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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Pinacidil
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Accession:CHEBI:34923 term browser browse the term
Definition:An organic molecular entity that has formula C13H19N5.H2O.
Synonyms:related_synonym: Formula=C13H19N5.H2O;   InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2;   InChIKey=AFJCNBBHEVLGCZ-UHFFFAOYSA-N;   SMILES=O.CC(N\\C(NC#N)=N\\c1ccncc1)C(C)(C)C
 xref: CAS:85371-64-8;   KEGG:C13729;   KEGG:D05482
 xref_mesh: MESH:D020110


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Pinacidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 affects response to substance
increases activity
ISO
EXP
ABCC9 affects the susceptibility to Pinacidil
Pinacidil results in increased activity of ABCC9 protein
CTD PMID:18511652, PMID:28842488 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Casp3 caspase 3 decreases expression EXP Pinacidil results in decreased expression of CASP3 mRNA CTD PMID:17612592 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases expression EXP Pinacidil results in decreased expression of CASP8 mRNA CTD PMID:17612592 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression EXP Pinacidil results in decreased expression of CASP9 mRNA CTD PMID:17612592 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Pinacidil promotes the reaction [KCNJ11 protein results in increased transport of Potassium] CTD PMID:18420708 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein] CTD PMID:16257489 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Pinacidil inhibits the reaction [Rotenone results in increased expression of TNF protein]
CTD PMID:16257489, PMID:19012619 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              Pinacidil 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            Pinacidil 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.