...79,700,605

G

prostaglandin E receptor 2 (subtype EP2)

increases expression

Mercury results in increased expression of PTGER2 mRNA

NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277

G

prostate tumor over expressed gene 1

decreases expression

Mercury analog results in decreased expression of PTOV1 mRNA

NCBI chr 7:44,512,491...44,523,542
Ensembl chr 7:44,512,491...44,519,212

G

pituitary tumor-transforming gene 1

increases expression

Mercury results in increased expression of PTTG1 mRNA

NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078

G

purine rich element binding protein B

increases expression

Mercury analog results in increased expression of PURB mRNA

NCBI chr11:6,417,599...6,426,076
Ensembl chr11:6,417,599...6,425,917

G

parvalbumin

decreases expression

Mercury analog results in decreased expression of PVALB mRNA

NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600

G

peroxidasin

decreases expression

Mercury results in decreased expression of PXDN mRNA

NCBI chr12:29,986,641...30,067,657
Ensembl chr12:29,987,607...30,067,657

G

paxillin

affects localization

Mercury affects the localization of PXN protein

NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046

G

Rac family small GTPase 1

increases expression

Mercury results in increased expression of RAC1 mRNA

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

Rac GTPase-activating protein 1

increases expression

Mercury results in increased expression of RACGAP1 mRNA

NCBI chr15:99,518,377...99,549,504
Ensembl chr15:99,518,377...99,549,537

G

RAD18 E3 ubiquitin protein ligase

decreases expression

Mercury results in decreased expression of RAD18 mRNA

NCBI chr 6:112,596,812...112,673,650
Ensembl chr 6:112,596,811...112,673,647

G

Ral GTPase activating protein, alpha subunit 1

decreases expression

Mercury results in decreased expression of RALGAPA1 mRNA

NCBI chr12:55,649,673...55,868,522
Ensembl chr12:55,649,681...55,867,952

G

retinoic acid receptor, alpha

decreases expression

Mercury results in decreased expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

RNA binding protein, fox-1 homolog (C. elegans) 3

multiple interactions

[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of RBFOX3 mRNA

NCBI chr11:118,380,586...118,802,423
Ensembl chr11:118,380,588...118,802,423

G

RNA binding motif protein 22

decreases expression

Mercury analog results in decreased expression of RBM22 mRNA

NCBI chr18:60,693,858...60,705,801
Ensembl chr18:60,693,808...60,705,882

G

RNA binding protein gene with multiple splicing

increases expression

Mercury results in increased expression of RBPMS mRNA

NCBI chr 8:34,272,671...34,419,925
Ensembl chr 8:34,272,671...34,419,891

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased localization of RELA protein]
Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of RELA protein

PMID:11437639 PMID:15282405 PMID:28035397

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

reelin

decreases expression

Mercury results in decreased expression of RELN mRNA

NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700

G

Rho-related BTB domain containing 2

increases expression

Mercury results in increased expression of RHOBTB2 mRNA

NCBI chr14:70,022,439...70,062,296
Ensembl chr14:70,022,439...70,043,085

G

ribonuclease H1

decreases expression

Mercury results in decreased expression of RNASEH1 mRNA

NCBI chr12:28,699,600...28,709,591
Ensembl chr12:28,699,601...28,709,588

G

ribonuclease H2, large subunit

decreases expression
increases expression

Mercury results in decreased expression of RNASEH2A mRNA
Mercury results in increased expression of RNASEH2A mRNA

PMID:16823088 PMID:17547211

NCBI chr 8:85,683,239...85,694,498
Ensembl chr 8:85,683,239...85,696,396

G

Rho family GTPase 2

increases methylation

Mercury results in increased methylation of RND2 gene

NCBI chr11:101,359,001...101,362,679
Ensembl chr11:101,355,825...101,362,679

G

ring finger protein 138

increases expression

Mercury results in increased expression of RNF138 mRNA

NCBI chr18:21,134,202...21,161,281
Ensembl chr18:21,134,398...21,161,281

G

ring finger protein 141

decreases expression

Mercury results in decreased expression of RNF141 mRNA

NCBI chr 7:110,398,676...110,443,659
Ensembl chr 7:110,399,639...110,443,664

G

RNA guanylyltransferase and 5'-phosphatase

affects expression

Mercury affects the expression of RNGTT mRNA

NCBI chr 4:33,310,300...33,502,610
Ensembl chr 4:33,310,311...33,502,614

G

ribosomal protein L19

decreases expression

Mercury results in decreased expression of RPL19 mRNA

NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318

G

ribosomal protein L28

decreases expression

Mercury results in decreased expression of RPL28 mRNA

NCBI chr 7:4,795,964...4,797,546
Ensembl chr 7:4,795,873...4,798,065

G

ribonuclease P 21 subunit

decreases expression

Mercury analog results in decreased expression of RPP21 mRNA

NCBI chr17:36,566,565...36,568,738
Ensembl chr17:36,566,537...36,568,961

G

ribosomal protein S5

decreases expression

Mercury results in decreased expression of RPS5 mRNA

NCBI chr 7:12,656,223...12,660,613
Ensembl chr 7:12,656,217...12,660,613

G

ribosomal protein S6 kinase polypeptide 1

decreases expression

Mercury analog results in decreased expression of RPS6KC1 mRNA

NCBI chr 1:190,505,076...190,645,207
Ensembl chr 1:190,432,399...190,643,967

G

ribosome binding protein 1

decreases expression

Mercury results in decreased expression of RRBP1 mRNA

NCBI chr 2:143,789,315...143,853,216
Ensembl chr 2:143,789,315...143,853,183

G

radical S-adenosyl methionine domain containing 2

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of RSAD2 mRNA

NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451

G

reticulon 4

decreases expression

Mercury results in decreased expression of RTN4 mRNA

NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331

G

receptor transporter protein 3

decreases expression

Mercury results in decreased expression of RTP3 mRNA

NCBI chr 9:110,814,003...110,818,781
Ensembl chr 9:110,814,003...110,819,651

G

RUN and cysteine rich domain containing beclin 1 interacting protein like

increases expression

Mercury results in increased expression of RUBCNL mRNA

NCBI chr14:75,253,467...75,289,977
Ensembl chr14:75,253,467...75,289,972

G

S100 calcium binding protein A4

decreases expression

Mercury analog results in decreased expression of S100A4 mRNA

NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352

G

S100 protein, beta polypeptide, neural

increases secretion

Mercury results in increased secretion of S100B mRNA

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

serum amyloid A 1

increases expression

Mercury results in increased expression of SAA1 mRNA

NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404

G

serum amyloid A 2

increases expression

Mercury results in increased expression of SAA2 mRNA

NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737

G

sin3 associated polypeptide

increases expression

Mercury results in increased expression of SAP30 mRNA

NCBI chr 8:57,935,740...57,940,874
Ensembl chr 8:57,935,741...57,940,894

G

SR-related CTD-associated factor 4

increases expression

Mercury results in increased expression of SCAF4 mRNA

NCBI chr16:90,021,504...90,082,074
Ensembl chr16:90,022,568...90,081,391

G

scavenger receptor class B, member 1

increases expression

Mercury results in increased expression of SCARB1 mRNA

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

secretogranin III

increases expression

Mercury results in increased expression of SCG3 mRNA

NCBI chr 9:75,550,648...75,591,733
Ensembl chr 9:75,550,471...75,591,338

G

SEC24 homolog C, COPII coat complex component

increases expression

Mercury results in increased expression of SEC24C mRNA

NCBI chr14:20,722,709...20,744,920
Ensembl chr14:20,724,376...20,744,920

G

selenoprotein P

affects abundance
increases expression
multiple interactions

SELENOP gene polymorphism affects the abundance of Mercury
Mercury results in increased expression of SELENOP protein
[Mercury results in increased expression of SELENOP protein] which results in increased abundance of Selenium; SELENOP protein binds to and results in decreased susceptibility to Mercury

PMID:16451871 PMID:21967774 PMID:27989593

NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990

G

SUMO/sentrin specific peptidase 6

increases expression

Mercury results in increased expression of SENP6 mRNA

NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235

G

serine (or cysteine) peptidase inhibitor, clade A, member 3B

affects expression

Mercury affects the expression of SERPINA3 protein

NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804

G

serine (or cysteine) peptidase inhibitor, clade B, member 1a

decreases expression

Mercury results in decreased expression of SERPINB1 mRNA

NCBI chr13:33,026,075...33,037,189
Ensembl chr13:33,026,075...33,035,168

G

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

decreases expression

Mercury results in decreased expression of SERPINC1 mRNA

NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433

G

serine (or cysteine) peptidase inhibitor, clade G, member 1

affects expression

Mercury affects the expression of SERPING1 protein

NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788

G

secreted frizzled-related protein 1

decreases expression

Mercury results in decreased expression of SFRP1 mRNA

NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648

G

SH3-domain binding protein 2

increases expression

Mercury results in increased expression of SH3BP2 mRNA

NCBI chr 5:34,683,128...34,720,983
Ensembl chr 5:34,683,182...34,720,985

G

SH3-domain GRB2-like endophilin B2

increases expression

Mercury results in increased expression of SH3GLB2 mRNA

NCBI chr 2:30,234,789...30,249,380
Ensembl chr 2:30,234,821...30,249,349

G

SH3 and PX domains 2A

increases expression

Mercury results in increased expression of SH3PXD2A mRNA

NCBI chr19:47,248,613...47,453,053
Ensembl chr19:47,248,613...47,452,840

G

src homology 2 domain-containing transforming protein C1

decreases expression

Mercury results in decreased expression of SHC1 mRNA

NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334

G

sirtuin 5

decreases expression

Mercury analog results in decreased expression of SIRT5 mRNA

NCBI chr13:43,518,849...43,549,073
Ensembl chr13:43,518,972...43,548,679

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

increases expression

Mercury results in increased expression of SLC11A1 mRNA

NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

decreases expression
multiple interactions
increases uptake

Mercury results in decreased expression of SLC11A2 mRNA
[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury
SLC11A2 mRNA results in increased uptake of Mercury
SLC11A2 results in increased uptake of Mercury

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

solute carrier family 12, member 2

affects transport

SLC12A2 protein mutant form affects the transport of Mercury

NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893

G

solute carrier family 18 (vesicular monoamine), member 2

decreases expression

Mercury analog results in decreased expression of SLC18A2 mRNA

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 22 (organic cation transporter), member 1

increases expression

Mercury results in increased expression of SLC22A1 mRNA

NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716

G

solute carrier family 22 (organic anion transporter), member 19

multiple interactions
increases expression

EPO protein inhibits the reaction [Mercury results in increased expression of SLC22A19 protein]

NCBI chr19:7,650,440...7,688,675
Ensembl chr19:7,650,426...7,688,675

G

solute carrier family 22 (organic cation transporter), member 4

multiple interactions

Acetylcysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Cysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Mercury binds to and results in decreased activity of SLC22A4 protein

NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916

G

solute carrier family 22 (organic anion transporter), member 6

multiple interactions
affects response to substance

SLC22A6 gene SNP affects the susceptibility to and affects the abundance of Mercury; SLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Mercury]
SLC22A6 gene SNP affects the susceptibility to Mercury
EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of SLC22A6 protein]; Mercury results in increased expression of and affects the localization of SLC22A6 protein

PMID:15908511 PMID:23052037 PMID:32909846 PMID:32946573

NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663

G

solute carrier family 22 (organic anion transporter), member 8

multiple interactions

[SLC22A8 gene SNP affects the susceptibility to Mercury] which affects the abundance of Mercury; SLC22A8 gene SNP affects the susceptibility to and affects the abundance of Mercury
EPO protein affects the reaction [Mercury affects the localization of SLC22A8 protein]; EPO protein promotes the reaction [Mercury results in increased expression of SLC22A8 protein]; Mercury results in increased expression of and affects the localization of SLC22A8 protein

PMID:23052037 PMID:32909846 PMID:32946573

NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199

G

solute carrier family 25 (mitochondrial carrier, glutamate), member 22

decreases expression

Mercury results in decreased expression of SLC25A22 mRNA

NCBI chr 7:141,009,662...141,017,787
Ensembl chr 7:141,009,657...141,017,805

G

solute carrier family 2 (facilitated glucose transporter), member 4

decreases expression

Mercury results in decreased expression of SLC2A4 mRNA

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 30 (zinc transporter), member 1

increases expression

Mercury results in increased expression of SLC30A1 mRNA

NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359

G

solute carrier family 39 (metal ion transporter), member 8

multiple interactions

Mercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]

NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333

G

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

affects import

SLC3A2 protein affects the import of Mercury

NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733

G

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

affects response to substance

SLC6A4 promoter polymorphism affects the susceptibility to Mercury

NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

decreases expression

Mercury results in decreased expression of SLC7A2 mRNA

NCBI chr 8:41,315,404...41,375,107
Ensembl chr 8:41,315,433...41,375,345

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

multiple interactions

SLC7A5 gene SNP affects the susceptibility to and affects the abundance of Mercury

NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433

G

slit guidance ligand 3

decreases expression

Mercury results in decreased expression of SLIT3 mRNA

NCBI chr11:35,012,283...35,599,334
Ensembl chr11:35,012,051...35,599,334

G

SMAD family member 2

increases expression

Mercury results in increased expression of SMAD2 mRNA

NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034

G

structural maintenance of chromosomes 4

increases expression

Mercury results in increased expression of SMC4 mRNA

NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956

G

small integral membrane protein 14

increases expression

Mercury results in increased expression of SMIM14 mRNA

NCBI chr 5:65,604,187...65,694,492
Ensembl chr 5:65,604,187...65,694,527

G

small nucleolar RNA host gene 10

decreases expression

Mercury analog results in decreased expression of SNHG10 mRNA

NCBI chr12:104,996,876...104,998,538
Ensembl chr12:104,996,704...104,998,775

G

small nuclear ribonucleoprotein polypeptide A

increases expression

Mercury results in increased expression of SNRPA mRNA

NCBI chr 7:26,886,431...26,895,696
Ensembl chr 7:26,886,430...26,895,696

G

superoxide dismutase 1, soluble

increases expression
multiple interactions

Mercury results in increased expression of SOD1 mRNA
[Mercury co-treated with Hydrogen Peroxide] results in increased expression of SOD1 mRNA

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

Mercury analog results in decreased expression of SOS1 mRNA

NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882

G

SRY (sex determining region Y)-box 18

increases expression

Mercury results in increased expression of SOX18 mRNA

NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433

G

serine peptidase inhibitor, Kazal type 1

decreases expression

Mercury results in decreased expression of SPINK1 mRNA

NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622

G

secreted phosphoprotein 1

increases expression

Mercury results in increased expression of SPP1 mRNA

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

spectrin beta, non-erythrocytic 1

increases expression

Mercury results in increased expression of SPTBN1 mRNA

NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175

G

serum response factor

decreases expression

Mercury results in decreased expression of SRF mRNA

NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101

G

serine/arginine-rich protein specific kinase 3

decreases expression

Mercury analog results in decreased expression of SRPK3 mRNA

NCBI chr X:72,818,011...72,822,531
Ensembl chr X:72,818,011...72,822,531

G

serine and arginine-rich splicing factor 2

increases expression

Mercury results in increased expression of SRSF2 mRNA

NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920

G

serine and arginine-rich splicing factor 7

increases expression

Mercury results in increased expression of SRSF7 mRNA

NCBI chr17:80,507,509...80,514,734
Ensembl chr17:80,507,509...80,514,736

G

single-stranded DNA binding protein 1

increases expression

Mercury results in increased expression of SSBP1 mRNA

NCBI chr 6:40,448,302...40,458,757
Ensembl chr 6:40,448,286...40,461,634

G

signal sequence receptor, beta

decreases expression

Mercury results in decreased expression of SSR2 mRNA

NCBI chr 3:88,486,915...88,495,727
Ensembl chr 3:88,483,183...88,495,726

G

somatostatin receptor 3

decreases expression

Mercury results in decreased expression of SSTR3 mRNA

NCBI chr15:78,421,214...78,433,565
Ensembl chr15:78,421,208...78,428,885

G

serine/threonine kinase 24

decreases expression

Mercury analog results in decreased expression of STK24 mRNA

NCBI chr14:121,521,599...121,618,269
Ensembl chr14:121,523,755...121,617,423

G

STIP1 homology and U-Box containing protein 1

decreases expression

Mercury results in decreased expression of STUB1 mRNA

NCBI chr17:26,049,608...26,051,893
Ensembl chr17:26,049,479...26,052,378

G

SUB1 homolog, transcriptional regulator

decreases expression

Mercury results in decreased expression of SUB1 mRNA

NCBI chr15:11,981,422...11,996,091
Ensembl chr15:11,981,425...11,997,069

G

SUZ RNA binding domain containing 1

affects expression

Mercury affects the expression of SZRD1 mRNA

NCBI chr 4:140,840,326...140,867,110
Ensembl chr 4:140,840,312...140,867,086

G

tachykinin 1

increases expression

Mercury results in increased expression of TAC1 mRNA

NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834

G

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

decreases expression

Mercury results in decreased expression of TAP1 mRNA

NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199

G

TAR DNA binding protein

multiple interactions

[methylmercuric chloride results in increased abundance of Mercury] which affects the localization of TARDBP protein

NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476

G

tyrosine aminotransferase

increases activity
multiple interactions

Mercury results in increased activity of TAT protein
Mercury inhibits the reaction [Dexamethasone results in increased activity of TAT protein]

NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435

G

transcription factor 3

decreases expression

Mercury results in decreased expression of TCF3 mRNA

NCBI chr10:80,245,375...80,269,814
Ensembl chr10:80,245,348...80,269,481

G

testin LIM domain protein

decreases expression

Mercury results in decreased expression of TES mRNA

NCBI chr 6:17,065,148...17,105,824
Ensembl chr 6:17,065,148...17,105,827

G

transforming growth factor, beta 2

increases expression

Mercury results in increased expression of TGFB2 mRNA

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

thioesterase superfamily member 6

decreases expression

Mercury analog results in decreased expression of THEM6 mRNA

NCBI chr15:74,593,083...74,596,222
Ensembl chr15:74,593,053...74,596,488

G

THUMP domain containing 2

decreases expression

Mercury analog results in decreased expression of THUMPD2 mRNA

NCBI chr17:81,331,676...81,372,542
Ensembl chr17:81,333,761...81,372,511

G

THUMP domain containing 3

decreases expression

Mercury results in decreased expression of THUMPD3 mRNA

NCBI chr 6:113,023,292...113,045,239
Ensembl chr 6:113,023,186...113,045,234

G

translocase of inner mitochondrial membrane 13

decreases expression

Mercury results in decreased expression of TIMM13 mRNA

NCBI chr10:80,735,284...80,736,803
Ensembl chr10:80,735,284...80,736,803

G

translocase of inner mitochondrial membrane 23

increases expression

Mercury results in increased expression of TIMM23 mRNA

NCBI chr14:31,902,123...31,923,848
Ensembl chr14:31,902,119...31,923,855

G

tight junction protein 1

decreases expression

Mercury results in decreased expression of TJP1 mRNA

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

thymidine kinase 2, mitochondrial

affects expression

Mercury affects the expression of TK2 mRNA

NCBI chr 8:104,953,323...104,975,224
Ensembl chr 8:104,953,317...104,975,190

G

TM2 domain containing 1

increases expression

Mercury results in increased expression of TM2D1 mRNA

NCBI chr 4:98,243,607...98,271,523
Ensembl chr 4:98,243,607...98,271,543

G

TATA element modulatory factor 1

decreases expression

Mercury results in decreased expression of TMF1 mRNA

NCBI chr 6:97,128,911...97,156,107
Ensembl chr 6:97,129,958...97,156,083

G

tumor necrosis factor

increases expression
multiple interactions
affects expression

Mercury results in increased expression of TNF mRNA
Mercury promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Mercury results in increased expression of TNF protein
Mercury affects the expression of TNF mRNA
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of TNF mRNA]
Mercury results in increased expression of TNF mRNA; Mercury results in increased expression of TNF protein

PMID:12730625 PMID:12928768 PMID:15282405 PMID:20176347 PMID:20600710 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor, alpha-induced protein 3

increases expression

Mercury results in increased expression of TNFAIP3 mRNA

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

G

tumor necrosis factor, alpha-induced protein 8

increases expression
decreases expression

Mercury results in increased expression of TNFAIP8 mRNA
Mercury results in decreased expression of TNFAIP8 mRNA

PMID:17547211 PMID:22688007

NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240

G

tumor necrosis factor receptor superfamily, member 1a

increases expression

Mercury results in increased expression of TNFRSF1A mRNA; Mercury results in increased expression of TNFRSF1A protein

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor (ligand) superfamily, member 10

decreases expression

Mercury results in decreased expression of TNFSF10 mRNA

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

tensin 2

decreases expression

Mercury analog results in decreased expression of TNS2 mRNA

NCBI chr15:102,006,910...102,024,836
Ensembl chr15:102,008,848...102,024,836

G

TOX high mobility group box family member 3

increases expression

Mercury results in increased expression of TOX3 mRNA

NCBI chr 8:90,973,665...91,075,746
Ensembl chr 8:90,973,668...91,074,971

G

tropomyosin 2, beta

increases expression

Mercury results in increased expression of TPM2 mRNA

NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765

G

TNFRSF1A-associated via death domain

increases expression

Mercury results in increased expression of TRADD protein

NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241

G

T cell receptor alpha joining 42

decreases expression

Mercury results in decreased expression of ZNF10 mRNA

NCBI chr14:54,413,230...54,413,293
Ensembl chr14:54,413,230...54,413,293

G

transferrin

increases secretion

Mercury results in increased secretion of TF protein

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

tribbles pseudokinase 3

decreases expression

Mercury results in decreased expression of TRIB3 mRNA

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

G

thyroid hormone receptor interactor 13

increases expression

Mercury results in increased expression of TRIP13 mRNA

NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903

G

transformation related protein 53

affects folding

Mercury affects the folding of TRP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

tetraspanin 7

decreases expression

Mercury results in decreased expression of TSPAN7 mRNA

NCBI chr X:10,351,355...10,462,843
Ensembl chr X:10,351,397...10,462,844

G

thiosulfate sulfurtransferase, mitochondrial

decreases expression

Mercury results in decreased expression of TST mRNA

NCBI chr15:78,283,756...78,290,065
Ensembl chr15:78,283,756...78,290,107

G

tubulin, alpha 8

decreases expression

Mercury analog results in decreased expression of TUBA8 mRNA

NCBI chr 6:121,187,666...121,209,304
Ensembl chr 6:121,187,655...121,203,813

G

twinfilin actin binding protein 2

decreases expression

Mercury results in decreased expression of TWF2 mRNA

NCBI chr 9:106,080,307...106,092,586
Ensembl chr 9:106,080,307...106,092,588

G

thioredoxin 1

affects binding

Mercury binds to TXN protein

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin domain containing 11

decreases expression

Mercury analog results in decreased expression of TXNDC11 mRNA

NCBI chr16:10,892,775...10,952,541
Ensembl chr16:10,892,775...10,952,514

G

thioredoxin reductase 1

increases expression

Mercury results in increased expression of TXNRD1 mRNA

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

thioredoxin reductase 2

decreases activity

Mercury results in decreased activity of TXNRD2 protein

NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823

G

thymidylate synthase

increases expression

Mercury results in increased expression of TYMS mRNA

NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615

G

ubiquitin-conjugating enzyme E2C

increases expression

Mercury results in increased expression of UBE2C mRNA

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

ubiquitin-conjugating enzyme E2L 3

decreases expression

Mercury analog results in decreased expression of UBE2L3 mRNA

NCBI chr16:16,969,879...17,019,363
Ensembl chr16:16,969,877...17,020,513

G

ubiquitin-conjugating enzyme E2N

decreases expression

Mercury results in decreased expression of UBE2N mRNA

NCBI chr10:95,351,024...95,381,520
Ensembl chr10:95,351,007...95,381,519

G

UDP-glucose ceramide glucosyltransferase

increases expression

Mercury results in increased expression of UGCG mRNA

NCBI chr 4:59,189,452...59,222,833
Ensembl chr 4:59,189,257...59,222,833

G

ubiquinol-cytochrome c reductase binding protein

increases expression

Mercury results in increased expression of UQCRB mRNA

NCBI chr13:67,048,640...67,053,414
Ensembl chr13:67,048,681...67,053,442

G

uroporphyrinogen decarboxylase

decreases activity

Mercury results in decreased activity of UROD protein

NCBI chr 4:116,847,161...116,851,561
Ensembl chr 4:116,847,162...116,851,610

G

ubiquitin specific peptidase 39

increases expression

Mercury results in increased expression of USP39 mRNA

NCBI chr 6:72,295,749...72,322,190
Ensembl chr 6:72,295,661...72,322,167

G

ubiquitin specific peptidase 53

decreases expression

Mercury analog results in decreased expression of USP53 mRNA

NCBI chr 3:122,725,142...122,778,184
Ensembl chr 3:122,725,142...122,778,159

G

ubiquitin specific peptidase like 1

increases expression

Mercury results in increased expression of USPL1 mRNA

NCBI chr 5:149,121,338...149,152,246
Ensembl chr 5:149,121,160...149,152,244

G

vasodilator-stimulated phosphoprotein

decreases expression

Mercury analog results in decreased expression of VASP mRNA

NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

affects abundance

VDR gene polymorphism affects the abundance of Mercury

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

G

vimentin

increases expression

Mercury results in increased expression of VIM mRNA

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

vacuolar protein sorting 36

decreases expression

Mercury analog results in decreased expression of VPS36 mRNA

NCBI chr 8:22,682,849...22,710,969
Ensembl chr 8:22,682,825...22,710,859

G

vitronectin

decreases expression

Mercury results in decreased expression of VTN mRNA

NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150

G

von Willebrand factor A domain containing 1

increases expression

Mercury results in increased expression of VWA1 mRNA

NCBI chr 4:155,852,952...155,859,042
Ensembl chr 4:155,852,606...155,859,155

G

WD repeat domain 12

decreases expression

Mercury results in decreased expression of WDR12 mRNA

NCBI chr 1:60,110,520...60,137,659
Ensembl chr 1:60,108,944...60,137,804

G

WD repeat domain, phosphoinositide interacting 1

decreases expression

Mercury results in decreased expression of WIPI1 mRNA

NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793

G

inactive X specific transcripts

increases expression

Mercury results in increased expression of XIST mRNA

NCBI chr X:102,503,979...102,526,839
Ensembl chr X:102,503,972...102,537,573

G

Y box protein 1

increases expression

Mercury results in increased expression of YBX1 mRNA

NCBI chr 4:119,134,524...119,153,462
Ensembl chr 4:119,135,178...119,151,801

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta

decreases expression

Mercury analog results in decreased expression of YWHAQ mRNA

NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

decreases expression

Mercury results in decreased expression of YWHAZ mRNA

NCBI chr15:36,770,505...36,803,228
Ensembl chr15:36,771,014...36,797,173

G

zinc finger and BTB domain containing 1

increases expression

Mercury results in increased expression of ZBTB1 mRNA

NCBI chr12:76,416,825...76,443,729
Ensembl chr12:76,417,040...76,443,724

G

zinc finger and BTB domain containing 10

increases expression

Mercury results in increased expression of ZBTB10 mRNA

NCBI chr 3:9,315,627...9,350,393
Ensembl chr 3:9,315,662...9,350,393

G

zinc finger and BTB domain containing 16

increases expression

Mercury results in increased expression of ZBTB16 mRNA

NCBI chr 9:48,563,097...48,747,525
Ensembl chr 9:48,565,597...48,747,522

G

zinc finger and BTB domain containing 38

increases expression

Mercury results in increased expression of ZBTB38 mRNA

NCBI chr 9:96,564,820...96,613,728
Ensembl chr 9:96,564,823...96,634,884

G

zinc finger, AN1-type domain 3

decreases expression

Mercury analog results in decreased expression of ZFAND3 mRNA

NCBI chr17:30,224,013...30,429,797
Ensembl chr17:30,223,707...30,429,802

G

zinc finger homeodomain 4

decreases expression

Mercury analog results in decreased expression of ZFHX4 mRNA

NCBI chr 3:5,276,268...5,480,921
Ensembl chr 3:5,283,586...5,480,917

G

zinc finger protein 174

decreases expression

Mercury results in decreased expression of ZNF174 mRNA

NCBI chr16:3,665,105...3,691,751
Ensembl chr16:3,665,132...3,676,744

G

zinc finger protein 997

increases expression

Mercury results in increased expression of CXCL5 mRNA

NCBI chr13:66,258,188...66,271,523
Ensembl chr13:66,261,294...66,271,953

G

ZW10 interactor

increases expression

Mercury results in increased expression of ZWINT mRNA

NCBI chr10:72,490,678...72,510,796
Ensembl chr10:72,490,677...72,510,796

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22289
chemical entity	22288
molecular entity	22284
transition element molecular entity	18499
d-block molecular entity	18498
zinc group molecular entity	13237
mercury molecular entity	6820
elemental mercury	572
mercury cation +	0
mercury(0)	572
Path 2
Term	Annotations
CHEBI ontology	22289
subatomic particle	22284
composite particle	22284
hadron	22284
baryon	22284
nucleon	22284
atomic nucleus	22284
atom	22284
metal atom	19384
transition element atom	18661
d-block element atom	18657
d-block molecular entity	18498
zinc group molecular entity	13237
mercury molecular entity	6820
elemental mercury	572
mercury cation +	0
mercury(0)	572

paths to the root