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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Pinacidil
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Accession:CHEBI:34923 term browser browse the term
Definition:An organic molecular entity that has formula C13H19N5.H2O.
Synonyms:related_synonym: Formula=C13H19N5.H2O;   InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2;   InChIKey=AFJCNBBHEVLGCZ-UHFFFAOYSA-N;   SMILES=O.CC(N\\C(NC#N)=N\\c1ccncc1)C(C)(C)C
 xref: CAS:85371-64-8;   KEGG:C13729;   KEGG:D05482
 xref_mesh: MESH:D020110



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Pinacidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 affects response to substance
affects binding
increases activity
ISO
EXP
ABCC9 affects the susceptibility to Pinacidil
Pinacidil binds to Abcc9 protein
Pinacidil results in increased activity of ABCC9 protein
CTD
RGD
PMID:18511652 PMID:28842488 PMID:23078514 RGD:12792001 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Casp3 caspase 3 decreases expression EXP Pinacidil results in decreased expression of CASP3 mRNA CTD PMID:17612592 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression EXP Pinacidil results in decreased expression of CASP8 mRNA CTD PMID:17612592 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression EXP Pinacidil results in decreased expression of CASP9 mRNA CTD PMID:17612592 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Pinacidil promotes the reaction [KCNJ11 protein results in increased transport of Potassium] CTD PMID:18420708 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein] CTD PMID:16257489 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Pinacidil inhibits the reaction [Rotenone results in increased expression of TNF protein]
CTD PMID:16257489 PMID:19012619 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          carbon atom 19633
            organic molecular entity 19633
              Pinacidil 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            Pinacidil 7
paths to the root