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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenolphthalein
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Accession:CHEBI:34914 term browser browse the term
Definition:A phenol that has formula C20H14O4.
Synonyms:related_synonym: 3,3-Bis(4-hydroxyphenyl)phthalide;   Formula=C20H14O4;   InChI=1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H;   InChIKey=KJFMBFZCATUALV-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1(OC(=O)c2ccccc12)c1ccc(O)cc1;   euchessina;   phthalimetten;   phthalin
 xref: CAS:77-09-8;   Drug_Central:2135;   KEGG:C14286;   KEGG:D05456;   LINCS:LSM-2432
 xref_mesh: MESH:D020113


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phenolphthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions		 ISO Phenolphthalein results in decreased activity of AKR1C4 protein
Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin]
Phenolphthalein results in decreased activity of AKR1C1 protein		 CTD PMID:8543560 PMID:12604236 PMID:23933386 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Phenolphthalein results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions		 ISO Phenolphthalein results in decreased activity of AKR1C3 protein
Phenolphthalein inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]		 CTD PMID:12604236 PMID:23933386 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 multiple interactions
decreases activity		 ISO Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin]
Phenolphthalein results in decreased activity of AKR1C1 protein		 CTD PMID:12604236 PMID:23933386 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity		 ISO Phenolphthalein binds to ESR1 protein
Phenolphthalein binds to and results in decreased activity of ESR1 protein
Phenolphthalein results in increased activity of ESR1 protein		 CTD PMID:12598185 PMID:25012808 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenolphthalein inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Phenolphthalein binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Phenolphthalein binds to and results in decreased activity of NR1I3 protein alternative form; Phenolphthalein binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] CTD PMID:28111842 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Phenolphthalein binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tyms thymidylate synthetase decreases activity ISO Phenolphthalein results in decreased activity of TYMS protein CTD PMID:21696158 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          heteroatomic molecular entity 19662
            hydroxides 19158
              organic hydroxy compound 18656
                phenols 18252
                  phenolphthalein 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic ester 15883
                                        lactone 11257
                                          gamma-lactone 6755
                                            2-benzofuran-1(3H)-one 93
                                              phenolphthalein 11
paths to the root