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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tris(2-chloroethyl) phosphate
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Accession:CHEBI:35037 term browser browse the term
Definition:A trialkyl phosphate that is the tris(2-chloroethyl) ester of phosphoric acid.
Synonyms:related_synonym: Formula=C6H12Cl3O4P;   InChI=1S/C6H12Cl3O4P/c7-1-4-11-14(10,12-5-2-8)13-6-3-9/h1-6H2;   InChIKey=HQUQLFOMPYWACS-UHFFFAOYSA-N;   Phosphoric acid, tris(2-chloroethyl)ester;   SMILES=ClCCOP(=O)(OCCCl)OCCCl;   Tri(2-chloroethyl) phosphate;   Tris(2-chloroethyl) orthophosphate;   Tris(beta-chloroethyl) phosphate;   Tris(chloroethyl)phosphate
 xref: Beilstein:1710938;   CAS:115-96-8;   KEGG:C14445
 xref_mesh: MESH:C031324
 xref: PMID:19462192;   Reaxys:1710938;   Wikipedia:Tris(2-chloroethyl)_phosphate


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tris(2-chloroethyl) phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of ADM mRNA CTD PMID:33367866 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adm2 adrenomedullin 2 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of ADM2 mRNA CTD PMID:33367866 NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tris(chloroethyl)phosphate results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:26378621 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aplnr apelin receptor multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of APLNR mRNA CTD PMID:33367866 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
G Ar androgen receptor multiple interactions ISO tris(chloroethyl)phosphate binds to and results in decreased activity of AR protein CTD PMID:23398518 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of ASNS mRNA CTD PMID:33367866 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of ATF4 mRNA CTD PMID:33367866 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G C3ar1 complement C3a receptor 1 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of C3AR1 mRNA CTD PMID:33367866 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701 		JBrowse link
G C5ar1 complement C5a receptor 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of C5AR1 mRNA CTD PMID:29143341 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G C7 complement C7 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of C7 mRNA CTD PMID:29143341 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression EXP tris(chloroethyl)phosphate results in increased expression of CAMK2A mRNA CTD PMID:24717766 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP tris(chloroethyl)phosphate results in increased expression of CAMK2B mRNA; tris(chloroethyl)phosphate results in increased expression of CAMK2B protein CTD PMID:24717766 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Cat catalase increases expression
increases activity		 ISO
EXP		 tris(chloroethyl)phosphate results in increased expression of CAT mRNA
tris(chloroethyl)phosphate results in increased activity of CAT protein
tris(chloroethyl)phosphate results in increased expression of CAT mRNA; tris(chloroethyl)phosphate results in increased expression of CAT protein		 CTD PMID:26049154 PMID:26183808 PMID:30974155 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of CD36 mRNA] CTD PMID:35780845 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of CDH5 mRNA CTD PMID:33367866 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tris(chloroethyl)phosphate results in increased expression of CDKN1A protein CTD PMID:28886428 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of COL10A1 mRNA CTD PMID:33367866 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col13a1 collagen type XIII alpha 1 chain multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of COL13A1 mRNA CTD PMID:33367866 NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032 		JBrowse link
G Col24a1 collagen type XXIV alpha 1 chain multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of COL24A1 mRNA CTD PMID:33367866 NCBI chr 2:234,212,256...234,469,445
Ensembl chr 2:234,212,324...234,469,441 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of CPT1A mRNA CTD PMID:30966736 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of CSF1R mRNA CTD PMID:33367866 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of CTH mRNA CTD PMID:33367866 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases expression		 ISO tris(chloroethyl)phosphate results in increased expression of CYP11A1 mRNA
[tris(chloroethyl)phosphate co-treated with CGB3 protein] results in decreased expression of CYP11A1 mRNA
tris(chloroethyl)phosphate results in decreased expression of CYP11A1 mRNA		 CTD PMID:22446829 PMID:26049154 PMID:26183808 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO tris(chloroethyl)phosphate results in increased expression of CYP11B2 mRNA CTD PMID:22446829 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO tris(chloroethyl)phosphate inhibits the reaction [CGB3 protein results in increased expression of CYP17A1 mRNA]
tris(chloroethyl)phosphate results in decreased expression of CYP17A1 mRNA		 CTD PMID:26049154 PMID:26183808 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of CYP19A1 mRNA CTD PMID:22446829 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
increases expression		 EXP tris(chloroethyl)phosphate results in decreased expression of CYP1A1 protein
tris(chloroethyl)phosphate results in increased expression of CYP1A1 mRNA		 CTD PMID:30974155 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of CYP27A1 mRNA]; Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of CYP27A1 protein]
tris(chloroethyl)phosphate results in decreased expression of CYP27A1 mRNA; tris(chloroethyl)phosphate results in decreased expression of CYP27A1 protein		 CTD PMID:35780845 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases expression		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of CYP7A1 mRNA] CTD PMID:35780845 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions
decreases expression		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of CYP8B1 mRNA] CTD PMID:35780845 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of DDIT3 mRNA CTD PMID:33367866 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ebi3 Epstein-Barr virus induced 3 increases expression ISO tris(chloroethyl)phosphate results in increased expression of EBI3 mRNA CTD PMID:29143341 NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO tris(chloroethyl)phosphate results in decreased activity of ESR1 protein CTD PMID:24844797 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of FASN protein]
tris(chloroethyl)phosphate results in increased expression of FASN mRNA; tris(chloroethyl)phosphate results in increased expression of FASN protein		 CTD PMID:35780845 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
decreases expression		 ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FGF21 mRNA
tris(chloroethyl)phosphate results in decreased expression of FGF21 mRNA		 CTD PMID:33367866 PMID:35780845 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Flcn folliculin multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FLCN mRNA CTD PMID:33367866 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of FOXO3 protein CTD PMID:30090360 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP tris(chloroethyl)phosphate results in decreased expression of GAP43 mRNA; tris(chloroethyl)phosphate results in decreased expression of GAP43 protein CTD PMID:24717766 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of GDF15 mRNA CTD PMID:33367866 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased activity of GPT protein] CTD PMID:35780845 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of GPX1 mRNA CTD PMID:26049154 PMID:26183808 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO tris(chloroethyl)phosphate results in increased expression of GPX2 mRNA CTD PMID:26049154 PMID:26183808 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP tris(chloroethyl)phosphate results in increased expression of GSTA2 mRNA CTD PMID:30974155 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression
decreases expression		 ISO tris(chloroethyl)phosphate results in increased expression of GSTA1 mRNA
tris(chloroethyl)phosphate results in decreased expression of GSTA1 mRNA		 CTD PMID:26049154 PMID:26183808 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Hpx hemopexin decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of HPX mRNA CTD PMID:29143341 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 decreases expression
multiple interactions		 ISO tris(chloroethyl)phosphate results in decreased expression of HSD17B13 mRNA
tris(chloroethyl)phosphate inhibits the reaction [CGB3 protein results in increased expression of HSD17B13 mRNA]		 CTD PMID:26049154 NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
multiple interactions		 ISO tris(chloroethyl)phosphate results in decreased expression of HSD3B1 mRNA
[tris(chloroethyl)phosphate co-treated with CGB3 protein] results in decreased expression of HSD3B1 mRNA		 CTD PMID:26049154 PMID:26183808 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO tris(chloroethyl)phosphate results in increased expression of HSD3B2 mRNA CTD PMID:22446829 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO tris(chloroethyl)phosphate results in decreased secretion of IL6 protein CTD PMID:28886428 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of IL6R protein CTD PMID:28886428 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression
decreases expression		 ISO tris(chloroethyl)phosphate results in increased expression of LDLR mRNA
tris(chloroethyl)phosphate results in decreased expression of LDLR mRNA		 CTD PMID:26049154 PMID:26183808 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions		 ISO tris(chloroethyl)phosphate results in increased expression of LPL mRNA
Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of LPL mRNA]		 CTD PMID:35780845 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO tris(chloroethyl)phosphate results in decreased expression of and results in decreased phosphorylation of MTOR protein CTD PMID:26378621 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nefh neurofilament heavy chain decreases expression
increases expression		 EXP tris(chloroethyl)phosphate results in decreased expression of NEFH mRNA
tris(chloroethyl)phosphate results in increased expression of NEFH protein		 CTD PMID:24717766 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression		 ISO Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of NR0B2 protein] CTD PMID:35780845 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression
multiple interactions		 ISO tris(chloroethyl)phosphate results in decreased expression of NR1H4 mRNA; tris(chloroethyl)phosphate results in decreased expression of NR1H4 protein
Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of NR1H4 mRNA]; Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of NR1H4 protein]		 CTD PMID:35780845 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO tris(chloroethyl)phosphate results in increased expression of P2RX7 mRNA CTD PMID:29143341 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of PCK2 mRNA CTD PMID:33367866 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO tris(chloroethyl)phosphate results in decreased expression of PPARA protein
Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of PPARA mRNA]; Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of PPARA protein]
tris(chloroethyl)phosphate results in decreased expression of PPARA mRNA; tris(chloroethyl)phosphate results in decreased expression of PPARA protein		 CTD PMID:30966736 PMID:35780845 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
increases expression		 ISO tris(chloroethyl)phosphate results in decreased expression of PPARG protein
Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of PPARG mRNA]; Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of PPARG protein]
tris(chloroethyl)phosphate results in increased expression of PPARG mRNA; tris(chloroethyl)phosphate results in increased expression of PPARG protein		 CTD PMID:30966736 PMID:35780845 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of PTPRB mRNA CTD PMID:33367866 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of RB1 protein; tris(chloroethyl)phosphate results in increased expression of RB1 protein modified form CTD PMID:28886428 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of RELA protein; tris(chloroethyl)phosphate results in decreased expression of RELA protein modified form CTD PMID:28886428 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of RUNX2 mRNA CTD PMID:33367866 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Runx3 RUNX family transcription factor 3 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of RUNX3 mRNA CTD PMID:33367866 NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of SIRT1 mRNA; tris(chloroethyl)phosphate results in increased expression of SIRT1 protein CTD PMID:26378621 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of SIRT3 mRNA; tris(chloroethyl)phosphate results in decreased expression of SIRT3 protein CTD PMID:30090360 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of SMPD3 mRNA CTD PMID:33367866 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO tris(chloroethyl)phosphate results in increased expression of SOD1 mRNA CTD PMID:26049154 PMID:26183808 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression		 ISO tris(chloroethyl)phosphate results in increased expression of SOD2 mRNA
tris(chloroethyl)phosphate results in decreased expression of SOD2 protein		 CTD PMID:26049154 PMID:26183808 PMID:30090360 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in decreased expression of SP7 mRNA CTD PMID:33367866 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO tris(chloroethyl)phosphate results in increased expression of SREBF1 mRNA; tris(chloroethyl)phosphate results in increased expression of SREBF1 protein
Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of SREBF1 mRNA]; Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased expression of SREBF1 protein]		 CTD PMID:35780845 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of STAR mRNA CTD PMID:26183808 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of SULT1E1 mRNA CTD PMID:22446829 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of SULT2A1 mRNA CTD PMID:22446829 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tp53 tumor protein p53 affects binding
decreases expression		 ISO tris(chloroethyl)phosphate binds to TP53 gene
tris(chloroethyl)phosphate results in decreased expression of TP53 protein		 CTD PMID:25510514 PMID:28886428 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of TRIB3 mRNA CTD PMID:33367866 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Tspo translocator protein decreases expression ISO tris(chloroethyl)phosphate results in decreased expression of TSPO mRNA CTD PMID:26049154 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        polyatomic entity 19787
          heteroatomic molecular entity 19743
            halide 18635
              organohalogen compound 18507
                organochlorine compound 18307
                  tris(2-chloroethyl) phosphate 78
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      chalcogen 19534
                        oxygen atom 19509
                          oxygen molecular entity 19509
                            hydroxides 19320
                              oxoacid 18744
                                pnictogen oxoacid 13224
                                  phosphorus oxoacid 12429
                                    phosphoric acids 11430
                                      phosphoric acid 11430
                                        phosphoric acid derivative 11239
                                          phosphate 11238
                                            organic phosphate 11238
                                              alkyl phosphate 4158
                                                trialkyl phosphate 910
                                                  tris(2-chloroethyl) phosphate 78
paths to the root