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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tributyrin
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Accession:CHEBI:35020 term browser browse the term
Definition:A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid.
Synonyms:exact_synonym: propane-1,2,3-triyl tributanoate
 related_synonym: 1,2,3-Propanetriol, tributyrate;   1,2,3-Propanetriyl tributanoate;   1,2,3-Tributyrylglycerol;   1,2,3-tributanoylglycerol;   2,3-Bis(butyryloxy)propyl butyrate;   Butanoic acid, 1,2,3-propanetriyl ester;   Butyrin;   Butyryl triglyceride;   Formula=C15H26O6;   Glycerin tributyrate;   Glycerol tributanoate;   Glycerol tributyrate;   Glyceroltributyrin;   Glyceryl tributyrate;   InChI=1S/C15H26O6/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3;   InChIKey=UYXTWWCETRIEDR-UHFFFAOYSA-N;   SMILES=CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC;   Tri-n-butyrin;   Tributin;   Tributyryl glyceride;   propane-1,2,3-triyl tributyrate
 xref: CAS:60-01-5;   HMDB:HMDB0031094;   KEGG:C13870
 xref_mesh: MESH:C005830
 xref: MetaCyc:CPD-13014;   PMID:23568954;   PMID:23630018;   PMID:23887917;   PMID:24121865;   PMID:24302446;   PMID:24506942;   PMID:24576724;   PMID:24890666;   Reaxys:1714746;   Wikipedia:Butyrin

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tributyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tributyrin results in decreased expression of BCL2 mRNA CTD PMID:11876963 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cd86 CD86 molecule increases expression ISO tributyrin results in increased expression of CD86 protein CTD PMID:30503584 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO tributyrin results in increased expression of IL1B protein CTD PMID:30503584 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]; IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein] CTD PMID:16252257 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein CTD PMID:29198882 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions		 ISO tributyrin affects the phosphorylation of MAPK1 protein
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]		 CTD PMID:16252257 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation		 ISO IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein] CTD PMID:16252257 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:21051124 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21051124 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO tributyrin results in increased activity of TRPA1 protein CTD PMID:29198882 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pro-agent 10095
          prodrug 9899
            tributyrin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          fatty acid 16012
                                            short-chain fatty acid 15700
                                              fatty acid 4:0 7901
                                                butyric acid 6271
                                                  butyrate ester 1767
                                                    tributyrin 11
paths to the root