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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nocodazole
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Accession:CHEBI:34892 term browser browse the term
Definition:A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Synonyms:exact_synonym: methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
 related_synonym: (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester;   Formula=C14H11N3O3S;   InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19);   InChIKey=KYRVNWMVYQXFEU-UHFFFAOYSA-N;   N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl ester;   N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl ester;   R 17934;   R17,934;   SMILES=COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1cccs1;   methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate;   methyl N-(5-thenoyl-2-benzimidazolyl)carbamate;   nocodazol;   nocodazolum;   oncodazole
 xref: Beilstein:1085978;   CAS:31430-18-9;   DrugBank:DB08313;   KEGG:C13719;   KEGG:D05197;   LINCS:LSM-2260
 xref_mesh: MESH:D015739
 xref: PDBeChem:NZO;   PMID:11679255;   PMID:20399776;   PMID:22002881;   PMID:23869451;   PMID:518692;   PMID:6384770;   PMID:7199049;   PMID:7284368;   PMID:7344613;   Reaxys:1085978;   Wikipedia:Nocodazole


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nocodazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Nocodazole results in decreased expression of ABCC2 mRNA; Nocodazole results in decreased expression of ABCC2 protein CTD PMID:10691972 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Nocodazole results in increased expression of ABCC3 mRNA CTD PMID:10691972 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO Nocodazole results in increased expression of ACTA2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Nocodazole results in increased expression of ACTA2 mRNA]		 CTD PMID:31170432 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases activity ISO
EXP		 Nocodazole results in decreased activity of AHR protein CTD PMID:16611024 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Anapc2 anaphase promoting complex subunit 2 multiple interactions ISO Nocodazole promotes the reaction [CCAR1 protein binds to ANAPC2 protein] CTD PMID:21903591 NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178 		JBrowse link
G Ar androgen receptor multiple interactions
decreases localization		 ISO Nocodazole inhibits the reaction [Dihydrotestosterone results in increased localization of AR protein]
Nocodazole results in decreased localization of AR protein		 CTD PMID:20807808 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Doxorubicin inhibits the reaction [Nocodazole inhibits the reaction [Hydroxyurea results in increased phosphorylation of ATM protein]]; Nocodazole inhibits the reaction [Hydroxyurea results in increased phosphorylation of ATM protein] CTD PMID:31597699 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO Nocodazole inhibits the reaction [Copper affects the localization of ATP7B protein] CTD PMID:10982773 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Aurka aurora kinase A multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein; MLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein] CTD PMID:24976383 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Aurkb aurora kinase B multiple interactions ISO 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKB protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKB protein CTD PMID:24976383 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Nocodazole analog results in increased expression of BAX protein CTD PMID:28412508 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation
decreases expression
multiple interactions		 ISO Nocodazole results in increased phosphorylation of BCL2 protein
Nocodazole analog results in decreased expression of BCL2 protein
TYMP inhibits the reaction [Nocodazole results in increased phosphorylation of BCL2 protein]		 CTD PMID:15907805 PMID:28412508 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Nocodazole affects the reaction [BIRC5 protein affects the susceptibility to Melphalan] CTD PMID:16373717 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions
increases phosphorylation		 ISO [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form; chromium hexavalent ion inhibits the reaction [Nocodazole results in increased phosphorylation of BUB1 protein] CTD PMID:21670593 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 multiple interactions ISO [CAPZA1 protein co-treated with CAPZA2 protein] results in decreased susceptibility to Nocodazole CTD PMID:22918941 NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480 		JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 multiple interactions ISO [CAPZA1 protein co-treated with CAPZA2 protein] results in decreased susceptibility to Nocodazole CTD PMID:22918941 NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
decreases expression		 ISO Nocodazole results in increased cleavage of CASP3 protein
[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein; [Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein; Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]; NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]]
Nocodazole analog results in decreased expression of CASP3 protein		 CTD PMID:21903591 PMID:28412508 PMID:31597699 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO Caspase Inhibitors inhibits the reaction [Nocodazole analog results in increased expression of CASP8 protein modified form]
Nocodazole analog results in increased cleavage of CASP8 protein		 CTD PMID:28412508 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Nocodazole analog results in increased cleavage of CASP9 protein CTD PMID:28412508 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 multiple interactions
increases expression		 ISO Nocodazole inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]; Nocodazole promotes the reaction [CCAR1 protein binds to ANAPC2 protein]
Nocodazole results in increased expression of CCAR1 protein		 CTD PMID:19073175 PMID:21903591 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Nocodazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Nocodazole analog results in increased expression of CCNB1 protein; Nocodazole results in increased expression of CCNB1 protein CTD PMID:21670593 PMID:28412508 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Nocodazole analog results in increased expression of CDK1 protein CTD PMID:28412508 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 multiple interactions ISO [Nocodazole co-treated with chromium hexavalent ion] results in decreased expression of and results in decreased phosphorylation of CDT1 protein CTD PMID:21670593 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Cftr CF transmembrane conductance regulator affects localization
multiple interactions		 ISO
EXP		 Nocodazole affects the localization of CFTR protein
Nocodazole inhibits the reaction [Cyclic AMP affects the localization of and results in increased activity of CFTR protein]		 CTD PMID:12529251 PMID:15994425 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Nocodazole results in decreased expression of CHEK1 protein CTD PMID:26914363 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 Nocodazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Nocodazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Nocodazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Nocodazole inhibits the reaction [benzotriphenylene results in increased expression of and results in increased activity of CYP1A1 protein]; Nocodazole inhibits the reaction [benzotriphenylene results in increased expression of CYP1A1 mRNA]		 CTD PMID:8190110 PMID:16611024 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Nocodazole inhibits the reaction [EGF protein results in increased expression of PSA mRNA] CTD PMID:20807808 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [TYMP co-treated with Nocodazole] results in decreased expression of FASLG mRNA; [TYMP co-treated with Nocodazole] results in decreased expression of FASLG protein CTD PMID:15907805 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbxo5 F-box protein 5 multiple interactions ISO [Nocodazole co-treated with chromium hexavalent ion] results in decreased expression of FBXO5 protein CTD PMID:21670593 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP Nocodazole results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Gmnn geminin, DNA replication inhibitor multiple interactions ISO [Nocodazole co-treated with chromium hexavalent ion] results in increased ubiquitination of GMNN protein CTD PMID:21670593 NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Nocodazole results in increased expression of H2AX protein modified form CTD PMID:26914363 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Nocodazole results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Nocodazole results in increased expression of HSPA5 protein CTD PMID:26732598 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Nocodazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions		 ISO Nocodazole results in increased phosphorylation of JUN protein
TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of JUN protein]		 CTD PMID:12221076 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases response to substance ISO LCMT1 results in decreased susceptibility to Nocodazole CTD PMID:17724024 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112 		JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 affects response to substance ISO LZTS1 protein affects the susceptibility to Nocodazole CTD PMID:17349584 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK1 protein]		 CTD PMID:15907805 PMID:17822405 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK3 protein]		 CTD PMID:15907805 PMID:17822405 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK8 protein] CTD PMID:12221076 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Nocodazole results in increased phosphorylation of MAPK9 protein
TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK9 protein]		 CTD PMID:12221076 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Nocodazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Myt1 myelin transcription factor 1 increases phosphorylation ISO Nocodazole results in increased phosphorylation of MYT1 protein CTD PMID:16611024 NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Nocodazole results in decreased expression of NANOG protein CTD PMID:21559451 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Nocodazole inhibits the reaction [NGF protein affects the localization of NTRK1 protein]; Nocodazole inhibits the reaction [NGF protein affects the localization of RAP1A protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK1 protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK3 protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of RAP1A protein] CTD PMID:17822405 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Notch1 notch receptor 1 decreases expression
multiple interactions		 ISO Nocodazole results in decreased expression of NOTCH1 protein
BI 2536 inhibits the reaction [Nocodazole results in decreased expression of NOTCH1 protein]; Doxorubicin inhibits the reaction [Nocodazole promotes the reaction [Hydroxyurea results in decreased expression of NOTCH1 protein]]; Nocodazole promotes the reaction [Hydroxyurea results in decreased expression of NOTCH1 protein]; NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]]		 CTD PMID:31597699 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions ISO Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin] CTD PMID:16174794 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Npm1 nucleophosmin 1 affects phosphorylation ISO Nocodazole affects the phosphorylation of NPM1 protein CTD PMID:15190079 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Nocodazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions EXP Nocodazole inhibits the reaction [NGF protein affects the localization of NTRK1 protein] CTD PMID:17822405 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Optn optineurin affects localization ISO Nocodazole affects the localization of OPTN protein CTD PMID:25096716 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO TYMP inhibits the reaction [Nocodazole results in increased cleavage of PARP1 protein]
Nocodazole analog results in increased cleavage of PARP1 protein; Nocodazole results in increased cleavage of PARP1 protein		 CTD PMID:15907805 PMID:21903591 PMID:28412508 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plk1 polo-like kinase 1 multiple interactions
decreases phosphorylation		 ISO [Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein; Doxorubicin affects the reaction [[Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein]
Nocodazole results in decreased phosphorylation of PLK1 protein		 CTD PMID:31597699 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Nocodazole results in decreased expression of POU5F1 protein CTD PMID:21559451 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases response to substance ISO PPP2R2A results in decreased susceptibility to Nocodazole CTD PMID:17724024 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Qrich1 glutamine-rich 1 multiple interactions
increases phosphorylation		 ISO Genistein inhibits the reaction [Nocodazole results in increased phosphorylation of QRICH1 protein] CTD PMID:17510977 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 multiple interactions ISO Nocodazole results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein] CTD PMID:21646468 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions EXP Nocodazole inhibits the reaction [NGF protein affects the localization of RAP1A protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of RAP1A protein] CTD PMID:17822405 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Nocodazole inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein] CTD PMID:29247640 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nocodazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO Nocodazole results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein] CTD PMID:21646468 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
G Tf transferrin decreases expression ISO Nocodazole results in decreased expression of TRF protein CTD PMID:34089742 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK9 protein]
Nocodazole analog results in increased expression of TP53 protein; Nocodazole results in increased expression of TP53 protein		 CTD PMID:12221076 PMID:21559451 PMID:28412508 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO Nocodazole inhibits the reaction [TUBA1A protein binds to TUBA1A protein] CTD PMID:19222062 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO [TYMP co-treated with Nocodazole] results in decreased expression of FASLG mRNA; [TYMP co-treated with Nocodazole] results in decreased expression of FASLG protein; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]; TYMP inhibits the reaction [Nocodazole results in increased cleavage of PARP1 protein]; TYMP inhibits the reaction [Nocodazole results in increased phosphorylation of BCL2 protein] CTD PMID:15907805 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Nocodazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        pharmacological role 19090
          tubulin modulator 2555
            nocodazole 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic ester 15960
                                        carbamate ester 7468
                                          nocodazole 69
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