Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-Zearalanol
go back to main search page
Accession:CHEBI:35064 term browser browse the term
Definition:A macrolide that has formula C18H26O5.
Synonyms:related_synonym: Formula=C18H26O5;   InChI=1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14+/m0/s1;   InChIKey=DWTTZBARDOXEAM-GXTWGEPZSA-N;   SMILES=C[C@H]1CCC[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1;   Zeranol;   ralabol;   zearalanol;   zearanol
 xref: CAS:26538-44-3;   Drug_Central:2860;   KEGG:C14752;   KEGG:D06362
 xref_mesh: MESH:D015029


show annotations for term's descendants           Sort by:
 
alpha-Zearalanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Zeranol binds to AFP protein CTD PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein] CTD PMID:16757814 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
Zeranol results in increased expression of BCL2 protein
CTD PMID:16757814 PMID:27224899 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Zeranol results in decreased expression of BCL2L1 protein CTD PMID:24120472 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO Zeranol results in increased expression of CCND1 protein
Zeranol results in decreased expression of CCND1 protein
CTD PMID:22113133 PMID:24120472 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Zeranol results in decreased expression of CDK2 protein CTD PMID:24120472 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Zeranol results in decreased expression of CDK4 protein CTD PMID:24120472 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Zeranol results in increased expression of CITED2 mRNA CTD PMID:11331657 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zeranol results in increased expression of CRH mRNA]
Zeranol results in increased expression of CRH mRNA; Zeranol results in increased expression of CRH protein
CTD PMID:23538034 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression ISO Zeranol results in increased expression of CRHR1 mRNA CTD PMID:24120472 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein] CTD PMID:16757814 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases activity
ISO
EXP
Zeranol binds to ESR1 protein
Zeranol results in increased activity of ESR1 protein
CTD PMID:11331656 PMID:19913605 PMID:30742918 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP
ISO
Zeranol binds to ESR2 protein CTD PMID:19913605 PMID:30742918 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gstm3 glutathione S-transferase mu 3 increases expression ISO Zeranol results in increased expression of GSTM3 mRNA CTD PMID:11331657 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Zeranol results in increased expression of GSTM3 mRNA CTD PMID:11331657 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Ifng interferon gamma decreases secretion ISO Zeranol results in decreased secretion of IFNG protein CTD PMID:14636701 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Zeranol results in increased expression of JAG1 protein CTD PMID:22113133 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Zeranol results in increased expression of SERPINA3 mRNA CTD PMID:10811566 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
JBrowse link
G Maoa monoamine oxidase A increases expression ISO Zeranol results in increased expression of MAOA mRNA CTD PMID:10811566 PMID:11331657 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
increases phosphorylation
multiple interactions
increases expression
ISO Zeranol results in decreased expression of MAPK1 protein
Zeranol results in increased phosphorylation of MAPK1 protein
ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of MAPK1 protein]; ML 204 inhibits the reaction [Zeranol results in increased phosphorylation of MAPK1 protein]
Zeranol results in increased expression of MAPK1 protein modified form
CTD PMID:23538034 PMID:24120472 PMID:27224899 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
increases phosphorylation
multiple interactions
decreases expression
ISO Zeranol results in increased expression of MAPK3 protein modified form
Zeranol results in increased phosphorylation of MAPK3 protein
ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of MAPK3 protein]; ML 204 inhibits the reaction [Zeranol results in increased phosphorylation of MAPK3 protein]
Zeranol results in decreased expression of MAPK3 protein
CTD PMID:23538034 PMID:24120472 PMID:27224899 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir34b microRNA 34b decreases expression ISO Zeranol results in decreased expression of MIR34B mRNA CTD PMID:22113133 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Zeranol inhibits the reaction [Homocysteine results in decreased expression of NOS3 protein] CTD PMID:16757814 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor increases expression ISO Zeranol results in increased expression of PGR mRNA CTD PMID:24120472 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel increases expression ISO Zeranol results in increased expression of PKD2 protein CTD PMID:27224899 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases phosphorylation
ISO ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of PRKCB protein] CTD PMID:27224899 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases expression ISO Zeranol results in increased expression of PRKCD protein modified form CTD PMID:23538034 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased expression of PTGS2 mRNA]; ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased expression of PTGS2 protein] CTD PMID:27224899 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Zeranol results in decreased expression of PTMA protein alternative form CTD PMID:10606005 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Rln1 relaxin 1 increases expression ISO Zeranol results in increased expression of RLN1 mRNA CTD PMID:24120472 NCBI chr 1:247,483,298...247,486,331
Ensembl chr 1:247,483,302...247,486,202
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Zeranol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slc6a14 solute carrier family 6 member 14 increases expression ISO Zeranol results in increased expression of SLC6A14 mRNA CTD PMID:11331657 NCBI chr  X:120,624,522...120,647,964
Ensembl chr  X:120,624,518...120,649,111
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Zeranol results in increased expression of TFF1 mRNA CTD PMID:10811566 PMID:11331657 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Zeranol results in increased expression of TGFB3 mRNA CTD PMID:10811566 PMID:11331657 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 increases expression ISO Zeranol results in increased expression of TRPC3 protein CTD PMID:27224899 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression ISO Zeranol results in increased expression of TRPC6 protein CTD PMID:27224899 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          oxygen atom 19387
            oxygen molecular entity 19387
              organooxygen compound 18846
                polyketide 8634
                  macrolide 1607
                    alpha-Zearalanol 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic ester 14370
                                        lactone 5993
                                          macrocyclic lactone 1739
                                            macrolide 1607
                                              alpha-Zearalanol 36
paths to the root