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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pentetrazol
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Accession:CHEBI:34910 term browser browse the term
Definition:An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Synonyms:related_synonym: 1,5-pentamethylenetetrazole;   6,7,8,9-tetrahydro-5-azepotetrazole;   6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine;   7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene;   Cardiazol;   Cardiazole;   Cardifortan;   Cardiotonicum;   Cardosal;   Cardosan;   Cenalene-M;   Cenazol;   Coranormol;   Coratoline;   Corazol;   Corazole;   Corvasol;   Coryvet;   Deumacard;   Diovascole;   Formula=C6H10N4;   Gewazol;   InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2;   InChIKey=CWRVKFFCRWGWCS-UHFFFAOYSA-N;   Kardiazol;   Korazol;   Metrazol;   Pentylenetetrazole;   Phrenazol;   SMILES=C1CCc2nnnn2CC1;   Ventrazol;   alpha,beta-cyclopentamethylenetetrazole;   pentamethylene-1,5-tetrazole;   pentetrazolum;   pentylenetetrazol
 xref: CAS:54-95-5;   Drug_Central:3428;   KEGG:C13692;   KEGG:D07409;   LINCS:LSM-3287
 xref_mesh: MESH:D010433
 xref: PMID:19797046;   PMID:21689733;   PMID:22049436;   PMID:23852314;   PMID:23893477;   PMID:24397543;   Patent:US1564631;   Patent:US1599493;   Reaxys:135492;   Wikipedia:Pentylenetetrazol


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pentetrazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase increases response to substance ISO ABAT mRNA results in increased susceptibility to Pentylenetetrazole CTD PMID:10850552 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pentylenetetrazole CTD PMID:19488739 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions
EXP Pentylenetetrazole results in increased expression of AGER protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of AGER protein]
CTD PMID:32653415 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
decreases activity
ISO carvacryl acetate inhibits the reaction [Pentylenetetrazole results in decreased activity of ALAD protein] CTD PMID:25490531 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of APP protein]
Pentylenetetrazole results in increased expression of APP mRNA; Pentylenetetrazole results in increased expression of APP protein
CTD PMID:9720974, PMID:32653415 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
increases expression
EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BACE1 protein] CTD PMID:32653415 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions
EXP
ISO
Pentylenetetrazole results in increased expression of BDNF mRNA; Pentylenetetrazole results in increased expression of BDNF protein
Pentylenetetrazole results in decreased expression of BDNF protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BDNF protein]
CTD PMID:11279263, PMID:32450180, PMID:32653415 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions
EXP
ISO
Pentylenetetrazole results in decreased expression of CAT protein
Pentylenetetrazole results in decreased activity of CAT protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]
CTD PMID:16122723, PMID:32450180 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
Pentylenetetrazole results in increased expression of FOS mRNA; Pentylenetetrazole results in increased expression of FOS protein
delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]
CTD PMID:1380685, PMID:3037702, PMID:7534335, PMID:7887109, PMID:8809800, PMID:11421588, PMID:15857624 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad2 glutamate decarboxylase 2 increases response to substance ISO GAD2 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:8954991 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gcg glucagon decreases expression
multiple interactions
EXP Pentylenetetrazole results in decreased expression of GCG protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased expression of GCG protein]
CTD PMID:32653415 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
EXP Pentylenetetrazole results in decreased phosphorylation of GSK3B protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased phosphorylation of GSK3B protein]
CTD PMID:32653415 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO Pentylenetetrazole results in decreased expression of HMOX1 protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]
CTD PMID:32450180 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression
multiple interactions
EXP Pentylenetetrazole results in increased expression of IGF1 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of IGF1 protein]
CTD PMID:32653415 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26910900 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation
EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased phosphorylation of MAPT protein] CTD PMID:32653415 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
EXP Pentylenetetrazole results in increased expression of MMP9 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of MMP9 protein]
CTD PMID:32653415 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Pentylenetetrazole CTD PMID:14960011 NCBI chr 5:99,413,184...99,566,356
Ensembl chr 5:99,413,187...99,566,318
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
multiple interactions
ISO Pentylenetetrazole results in increased expression of NR4A1 mRNA
Dexamethasone inhibits the reaction [Pentylenetetrazole results in increased expression of NR4A1 mRNA]
CTD PMID:8164692 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Pentylenetetrazole results in increased expression of NR4A2 mRNA CTD PMID:8164692 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Pentylenetetrazole CTD PMID:18657176 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in decreased susceptibility to Pentylenetetrazole] CTD PMID:23638761 NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 gene results in decreased susceptibility to Pentylenetetrazole CTD PMID:17126860 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase affects response to substance ISO PAM protein affects the susceptibility to Pentylenetetrazole CTD PMID:19815072 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Pentylenetetrazole CTD PMID:15911120 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Pentylenetetrazole results in decreased expression of SOD1 protein CTD PMID:16122723 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Pentylenetetrazole results in increased expression of VEGFA protein
daidzin inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]
CTD PMID:32450180 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                organonitrogen heterocyclic compound 17481
                  pentetrazol 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      p-block molecular entity 19696
                        carbon group molecular entity 19599
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heterobicyclic compound 16763
                                      pentetrazol 33
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.