CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tributyrin
Accession: CHEBI:35020
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Definition: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid.
Synonyms: exact_synonym: propane-1,2,3-triyl tributanoate
related_synonym: 1,2,3-Propanetriol, tributyrate; 1,2,3-Propanetriyl tributanoate; 1,2,3-Tributyrylglycerol; 1,2,3-tributanoylglycerol; 2,3-Bis(butyryloxy)propyl butyrate; Butanoic acid, 1,2,3-propanetriyl ester; Butyrin; Butyryl triglyceride; Formula=C15H26O6; Glycerin tributyrate; Glycerol tributanoate; Glycerol tributyrate; Glyceroltributyrin; Glyceryl tributyrate; InChI=1S/C15H26O6/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3; InChIKey=UYXTWWCETRIEDR-UHFFFAOYSA-N; SMILES=CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC; Tri-n-butyrin; Tributin; Tributyryl glyceride; propane-1,2,3-triyl tributyrate
xref: CAS:60-01-5; HMDB:HMDB0031094; KEGG:C13870
xref_mesh: MESH:C005830
xref: MetaCyc:CPD-13014; PMID:23568954; PMID:23630018; PMID:23887917; PMID:24121865; PMID:24302446; PMID:24506942; PMID:24576724; PMID:24890666; Reaxys:1714746; Wikipedia:Butyrin
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
tributyrin results in decreased expression of BCL2 mRNA
CTD
PMID:11876963
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Cd86
CD86 molecule
increases expression
ISO
tributyrin results in increased expression of CD86 protein
CTD
PMID:30503584
NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361
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Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression
ISO
tributyrin results in decreased expression of HIF1A mRNA; tributyrin results in decreased expression of HIF1A protein
CTD
PMID:39241941
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
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Ifng
interferon gamma
multiple interactions
ISO
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein
CTD
PMID:29198882 PMID:36870414
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il17a
interleukin 17A
multiple interactions
ISO
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein
CTD
PMID:36870414
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
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Il1b
interleukin 1 beta
increases expression
ISO
tributyrin results in increased expression of IL1B protein
CTD
PMID:30503584
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il2
interleukin 2
multiple interactions
ISO
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]; IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein]
CTD
PMID:16252257
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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Il4
interleukin 4
multiple interactions
ISO
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein
CTD
PMID:29198882 PMID:36870414
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
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Mapk1
mitogen activated protein kinase 1
affects phosphorylation multiple interactions
ISO
tributyrin affects the phosphorylation of MAPK1 protein IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]
CTD
PMID:16252257
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
multiple interactions affects phosphorylation
ISO
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein]
CTD
PMID:16252257
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Sirt4
sirtuin 4
increases expression
ISO
tributyrin results in increased expression of SIRT4 mRNA; tributyrin results in increased expression of SIRT4 protein
CTD
PMID:39241941
NCBI chr12:46,785,852...46,800,179
Ensembl chr12:46,791,898...46,800,173
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Tlr2
toll-like receptor 2
multiple interactions
EXP
tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
CTD
PMID:21051124
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
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Tnf
tumor necrosis factor
multiple interactions
EXP
tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:21051124
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
tributyrin results in increased activity of TRPA1 protein
CTD
PMID:29198882
NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325
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