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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tris(2-chloroethyl) phosphate
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Accession:CHEBI:35037 term browser browse the term
Definition:A trialkyl phosphate that is the tris(2-chloroethyl) ester of phosphoric acid.
Synonyms:related_synonym: Formula=C6H12Cl3O4P;   InChI=1S/C6H12Cl3O4P/c7-1-4-11-14(10,12-5-2-8)13-6-3-9/h1-6H2;   InChIKey=HQUQLFOMPYWACS-UHFFFAOYSA-N;   Phosphoric acid, tris(2-chloroethyl)ester;   SMILES=ClCCOP(=O)(OCCCl)OCCCl;   Tri(2-chloroethyl) phosphate;   Tris(2-chloroethyl) orthophosphate;   Tris(beta-chloroethyl) phosphate;   Tris(chloroethyl)phosphate
 xref: Beilstein:1710938;   CAS:115-96-8;   KEGG:C14445
 xref_mesh: MESH:C031324
 xref: PMID:19462192;   Reaxys:1710938;   Wikipedia:Tris(2-chloroethyl)_phosphate


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tris(2-chloroethyl) phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tris(chloroethyl)phosphate results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:26378621 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ar androgen receptor multiple interactions ISO tris(chloroethyl)phosphate binds to and results in decreased activity of AR protein CTD PMID:23398518 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G C5ar1 complement C5a receptor 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of C5AR1 mRNA CTD PMID:29143341 NCBI chr 1:78,186,777...78,195,132
Ensembl chr 1:78,186,776...78,195,328
JBrowse link
G C7 complement C7 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of C7 mRNA CTD PMID:29143341 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression EXP tris(chloroethyl)phosphate results in increased expression of CAMK2A mRNA CTD PMID:24717766 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP tris(chloroethyl)phosphate results in increased expression of CAMK2B mRNA; tris(chloroethyl)phosphate results in increased expression of CAMK2B protein CTD PMID:24717766 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Cat catalase increases expression
increases activity
ISO
EXP
tris(chloroethyl)phosphate results in increased expression of CAT mRNA
tris(chloroethyl)phosphate results in increased expression of CAT mRNA; tris(chloroethyl)phosphate results in increased expression of CAT protein
tris(chloroethyl)phosphate results in increased activity of CAT protein
CTD PMID:26049154, PMID:26183808, PMID:30974155 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tris(chloroethyl)phosphate results in increased expression of CDKN1A protein CTD PMID:28886428 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of CPT1A mRNA CTD PMID:30966736 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
ISO tris(chloroethyl)phosphate results in increased expression of CYP11A1 mRNA
tris(chloroethyl)phosphate results in decreased expression of CYP11A1 mRNA
[tris(chloroethyl)phosphate co-treated with CGB3 protein] results in decreased expression of CYP11A1 mRNA
CTD PMID:22446829, PMID:26049154, PMID:26183808 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO tris(chloroethyl)phosphate results in increased expression of CYP11B2 mRNA CTD PMID:22446829 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO tris(chloroethyl)phosphate inhibits the reaction [CGB3 protein results in increased expression of CYP17A1 mRNA]
tris(chloroethyl)phosphate results in decreased expression of CYP17A1 mRNA
CTD PMID:26049154, PMID:26183808 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of CYP19A1 mRNA CTD PMID:22446829 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
increases expression
EXP tris(chloroethyl)phosphate results in decreased expression of CYP1A1 protein
tris(chloroethyl)phosphate results in increased expression of CYP1A1 mRNA
CTD PMID:30974155 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ebi3 Epstein-Barr virus induced 3 increases expression ISO tris(chloroethyl)phosphate results in increased expression of EBI3 mRNA CTD PMID:29143341 NCBI chr 9:11,110,874...11,114,843
Ensembl chr 9:11,110,874...11,114,843
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO tris(chloroethyl)phosphate results in decreased activity of ESR1 protein CTD PMID:24844797 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of FOXO3 protein CTD PMID:30090360 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP tris(chloroethyl)phosphate results in decreased expression of GAP43 mRNA; tris(chloroethyl)phosphate results in decreased expression of GAP43 protein CTD PMID:24717766 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of GPX1 mRNA CTD PMID:26049154, PMID:26183808 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO tris(chloroethyl)phosphate results in increased expression of GPX2 mRNA CTD PMID:26049154, PMID:26183808 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
decreases expression
EXP
ISO
tris(chloroethyl)phosphate results in increased expression of GSTA2 mRNA
tris(chloroethyl)phosphate results in decreased expression of GSTA1 mRNA
tris(chloroethyl)phosphate results in increased expression of GSTA1 mRNA
CTD PMID:26049154, PMID:26183808, PMID:30974155 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression
decreases expression
ISO tris(chloroethyl)phosphate results in increased expression of GSTA1 mRNA
tris(chloroethyl)phosphate results in decreased expression of GSTA1 mRNA
CTD PMID:26049154, PMID:26183808 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Hpx hemopexin decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of HPX mRNA CTD PMID:29143341 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 decreases expression
multiple interactions
ISO tris(chloroethyl)phosphate results in decreased expression of HSD17B13 mRNA
tris(chloroethyl)phosphate inhibits the reaction [CGB3 protein results in increased expression of HSD17B13 mRNA]
CTD PMID:26049154 NCBI chr14:7,113,544...7,128,218
Ensembl chr14:7,113,544...7,128,218
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
multiple interactions
ISO tris(chloroethyl)phosphate results in decreased expression of HSD3B1 mRNA
[tris(chloroethyl)phosphate co-treated with CGB3 protein] results in decreased expression of HSD3B1 mRNA
CTD PMID:26049154, PMID:26183808
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO tris(chloroethyl)phosphate results in increased expression of HSD3B2 mRNA CTD PMID:22446829 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Il6 interleukin 6 decreases secretion ISO tris(chloroethyl)phosphate results in decreased secretion of IL6 protein CTD PMID:28886428 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of IL6R protein CTD PMID:28886428 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Ldlr low density lipoprotein receptor increases expression
decreases expression
ISO tris(chloroethyl)phosphate results in increased expression of LDLR mRNA
tris(chloroethyl)phosphate results in decreased expression of LDLR mRNA
CTD PMID:26049154, PMID:26183808 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO tris(chloroethyl)phosphate results in decreased expression of and results in decreased phosphorylation of MTOR protein CTD PMID:26378621 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nefh neurofilament heavy decreases expression
increases expression
EXP tris(chloroethyl)phosphate results in decreased expression of NEFH mRNA
tris(chloroethyl)phosphate results in increased expression of NEFH protein
CTD PMID:24717766 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO tris(chloroethyl)phosphate results in increased expression of P2RX7 mRNA CTD PMID:29143341 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of PPARA protein CTD PMID:30966736 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of PPARG protein CTD PMID:30966736 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of RB1 protein; tris(chloroethyl)phosphate results in increased expression of RB1 protein modified form CTD PMID:28886428 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of RELA protein; tris(chloroethyl)phosphate results in decreased expression of RELA protein modified form CTD PMID:28886428 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of SIRT1 mRNA; tris(chloroethyl)phosphate results in increased expression of SIRT1 protein CTD PMID:26378621 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of SIRT3 mRNA; tris(chloroethyl)phosphate results in decreased expression of SIRT3 protein CTD PMID:30090360 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of SOD1 mRNA CTD PMID:26049154, PMID:26183808 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression
ISO tris(chloroethyl)phosphate results in increased expression of SOD2 mRNA
tris(chloroethyl)phosphate results in decreased expression of SOD2 protein
CTD PMID:26049154, PMID:26183808, PMID:30090360 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of STAR mRNA CTD PMID:26183808 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of SULT1E1 mRNA CTD PMID:22446829 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of SULT2A1 mRNA CTD PMID:22446829 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tp53 tumor protein p53 affects binding
decreases expression
ISO tris(chloroethyl)phosphate binds to TP53 gene
tris(chloroethyl)phosphate results in decreased expression of TP53 protein
CTD PMID:25510514, PMID:28886428 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tspo translocator protein decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of TSPO mRNA CTD PMID:26049154 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        polyatomic entity 19697
          heteroatomic molecular entity 19622
            halide 17976
              organohalogen compound 17712
                organochlorine compound 17466
                  tris(2-chloroethyl) phosphate 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              oxoacid 18193
                                pnictogen oxoacid 10146
                                  phosphorus oxoacid 9033
                                    phosphoric acids 7795
                                      phosphoric acid 7795
                                        phosphoric acid derivative 7474
                                          phosphate 7474
                                            organic phosphate 7473
                                              alkyl phosphate 4088
                                                trialkyl phosphate 878
                                                  tris(2-chloroethyl) phosphate 44
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.