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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ceftibuten
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Accession:CHEBI:3510 term browser browse the term
Definition:A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to treat urinary-tract and respiratory-tract infections.
Synonyms:exact_synonym: 7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (+)-(6R,7R)-7-((Z)-2-(2-amino-4-thiazolyl)-4-carboxycrotonamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;   (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Formula=C15H14N4O6S2;   InChI=1S/C15H14N4O6S2/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25)/b6-1-/t10-,13-/m1/s1;   InChIKey=UNJFKXSSGBWRBZ-BJCIPQKHSA-N;   SMILES=[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=C/CC(O)=O)\\c1csc(N)n1)C(O)=O;   ceftibutene;   ceftibuteno;   ceftibutenum;   cis-ceftibuten
 alt_id: CHEBI:554578
 xref: Beilstein:5892046;   CAS:97519-39-6;   DrugBank:DB01415;   Drug_Central:562;   KEGG:C08117;   KEGG:D00922
 xref_mesh: MESH:C054360
 xref: PMID:29017833;   PMID:9250548;   Patent:CN105153198;   Patent:CN106397455;   Patent:EP136721;   Patent:US4634697;   Wikipedia:Ceftibuten



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ceftibuten term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of ceftibuten CTD PMID:14567632 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
multiple interactions
ISO SLC22A6 protein results in increased uptake of ceftibuten
ceftibuten inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions
ISO SLC22A8 protein results in increased uptake of ceftibuten
ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        antimicrobial agent 17469
          antibacterial agent 13972
            antibacterial drug 3188
              ceftibuten 3
                ceftibuten dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        carboacyl group 17466
                                          univalent carboacyl group 17466
                                            carbamoyl group 17282
                                              carboxamide 17282
                                                lactam 8306
                                                  beta-lactam 796
                                                    beta-lactam antibiotic 781
                                                      cephem 547
                                                        cephalosporin 546
                                                          ceftibuten 3
                                                            ceftibuten dihydrate 0
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