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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:saxitoxin
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Accession:CHEBI:34970 term browser browse the term
Definition:An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.
Synonyms:exact_synonym: [(3aS,4R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
 related_synonym: Formula=C10H17N7O4;   InChI=1S/C10H17N7O4/c11-6-15-5-4(3-21-8(13)18)14-7(12)17-2-1-9(19,20)10(5,17)16-6/h4-5,19-20H,1-3H2,(H2,12,14)(H2,13,18)(H3,11,15,16)/t4-,5-,10-/m0/s1;   InChIKey=RPQXVSUAYFXFJA-HGRQIUPRSA-N;   SMILES=NC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]22NC(=N)N[C@@H]12
 xref: CAS:35523-89-8;   Chemspider:34106;   FooDB:FDB000437;   HMDB:HMDB0029368;   KEGG:C13757;   KNApSAcK:C00051761
 xref_mesh: MESH:D012530
 xref: PMID:22628533;   PMID:23966031;   PMID:24184516;   PMID:24460188;   PMID:32323358;   PMID:32485372;   PMID:33086288;   PMID:33104353;   PMID:33113659;   PMID:33526182;   PMID:33748075;   PMID:33813339;   Reaxys:47858;   Wikipedia:Saxitoxin


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saxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity
ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein
CTD PMID:29128272 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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neosaxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions ISO neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:32471037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        poison 18322
          toxin 15401
            saxitoxin 2
              neosaxitoxin 1
              saxitoxin acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterotricyclic compound 14645
                                      pyrrolopurine 2
                                        paralytic shellfish toxin 2
                                          saxitoxin 2
                                            neosaxitoxin 1
                                            saxitoxin acetate 0
paths to the root