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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tributyrin
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Accession:CHEBI:35020 term browser browse the term
Definition:A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid.
Synonyms:exact_synonym: propane-1,2,3-triyl tributanoate
 related_synonym: 1,2,3-Propanetriol, tributyrate;   1,2,3-Propanetriyl tributanoate;   1,2,3-Tributyrylglycerol;   1,2,3-tributanoylglycerol;   2,3-Bis(butyryloxy)propyl butyrate;   Butanoic acid, 1,2,3-propanetriyl ester;   Butyrin;   Butyryl triglyceride;   Formula=C15H26O6;   Glycerin tributyrate;   Glycerol tributanoate;   Glycerol tributyrate;   Glyceroltributyrin;   Glyceryl tributyrate;   InChI=1S/C15H26O6/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3;   InChIKey=UYXTWWCETRIEDR-UHFFFAOYSA-N;   SMILES=CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC;   Tri-n-butyrin;   Tributin;   Tributyryl glyceride;   propane-1,2,3-triyl tributyrate
 xref: CAS:60-01-5;   HMDB:HMDB0031094;   KEGG:C13870
 xref_mesh: MESH:C005830
 xref: MetaCyc:CPD-13014;   PMID:23568954;   PMID:23630018;   PMID:23887917;   PMID:24121865;   PMID:24302446;   PMID:24506942;   PMID:24576724;   PMID:24890666;   Reaxys:1714746;   Wikipedia:Butyrin


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tributyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tributyrin results in decreased expression of BCL2 mRNA CTD PMID:11876963 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cd86 CD86 molecule increases expression ISO tributyrin results in increased expression of CD86 protein CTD PMID:30503584 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO tributyrin results in decreased expression of HIF1A mRNA; tributyrin results in decreased expression of HIF1A protein CTD PMID:39241941 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 PMID:36870414 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein CTD PMID:36870414 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO tributyrin results in increased expression of IL1B protein CTD PMID:30503584 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]; IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein] CTD PMID:16252257 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein CTD PMID:29198882 PMID:36870414 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions 		ISO tributyrin affects the phosphorylation of MAPK1 protein
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein] 		CTD PMID:16252257 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation 		ISO IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein] CTD PMID:16252257 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Sirt4 sirtuin 4 increases expression ISO tributyrin results in increased expression of SIRT4 mRNA; tributyrin results in increased expression of SIRT4 protein CTD PMID:39241941 NCBI chr12:46,785,852...46,800,179
Ensembl chr12:46,791,898...46,800,173 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:21051124 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21051124 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO tributyrin results in increased activity of TRPA1 protein CTD PMID:29198882 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pro-agent 12349
          prodrug 12109
            tributyrin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      monocarboxylic acid 18309
                                        fatty acid 17010
                                          short-chain fatty acid 16035
                                            fatty acid 4:0 8299
                                              butyric acid 6785
                                                butyrate ester 2157
                                                  tributyrin 14
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