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ONTOLOGY REPORT - ANNOTATIONS


Term:nocodazole
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Accession:CHEBI:34892 term browser browse the term
Definition:A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Synonyms:exact_synonym: methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
 related_synonym: (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester;   Formula=C14H11N3O3S;   InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19);   InChIKey=KYRVNWMVYQXFEU-UHFFFAOYSA-N;   N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl ester;   N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl ester;   R 17934;   R17,934;   SMILES=COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1cccs1;   methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate;   methyl N-(5-thenoyl-2-benzimidazolyl)carbamate;   nocodazol;   nocodazolum;   oncodazole
 xref: Beilstein:1085978 "Beilstein";   CAS:31430-18-9 "ChemIDplus";   CAS:31430-18-9 "KEGG COMPOUND";   CAS:31430-18-9 "NIST Chemistry WebBook";   DrugBank:DB08313;   KEGG:C13719;   KEGG:D05197;   LINCS:LSM-2260
 xref_mesh: MESH:D015739
 xref: PDBeChem:NZO;   PMID:11679255 "Europe PMC";   PMID:20399776 "Europe PMC";   PMID:22002881 "Europe PMC";   PMID:23869451 "Europe PMC";   PMID:518692 "Europe PMC";   PMID:6384770 "Europe PMC";   PMID:7199049 "Europe PMC";   PMID:7284368 "Europe PMC";   PMID:7344613 "Europe PMC";   Reaxys:1085978 "Reaxys";   Wikipedia:Nocodazole


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nocodazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Anapc2 anaphase promoting complex subunit 2 JBrowse link 3 2,490,496 2,502,247 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:6480464
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:6480464
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase JBrowse link 3 120,373,604 120,404,910 RGD:6480464
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 JBrowse link 2 207,305,748 207,350,812 RGD:6480464
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 JBrowse link 4 44,936,290 44,972,270 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccar1 cell division cycle and apoptosis regulator 1 JBrowse link 20 32,373,443 32,416,044 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdt1 chromatin licensing and DNA replication factor 1 JBrowse link 19 55,381,565 55,386,511 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Fbxo5 F-box protein 5 JBrowse link 1 42,461,277 42,467,646 RGD:6480464
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:6480464
G Gmnn geminin, DNA replication inhibitor JBrowse link 17 42,302,523 42,310,783 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Lcmt1 leucine carboxyl methyltransferase 1 JBrowse link 1 193,335,629 193,391,620 RGD:6480464
G Lzts1 leucine zipper tumor suppressor 1 JBrowse link 16 22,250,452 22,306,667 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Myt1 myelin transcription factor 1 JBrowse link 3 177,281,365 177,341,550 RGD:6480464
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 3,616,878 3,662,656 RGD:6480464
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:6480464
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6480464
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:6480464
G Qrich1 glutamine-rich 1 JBrowse link 8 117,305,803 117,346,738 RGD:6480464
G Rangap1 RAN GTPase activating protein 1 JBrowse link 7 122,939,266 122,967,178 RGD:6480464
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Sumo1 small ubiquitin-like modifier 1 JBrowse link 9 66,453,428 66,483,614 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          tubulin modulator 2480
            nocodazole 65
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        carbamate ester 7332
                                          nocodazole 65
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.