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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Trenbolone
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Accession:CHEBI:35018 term browser browse the term
Definition:An oxo steroid that has formula C18H22O2.
Synonyms:related_synonym: 17-beta-Hydroxyestra-4,9,11-trien-3-one;   Formula=C18H22O2;   InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1;   InChIKey=MEHHPFQKXOUFFV-OWSLCNJRSA-N;   SMILES=C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O
 xref: CAS:10161-33-8;   KEGG:C14261;   KEGG:D08627
 xref_mesh: MESH:D014204
 xref: VSDB:2402


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Trenbolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
affects expression
increases expression
EXP Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]; Flutamide inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]; fulvestrant inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]; trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]]
Trenbolone Acetate analog affects the expression of APP protein modified form
CTD PMID:25461682 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
increases activity
ISO
EXP
Trenbolone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; triclocarban promotes the reaction [Trenbolone Acetate results in increased activity of AR protein]
Trenbolone Acetate binds to AR protein
CTD PMID:14565775 PMID:16818248 PMID:18324785 PMID:20371976 PMID:20821581 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; Flutamide promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; fulvestrant affects the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; Testosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]] CTD PMID:25461682 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Trenbolone Acetate results in increased expression of ODC1 mRNA CTD PMID:17688994 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases expression
EXP Flutamide inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; fulvestrant inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; Testosterone affects the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein]; Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]; trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]] CTD PMID:25461682 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      group 19689
        inorganic group 19168
          oxo group 18505
            organic oxo compound 18505
              carbonyl compound 18505
                ketone 16829
                  oxo steroid 9722
                    Trenbolone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          Trenbolone 5
paths to the root