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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trifluralin
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Accession:CHEBI:35027 term browser browse the term
Definition:A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.
Synonyms:exact_synonym: 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)aniline
 related_synonym: 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine;   Formula=C13H16F3N3O4;   InChI=1S/C13H16F3N3O4/c1-3-5-17(6-4-2)12-10(18(20)21)7-9(13(14,15)16)8-11(12)19(22)23/h7-8H,3-6H2,1-2H3;   InChIKey=ZSDSQXJSNMTJDA-UHFFFAOYSA-N;   SMILES=CCCN(CCC)c1c(cc(cc1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O;   alpha,alpha,alpha-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine
 xref: CAS:1582-09-8;   KEGG:C14343
 xref_mesh: MESH:D014274
 xref: PMID:21544921;   PMID:24584589;   PMID:24984475;   PMID:25277710;   PPDB:667;   Pesticides:trifluralin;   Reaxys:1893555;   Wikipedia:Trifluralin


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trifluralin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Trifluralin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to Trifluralin CTD PMID:15853388 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Trifluralin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:14613717 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Trifluralin binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Trifluralin binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP
ISO
Trifluralin binds to and results in increased activity of NR1I2 protein CTD PMID:14613717 PMID:21115097 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Trifluralin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Trifluralin binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Trifluralin results in increased expression of and results in increased secretion of TSHB protein CTD PMID:18582544 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Trifluralin results in increased expression of UGT1A1 mRNA CTD PMID:18582544 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Trifluralin results in increased expression of UGT1A6 mRNA CTD PMID:18582544 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Trifluralin results in increased expression of UGT2B1 mRNA CTD PMID:18582544 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        agrochemical 15037
          trifluralin 12
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  halohydrocarbon 14049
                                    haloalkane 11706
                                      fluoroalkane 7212
                                        fluoromethanes 6408
                                          tetrafluoromethane 6408
                                            trifluoromethyl group 6408
                                              (trifluoromethyl)benzenes 6408
                                                trifluralin 12
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