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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pentetrazol
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Accession:CHEBI:34910 term browser browse the term
Definition:An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Synonyms:related_synonym: 1,5-pentamethylenetetrazole;   6,7,8,9-tetrahydro-5-azepotetrazole;   6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine;   7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene;   Cardiazol;   Cardiazole;   Cardifortan;   Cardiotonicum;   Cardosal;   Cardosan;   Cenalene-M;   Cenazol;   Coranormol;   Coratoline;   Corazol;   Corazole;   Corvasol;   Coryvet;   Deumacard;   Diovascole;   Formula=C6H10N4;   Gewazol;   InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2;   InChIKey=CWRVKFFCRWGWCS-UHFFFAOYSA-N;   Kardiazol;   Korazol;   Metrazol;   Pentylenetetrazole;   Phrenazol;   SMILES=C1CCc2nnnn2CC1;   Ventrazol;   alpha,beta-cyclopentamethylenetetrazole;   pentamethylene-1,5-tetrazole;   pentetrazolum;   pentylenetetrazol
 xref: CAS:54-95-5;   Drug_Central:3428;   KEGG:C13692;   KEGG:D07409;   LINCS:LSM-3287
 xref_mesh: MESH:D010433
 xref: PMID:19797046;   PMID:21689733;   PMID:22049436;   PMID:23852314;   PMID:23893477;   PMID:24397543;   Patent:US1564631;   Patent:US1599493;   Reaxys:135492;   Wikipedia:Pentylenetetrazol



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pentetrazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase increases response to substance ISO ABAT mRNA results in increased susceptibility to Pentylenetetrazole CTD PMID:10850552 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pentylenetetrazole CTD PMID:19488739 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions
EXP Pentylenetetrazole results in increased expression of AGER protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of AGER protein]
CTD PMID:32653415 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
decreases activity
ISO carvacryl acetate inhibits the reaction [Pentylenetetrazole results in decreased activity of ALAD protein] CTD PMID:25490531 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of APP protein]
Pentylenetetrazole results in increased expression of APP mRNA; Pentylenetetrazole results in increased expression of APP protein
CTD PMID:9720974 PMID:32653415 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
increases expression
EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BACE1 protein] CTD PMID:32653415 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions
EXP
ISO
Pentylenetetrazole results in increased expression of BDNF mRNA; Pentylenetetrazole results in increased expression of BDNF protein
Pentylenetetrazole results in decreased expression of BDNF protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BDNF protein]
CTD PMID:11279263 PMID:32450180 PMID:32653415 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP Thiamine inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 protein] CTD PMID:33771525 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions
EXP
ISO
Pentylenetetrazole results in decreased expression of CAT protein
Pentylenetetrazole results in decreased activity of CAT protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]
CTD PMID:16122723 PMID:32450180 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cnr1 cannabinoid receptor 1 increases response to substance ISO CNR1 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26460022 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
Pentylenetetrazole results in increased expression of FOS mRNA; Pentylenetetrazole results in increased expression of FOS protein
delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]
CTD PMID:1380685 PMID:3037702 PMID:7534335 PMID:7887109 PMID:8809800 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad2 glutamate decarboxylase 2 increases response to substance ISO GAD2 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:8954991 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gcg glucagon decreases expression
multiple interactions
EXP Pentylenetetrazole results in decreased expression of GCG protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased expression of GCG protein]
CTD PMID:32653415 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
EXP Pentylenetetrazole results in decreased phosphorylation of GSK3B protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased phosphorylation of GSK3B protein]
CTD PMID:32653415 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO Pentylenetetrazole results in decreased expression of HMOX1 protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]
CTD PMID:32450180 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression
multiple interactions
EXP Pentylenetetrazole results in increased expression of IGF1 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of IGF1 protein]
CTD PMID:32653415 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26910900 NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation
EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased phosphorylation of MAPT protein] CTD PMID:32653415 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
EXP Pentylenetetrazole results in increased expression of MMP9 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of MMP9 protein]
CTD PMID:32653415 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Pentylenetetrazole CTD PMID:14960011 NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
multiple interactions
ISO Pentylenetetrazole results in increased expression of NR4A1 mRNA
Dexamethasone inhibits the reaction [Pentylenetetrazole results in increased expression of NR4A1 mRNA]
CTD PMID:8164692 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Pentylenetetrazole results in increased expression of NR4A2 mRNA CTD PMID:8164692 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Pentylenetetrazole CTD PMID:18657176 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in decreased susceptibility to Pentylenetetrazole] CTD PMID:23638761 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 gene results in decreased susceptibility to Pentylenetetrazole CTD PMID:17126860 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase affects response to substance ISO PAM protein affects the susceptibility to Pentylenetetrazole CTD PMID:19815072 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Pentylenetetrazole CTD PMID:15911120 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Pentylenetetrazole results in decreased expression of SOD1 protein CTD PMID:16122723 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Pentylenetetrazole results in increased expression of VEGFA protein
daidzin inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]
CTD PMID:32450180 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 20089
    chemical entity 20088
      atom 20058
        nonmetal atom 19979
          nitrogen atom 18963
            nitrogen molecular entity 18937
              organonitrogen compound 18736
                organonitrogen heterocyclic compound 17766
                  pentetrazol 35
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      p-block molecular entity 19990
                        carbon group molecular entity 19885
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterobicyclic compound 17170
                                      pentetrazol 35
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