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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Pinacidil
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Accession:CHEBI:34923 term browser browse the term
Definition:An organic molecular entity that has formula C13H19N5.H2O.
Synonyms:related_synonym: Formula=C13H19N5.H2O;   InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2;   InChIKey=AFJCNBBHEVLGCZ-UHFFFAOYSA-N;   SMILES=O.CC(N\\C(NC#N)=N\\c1ccncc1)C(C)(C)C
 xref: CAS:85371-64-8;   KEGG:C13729;   KEGG:D05482
 xref_mesh: MESH:D020110


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Pinacidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 affects response to substance
increases activity
affects binding		 ISO
EXP		 ABCC9 affects the susceptibility to Pinacidil
Pinacidil results in increased activity of ABCC9 protein
Pinacidil binds to Abcc9 protein		 CTD
RGD		 PMID:18511652 PMID:28842488 PMID:23078514 RGD:12792001 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Casp3 caspase 3 decreases expression EXP Pinacidil results in decreased expression of CASP3 mRNA CTD PMID:17612592 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression EXP Pinacidil results in decreased expression of CASP8 mRNA CTD PMID:17612592 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression EXP Pinacidil results in decreased expression of CASP9 mRNA CTD PMID:17612592 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Pinacidil promotes the reaction [KCNJ11 protein results in increased transport of Potassium] CTD PMID:18420708 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein] CTD PMID:16257489 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Pinacidil inhibits the reaction [Rotenone results in increased expression of TNF protein]		 CTD PMID:16257489 PMID:19012619 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    chemical entity 19915
      atom 19915
        nonmetal atom 19838
          carbon atom 19790
            organic molecular entity 19790
              Pinacidil 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            Pinacidil 7
paths to the root