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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trifluralin
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Accession:CHEBI:35027 term browser browse the term
Definition:A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.
Synonyms:exact_synonym: 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)aniline
 related_synonym: 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine;   Formula=C13H16F3N3O4;   InChI=1S/C13H16F3N3O4/c1-3-5-17(6-4-2)12-10(18(20)21)7-9(13(14,15)16)8-11(12)19(22)23/h7-8H,3-6H2,1-2H3;   InChIKey=ZSDSQXJSNMTJDA-UHFFFAOYSA-N;   SMILES=CCCN(CCC)c1c(cc(cc1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O;   alpha,alpha,alpha-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine
 xref: CAS:1582-09-8;   KEGG:C14343
 xref_mesh: MESH:D014274
 xref: PMID:21544921;   PMID:24584589;   PMID:24984475;   PMID:25277710;   PPDB:667;   Pesticides:trifluralin;   Reaxys:1893555;   Wikipedia:Trifluralin



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trifluralin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Trifluralin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to Trifluralin CTD PMID:15853388 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Trifluralin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:14613717 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Trifluralin binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Trifluralin binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP
ISO
Trifluralin binds to and results in increased activity of NR1I2 protein CTD PMID:14613717 PMID:21115097 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Trifluralin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Trifluralin binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Trifluralin results in increased expression of and results in increased secretion of TSHB protein CTD PMID:18582544 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Trifluralin results in increased expression of UGT1A1 mRNA CTD PMID:18582544 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Trifluralin results in increased expression of UGT1A6 mRNA CTD PMID:18582544 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Trifluralin results in increased expression of UGT2B1 mRNA CTD PMID:18582544 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        agrochemical 15233
          trifluralin 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            organic hydride 18675
                              organic fundamental parent 18657
                                hydrocarbon 18408
                                  halohydrocarbon 15404
                                    haloalkane 12107
                                      fluoroalkane 7729
                                        fluoromethanes 6698
                                          tetrafluoromethane 6698
                                            trifluoromethyl group 6698
                                              (trifluoromethyl)benzenes 6699
                                                trifluralin 12
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