Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenthoate
go back to main search page
Accession:CHEBI:34917 term browser browse the term
Definition:An organic thiophosphate that is ethyl mandelate in which the hydroxy group has been replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.
Synonyms:exact_synonym: ethyl [(dimethoxyphosphorothioyl)sulfanyl](phenyl)acetate
 related_synonym: Dimephenthioate;   Ethyl alpha-((dimethoxyphosphenothioyl)thio)benzeneacetate;   Fenthoate;   Formula=C12H17O4PS2;   InChI=1S/C12H17O4PS2/c1-4-16-12(13)11(10-8-6-5-7-9-10)19-17(18,14-2)15-3/h5-9,11H,4H2,1-3H3;   InChIKey=XAMUDJHXFNRLCY-UHFFFAOYSA-N;   O,O-Dimethyl S-alpha-Ethoxycarbonylbenzyl phosphorodithioate;   S-[alpha-(Ethoxycarbonyl)benzyl] O,O-dimethyl phosphorodithioate;   SMILES=CCOC(=O)C(SP(=S)(OC)OC)c1ccccc1
 xref: Beilstein:2474108;   CAS:2597-03-7;   KEGG:C14429
 xref_mesh: MESH:C008838
 xref: PPDB:518;   Patent:CN102037953;   Patent:CN102037996;   Reaxys:2474108;   Wikipedia:Phenthoate



show annotations for term's descendants           Sort by:
 
phenthoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO [phenthoate binds to ALB protein] which affects the activity of ACHE protein CTD PMID:31362050 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin multiple interactions ISO [phenthoate binds to ALB protein] which affects the activity of ACHE protein; phenthoate binds to and affects the folding of ALB protein CTD PMID:31362050 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO phenthoate results in increased expression of CYP1A2 mRNA CTD PMID:22310298 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
increases expression
ISO phenthoate results in decreased activity of CYP2B6 protein
phenthoate results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO phenthoate results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO phenthoate results in decreased activity of CYP2E1 protein
phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases activity
increases expression
ISO phenthoate results in decreased activity of CYP3A4 protein
phenthoate results in increased activity of CYP3A4 protein
phenthoate results in increased expression of CYP3A4 mRNA
CTD PMID:20183062 PMID:22310298 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO phenthoate results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phenthoate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
ISO phenthoate results in increased expression of NR1I3 mRNA
phenthoate results in increased activity of NR1I3 protein
CTD PMID:22310298 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        agrochemical 15187
          phenthoate 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                pnictogen oxoacid 10733
                                  phosphorus oxoacid 9728
                                    phosphoric acids 8536
                                      phosphoric acid 8536
                                        phosphoric acid derivative 8242
                                          phosphate 8242
                                            organic phosphate 8241
                                              organic thiophosphate 3816
                                                phenthoate 10
paths to the root