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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propanil
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Accession:CHEBI:34936 term browser browse the term
Definition:An anilide resulting from the formal condensation of the carboxy group of propanoic acid with the amino group of 3,4-dichloroaniline. It is a herbicide used for the treatment of numerous grasses and broad-leaved weeds in rice, potatoes, and wheat.
Synonyms:related_synonym: 3',4'-dichlorophenylpropionanilide;   3,4-DCPA;   3,4-dichloropropionanilide;   Arrosol;   BAY 30130;   Cekupropanil;   Chem Rice;   Crystal propanil-4;   DCPA;   DPA;   Dipram;   Dropaven;   Erban;   FW 734;   Formula=C9H9Cl2NO;   Herbax;   Herbax 4E;   InChI=1S/C9H9Cl2NO/c1-2-9(13)12-6-3-4-7(10)8(11)5-6/h3-5H,2H2,1H3,(H,12,13);   InChIKey=LFULEKSKNZEWOE-UHFFFAOYSA-N;   N-(3,4-Dichlorophenyl)propanamide;   N-(3,4-dichlorophenyl)propionamide;   Prop-Job;   Propanac;   Propanex;   Propanile;   Riselect;   Rogue;   S 10145;   SMILES=C1=C(C(=CC=C1NC(CC)=O)Cl)Cl;   Stam;   Stam 80 EDF;   Stam F 34;   Stam M-4;   Stampede;   Strel;   Supernox;   Surcopur;   Surpur;   Synpran N;   Vertac;   Wham DF;   Wham EZ;   propanilo;   propasint
 xref: CAS:709-98-8;   KEGG:C14229;   LINCS:LSM-19981
 xref_mesh: MESH:D011411
 xref: PMID:19953415;   PMID:25422118;   PMID:30230318;   PMID:30317116;   PPDB:545;   Pesticides:propanil;   Reaxys:2365645;   Wikipedia:Propanil


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propanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Propanil binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 Propanil binds to AR protein
Dihydrotestosterone inhibits the reaction [Propanil results in increased activity of AR protein]; Propanil inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]		 CTD PMID:14565775 PMID:15064155 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Propanil results in increased expression of DNAJB1 mRNA CTD PMID:24356939 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Propanil binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Propanil results in decreased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Propanil results in increased expression of HSPA1B mRNA CTD PMID:24356939 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Propanil results in decreased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Lipopolysaccharides promotes the reaction [Propanil results in increased expression of IFNG mRNA]; Lipopolysaccharides promotes the reaction [Propanil results in increased expression of IFNG protein] CTD PMID:7679225 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions
decreases stability		 ISO Propanil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Propanil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein]
Propanil results in decreased stability of IL2 mRNA		 CTD PMID:9925799 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion		 ISO Propanil promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Propanil results in decreased secretion of IL6 protein
Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:9201266 PMID:9221836 PMID:17585980 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Propanil inhibits the reaction [[NFKB1 protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter] CTD PMID:11312646 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17355946 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Propanil binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Propanil binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:11312646 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sqle squalene epoxidase decreases expression ISO Propanil results in decreased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Propanil binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Propanil binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
decreases secretion
increases expression		 ISO Propanil results in decreased expression of TNF protein
Lipopolysaccharides promotes the reaction [Propanil results in increased expression of TNF protein]; Propanil inhibits the reaction [[NFKB1 protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Propanil results in decreased secretion of TNF protein		 CTD PMID:7679225 PMID:9201266 PMID:9221836 PMID:11312646 PMID:17355946 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Zfp628 zinc finger protein 628 decreases expression ISO Propanil results in decreased expression of ZNF628 mRNA CTD PMID:24356939 NCBI chr 1:68,913,600...68,921,186
Ensembl chr 1:68,910,401...68,921,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        xenobiotic 18687
          3,4-dichloroaniline 172
            propanil 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    main group molecular entity 19959
                      s-block molecular entity 19758
                        hydrogen molecular entity 19764
                          hydrides 19134
                            inorganic hydride 17935
                              pnictogen hydride 17901
                                nitrogen hydride 17789
                                  azane 17542
                                    ammonia 17541
                                      organic amino compound 17541
                                        aromatic amine 14924
                                          anilines 13980
                                            substituted aniline 13657
                                              chloroaniline 233
                                                dichloroaniline 218
                                                  3,4-dichloroaniline 172
                                                    propanil 20
paths to the root