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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nickel dichloride
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Accession:CHEBI:34887 term browser browse the term
Definition:A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Synonyms:exact_synonym: nickel(2+) chloride
 related_synonym: Formula=Cl2Ni;   InChI=1S/2ClH.Ni/h2*1H;/q;;+2/p-2;   InChIKey=QMMRZOWCJAIUJA-UHFFFAOYSA-L;   NiCl2;   Nickel chloride;   Nickel(II) chloride;   SMILES=Cl[Ni]Cl;   nickelous chloride
 xref: CAS:7718-54-9;   KEGG:C14711
 xref_mesh: MESH:C022838
 xref: PMID:11739495;   PMID:12603851;   PMID:21928331;   PMID:23179351;   PMID:23622879;   PMID:23702803;   PMID:23735035;   PMID:7671317;   Reaxys:3902827;   Reaxys:8128171;   Wikipedia:Nickel_dichloride


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nickel dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO nickel chloride results in increased expression of ABCA1 mRNA CTD PMID:17312168 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
increases expression
multiple interactions
EXP ABCB1 protein results in decreased susceptibility to nickel chloride
nickel chloride results in increased expression of ABCB1 mRNA; nickel chloride results in increased expression of ABCB1 protein
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]; fumonisin B1 inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]
CTD PMID:24448832 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP nickel chloride results in increased expression of ABCC1 mRNA CTD PMID:22110744 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO nickel chloride results in increased expression of ABCG1 mRNA CTD PMID:17312168 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abtb1 ankyrin repeat and BTB domain containing 1 affects expression EXP nickel chloride affects the expression of ABTB1 mRNA CTD PMID:22546817 NCBI chr 4:120,778,580...120,784,807
Ensembl chr 4:120,778,580...120,784,807
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO nickel chloride results in decreased expression of ACADM mRNA CTD PMID:17312168 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO nickel chloride results in increased expression of ACKR3 mRNA CTD PMID:17312168 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Acly ATP citrate lyase affects expression EXP nickel chloride affects the expression of ACLY mRNA CTD PMID:22546817 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aco1 aconitase 1 decreases activity
increases activity
multiple interactions
ISO nickel chloride results in decreased activity of ACO1 protein
nickel chloride results in increased activity of ACO1 protein
[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]; [nickel chloride results in increased activity of ACO1 protein] which results in increased expression of and results in increased stability of TFRC mRNA; Iron inhibits the reaction [nickel chloride results in increased activity of ACO1 protein]
CTD PMID:16039939 PMID:16649251 PMID:17018869 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 decreases activity ISO nickel chloride results in decreased activity of ACO2 protein CTD PMID:17018869 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO nickel chloride results in decreased expression of ACOX1 mRNA CTD PMID:17312168 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 affects expression EXP nickel chloride affects the expression of ACSF2 mRNA CTD PMID:22110744 NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression
affects expression
ISO
EXP
nickel chloride results in decreased expression of ACSL1 mRNA
nickel chloride affects the expression of ACSL1 mRNA
CTD PMID:17547211 PMID:22110744 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO nickel chloride results in increased expression of ACTA2 mRNA; nickel chloride results in increased expression of ACTA2 protein
sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of ACTA2 mRNA]; sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of ACTA2 protein]
CTH gene mutant form promotes the reaction [nickel chloride results in increased expression of ACTA2 protein]
CTD PMID:30055191 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta decreases expression
increases expression
ISO nickel chloride results in decreased expression of ACTB protein
nickel chloride results in increased expression of ACTB mRNA
CTD PMID:20452446 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actn2 actinin alpha 2 affects expression EXP nickel chloride affects the expression of ACTN2 mRNA CTD PMID:22546817 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 affects expression EXP nickel chloride affects the expression of ADAM17 mRNA CTD PMID:22546817 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions
decreases activity
EXP
ISO
nickel chloride inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA]
nickel chloride results in decreased activity of ADCYAP1 protein
CTD PMID:18198219 PMID:22009744 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Adm adrenomedullin increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of ADM mRNA
nickel chloride affects the expression of ADM mRNA
CTD PMID:17312168 PMID:17547211 PMID:21455298 PMID:22110744 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Afp alpha-fetoprotein affects expression EXP nickel chloride affects the expression of AFP mRNA CTD PMID:22110744 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression EXP nickel chloride affects the expression of AIFM1 mRNA CTD PMID:22546817 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 affects expression EXP nickel chloride affects the expression of AIFM2 mRNA CTD PMID:22546817 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 decreases expression ISO nickel chloride results in decreased expression of AIMP1 mRNA CTD PMID:17312168 NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
JBrowse link
G Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 affects expression EXP nickel chloride affects the expression of AIPL1 mRNA CTD PMID:22546817 NCBI chr10:58,599,690...58,631,194
Ensembl chr10:58,599,856...58,608,907
JBrowse link
G Ak1 adenylate kinase 1 affects expression EXP nickel chloride affects the expression of AK1 mRNA CTD PMID:22546817 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO nickel chloride results in increased expression of AK3 mRNA CTD PMID:17312168 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Ak4 adenylate kinase 4 increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in increased expression of AK4 mRNA
nickel chloride affects the expression of AK4 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA]
CTD PMID:12729255 PMID:22110744 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akap11 A-kinase anchoring protein 11 decreases expression ISO nickel chloride results in decreased expression of AKAP11 mRNA CTD PMID:17312168 NCBI chr15:60,722,138...60,766,673
Ensembl chr15:60,722,160...60,766,579
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases expression ISO nickel chloride results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 affects expression EXP nickel chloride affects the expression of AKR1B8 mRNA CTD PMID:22110744 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression EXP nickel chloride affects the expression of AKR1D1 mRNA CTD PMID:22110744 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases response to substance
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; [nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of AKT1 protein; [nickel chloride results in increased phosphorylation of AKT1 protein] which results in decreased activity of and results in increased phosphorylation of GSK3B protein; nickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]
AKT1 protein results in decreased susceptibility to nickel chloride
AKT1 protein affects the reaction [nickel chloride results in increased expression of HIF1A protein]; AKT1 protein affects the reaction [nickel chloride results in increased expression of NDRG1 protein]
CTD PMID:14729612 PMID:21837363 PMID:23828460 PMID:25614230 PMID:30724446 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression EXP nickel chloride affects the expression of AKT2 mRNA CTD PMID:22546817 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin multiple interactions EXP [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein CTD PMID:17657459 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
increases expression
ISO nickel chloride results in decreased expression of ALDH1A1 mRNA
nickel chloride results in increased expression of ALDH1A1 protein
CTD PMID:12729255 PMID:14645679 PMID:26962057 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects expression EXP nickel chloride affects the expression of ALDH1B1 mRNA CTD PMID:22110744 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions
affects expression
ISO
EXP
nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]
nickel chloride affects the expression of ALDH3A1 mRNA
CTD PMID:14645679 PMID:22110744 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions
increases expression
ISO HIF1A affects the reaction [nickel chloride results in increased expression of ALDOA mRNA] CTD PMID:12426141 PMID:12839937 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Amacr alpha-methylacyl-CoA racemase affects expression EXP nickel chloride affects the expression of AMACR mRNA CTD PMID:22110744 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 affects expression EXP nickel chloride affects the expression of AMPD3 mRNA CTD PMID:22110744 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Anapc4 anaphase promoting complex subunit 4 affects expression EXP nickel chloride affects the expression of ANAPC4 mRNA CTD PMID:22546817 NCBI chr14:60,471,962...60,503,803
Ensembl chr14:60,471,962...60,503,803
JBrowse link
G Anapc7 anaphase promoting complex subunit 7 affects expression EXP nickel chloride affects the expression of ANAPC7 mRNA CTD PMID:22546817 NCBI chr12:39,613,898...39,641,999
Ensembl chr12:39,614,733...39,641,285
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO nickel chloride results in increased expression of ANGPTL4 mRNA CTD PMID:17312168 PMID:21455298 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of ANKRD37 mRNA
nickel chloride affects the expression of ANKRD37 mRNA
CTD PMID:21455298 PMID:22110744 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Anxa2 annexin A2 affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of ANXA2 mRNA
nickel chloride results in increased expression of ANXA2 protein
CTD PMID:11250053 PMID:22110744 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 affects expression EXP nickel chloride affects the expression of APBB1 mRNA CTD PMID:22546817 NCBI chr 1:170,387,625...170,411,263
Ensembl chr 1:170,387,609...170,404,056
JBrowse link
G Apbb2 amyloid beta precursor protein binding family B member 2 affects expression EXP nickel chloride affects the expression of APBB2 mRNA CTD PMID:22546817 NCBI chr14:43,205,047...43,526,968
Ensembl chr14:43,512,901...43,523,080
JBrowse link
G Apbb3 amyloid beta precursor protein binding family B member 3 affects expression EXP nickel chloride affects the expression of APBB3 mRNA CTD PMID:22546817 NCBI chr18:29,497,865...29,504,995
Ensembl chr18:29,497,863...29,504,995
JBrowse link
G Apc APC regulator of WNT signaling pathway affects expression EXP nickel chloride affects the expression of APC mRNA CTD PMID:22546817 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 affects expression EXP nickel chloride affects the expression of APEX2 mRNA CTD PMID:22546817 NCBI chr  X:23,146,085...23,166,676
Ensembl chr  X:23,146,085...23,166,675
JBrowse link
G Apln apelin affects expression EXP nickel chloride affects the expression of APLN mRNA CTD PMID:22110744 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Apol2 apolipoprotein L, 2 increases expression ISO nickel chloride results in increased expression of APOL2 mRNA CTD PMID:21455298 NCBI chr 7:118,727,658...118,735,453
Ensembl chr 7:118,728,617...118,732,738
Ensembl chr 7:118,728,617...118,732,738
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase affects expression EXP nickel chloride affects the expression of ARAF mRNA CTD PMID:22546817 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Arg1 arginase 1 affects expression EXP nickel chloride affects the expression of ARG1 mRNA CTD PMID:22546817 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 affects expression EXP nickel chloride affects the expression of ARHGEF6 mRNA CTD PMID:22546817 NCBI chr  X:159,722,031...159,841,344
Ensembl chr  X:159,723,866...159,841,072
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 affects expression EXP nickel chloride affects the expression of ARL6IP1 mRNA CTD PMID:22110744 NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO HIF1A affects the reaction [nickel chloride results in increased expression of ARNT mRNA]
nickel chloride promotes the reaction [HIF1A protein binds to ARNT protein]
CTD PMID:12729255 PMID:29355601 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Arrb2 arrestin, beta 2 affects localization ISO nickel chloride affects the localization of ARRB2 protein CTD PMID:16959833 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Arrdc4 arrestin domain containing 4 increases expression ISO nickel chloride results in increased expression of ARRDC4 mRNA CTD PMID:21455298 NCBI chr 1:129,766,097...129,780,076
Ensembl chr 1:129,766,100...129,780,356
JBrowse link
G Asic2 acid sensing ion channel subunit 2 affects expression EXP nickel chloride affects the expression of ASIC2 mRNA CTD PMID:22546817 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Asl argininosuccinate lyase affects expression EXP nickel chloride affects the expression of ASL mRNA CTD PMID:22110744 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO nickel chloride results in increased expression of ASNS mRNA CTD PMID:17312168 PMID:17547211 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO [nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of ATF2 protein CTD PMID:23536762 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf3 activating transcription factor 3 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of ATF3 mRNA
nickel chloride affects the expression of ATF3 mRNA
CTD PMID:17312168 PMID:22110744 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atm ATM serine/threonine kinase increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of ATM mRNA
nickel chloride affects the expression of ATM mRNA
CTD PMID:12426141 PMID:12839937 PMID:22546817 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression ISO nickel chloride results in decreased expression of ATP2A2 mRNA CTD PMID:17312168 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Aurka aurora kinase A affects expression EXP nickel chloride affects the expression of AURKA mRNA CTD PMID:22546817 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding affects expression EXP nickel chloride affects the expression of AZGP1 mRNA CTD PMID:22110744 NCBI chr12:19,196,565...19,203,094
Ensembl chr12:19,196,611...19,202,647
JBrowse link
G Bach1 BTB domain and CNC homolog 1 increases expression ISO nickel chloride results in increased expression of BACH1 mRNA CTD PMID:17312168 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
affects expression
EXP nickel chloride results in increased expression of BAD protein
nickel chloride affects the expression of BAD mRNA
CTD PMID:20391133 PMID:22546817 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag1 BAG cochaperone 1 affects expression EXP nickel chloride affects the expression of BAG1 mRNA CTD PMID:22546817 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bag3 BAG cochaperone 3 affects expression EXP nickel chloride affects the expression of BAG3 mRNA CTD PMID:22546817 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
affects expression
EXP nickel chloride results in increased expression of BAK1 mRNA
nickel chloride affects the expression of BAK1 mRNA
CTD PMID:21843586 PMID:22546817 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects expression
EXP
ISO
nickel chloride results in increased expression of BAX protein
[nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein]
nickel chloride affects the expression of BAX mRNA
CTD PMID:20391133 PMID:22546817 PMID:31943712 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in increased expression of BBC3 mRNA
nickel chloride affects the expression of BBC3 mRNA
TP53 protein affects the reaction [nickel chloride results in increased expression of BBC3 mRNA]
CTD PMID:22546817 PMID:23566959 PMID:28552779 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member affects expression EXP nickel chloride affects the expression of BCAR3 mRNA CTD PMID:22546817 NCBI chr 2:226,563,050...226,679,449
Ensembl chr 2:226,563,050...226,679,438
JBrowse link
G Bcl10 BCL10, immune signaling adaptor affects expression EXP nickel chloride affects the expression of BCL10 mRNA CTD PMID:22546817 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
decreases response to substance
increases expression
ISO
EXP
nickel chloride results in decreased expression of BCL2 mRNA
BCL2 protein results in decreased susceptibility to nickel chloride
nickel chloride results in decreased expression of BCL2 protein
nickel chloride results in increased expression of BCL2 protein
CTD PMID:17442357 PMID:20391133 PMID:21837363 PMID:23828460 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO nickel chloride results in increased expression of BCL2A1 mRNA CTD PMID:17312168 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases response to substance
affects expression
decreases expression
ISO
EXP
nickel chloride results in increased expression of BCL2L1 protein
BCL2L1 protein results in decreased susceptibility to nickel chloride
nickel chloride affects the expression of BCL2L1 mRNA
nickel chloride results in decreased expression of BCL2L1 protein
CTD PMID:20391133 PMID:21837363 PMID:22546817 PMID:23828460 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l10 BCL2 like 10 affects expression EXP nickel chloride affects the expression of BCL2L10 mRNA CTD PMID:22546817 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl2l11 BCL2 like 11 affects expression EXP nickel chloride affects the expression of BCL2L11 mRNA CTD PMID:22110744 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l13 BCL2 like 13 affects expression EXP nickel chloride affects the expression of BCL2L13 mRNA CTD PMID:22546817 NCBI chr 4:153,385,200...153,438,096
Ensembl chr 4:153,385,205...153,436,660
JBrowse link
G Bcl2l2 Bcl2-like 2 affects expression EXP nickel chloride affects the expression of BCL2L2 mRNA CTD PMID:22546817 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bcl3 BCL3, transcription coactivator affects expression EXP nickel chloride affects the expression of BCL3 mRNA CTD PMID:22546817 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl6 BCL6, transcription repressor affects expression EXP nickel chloride affects the expression of BCL6 mRNA CTD PMID:22546817 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone affects expression EXP nickel chloride affects the expression of BCS1L mRNA CTD PMID:22110744 NCBI chr 9:81,868,158...81,872,201
Ensembl chr 9:81,868,265...81,872,197
JBrowse link
G Bex3 brain expressed X-linked 3 affects expression EXP nickel chloride affects the expression of BEX3 mRNA CTD PMID:22546817 NCBI chr  X:106,823,442...106,825,016
Ensembl chr  X:106,823,491...106,825,014
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 affects expression EXP nickel chloride affects the expression of BHLHE41 mRNA CTD PMID:22110744 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Bid BH3 interacting domain death agonist increases expression
affects expression
EXP nickel chloride results in increased expression of BID mRNA
nickel chloride affects the expression of BID mRNA
CTD PMID:21843586 PMID:22546817 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bik BCL2-interacting killer affects expression EXP nickel chloride affects the expression of BIK mRNA CTD PMID:22546817 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of BIRC3 mRNA
nickel chloride affects the expression of BIRC3 mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression EXP nickel chloride affects the expression of BIRC5 mRNA CTD PMID:22546817 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bles03 basophilic leukemia expressed protein BLES03 decreases expression ISO nickel chloride results in decreased expression of BLES03 mRNA CTD PMID:17312168 NCBI chr 1:220,806,563...220,808,817
Ensembl chr 1:220,806,473...220,808,804
JBrowse link
G Bmf Bcl2 modifying factor affects expression EXP nickel chloride affects the expression of BMF mRNA CTD PMID:22546817 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression
multiple interactions
affects expression
ISO
EXP
nickel chloride results in increased expression of BNIP3 mRNA
HIF1A protein promotes the reaction [nickel chloride results in increased expression of BNIP3 protein]
nickel chloride affects the expression of BNIP3 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of BNIP3 mRNA]
CTD PMID:12426141 PMID:12729255 PMID:12839937 PMID:17312168 PMID:22110744 PMID:22546817 PMID:28552779 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of BNIP3L mRNA
nickel chloride affects the expression of BNIP3L mRNA
CTD PMID:21455298 PMID:22110744 PMID:22546817 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Bok BCL2 family apoptosis regulator BOK affects expression EXP nickel chloride affects the expression of BOK mRNA CTD PMID:22546817 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO nickel chloride results in decreased expression of BRCA1 mRNA; nickel chloride results in decreased expression of BRCA1 protein CTD PMID:28472268 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brinp2 BMP/retinoic acid inducible neural specific 2 affects expression EXP nickel chloride affects the expression of BRINP2 mRNA CTD PMID:22546817 NCBI chr13:75,948,679...76,049,363
Ensembl chr13:75,948,679...76,049,363
JBrowse link
G Btd biotinidase affects expression EXP nickel chloride affects the expression of BTD mRNA CTD PMID:22110744 NCBI chr16:7,758,192...7,791,301
Ensembl chr16:7,758,996...7,791,243
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO nickel chloride results in increased expression of BTG1 mRNA CTD PMID:17312168 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions
increases expression
ISO TP53 protein affects the reaction [nickel chloride results in increased expression of BTG2 mRNA] CTD PMID:23566959 PMID:28552779 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btg3 BTG anti-proliferation factor 3 affects expression EXP nickel chloride affects the expression of BTG3 mRNA CTD PMID:22546817 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 affects expression EXP nickel chloride affects the expression of BZW1 mRNA CTD PMID:22546817 NCBI chr 9:65,279,675...65,293,471
Ensembl chr 9:65,279,675...65,291,651
JBrowse link
G C1s complement C1s affects expression EXP nickel chloride affects the expression of C1S mRNA CTD PMID:22110744 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609
JBrowse link
G C2cd4d C2 calcium-dependent domain containing 4D affects expression EXP nickel chloride affects the expression of C2CD4D mRNA CTD PMID:22110744 NCBI chr 2:195,599,706...195,604,730
Ensembl chr 2:195,603,599...195,604,624
JBrowse link
G C3 complement C3 affects expression EXP nickel chloride affects the expression of C3 mRNA CTD PMID:22110744 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C7 complement C7 affects expression EXP nickel chloride affects the expression of C7 mRNA CTD PMID:22546817 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G C8b complement C8 beta chain affects expression EXP nickel chloride affects the expression of C8B mRNA CTD PMID:22110744 NCBI chr 5:124,298,269...124,338,055
Ensembl chr 5:124,300,477...124,338,053
JBrowse link
G C9 complement C9 affects expression EXP nickel chloride affects the expression of C9 mRNA CTD PMID:22546817 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826
JBrowse link
G Ca9 carbonic anhydrase 9 increases expression
multiple interactions
ISO nickel chloride results in increased expression of CA9 mRNA
HIF1A protein promotes the reaction [nickel chloride results in increased expression of CA9 protein]
CTD PMID:21455298 PMID:28552779 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Calm1 calmodulin 1 affects expression EXP nickel chloride affects the expression of CALM1 mRNA CTD PMID:22546817 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 affects expression EXP nickel chloride affects the expression of CALM2 mRNA CTD PMID:22546817 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta affects expression EXP nickel chloride affects the expression of CAMK2B mRNA CTD PMID:22546817 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta affects expression EXP nickel chloride affects the expression of CAMK2D mRNA CTD PMID:22546817 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma affects expression EXP nickel chloride affects the expression of CAMK2G mRNA CTD PMID:22546817 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Card10 caspase recruitment domain family, member 10 affects expression EXP nickel chloride affects the expression of CARD10 mRNA CTD PMID:22546817 NCBI chr 7:119,998,639...120,028,632
Ensembl chr 7:119,999,472...120,027,026
JBrowse link
G Card9 caspase recruitment domain family, member 9 affects expression EXP nickel chloride affects the expression of CARD9 mRNA CTD PMID:22546817 NCBI chr 3:3,798,346...3,806,841
Ensembl chr 3:3,798,347...3,806,713
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression ISO nickel chloride results in increased expression of CARS1 mRNA CTD PMID:17312168 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein] which results in increased secretion of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP1 protein; [Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP1 protein]
CASP1 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]
CTD PMID:24158569 PMID:31943712 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 affects expression EXP nickel chloride affects the expression of CASP2 mRNA CTD PMID:22546817 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
increases cleavage
affects expression
multiple interactions
EXP
ISO
nickel chloride results in increased activity of CASP3 protein
nickel chloride results in increased expression of CASP3 mRNA; nickel chloride results in increased expression of CASP3 protein modified form
nickel chloride results in increased cleavage of CASP3 protein
nickel chloride affects the expression of CASP3 mRNA
[nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP3 protein; [TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]] which results in decreased cleavage of CASP3 protein; cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of CASP3 protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP3 protein]
pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP3 protein]
CTD PMID:21828359 PMID:21843586 PMID:22172632 PMID:22546817 PMID:23566959 PMID:26378417 PMID:28552779 PMID:31943712 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 affects expression EXP nickel chloride affects the expression of CASP6 mRNA CTD PMID:22546817 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
affects expression
increases activity
EXP
ISO
pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP7 protein]
nickel chloride results in increased cleavage of CASP7 protein
cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of CASP7 protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of CASP7 protein]
nickel chloride affects the expression of CASP7 mRNA
CTD PMID:21828359 PMID:21843586 PMID:22172632 PMID:22546817 PMID:28552779 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 affects expression EXP nickel chloride affects the expression of CASP8 mRNA CTD PMID:22546817 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
decreases expression
affects expression
multiple interactions
EXP
ISO
nickel chloride results in increased activity of CASP9 protein
nickel chloride results in decreased expression of CASP9 protein
nickel chloride affects the expression of CASP9 mRNA
[TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]] which results in decreased cleavage of CASP3 protein; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]
pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]
CTD PMID:21843586 PMID:22546817 PMID:23566959 PMID:28552779 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases response to substance
multiple interactions
decreases activity
decreases expression
ISO
EXP
CAT protein results in decreased susceptibility to nickel chloride
chromous chloride affects the reaction [nickel chloride results in decreased activity of CAT protein]; nickel chloride affects the reaction [chromous chloride results in decreased activity of CAT protein]
[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in decreased activity of CAT protein; [nickel chloride results in increased abundance of Nickel] which results in decreased activity of CAT protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in decreased activity of CAT protein]; Hydroxyapatites analog inhibits the reaction [nickel chloride results in decreased activity of CAT protein]
nickel chloride results in decreased expression of CAT protein
CTD PMID:22648416 PMID:23828460 PMID:25220231 PMID:30389395 PMID:31639282 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase affects expression EXP nickel chloride affects the expression of CBS mRNA CTD PMID:22110744 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cbx6 chromobox 6 decreases expression ISO nickel chloride results in decreased expression of CBX6 mRNA CTD PMID:17312168 NCBI chr 7:121,047,996...121,058,109
Ensembl chr 7:121,050,302...121,058,029
JBrowse link
G Ccdc181 coiled-coil domain containing 181 affects expression EXP nickel chloride affects the expression of CCDC181 mRNA CTD PMID:22110744 NCBI chr13:82,574,980...82,588,637
Ensembl chr13:82,574,966...82,588,640
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases secretion
multiple interactions
ISO nickel chloride results in increased secretion of CCL1 protein
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL1 mRNA]
CTD PMID:18437699 PMID:23090859 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 affects expression ISO nickel chloride affects the expression of CCL12 mRNA CTD PMID:24670797 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
increases secretion
decreases expression
decreases secretion
ISO nickel chloride results in increased expression of CCL2 mRNA
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]
nickel chloride results in increased secretion of CCL2 protein
nickel chloride results in decreased expression of CCL2 mRNA
nickel chloride results in decreased secretion of CCL2 protein
CTD PMID:12839937 PMID:17312168 PMID:18437699 PMID:23090859 PMID:25458486 PMID:29355601 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO nickel chloride results in increased expression of CCL20 mRNA CTD PMID:17312168 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases secretion
affects expression
ISO nickel chloride results in increased secretion of CCL22 protein
nickel chloride affects the expression of CCL22 mRNA
CTD PMID:18437699 PMID:24670797 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO nickel chloride results in increased secretion of CCL5 protein CTD PMID:18437699 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions
decreases secretion
ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of CCL7 protein; nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL7 mRNA]
nickel chloride results in decreased secretion of CCL7 protein
CTD PMID:18437699 PMID:23090859 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO nickel chloride results in increased expression of CCN5 mRNA CTD PMID:21455298 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ccnb1 cyclin B1 affects expression EXP nickel chloride affects the expression of CCNB1 mRNA CTD PMID:22546817 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO nickel chloride results in increased expression of CCNB2 mRNA CTD PMID:17547211 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnc cyclin C affects expression EXP nickel chloride affects the expression of CCNC mRNA CTD PMID:22546817 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
affects expression
decreases phosphorylation
decreases expression
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased phosphorylation of CCND1 protein]; nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein
nickel chloride affects the expression of CCND1 mRNA
CHUK protein affects the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein
nickel chloride results in decreased expression of CCND1 mRNA
CTD PMID:17312168 PMID:18792914 PMID:22546817 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO nickel chloride results in decreased expression of CCND2 mRNA CTD PMID:17312168 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne1 cyclin E1 affects expression EXP nickel chloride affects the expression of CCNE1 mRNA CTD PMID:22546817 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO nickel chloride results in decreased expression of CCNE2 mRNA CTD PMID:17312168 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnf cyclin F affects expression EXP nickel chloride affects the expression of CCNF mRNA CTD PMID:22546817 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 affects expression EXP nickel chloride affects the expression of CCNG1 mRNA CTD PMID:22546817 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 multiple interactions
affects expression
increases expression
ISO
EXP
HIF1A affects the reaction [nickel chloride results in increased expression of CCNG2 mRNA]
nickel chloride affects the expression of CCNG2 mRNA
CTD PMID:12729255 PMID:17312168 PMID:21455298 PMID:22546817 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccnh cyclin H affects expression EXP nickel chloride affects the expression of CCNH mRNA CTD PMID:22546817 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Ccnj cyclin J affects expression EXP nickel chloride affects the expression of CCNJ mRNA CTD PMID:22110744 PMID:22546817 NCBI chr 1:259,926,537...259,944,275
Ensembl chr 1:260,093,641...260,111,254
Ensembl chr 1:260,093,641...260,111,254
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO nickel chloride results in increased expression of CCR7 protein CTD PMID:15737199 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 affects expression EXP nickel chloride affects the expression of CCT2 mRNA CTD PMID:22546817 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 affects expression EXP nickel chloride affects the expression of CCT7 mRNA CTD PMID:22546817 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cd3g CD3g molecule affects expression EXP nickel chloride affects the expression of CD3G mRNA CTD PMID:22546817 NCBI chr 8:49,274,553...49,280,943
Ensembl chr 8:49,274,960...49,280,901
JBrowse link
G Cd40lg CD40 ligand affects expression ISO nickel chloride affects the expression of CD40LG mRNA CTD PMID:24670797 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO nickel chloride results in increased expression of CD44 protein CTD PMID:26962057 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd80 Cd80 molecule increases expression ISO nickel chloride results in increased expression of CD80 protein CTD PMID:25458486 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression
increases secretion
ISO nickel chloride results in increased expression of CD86 protein
nickel chloride results in increased secretion of CD86 protein
CTD PMID:15737199 PMID:19665512 PMID:19844976 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc20 cell division cycle 20 affects expression EXP nickel chloride affects the expression of CDC20 mRNA CTD PMID:22546817 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc23 cell division cycle 23 decreases expression ISO nickel chloride results in decreased expression of CDC23 mRNA CTD PMID:17312168 NCBI chr18:27,430,924...27,452,569
Ensembl chr18:27,430,905...27,452,420
JBrowse link
G Cdc25a cell division cycle 25A affects expression EXP nickel chloride affects the expression of CDC25A mRNA CTD PMID:22546817 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25b cell division cycle 25B affects expression EXP nickel chloride affects the expression of CDC25B mRNA CTD PMID:22546817 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C affects expression EXP nickel chloride affects the expression of CDC25C mRNA CTD PMID:22546817 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc27 cell division cycle 27 affects expression EXP nickel chloride affects the expression of CDC27 mRNA CTD PMID:22546817 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone affects expression EXP nickel chloride affects the expression of CDC37 mRNA CTD PMID:22546817 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdc37l1 cell division cycle 37-like 1 affects expression EXP nickel chloride affects the expression of CDC37L1 mRNA CTD PMID:22546817 NCBI chr 1:247,110,147...247,139,113
Ensembl chr 1:247,107,397...247,138,155
JBrowse link
G Cdc7 cell division cycle 7 affects expression EXP nickel chloride affects the expression of CDC7 mRNA CTD PMID:22546817 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdca2 cell division cycle associated 2 affects expression EXP nickel chloride affects the expression of CDCA2 mRNA CTD PMID:22546817 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdca5 cell division cycle associated 5 affects expression EXP nickel chloride affects the expression of CDCA5 mRNA CTD PMID:22546817 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases methylation
decreases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]; Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; decitabine inhibits the reaction [nickel chloride results in decreased expression of CDH1 mRNA]; HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]; nickel chloride promotes the reaction [SNAI1 protein binds to CDH1 promoter]; nickel chloride promotes the reaction [SNAI2 protein binds to CDH1 promoter]
nickel chloride results in decreased expression of CDH1 mRNA; nickel chloride results in decreased expression of CDH1 protein
CTD PMID:22648416 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh17 cadherin 17 affects expression EXP nickel chloride affects the expression of CDH17 mRNA CTD PMID:22110744 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdk11b cyclin-dependent kinase 11B affects expression EXP nickel chloride affects the expression of CDC2L1 mRNA CTD PMID:22546817 NCBI chr 5:173,051,900...173,078,049
Ensembl chr 5:173,052,063...173,078,046
JBrowse link
G Cdk13 cyclin-dependent kinase 13 affects expression EXP nickel chloride affects the expression of CDK13 mRNA CTD PMID:22546817 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk20 cyclin-dependent kinase 20 affects expression EXP nickel chloride affects the expression of CDK20 mRNA CTD PMID:22546817 NCBI chr17:1,935,900...1,942,867
Ensembl chr17:1,936,163...1,942,865
JBrowse link
G Cdk2ap1 cyclin-dependent kinase 2 associated protein 1 affects expression EXP nickel chloride affects the expression of CDK2AP1 mRNA CTD PMID:22546817 NCBI chr12:37,668,369...37,677,067
Ensembl chr12:37,668,369...37,677,063
JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression EXP nickel chloride affects the expression of CDK4 mRNA CTD PMID:22546817 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression EXP nickel chloride affects the expression of CDK5 mRNA CTD PMID:22546817 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression EXP nickel chloride affects the expression of CDK6 mRNA CTD PMID:22546817 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk9 cyclin-dependent kinase 9 affects expression EXP nickel chloride affects the expression of CDK9 mRNA CTD PMID:22546817 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in increased expression of CDKN1A mRNA
nickel chloride affects the expression of CDKN1A mRNA
nickel chloride results in increased expression of CDKN1A mRNA; nickel chloride results in increased expression of CDKN1A protein
HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1A protein]; nickel chloride promotes the reaction [TP63 mutant form results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [nickel chloride results in increased expression of CDKN1A mRNA]; TP63 protein mutant form inhibits the reaction [nickel chloride results in increased expression of CDKN1A mRNA]; TP63 protein mutant form inhibits the reaction [nickel chloride results in increased expression of CDKN1A protein]
CTD PMID:12426141 PMID:12839937 PMID:17547211 PMID:21466819 PMID:22546817 PMID:23566959 PMID:28552779 PMID:29110037 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression
multiple interactions
increases expression
EXP
ISO
nickel chloride affects the expression of CDKN1B mRNA
HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1B protein]
CTD PMID:22546817 PMID:28552779 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression EXP nickel chloride affects the expression of CDKN2A mRNA CTD PMID:22546817 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression EXP nickel chloride affects the expression of CDKN2B mRNA CTD PMID:22546817 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP nickel chloride affects the expression of CDKN2C mRNA CTD PMID:22546817 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 affects expression EXP nickel chloride affects the expression of CDKN3 mRNA CTD PMID:22546817 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 affects expression EXP nickel chloride affects the expression of CDT1 mRNA CTD PMID:22546817 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of CEBPB mRNA
nickel chloride affects the expression of CEBPB mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO nickel chloride results in increased expression of CEBPD mRNA CTD PMID:17312168 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO nickel chloride results in increased expression of CEBPG mRNA CTD PMID:17312168 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Cenpf centromere protein F affects expression EXP nickel chloride affects the expression of CENPF mRNA CTD PMID:22546817 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator affects expression EXP nickel chloride affects the expression of CFLAR mRNA CTD PMID:22546817 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 affects expression EXP nickel chloride affects the expression of CHD6 mRNA CTD PMID:22110744 NCBI chr 3:156,937,746...157,099,328
Ensembl chr 3:156,937,733...157,099,306
JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 affects expression EXP nickel chloride affects the expression of CHD7 mRNA CTD PMID:22110744 NCBI chr 5:21,769,087...21,952,036
Ensembl chr 5:21,830,882...21,950,696
JBrowse link
G Chi3l1 chitinase 3 like 1 affects expression ISO nickel chloride affects the expression of CHI3L1 mRNA CTD PMID:24670797 NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit decreases expression EXP nickel chloride results in decreased expression of CHRND mRNA CTD PMID:24619124 NCBI chr 9:94,286,550...94,294,968
Ensembl chr 9:94,286,550...94,294,968
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 affects expression EXP nickel chloride affects the expression of CHSY1 mRNA CTD PMID:22110744 NCBI chr 1:127,010,587...127,071,570
Ensembl chr 1:127,010,588...127,071,570
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
affects response to substance
ISO CHUK protein affects the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]
CHUK protein affects the susceptibility to nickel chloride
CTD PMID:18792914 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cidea cell death-inducing DFFA-like effector a affects expression EXP nickel chloride affects the expression of CIDEA mRNA CTD PMID:22546817 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cideb cell death-inducing DFFA-like effector b affects expression EXP nickel chloride affects the expression of CIDEB mRNA CTD PMID:22546817 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Cit citron rho-interacting serine/threonine kinase affects expression EXP nickel chloride affects the expression of CIT mRNA CTD PMID:22546817 NCBI chr12:46,334,669...46,494,152
Ensembl chr12:46,334,665...46,494,174
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO nickel chloride results in increased expression of CITED2 mRNA CTD PMID:21455298 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 affects expression EXP nickel chloride affects the expression of CIZ1 mRNA CTD PMID:22546817 NCBI chr 3:11,392,046...11,409,218
Ensembl chr 3:11,392,791...11,410,180
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO nickel chloride results in increased expression of CKS2 mRNA CTD PMID:17547211 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 affects expression EXP nickel chloride affects the expression of CLCF1 mRNA CTD PMID:22110744 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654
JBrowse link
G Clcn4 chloride voltage-gated channel 4 affects expression EXP nickel chloride affects the expression of CLCN4 mRNA CTD PMID:22110744 NCBI chr  X:25,016,177...25,082,563
Ensembl chr  X:25,016,401...25,080,410
JBrowse link
G Clk1 CDC-like kinase 1 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of CLK1 mRNA
nickel chloride affects the expression of CLK1 mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin affects expression EXP nickel chloride affects the expression of CLN3 mRNA CTD PMID:22110744 NCBI chr 1:197,986,384...197,999,726
Ensembl chr 1:197,986,385...197,997,664
JBrowse link
G Clptm1 CLPTM1 regulator of GABA type A receptor forward trafficking decreases expression ISO nickel chloride results in decreased expression of CLPTM1 mRNA CTD PMID:17547211 NCBI chr 1:80,549,051...80,580,665
Ensembl chr 1:80,549,043...80,580,662
JBrowse link
G Clrn3 clarin 3 affects expression EXP nickel chloride affects the expression of CLRN3 mRNA CTD PMID:22110744 NCBI chr 1:207,750,627...207,766,250
Ensembl chr 1:207,750,223...207,811,008
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain affects expression EXP nickel chloride affects the expression of COL18A1 mRNA CTD PMID:22546817 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression EXP nickel chloride affects the expression of COL3A1 mRNA CTD PMID:22110744 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Commd5 COMM domain containing 5 affects expression EXP nickel chloride affects the expression of COMMD5 mRNA CTD PMID:22546817 NCBI chr 7:117,963,213...117,965,010
Ensembl chr 7:118,502,676...118,504,097
Ensembl chr 7:118,502,676...118,504,097
JBrowse link
G Cp ceruloplasmin increases expression ISO nickel chloride results in increased expression of CP mRNA CTD PMID:21455298 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression EXP nickel chloride affects the expression of CPT1A mRNA CTD PMID:22110744 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 affects expression EXP nickel chloride affects the expression of CREB3L1 mRNA CTD PMID:22110744 NCBI chr 3:80,892,433...80,933,283
Ensembl chr 3:80,892,435...80,933,283
JBrowse link
G Crebrf CREB3 regulatory factor increases expression ISO nickel chloride results in increased expression of CREBRF mRNA CTD PMID:21455298 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205
JBrowse link
G Crk CRK proto-oncogene, adaptor protein affects expression EXP nickel chloride affects the expression of CRK mRNA CTD PMID:22546817 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Crlf2 cytokine receptor-like factor 2 increases expression
multiple interactions
affects expression
ISO nickel chloride results in increased expression of CRLF2 mRNA
[nickel chloride co-treated with Freund's Adjuvant] results in increased expression of CRLF2 protein
nickel chloride affects the expression of CRLF2 mRNA
CTD PMID:24670797 PMID:26044615 NCBI chr14:1,456,843...1,461,543
Ensembl chr14:1,456,844...1,461,543
JBrowse link
G Crp C-reactive protein multiple interactions ISO [nickel chloride results in increased abundance of Nickel] which results in increased expression of CRP mRNA; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of CRP mRNA] CTD PMID:31943712 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cryab crystallin, alpha B affects expression EXP nickel chloride affects the expression of CRYAB mRNA CTD PMID:22110744 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cse1l chromosome segregation 1 like affects expression EXP nickel chloride affects the expression of CSE1L mRNA CTD PMID:22546817 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060
JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO nickel chloride results in increased expression of CSF1 mRNA CTD PMID:17312168 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 increases expression
affects expression
ISO nickel chloride results in increased expression of CSF2 mRNA; nickel chloride results in increased expression of CSF2 protein
nickel chloride affects the expression of CSF2 mRNA
CTD PMID:17312168 PMID:21569788 PMID:24670797 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 increases expression
multiple interactions
ISO nickel chloride results in increased expression of CSF3 mRNA
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of CSF3 protein; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CSF3 mRNA]
CTD PMID:17312168 PMID:18437699 PMID:23090859 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csnk1d casein kinase 1, delta decreases expression
affects expression
ISO
EXP
nickel chloride results in decreased expression of CSNK1D mRNA
nickel chloride affects the expression of CSNK1D mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr10:110,147,786...110,182,413
Ensembl chr10:110,148,600...110,182,408
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression EXP nickel chloride affects the expression of CSNK2A2 mRNA CTD PMID:22546817 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 affects expression EXP nickel chloride affects the expression of CSRNP1 mRNA CTD PMID:22546817 NCBI chr 8:128,659,883...128,673,339
Ensembl chr 8:128,659,868...128,672,284
JBrowse link
G Csta cystatin A affects expression ISO nickel chloride affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972
JBrowse link
G Cstb cystatin B affects expression EXP nickel chloride affects the expression of CSTB mRNA CTD PMID:22546817 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Ctcf CCCTC-binding factor affects expression EXP nickel chloride affects the expression of CTCF mRNA CTD PMID:22546817 NCBI chr19:37,600,151...37,649,674
Ensembl chr19:37,600,148...37,649,673
JBrowse link
G Cth cystathionine gamma-lyase increases expression
multiple interactions
decreases expression
ISO nickel chloride results in increased expression of CTH mRNA
CTH gene mutant form promotes the reaction [nickel chloride results in increased expression of ACTA2 protein]
nickel chloride results in decreased expression of CTH mRNA; nickel chloride results in decreased expression of CTH protein
nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter]; nickel chloride inhibits the reaction [SP1 protein results in increased expression of CTH protein]; sodium bisulfide inhibits the reaction [nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter]]
CTD PMID:17312168 PMID:30055191 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctsc cathepsin C affects expression EXP nickel chloride affects the expression of CTSC mRNA CTD PMID:22110744 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cul1 cullin 1 affects expression EXP nickel chloride affects the expression of CUL1 mRNA CTD PMID:22546817 NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250
JBrowse link
G Cul2 cullin 2 affects expression EXP nickel chloride affects the expression of CUL2 mRNA CTD PMID:22546817 NCBI chr17:56,952,480...56,992,716
Ensembl chr17:56,952,480...56,992,694
JBrowse link
G Cwf19l1 CWF19 like cell cycle control factor 1 affects expression EXP nickel chloride affects the expression of CWF19L1 mRNA CTD PMID:22546817 NCBI chr 1:263,887,014...263,910,251
Ensembl chr 1:263,887,015...263,910,251
JBrowse link
G Cwf19l2 CWF19 like cell cycle control factor 2 affects expression EXP nickel chloride affects the expression of CWF19L2 mRNA CTD PMID:22546817 NCBI chr 6:18,970,616...19,037,176
Ensembl chr 6:18,970,564...19,055,924
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO nickel chloride results in increased expression of CX3CL1 mRNA CTD PMID:17312168 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression ISO nickel chloride results in decreased expression of CXADR mRNA CTD PMID:17312168 NCBI chr11:16,826,269...16,873,564
Ensembl chr11:16,826,399...16,873,562
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO nickel chloride results in increased expression of CXCL1 mRNA CTD PMID:17312168 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
increases expression
ISO nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]
nickel chloride results in increased expression of CXCL10 mRNA
CTD PMID:23090859 PMID:27427241 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 affects expression
multiple interactions
EXP
ISO
nickel chloride affects the expression of CXCL11 mRNA
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL11 mRNA]
CTD PMID:22110744 PMID:23090859 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases secretion ISO nickel chloride results in decreased secretion of CXCL12 protein CTD PMID:18437699 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 multiple interactions ISO nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL13 mRNA] CTD PMID:23090859 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO nickel chloride results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression ISO nickel chloride results in increased expression of CXCL16 mRNA CTD PMID:26044615 NCBI chr10:57,060,005...57,064,600
Ensembl chr10:57,060,007...57,064,600
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression
multiple interactions
ISO nickel chloride results in increased expression of CXCL2 mRNA
nickel chloride results in decreased expression of CXCL2 protein
nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL2 mRNA]
CTD PMID:17312168 PMID:23090859 PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO nickel chloride results in increased expression of CXCL1 mRNA CTD PMID:17312168 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO nickel chloride results in increased expression of CXCL6 mRNA CTD PMID:17312168 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 affects expression
multiple interactions
EXP
ISO
nickel chloride affects the expression of CXCL9 mRNA
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL9 mRNA]
CTD PMID:22110744 PMID:23090859 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO nickel chloride results in decreased expression of CYP1A1 protein
nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD PMID:14645679 PMID:21784029 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO nickel chloride results in decreased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO nickel chloride results in decreased expression of CYP1B1 mRNA CTD PMID:12839937 PMID:14645679 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 affects expression EXP nickel chloride affects the expression of CYP27A1 mRNA CTD PMID:22110744 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Dach1 dachshund family transcription factor 1 decreases expression ISO nickel chloride results in decreased expression of DACH1 mRNA CTD PMID:17312168 NCBI chr15:82,095,003...82,482,272
Ensembl chr15:82,099,159...82,482,009
JBrowse link
G Dad1 defender against cell death 1 affects expression EXP nickel chloride affects the expression of DAD1 mRNA CTD PMID:22546817 NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095
JBrowse link
G Dap death-associated protein affects expression EXP nickel chloride affects the expression of DAP mRNA CTD PMID:22546817 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dap3 death associated protein 3 affects expression EXP nickel chloride affects the expression of DAP3 mRNA CTD PMID:22546817 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dapl1 death associated protein-like 1 affects expression EXP nickel chloride affects the expression of DAPL1 mRNA CTD PMID:22110744 NCBI chr 3:45,538,408...45,559,281
Ensembl chr 3:45,538,797...45,559,331
JBrowse link
G Daxx death-domain associated protein affects expression EXP nickel chloride affects the expression of DAXX mRNA CTD PMID:22546817 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein affects expression EXP nickel chloride affects the expression of DBI mRNA CTD PMID:22110744 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase affects expression EXP nickel chloride affects the expression of DCXR mRNA CTD PMID:22110744 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of DDIT3 mRNA
nickel chloride affects the expression of DDIT3 mRNA
CTD PMID:12426141 PMID:12839937 PMID:22546817 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of DDIT4 mRNA
nickel chloride affects the expression of DDIT4 mRNA
CTD PMID:17312168 PMID:22110744 PMID:22546817 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO nickel chloride results in decreased expression of DDX17 mRNA CTD PMID:17312168 NCBI chr 7:120,761,843...120,765,012
Ensembl chr 7:120,761,826...120,780,641
JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 decreases expression ISO nickel chloride results in decreased expression of DEGS1 mRNA CTD PMID:17312168 NCBI chr13:100,665,265...100,672,731
Ensembl chr13:100,666,075...100,672,731
JBrowse link
G Depdc7 DEP domain containing 7 affects expression EXP nickel chloride affects the expression of DEPDC7 mRNA CTD PMID:22110744 NCBI chr 3:94,665,714...94,687,013
Ensembl chr 3:94,665,717...94,686,989
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein affects expression EXP nickel chloride affects the expression of DEPTOR mRNA CTD PMID:22110744 NCBI chr 7:94,795,161...95,000,750
Ensembl chr 7:94,795,214...94,995,809
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression
decreases expression
EXP
ISO
nickel chloride affects the expression of DHCR24 mRNA
nickel chloride results in decreased expression of DHCR24 mRNA
CTD PMID:17312168 PMID:22110744 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) affects expression EXP nickel chloride affects the expression of DHODH mRNA CTD PMID:22110744 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dicer1 dicer 1 ribonuclease III decreases expression ISO nickel chloride results in decreased expression of DICER1 mRNA CTD PMID:17312168 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Dipk2a divergent protein kinase domain 2A affects expression EXP nickel chloride affects the expression of DIPK2A mRNA CTD PMID:22110744 NCBI chr 8:102,140,713...102,159,828
Ensembl chr 8:102,088,505...102,159,828
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO nickel chloride results in increased expression of DKK1 mRNA CTD PMID:17547211 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 affects expression EXP nickel chloride affects the expression of DLG5 mRNA CTD PMID:22546817 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977
JBrowse link
G Dlgap5 DLG associated protein 5 affects expression EXP nickel chloride affects the expression of DLGAP5 mRNA CTD PMID:22546817 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of DNAJB13 mRNA
nickel chloride affects the expression of DNAJB13 mRNA
CTD PMID:21455298 PMID:22546817 NCBI chr 1:165,515,718...165,530,163
Ensembl chr 1:165,515,726...165,530,095
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 decreases expression ISO nickel chloride results in decreased expression of DNAJB4 mRNA CTD PMID:17312168 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO nickel chloride results in increased expression of DNAJB6 mRNA CTD PMID:17312168 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO nickel chloride results in increased expression of DNAJB9 mRNA CTD PMID:17312168 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnase1 deoxyribonuclease 1 affects expression EXP nickel chloride affects the expression of DNASE1 mRNA CTD PMID:22546817 NCBI chr10:11,757,681...11,760,672
Ensembl chr10:11,757,682...11,760,620
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 affects expression EXP nickel chloride affects the expression of DNASE1L3 mRNA CTD PMID:22546817 NCBI chr15:18,710,492...18,736,476
Ensembl chr15:18,710,492...18,736,473
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal affects expression EXP nickel chloride affects the expression of DNASE2 mRNA CTD PMID:22546817 NCBI chr19:26,022,855...26,025,523
Ensembl chr19:26,022,849...26,025,532
JBrowse link
G Dnm2 dynamin 2 affects expression EXP nickel chloride affects the expression of DNM2 mRNA CTD PMID:22546817 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Dpp7 dipeptidylpeptidase 7 affects expression EXP nickel chloride affects the expression of DPP7 mRNA CTD PMID:22110744 NCBI chr 3:2,569,135...2,573,387
Ensembl chr 3:2,569,135...2,573,387
JBrowse link
G Dst dystonin affects expression EXP nickel chloride affects the expression of DST mRNA CTD PMID:22546817 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Dstyk dual serine/threonine and tyrosine protein kinase affects expression EXP nickel chloride affects the expression of DSTYK mRNA CTD PMID:22546817 NCBI chr13:49,195,325...49,243,327
Ensembl chr13:49,195,325...49,243,316
JBrowse link
G Dtymk deoxythymidylate kinase affects expression EXP nickel chloride affects the expression of DTYMK mRNA CTD PMID:22546817 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of DUSP1 mRNA
nickel chloride affects the expression of DUSP1 mRNA
CTD PMID:17547211 PMID:22110744 PMID:22546817 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO nickel chloride results in increased expression of DUSP6 mRNA CTD PMID:17312168 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dzip1 DAZ interacting zinc finger protein 1 decreases expression ISO nickel chloride results in decreased expression of DZIP1 mRNA CTD PMID:17312168 NCBI chr15:104,117,551...104,168,574
Ensembl chr15:104,117,556...104,170,958
JBrowse link
G E2f1 E2F transcription factor 1 increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in increased expression of E2F1 mRNA
nickel chloride affects the expression of E2F1 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of E2F1 mRNA]
CTD PMID:12729255 PMID:22546817 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Eaf2 ELL associated factor 2 affects expression EXP nickel chloride affects the expression of EAF2 mRNA CTD PMID:22546817 NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092
JBrowse link
G Ebi3 Epstein-Barr virus induced 3 increases expression ISO nickel chloride results in increased expression of EBI3 mRNA CTD PMID:30421605 NCBI chr 9:11,110,874...11,114,843
Ensembl chr 9:11,110,874...11,114,843
JBrowse link
G Edaradd EDAR-associated death domain multiple interactions ISO nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDARADD mRNA] CTD PMID:23090859 NCBI chr17:90,802,280...90,843,476
Ensembl chr17:90,802,393...90,843,485
JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 decreases expression ISO nickel chloride results in decreased expression of EDEM3 mRNA CTD PMID:17312168 NCBI chr13:69,135,095...69,197,708
Ensembl chr13:69,135,128...69,199,511
JBrowse link
G Edn2 endothelin 2 increases expression ISO nickel chloride results in increased expression of EDN2 mRNA CTD PMID:21455298 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO nickel chloride results in increased expression of EEF2 mRNA CTD PMID:12729255 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 increases expression ISO nickel chloride results in increased expression of EFEMP2 mRNA CTD PMID:21455298 NCBI chr 1:220,853,695...220,861,420
Ensembl chr 1:220,854,403...220,861,420
JBrowse link
G Efna1 ephrin A1 increases expression ISO nickel chloride results in increased expression of EFNA1 mRNA CTD PMID:17312168 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of EGF protein CTD PMID:18437699 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor affects expression
multiple interactions
increases expression
EXP
ISO
nickel chloride affects the expression of EGFR mRNA
RECK protein inhibits the reaction [nickel chloride results in increased expression of EGFR protein]
CTD PMID:22546817 PMID:26026961 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases activity
increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in decreased activity of EGLN1 protein
nickel chloride results in increased expression of EGLN1 mRNA
nickel chloride affects the expression of EGLN1 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of EGLN1 mRNA]
CTD PMID:12729255 PMID:12839937 PMID:16649251 PMID:17312168 PMID:22110744 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of EGLN3 mRNA
nickel chloride affects the expression of EGLN3 mRNA
CTD PMID:21455298 PMID:22110744 PMID:22546817 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Egr1 early growth response 1 increases expression EXP nickel chloride results in increased expression of EGR1 mRNA CTD PMID:24619124 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eid1 EP300 interacting inhibitor of differentiation 1 decreases expression ISO nickel chloride results in decreased expression of EID1 mRNA CTD PMID:17312168 NCBI chr 3:117,938,500...117,940,219
Ensembl chr 3:117,938,500...117,940,219
JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked decreases expression ISO nickel chloride results in decreased expression of EIF1AX mRNA CTD PMID:17312168 NCBI chr  X:37,579,959...37,595,300
Ensembl chr  X:37,579,957...37,595,486
JBrowse link
G Elk1 ETS transcription factor ELK1 affects expression EXP nickel chloride affects the expression of ELK1 mRNA CTD PMID:22546817 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 affects expression EXP nickel chloride affects the expression of ELOVL6 mRNA CTD PMID:22110744 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Emp1 epithelial membrane protein 1 affects expression EXP nickel chloride affects the expression of EMP1 mRNA CTD PMID:22110744 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Enc1 ectodermal-neural cortex 1 affects expression EXP nickel chloride affects the expression of ENC1 mRNA CTD PMID:22110744 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Eno2 enolase 2 increases expression ISO nickel chloride results in increased expression of ENO2 mRNA CTD PMID:17312168 PMID:21455298 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
Ensembl chr 9:157,285,179...157,294,047
JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 decreases expression ISO nickel chloride results in decreased expression of ENTPD4 mRNA CTD PMID:17312168 NCBI chr15:51,222,954...51,250,787
Ensembl chr15:51,222,954...51,250,787
JBrowse link
G Epor erythropoietin receptor affects expression ISO nickel chloride affects the expression of EPOR mRNA CTD PMID:26044615 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Eral1 Era-like 12S mitochondrial rRNA chaperone 1 affects expression EXP nickel chloride affects the expression of ERAL1 mRNA CTD PMID:22546817 NCBI chr10:65,272,849...65,291,070
Ensembl chr10:65,272,849...65,291,064
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 affects expression EXP nickel chloride affects the expression of ERBB3 mRNA CTD PMID:22546817 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha affects expression
increases expression
multiple interactions
EXP
ISO
nickel chloride affects the expression of ERO1A mRNA
nickel chloride results in increased expression of ERO1A mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of ERO1A mRNA]
CTD PMID:12729255 PMID:22110744 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 affects expression EXP nickel chloride affects the expression of ERRFI1 mRNA CTD PMID:22110744 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase affects expression EXP nickel chloride affects the expression of ESPL1 mRNA CTD PMID:22546817 NCBI chr 7:143,896,890...143,923,868
Ensembl chr 7:143,897,014...143,923,868
JBrowse link
G Esr1 estrogen receptor 1 affects response to substance
decreases expression
multiple interactions
ISO ESR1 protein affects the susceptibility to nickel chloride
nickel chloride results in decreased expression of ESR1 mRNA; nickel chloride results in decreased expression of ESR1 protein
nickel chloride binds to and results in increased activity of ESR1 protein; nickel chloride inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12746304 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression ISO nickel chloride results in increased expression of F2RL1 mRNA CTD PMID:17312168 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G F5 coagulation factor V decreases expression ISO nickel chloride results in decreased expression of F5 mRNA CTD PMID:17547211 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G Fabp1 fatty acid binding protein 1 affects expression EXP nickel chloride affects the expression of FABP1 mRNA CTD PMID:22110744 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Faim Fas apoptotic inhibitory molecule affects expression EXP nickel chloride affects the expression of FAIM mRNA CTD PMID:22546817 NCBI chr 8:107,225,119...107,247,228
Ensembl chr 8:107,225,212...107,241,224
Ensembl chr 8:107,225,212...107,241,224
JBrowse link
G Fam102b family with sequence similarity 102, member B affects expression EXP nickel chloride affects the expression of FAM102B mRNA CTD PMID:22110744 NCBI chr 2:211,762,479...211,831,837
Ensembl chr 2:211,772,128...211,831,636
JBrowse link
G FAM120C family with sequence similarity 120C affects expression EXP nickel chloride affects the expression of FAM120C mRNA CTD PMID:22110744 NCBI chr  X:20,481,800...21,016,980
Ensembl chr  X:20,484,517...21,015,836
JBrowse link
G Fam13a family with sequence similarity 13, member A increases expression ISO nickel chloride results in increased expression of FAM13A mRNA CTD PMID:21455298 NCBI chr 4:89,183,180...89,281,282
Ensembl chr 4:89,183,768...89,281,222
JBrowse link
G Fancd2 FA complementation group D2 decreases expression ISO nickel chloride results in decreased expression of FANCD2 mRNA; nickel chloride results in decreased expression of FANCD2 protein CTD PMID:28472268 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fancl FA complementation group L decreases expression ISO nickel chloride results in decreased expression of FANCL mRNA CTD PMID:17312168 NCBI chr14:110,675,306...110,740,880
Ensembl chr14:110,676,090...110,740,317
JBrowse link
G Fas Fas cell surface death receptor affects expression EXP nickel chloride affects the expression of FAS mRNA CTD PMID:22546817 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression
EXP
ISO
nickel chloride affects the expression of FASN mRNA
nickel chloride results in decreased expression of FASN mRNA
CTD PMID:17312168 PMID:22110744 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbln5 fibulin 5 affects expression EXP nickel chloride affects the expression of FBLN5 mRNA CTD PMID:22110744 NCBI chr 6:125,644,797...125,723,957
Ensembl chr 6:125,644,804...125,723,944
JBrowse link
G Fbxo2 F-box protein 2 affects expression EXP nickel chloride affects the expression of FBXO2 mRNA CTD PMID:22546817 NCBI chr 5:164,972,483...164,977,912
Ensembl chr 5:164,972,480...164,977,916
JBrowse link
G Fbxo30 F-box protein 30 affects expression EXP nickel chloride affects the expression of FBXO30 mRNA CTD PMID:22110744 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO nickel chloride results in increased expression of FBXO32 mRNA CTD PMID:21455298 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fbxw2 F-box and WD repeat domain containing 2 decreases expression ISO nickel chloride results in decreased expression of FBXW2 mRNA CTD PMID:17312168 PMID:17547211 NCBI chr 3:13,871,513...13,897,033
Ensembl chr 3:13,871,517...13,896,838
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO nickel chloride results in decreased expression of FDPS mRNA CTD PMID:17547211 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fem1b fem-1 homolog B decreases expression
affects expression
ISO
EXP
nickel chloride results in decreased expression of FEM1B mRNA
nickel chloride affects the expression of FEM1B mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr 8:67,695,041...67,708,313
Ensembl chr 8:67,694,904...67,708,304
JBrowse link
G Fgf1 fibroblast growth factor 1 affects expression EXP nickel chloride affects the expression of FGF1 mRNA CTD PMID:22546817 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf11 fibroblast growth factor 11 increases expression ISO nickel chloride results in increased expression of FGF11 mRNA CTD PMID:21455298 NCBI chr10:56,403,320...56,410,816
Ensembl chr10:56,403,256...56,409,017
JBrowse link
G Fgf2 fibroblast growth factor 2 affects expression EXP nickel chloride affects the expression of FGF2 mRNA CTD PMID:22546817 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfbp3 fibroblast growth factor binding protein 3 affects expression EXP nickel chloride affects the expression of FGFBP3 mRNA CTD PMID:22110744 NCBI chr 1:255,555,050...255,557,055
Ensembl chr 1:255,555,050...255,557,055
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase affects expression EXP nickel chloride affects the expression of FGR mRNA CTD PMID:22546817 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression ISO nickel chloride results in decreased expression of FHIT protein CTD PMID:14971660 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fis1 fission, mitochondrial 1 affects expression EXP nickel chloride affects the expression of FIS1 mRNA CTD PMID:22546817 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 affects expression EXP nickel chloride affects the expression of FKBP11 mRNA CTD PMID:22110744 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Flot1 flotillin 1 affects expression EXP nickel chloride affects the expression of FLOT1 mRNA CTD PMID:22110744 NCBI chr20:3,427,890...3,438,418
Ensembl chr20:3,427,880...3,438,396
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO nickel chloride results in increased expression of FLRT2 mRNA CTD PMID:17312168 NCBI chr 6:119,518,459...119,613,534
Ensembl chr 6:119,519,714...119,609,296
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; Allopurinol inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of FN1 mRNA]
nickel chloride results in increased expression of FN1 mRNA; nickel chloride results in increased expression of FN1 protein
CTD PMID:22648416 PMID:30055191 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fn3k fructosamine 3 kinase increases expression EXP nickel chloride results in increased expression of FN3K mRNA CTD PMID:24619124 NCBI chr10:110,626,462...110,642,262
Ensembl chr10:110,631,494...110,642,260
JBrowse link
G Fnbp1 formin binding protein 1 increases expression ISO nickel chloride results in increased expression of FNBP1 mRNA CTD PMID:17312168 NCBI chr 3:9,865,657...9,936,333
Ensembl chr 3:9,861,237...9,936,405
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP nickel chloride results in increased expression of FOS mRNA CTD PMID:24619124 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [nickel chloride results in increased expression of GADD45A protein] which results in decreased expression of FOSB protein CTD PMID:23536762 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO nickel chloride results in increased expression of FOSL1 mRNA CTD PMID:17547211 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO nickel chloride results in increased expression of FOSL2 mRNA CTD PMID:17312168 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Foxo3 forkhead box O3 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of FOXO3 mRNA
nickel chloride affects the expression of FOXO3 mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxq1 forkhead box Q1 affects expression EXP nickel chloride affects the expression of FOXQ1 mRNA CTD PMID:22110744 NCBI chr17:34,224,308...34,226,941
Ensembl chr17:34,224,818...34,226,453
JBrowse link
G Fpgt fucose-1-phosphate guanylyltransferase decreases expression ISO nickel chloride results in decreased expression of FPGT mRNA CTD PMID:17312168 NCBI chr 2:261,382,015...261,402,950
Ensembl chr 2:261,382,060...261,402,903
JBrowse link
G Fstl3 follistatin like 3 affects expression EXP nickel chloride affects the expression of FSTL3 mRNA CTD PMID:22110744 NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein] CTD PMID:16039939 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO nickel chloride results in decreased expression of FURIN mRNA CTD PMID:17547211 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G Fut8 fucosyltransferase 8 increases expression ISO nickel chloride results in increased expression of FUT8 mRNA CTD PMID:17312168 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 affects expression EXP nickel chloride affects the expression of FZR1 mRNA CTD PMID:22546817 NCBI chr 7:11,201,690...11,213,614
Ensembl chr 7:11,201,690...11,213,613
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression EXP nickel chloride affects the expression of G6PC1 mRNA CTD PMID:22110744 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of G6PDX mRNA
nickel chloride affects the expression of G6PD mRNA
CTD PMID:12426141 PMID:22546817 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in increased expression of GADD45A mRNA
nickel chloride affects the expression of GADD45A mRNA
[nickel chloride results in increased expression of GADD45A protein] which results in increased expression of PPP2CA protein; nickel chloride results in increased expression of GADD45A mRNA
[nickel chloride results in increased expression of GADD45A protein] which results in decreased expression of FOSB protein; [nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of and results in decreased expression of JUN protein; [nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of ATF2 protein; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K3 protein]; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K4 protein]; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K6 protein]; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K7 protein]; nickel chloride results in increased stability of and results in increased expression of GADD45A protein
CTD PMID:12839937 PMID:22546817 PMID:23536762 PMID:23566959 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta affects expression EXP nickel chloride affects the expression of GADD45B mRNA CTD PMID:22546817 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma affects expression EXP nickel chloride affects the expression of GADD45G mRNA CTD PMID:22546817 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gak cyclin G associated kinase affects expression EXP nickel chloride affects the expression of GAK mRNA CTD PMID:22546817 NCBI chr14:2,100,104...2,174,332
Ensembl chr14:2,100,106...2,174,318
JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 decreases expression ISO nickel chloride results in decreased expression of GALNT11 mRNA CTD PMID:17312168 NCBI chr 4:6,297,255...6,330,765
Ensembl chr 4:6,297,258...6,330,765
JBrowse link
G Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 decreases expression EXP nickel chloride results in decreased expression of GALNT2 mRNA CTD PMID:24619124 NCBI chr19:57,043,858...57,115,123
Ensembl chr19:57,047,830...57,115,132
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression
affects expression
multiple interactions
ISO
EXP
nickel chloride results in increased expression of GAPDH mRNA
nickel chloride affects the expression of GAPDH mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]
CTD PMID:10646848 PMID:12426141 PMID:12839937 PMID:22546817 PMID:23566959 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO nickel chloride results in decreased expression of GAS1 mRNA CTD PMID:12839937 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gas2 growth arrest-specific 2 affects expression EXP nickel chloride affects the expression of GAS2 mRNA CTD PMID:22110744 NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO nickel chloride results in increased expression of GATA6 mRNA CTD PMID:17312168 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 affects expression
increases expression
multiple interactions
EXP
ISO
nickel chloride affects the expression of GBE1 mRNA
nickel chloride results in increased expression of GBE1 mRNA
HIF1A protein affects the reaction [nickel chloride results in increased expression of GBE1 mRNA]
CTD PMID:15094311 PMID:22110744 NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890
JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO nickel chloride results in increased expression of GBP1 mRNA CTD PMID:17312168 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gcat glycine C-acetyltransferase affects expression EXP nickel chloride affects the expression of GCAT mRNA CTD PMID:22110744 NCBI chr 7:120,263,068...120,269,365
Ensembl chr 7:120,263,054...120,269,451
JBrowse link
G Gch1 GTP cyclohydrolase 1 affects expression EXP nickel chloride affects the expression of GCH1 mRNA CTD PMID:22546817 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of GCLC mRNA
nickel chloride results in increased expression of GCLC mRNA
CTD PMID:17547211 PMID:21111804 PMID:22110744 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP nickel chloride results in increased expression of GCLM mRNA CTD PMID:22110744 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO nickel chloride results in increased expression of GCNT3 mRNA CTD PMID:17547211 NCBI chr 8:76,449,078...76,459,431
Ensembl chr 8:76,449,081...76,452,554
JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 affects expression EXP nickel chloride affects the expression of GDE1 mRNA CTD PMID:22110744 NCBI chr 1:188,367,550...188,407,125
Ensembl chr 1:188,394,814...188,407,132
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO nickel chloride results in increased expression of GDF15 mRNA CTD PMID:17312168 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdf5 growth differentiation factor 5 affects expression EXP nickel chloride affects the expression of GDF5 mRNA CTD PMID:22546817 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693
JBrowse link
G Gemin4 gem (nuclear organelle) associated protein 4 decreases expression ISO nickel chloride results in decreased expression of GEMIN4 mRNA CTD PMID:17312168 NCBI chr10:64,364,808...64,375,885
Ensembl chr10:64,368,809...64,375,816
JBrowse link
G Ggcx gamma-glutamyl carboxylase decreases expression ISO nickel chloride results in decreased expression of GGCX mRNA CTD PMID:17547211 NCBI chr 4:100,277,345...100,293,097
Ensembl chr 4:100,277,391...100,293,250
JBrowse link
G Gjb1 gap junction protein, beta 1 affects expression EXP nickel chloride affects the expression of GJB1 mRNA CTD PMID:22110744 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gla galactosidase, alpha increases expression ISO nickel chloride results in increased expression of GLA mRNA CTD PMID:17547211 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Glrx glutaredoxin increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of GLRX mRNA
nickel chloride affects the expression of GLRX mRNA
CTD PMID:17547211 PMID:22110744 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gmnn geminin, DNA replication inhibitor affects expression EXP nickel chloride affects the expression of GMNN mRNA CTD PMID:22546817 NCBI chr17:42,302,523...42,310,783
Ensembl chr17:42,302,540...42,310,783
JBrowse link
G Gnaq G protein subunit alpha q affects expression EXP nickel chloride affects the expression of GNAQ mRNA CTD PMID:22546817 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 decreases expression ISO nickel chloride results in decreased expression of GPER1 mRNA CTD PMID:17547211 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression
multiple interactions
ISO nickel chloride results in increased expression of GPI1 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of GPI1 mRNA]
CTD PMID:12426141 PMID:12729255 PMID:12839937 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression
multiple interactions
ISO nickel chloride results in increased expression of GPR137B mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of GPR137B mRNA]
CTD PMID:12729255 NCBI chr17:90,670,852...90,709,003
Ensembl chr17:90,670,872...90,746,804
JBrowse link
G Gpr146 G protein-coupled receptor 146 affects expression EXP nickel chloride affects the expression of GPR146 mRNA CTD PMID:22110744 NCBI chr12:17,343,396...17,358,631
Ensembl chr12:17,345,510...17,358,617
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of GPT protein; [nickel chloride results in increased abundance of Nickel] which results in increased activity of GPT protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of GPT protein] CTD PMID:31639282 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression EXP nickel chloride affects the expression of GPX1 mRNA CTD PMID:22110744 PMID:22546817 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP nickel chloride affects the expression of GRB14 mRNA CTD PMID:22110744 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grn granulin precursor affects expression EXP nickel chloride affects the expression of GRN mRNA CTD PMID:22110744 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
affects expression
ISO
EXP
[nickel chloride results in increased phosphorylation of AKT1 protein] which results in decreased activity of and results in increased phosphorylation of GSK3B protein; nickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of GSK3B protein]
nickel chloride affects the expression of GSK3B mRNA
CTD PMID:21837363 PMID:22546817 PMID:25614230 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression ISO nickel chloride results in decreased expression of GSTA3 mRNA CTD PMID:14645679 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO nickel chloride results in decreased expression of GSTM2 mRNA CTD PMID:14645679 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression ISO nickel chloride results in decreased expression of GSTT1 mRNA CTD PMID:12729255 PMID:14645679 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gusb glucuronidase, beta affects expression
increases activity
EXP nickel chloride affects the expression of GUSB mRNA
nickel chloride results in increased activity of GUSB protein
CTD PMID:12028813 PMID:22110744 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Gys1 glycogen synthase 1 affects expression EXP nickel chloride affects the expression of GYS1 mRNA CTD PMID:22110744 NCBI chr 1:101,427,195...101,447,092
Ensembl chr 1:101,427,195...101,447,092
JBrowse link
G H2ax H2A.X variant histone decreases expression
increases expression
increases phosphorylation
multiple interactions
ISO nickel chloride results in decreased expression of H2AX mRNA
nickel chloride results in increased expression of H2AX protein modified form
nickel chloride results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased phosphorylation of H2AX protein]; cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]
CTD PMID:17312168 PMID:22172632 PMID:28552779 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H2bu1 H2B.U histone 1 decreases acetylation
increases ubiquitination
ISO nickel chloride results in decreased acetylation of H2BU1 protein
nickel chloride results in increased ubiquitination of H2BU1 protein
CTD PMID:16522665 NCBI chr10:45,296,638...45,297,385
Ensembl chr10:45,296,638...45,297,385
JBrowse link
G H3f4 H3.4 histone decreases acetylation
increases methylation
ISO nickel chloride results in decreased acetylation of H3-4 protein
nickel chloride results in increased methylation of H3-4 protein
CTD PMID:16522665 PMID:19371620 NCBI chr10:45,304,696...45,305,106 JBrowse link
G H4c3 H4 clustered histone 3 increases expression ISO nickel chloride results in increased expression of H4C3 mRNA CTD PMID:17547211 NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262
JBrowse link
G H4f16 H4 histone 16 decreases acetylation ISO nickel chloride results in decreased acetylation of H4-16 protein CTD PMID:16522665 NCBI chr17:43,821,122...43,821,587 JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase affects expression EXP nickel chloride affects the expression of HADH mRNA CTD PMID:22110744 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hao1 hydroxyacid oxidase 1 decreases expression EXP nickel chloride results in decreased expression of HAO1 mRNA CTD PMID:22110744 NCBI chr 3:127,444,900...127,500,709
Ensembl chr 3:127,444,902...127,500,709
JBrowse link
G Haus1 HAUS augmin-like complex, subunit 1 affects expression EXP nickel chloride affects the expression of HAUS1 mRNA CTD PMID:22546817 NCBI chr18:74,140,759...74,151,965
Ensembl chr18:74,187,162...74,198,369
Ensembl chr18:74,187,162...74,198,369
JBrowse link
G Hcfc2 host cell factor C2 affects expression EXP nickel chloride affects the expression of HCFC2 mRNA CTD PMID:22546817 NCBI chr 7:27,107,931...27,136,658
Ensembl chr 7:27,108,116...27,136,652
JBrowse link
G Hdac3 histone deacetylase 3 affects expression EXP nickel chloride affects the expression of HDAC3 mRNA CTD PMID:22546817 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac7 histone deacetylase 7 affects expression EXP nickel chloride affects the expression of HDAC7 mRNA CTD PMID:22546817 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hdc histidine decarboxylase affects expression EXP nickel chloride affects the expression of HDC mRNA CTD PMID:22110744 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Hexb hexosaminidase subunit beta affects expression EXP nickel chloride affects the expression of HEXB mRNA CTD PMID:22110744 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
increases stability
affects response to substance
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; [nickel chloride co-treated with Tretinoin] results in increased expression of HIF1A protein; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; Cycloheximide promotes the reaction [nickel chloride results in increased expression of HIF1A protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; HIF1A protein affects the reaction [nickel chloride results in increased secretion of IL6 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of BNIP3 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CA9 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1A protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1B protein]; nickel chloride inhibits the reaction [HIF1A protein binds to HSP90AB1 protein]; nickel chloride inhibits the reaction [VHL protein binds to HIF1A protein]; nickel chloride promotes the reaction [HIF1A protein binds to ARNT protein]; nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]; nickel chloride results in increased expression of and affects the localization of HIF1A protein; nickel chloride results in increased expression of and results in increased stability of HIF1A protein; nickel chloride results in increased stability of and affects the localization of HIF1A protein; nickel chloride results in increased stability of and results in increased expression of HIF1A protein; Rotenone inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]
nickel chloride results in increased stability of HIF1A protein
AKT1 protein affects the reaction [nickel chloride results in increased expression of HIF1A protein]; HIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ALDOA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ARNT mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of BNIP3 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of CCNG2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of E2F1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of EGLN1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ERO1A mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GPI1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GPR137B mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of HK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of IER3 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of LDHA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of MKNK1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of P4HA2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PFKL mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PGK1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PKM mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PTK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of SLC2A1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of TPI1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GBE1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]
HIF1A protein affects the susceptibility to nickel chloride
CTD PMID:10646848 PMID:12426141 PMID:12729255 PMID:12839937 PMID:14729612 PMID:15094311 PMID:16649251 PMID:17312168 PMID:18792914 PMID:21828359 PMID:22648416 PMID:23566959 PMID:24497960 PMID:24577088 PMID:25614230 PMID:28552779 PMID:29355601 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor decreases expression ISO nickel chloride results in decreased expression of HIF1AN mRNA CTD PMID:16705796 NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of HIGD1A mRNA
nickel chloride results in increased expression of HIGD1A mRNA
CTD PMID:12839937 PMID:22110744 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO nickel chloride results in increased expression of HILPDA mRNA CTD PMID:21455298 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hip1 huntingtin interacting protein 1 affects expression EXP nickel chloride affects the expression of HIP1 mRNA CTD PMID:22110744 PMID:22546817 NCBI chr12:24,180,795...24,315,373
Ensembl chr12:24,180,937...24,315,373
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 affects expression EXP nickel chloride affects the expression of HIPK1 mRNA CTD PMID:22546817 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079
JBrowse link
G Hivep2 HIVEP zinc finger 2 increases expression ISO nickel chloride results in increased expression of HIVEP2 mRNA CTD PMID:17312168 NCBI chr 1:8,129,354...8,333,890
Ensembl chr 1:8,310,577...8,333,885
JBrowse link
G Hk1 hexokinase 1 increases expression ISO nickel chloride results in increased expression of HK1 mRNA CTD PMID:12426141 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hk2 hexokinase 2 increases expression
multiple interactions
ISO nickel chloride results in increased expression of HK2 mRNA; nickel chloride results in increased expression of HK2 protein
Dinoprostone promotes the reaction [nickel chloride results in increased expression of HK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of HK2 mRNA]
CTD PMID:12426141 PMID:12729255 PMID:12839937 PMID:21455298 PMID:23566959 PMID:27452194 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO nickel chloride results in decreased expression of HMGCR mRNA CTD PMID:17312168 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 affects expression EXP nickel chloride affects the expression of HMGCS2 mRNA CTD PMID:22110744 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 affects expression EXP nickel chloride affects the expression of HMGN5 mRNA CTD PMID:22110744 NCBI chr  X:80,134,557...80,142,902
Ensembl chr  X:80,134,557...80,142,902
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
affects expression
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HMOX1 mRNA]; nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of HMOX1 mRNA]
nickel chloride affects the expression of HMOX1 mRNA
CTD PMID:16806455 PMID:17312168 PMID:17547211 PMID:18830972 PMID:21111804 PMID:22110744 PMID:22546817 PMID:23090859 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrk harakiri, BCL2 interacting protein affects expression EXP nickel chloride affects the expression of HRK mRNA CTD PMID:22546817 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 affects expression EXP nickel chloride affects the expression of HSD17B13 mRNA CTD PMID:22110744 NCBI chr14:7,113,544...7,128,218
Ensembl chr14:7,113,544...7,128,218
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO nickel chloride inhibits the reaction [HIF1A protein binds to HSP90AB1 protein] CTD PMID:29355601 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression
increases expression
ISO nickel chloride results in decreased expression of HSPA1A mRNA
nickel chloride results in increased expression of HSPA1A mRNA
CTD PMID:12426141 PMID:12839937 PMID:17312168 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO nickel chloride results in decreased expression of HSPA1B mRNA CTD PMID:17312168 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression
increases expression
ISO
EXP
nickel chloride results in decreased expression of HSPA8 mRNA
nickel chloride results in increased expression of HSPA8 protein
CTD PMID:15736156 PMID:17312168 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects expression EXP nickel chloride affects the expression of HSPA9 mRNA CTD PMID:22546817 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 affects expression EXP nickel chloride affects the expression of HSPB8 mRNA CTD PMID:22110744 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
increases secretion
ISO nickel chloride results in increased expression of ICAM1 mRNA; nickel chloride results in increased expression of ICAM1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; [nickel chloride results in increased phosphorylation of NFKBIA protein] inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]
nickel chloride results in increased secretion of ICAM1 protein
CTD PMID:15737199 PMID:17312168 PMID:19844976 PMID:24080332 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein affects expression EXP nickel chloride affects the expression of ID1 mRNA CTD PMID:22110744 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases activity ISO nickel chloride results in increased activity of IDH2 protein CTD PMID:17018869 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta affects expression EXP nickel chloride affects the expression of IDH3B mRNA CTD PMID:22546817 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Ier2 immediate early response 2 increases expression ISO nickel chloride results in increased expression of IER2 mRNA CTD PMID:17547211 NCBI chr19:25,774,146...25,775,670
Ensembl chr19:25,774,143...25,775,659
JBrowse link
G Ier3 immediate early response 3 multiple interactions
affects expression
increases expression
ISO
EXP
HIF1A affects the reaction [nickel chloride results in increased expression of IER3 mRNA]
nickel chloride affects the expression of IER3 mRNA
CTD PMID:12729255 PMID:22110744 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO nickel chloride results in increased expression of IFI44L mRNA CTD PMID:21455298 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression ISO nickel chloride results in increased expression of IFIH1 mRNA CTD PMID:17312168 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 affects expression EXP nickel chloride affects the expression of IFITM1 mRNA CTD PMID:22546817 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 affects expression EXP nickel chloride affects the expression of IFITM3 mRNA CTD PMID:22110744 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifng interferon gamma multiple interactions ISO nickel chloride inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IFNG promoter]
[MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IFNG protein; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]
CTD PMID:8975779 PMID:21544193 PMID:21569788 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO nickel chloride results in increased expression of IFNGR1 mRNA CTD PMID:17312168 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO nickel chloride results in increased expression of IFNGR2 mRNA CTD PMID:17312168 NCBI chr11:31,694,339...31,712,611
Ensembl chr11:31,694,339...31,712,611
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 affects expression EXP nickel chloride affects the expression of IFRD1 mRNA CTD PMID:22110744 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IGF1 protein CTD PMID:18437699 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 affects expression EXP nickel chloride affects the expression of IGF2 mRNA CTD PMID:22546817 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO nickel chloride results in increased expression of IGFBP1 mRNA CTD PMID:21455298 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO nickel chloride results in increased expression of IGFBP3 mRNA CTD PMID:21455298 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 decreases expression ISO nickel chloride results in decreased expression of IGFBP4 mRNA CTD PMID:12839937 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Igfbpl1 insulin-like growth factor binding protein-like 1 affects expression EXP nickel chloride affects the expression of IGFBPL1 mRNA CTD PMID:22110744 NCBI chr 5:61,395,407...61,410,812
Ensembl chr 5:61,395,408...61,410,812
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO nickel chloride results in decreased expression of IGSF1 mRNA CTD PMID:17547211 NCBI chr  X:136,792,637...136,808,107
Ensembl chr  X:136,792,643...136,807,885
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects response to substance
increases phosphorylation
multiple interactions
ISO IKBKB affects the susceptibility to nickel chloride
nickel chloride results in increased phosphorylation of IKBKB protein
chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]; IKBKB gene mutant form inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]; Quercetin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]; SC 514 inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]
IKBKB affects the reaction [nickel chloride results in increased activity of PTGS2 promoter]
CTD PMID:16982623 PMID:21466819 PMID:30016632 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO nickel chloride results in decreased expression of IKBKE mRNA CTD PMID:21466819 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il10 interleukin 10 affects expression
multiple interactions
increases expression
EXP
ISO
nickel chloride affects the expression of IL10 mRNA
Apigenin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
nickel chloride results in increased expression of IL10 mRNA; nickel chloride results in increased expression of IL10 protein
[MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IL10 protein
CTD PMID:21544193 PMID:22546817 PMID:27427241 PMID:30016632 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 affects expression ISO nickel chloride affects the expression of IL13 mRNA CTD PMID:24670797 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 multiple interactions ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL15 protein CTD PMID:18437699 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il18 interleukin 18 affects expression EXP
ISO
nickel chloride affects the expression of IL18 mRNA CTD PMID:22546817 PMID:24670797 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il18r1 interleukin 18 receptor 1 increases expression ISO nickel chloride results in increased expression of IL18R1 mRNA CTD PMID:17312168 NCBI chr 9:47,184,404...47,217,403
Ensembl chr 9:47,185,443...47,219,175
JBrowse link
G Il1a interleukin 1 alpha increases expression
decreases expression
multiple interactions
ISO nickel chloride results in increased expression of IL1A mRNA
nickel chloride results in decreased expression of IL1A protein
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1A protein
CTD PMID:11378323 PMID:17312168 PMID:18437699 PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
increases secretion
increases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; [Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein; CASP1 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of IL1B mRNA]; NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]
[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein]
nickel chloride results in decreased expression of IL1B mRNA
nickel chloride results in increased secretion of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein] which results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein; [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; Sodium inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]
nickel chloride results in increased expression of IL1B mRNA; nickel chloride results in increased expression of IL1B protein
CTD PMID:11378323 PMID:16687389 PMID:18437699 PMID:19844976 PMID:21569788 PMID:23090859 PMID:24158569 PMID:27427241 PMID:30016632 PMID:31639282 PMID:31943712 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL2 protein; nickel chloride inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IL2 promoter] CTD PMID:18437699 PMID:21569788 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il27 interleukin 27 increases expression ISO nickel chloride results in increased expression of IL27 mRNA CTD PMID:30421605 NCBI chr 1:198,003,615...198,010,112
Ensembl chr 1:198,003,683...198,008,893
JBrowse link
G Il36b interleukin 36, beta multiple interactions ISO nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL36B mRNA] CTD PMID:23090859 NCBI chr 3:1,366,123...1,464,851
Ensembl chr 3:1,366,119...1,371,626
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL4 protein CTD PMID:18437699 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases secretion
multiple interactions
ISO nickel chloride results in increased secretion of IL5 protein
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL5 protein
CTD PMID:18437699 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases secretion
increases expression
decreases secretion
ISO Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of IL6 mRNA]
nickel chloride results in decreased expression of IL6 mRNA
nickel chloride results in increased secretion of IL6 protein
nickel chloride results in increased expression of IL6 mRNA; nickel chloride results in increased expression of IL6 protein
nickel chloride results in decreased secretion of IL6 protein
[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL6 mRNA; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; HIF1A protein affects the reaction [nickel chloride results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL6 mRNA]
CTD PMID:11378323 PMID:16687389 PMID:17312168 PMID:18437699 PMID:23090859 PMID:25458486 PMID:27427241 PMID:30016632 PMID:31943712 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase affects expression EXP nickel chloride affects the expression of ILKAP mRNA CTD PMID:22546817 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO nickel chloride results in increased expression of INHBA mRNA CTD PMID:17312168 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D affects expression EXP nickel chloride affects the expression of INPP5D mRNA CTD PMID:22546817 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 increases expression ISO nickel chloride results in increased expression of IQSEC1 mRNA CTD PMID:26378417 NCBI chr 4:123,400,717...123,454,656
Ensembl chr 4:123,307,624...123,453,478
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO nickel chloride results in increased expression of IRAK4 protein CTD PMID:21473897 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
JBrowse link
G Irf2 interferon regulatory factor 2 increases expression ISO nickel chloride results in increased expression of IRF2 mRNA CTD PMID:17312168 NCBI chr16:48,582,354...48,732,129
Ensembl chr16:48,582,026...48,732,932
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression
multiple interactions
ISO nickel chloride results in decreased expression of IRF3 mRNA
IRF3 protein inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]
CTD PMID:21466819 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO nickel chloride results in decreased expression of IRF7 mRNA CTD PMID:21466819 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Iscu iron-sulfur cluster assembly enzyme decreases activity ISO nickel chloride results in decreased activity of ISCU protein CTD PMID:23727075 NCBI chr12:48,621,454...48,627,297
Ensembl chr12:48,621,454...48,627,297
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression EXP nickel chloride affects the expression of ISG15 mRNA CTD PMID:22546817 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein increases expression ISO nickel chloride results in increased expression of ITGB3BP mRNA CTD PMID:17547211 NCBI chr 5:118,476,410...118,541,928
Ensembl chr 5:118,476,430...118,673,780
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression ISO nickel chloride results in increased expression of ITGB8 mRNA CTD PMID:17312168 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Itm2b integral membrane protein 2B affects expression EXP nickel chloride affects the expression of ITM2B mRNA CTD PMID:22546817 NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO nickel chloride results in increased expression of JAG1 mRNA CTD PMID:17312168 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jak2 Janus kinase 2 affects expression EXP nickel chloride affects the expression of JAK2 mRNA CTD PMID:22546817 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase increases expression
affects expression
EXP nickel chloride results in increased expression of JMJD6 mRNA
nickel chloride affects the expression of JMJD6 mRNA
CTD PMID:22110744 PMID:22546817 NCBI chr10:105,781,752...105,787,803
Ensembl chr10:105,781,753...105,787,803
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
EXP
ISO
nickel chloride affects the expression of JUN mRNA
[nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of and results in decreased expression of JUN protein
CTD PMID:22110744 PMID:23536762 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO nickel chloride results in increased expression of JUNB mRNA CTD PMID:12426141 PMID:12839937 PMID:17312168 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit affects expression EXP nickel chloride affects the expression of JUND mRNA CTD PMID:22546817 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kank4 KN motif and ankyrin repeat domains 4 affects expression EXP nickel chloride affects the expression of KANK4 mRNA CTD PMID:22110744 NCBI chr 5:117,376,425...117,440,643
Ensembl chr 5:117,376,423...117,440,254
JBrowse link
G Kat2b lysine acetyltransferase 2B affects expression EXP nickel chloride affects the expression of KAT2B mRNA CTD PMID:22546817 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Katna1 katanin catalytic subunit A1 affects expression EXP nickel chloride affects the expression of KATNA1 mRNA CTD PMID:22546817 NCBI chr 1:1,826,170...1,867,786
Ensembl chr 1:1,825,872...1,867,787
JBrowse link
G Kctd15 potassium channel tetramerization domain containing 15 affects expression EXP nickel chloride affects the expression of KCTD15 mRNA CTD PMID:22110744 NCBI chr 1:90,506,697...90,522,217
Ensembl chr 1:90,506,697...90,520,344
JBrowse link
G Kdm3a lysine demethylase 3A affects expression
increases expression
multiple interactions
EXP
ISO
nickel chloride affects the expression of KDM3A mRNA
nickel chloride results in increased expression of KDM3A mRNA; nickel chloride results in increased expression of KDM3A protein
Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A mRNA]; Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A protein]
CTD PMID:17312168 PMID:21455298 PMID:22110744 PMID:22318714 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kdm4b lysine demethylase 4B increases expression ISO nickel chloride results in increased expression of KDM4B mRNA CTD PMID:17312168 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Kdm6b lysine demethylase 6B increases expression ISO nickel chloride results in increased expression of KDM6B mRNA; nickel chloride results in increased expression of KDM6B protein CTD PMID:25427687 NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885
JBrowse link
G Kdm7a lysine demethylase 7A increases expression ISO nickel chloride results in increased expression of KDM7A mRNA CTD PMID:21455298 NCBI chr 4:66,915,603...66,957,971
Ensembl chr 4:66,922,013...66,955,732
JBrowse link
G Khdc4 KH domain containing 4, pre-mRNA splicing factor decreases expression ISO nickel chloride results in decreased expression of KHDC4 mRNA CTD PMID:17312168 NCBI chr 2:188,051,657...188,080,280
Ensembl chr 2:188,052,236...188,080,301
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects expression ISO nickel chloride affects the expression of KIT mRNA CTD PMID:24670797 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Kitlg KIT ligand decreases secretion
multiple interactions
ISO nickel chloride results in decreased secretion of KITLG protein
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of KITLG protein
CTD PMID:18437699 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klf10 Kruppel-like factor 10 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of KLF10 mRNA
nickel chloride affects the expression of KLF10 mRNA
CTD PMID:17547211 PMID:22546817 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Klf4 Kruppel like factor 4 increases expression ISO nickel chloride results in increased expression of KLF4 protein CTD PMID:26962057 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klf5 Kruppel-like factor 5 affects expression EXP nickel chloride affects the expression of KLF5 mRNA CTD PMID:22110744 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of KLF6 mRNA
nickel chloride affects the expression of KLF6 mRNA
CTD PMID:17547211 PMID:22110744 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO nickel chloride results in increased expression of KLHL24 mRNA CTD PMID:21455298 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Kmt2a lysine methyltransferase 2A affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of KMT2A mRNA
nickel chloride results in increased expression of KMT2A mRNA
CTD PMID:22110744 PMID:26378417 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Kpna4 karyopherin subunit alpha 4 increases expression ISO nickel chloride results in increased expression of KPNA4 mRNA CTD PMID:17547211 NCBI chr 2:165,684,345...165,739,874
Ensembl chr 2:165,684,345...165,739,874
JBrowse link
G Kynu kynureninase increases expression ISO nickel chloride results in increased expression of KYNU mRNA CTD PMID:17312168 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression ISO nickel chloride results in decreased expression of LAMC2 mRNA CTD PMID:12839937 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Lcn2 lipocalin 2 affects expression EXP nickel chloride affects the expression of LCN2 mRNA CTD PMID:22546817 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ldha lactate dehydrogenase A increases expression
multiple interactions
EXP
ISO
nickel chloride results in increased expression of LDHA mRNA
Dinoprostone promotes the reaction [nickel chloride results in increased expression of LDHA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of LDHA mRNA]
CTD PMID:12426141 PMID:12729255 PMID:12839937 PMID:22110744 PMID:27452194 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO nickel chloride results in decreased expression of LDLR mRNA CTD PMID:17312168 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 affects expression EXP nickel chloride affects the expression of LEF1 mRNA CTD PMID:22110744 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Lep leptin multiple interactions ISO
EXP
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein
nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
CTD PMID:10780946 PMID:18437699 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lgals2 galectin 2 affects expression EXP nickel chloride affects the expression of LGALS2 mRNA CTD PMID:22110744 NCBI chr 7:120,071,122...120,077,612
Ensembl chr 7:120,071,124...120,077,612
JBrowse link
G Lgals7 galectin 7 affects expression EXP nickel chloride affects the expression of LGALS7 mRNA CTD PMID:22546817 NCBI chr 1:87,044,823...87,047,223
Ensembl chr 1:87,045,335...87,047,223
JBrowse link
G Lig4 DNA ligase 4 decreases expression ISO nickel chloride results in decreased expression of LIG4 mRNA CTD PMID:28472268 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO nickel chloride results in decreased expression of LIN7C mRNA CTD PMID:17312168 NCBI chr 3:101,010,923...101,018,235
Ensembl chr 3:101,010,899...101,018,433
JBrowse link
G Lipa lipase A, lysosomal acid type decreases expression ISO nickel chloride results in decreased expression of LIPA mRNA CTD PMID:17547211 NCBI chr 1:252,816,536...252,959,348
Ensembl chr 1:252,816,527...252,849,904
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor affects expression EXP nickel chloride affects the expression of LITAF mRNA CTD PMID:22546817 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO nickel chloride results in increased expression of HSPA6 mRNA CTD PMID:15287566 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Lox lysyl oxidase increases expression ISO nickel chloride results in increased expression of LOX mRNA CTD PMID:17312168 PMID:21455298 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Loxl2 lysyl oxidase-like 2 affects expression EXP nickel chloride affects the expression of LOXL2 mRNA CTD PMID:22110744 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Lsp1 lymphocyte-specific protein 1 affects expression EXP nickel chloride affects the expression of LSP1 mRNA CTD PMID:22546817 NCBI chr 1:215,628,750...215,662,505
Ensembl chr 1:215,628,785...215,662,504
JBrowse link
G Lss lanosterol synthase decreases expression ISO nickel chloride results in decreased expression of LSS mRNA CTD PMID:17547211 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Ltb lymphotoxin beta increases expression ISO nickel chloride results in increased expression of LTB mRNA CTD PMID:17312168 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
Ensembl chr20:5,184,515...5,186,503
JBrowse link
G Luc7l3 LUC7-like 3 pre-mRNA splicing factor decreases expression ISO nickel chloride results in decreased expression of CROP mRNA CTD PMID:17312168 NCBI chr10:81,991,147...82,027,119
Ensembl chr10:81,991,147...82,027,119
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO nickel chloride results in increased activity of [TLR4 protein binds to LY96 protein] CTD PMID:25803856 NCBI chr 5:1,972,212...1,989,448 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase affects expression EXP nickel chloride affects the expression of LYN mRNA CTD PMID:22546817 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Madd MAP-kinase activating death domain affects expression EXP nickel chloride affects the expression of MADD mRNA CTD PMID:22546817 NCBI chr 3:79,960,301...80,003,023
Ensembl chr 3:79,960,301...80,003,032
JBrowse link
G Maff MAF bZIP transcription factor F increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of MAFF mRNA
nickel chloride affects the expression of MAFF mRNA
CTD PMID:17547211 PMID:22110744 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafk MAF bZIP transcription factor K affects expression EXP nickel chloride affects the expression of MAFK mRNA CTD PMID:22546817 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO nickel chloride promotes the reaction [Tretinoin results in increased expression of MAP2 mRNA] CTD PMID:25614230 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 affects expression EXP nickel chloride affects the expression of MAP2K1 mRNA CTD PMID:22110744 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 multiple interactions ISO GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K3 protein] CTD PMID:23536762 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K4 protein] CTD PMID:23536762 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 affects expression
increases response to substance
multiple interactions
EXP
ISO
nickel chloride affects the expression of MAP2K6 mRNA
MAP2K6 protein results in increased susceptibility to nickel chloride
[incomplete Freund's adjuvant co-treated with Freund's Adjuvant co-treated with nickel chloride] results in increased expression of MAP2K6 mRNA; [incomplete Freund's adjuvant co-treated with Freund's Adjuvant co-treated with nickel chloride] results in increased phosphorylation of MAP2K6 protein; [MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IFNG protein; [MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IL10 protein; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K6 protein]
CTD PMID:21544193 PMID:22110744 PMID:23536762 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K7 protein] CTD PMID:23536762 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 affects expression EXP nickel chloride affects the expression of MAP3K10 mRNA CTD PMID:22546817 NCBI chr 1:84,473,178...84,491,689
Ensembl chr 1:84,473,071...84,491,466
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 affects expression EXP nickel chloride affects the expression of MAP3K7 mRNA CTD PMID:22546817 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
Ensembl chr 9:47,186,558...47,244,416
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of MAP3K8 mRNA
nickel chloride affects the expression of MAP3K8 mRNA
CTD PMID:17312168 PMID:22546817 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO nickel chloride results in increased phosphorylation of MAPK1 protein
[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of MAPK1 protein; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein]; Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:25045119 PMID:30724446 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 affects expression EXP nickel chloride affects the expression of MAPK12 mRNA CTD PMID:22546817 NCBI chr 7:130,109,214...130,120,918
Ensembl chr 7:130,109,663...130,120,579
JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression EXP nickel chloride affects the expression of MAPK13 mRNA CTD PMID:22546817 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO nickel chloride results in increased phosphorylation of MAPK14 protein CTD PMID:15737199 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects expression
increases phosphorylation
multiple interactions
EXP
ISO
nickel chloride affects the expression of MAPK3 mRNA
nickel chloride results in increased phosphorylation of MAPK3 protein
[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of MAPK3 protein; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein]; Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:22546817 PMID:25045119 PMID:30724446 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP
ISO
pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]
MAPK8 affects the reaction [nickel chloride results in increased expression of PTGS2 mRNA]; MAPK8 affects the reaction [nickel chloride results in increased expression of PTGS2 protein]
CTD PMID:17065197 PMID:21843586 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 affects expression EXP nickel chloride affects the expression of MAPK8IP1 mRNA CTD PMID:22546817 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
EXP pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:21843586 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 affects expression EXP nickel chloride affects the expression of MAPRE1 mRNA CTD PMID:22546817 NCBI chr 3:149,221,346...149,249,469
Ensembl chr 3:149,221,377...149,249,273
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO nickel chloride results in increased expression of MARS1 mRNA CTD PMID:17312168 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO nickel chloride results in decreased expression of MAT2A mRNA CTD PMID:17312168 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Mbl2 mannose binding lectin 2 affects expression EXP nickel chloride affects the expression of MBL2 mRNA CTD PMID:22110744 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 increases expression ISO nickel chloride results in increased expression of MBNL2 mRNA CTD PMID:17312168 NCBI chr15:105,640,097...105,797,933
Ensembl chr15:105,640,097...105,797,932
JBrowse link
G Mboat1 membrane bound O-acyltransferase domain containing 1 affects expression EXP nickel chloride affects the expression of MBOAT1 mRNA CTD PMID:22110744 NCBI chr17:36,061,775...36,177,457
Ensembl chr17:36,061,775...36,177,457
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
affects expression
multiple interactions
increases expression
ISO
EXP
nickel chloride results in decreased expression of MCL1 mRNA
nickel chloride affects the expression of MCL1 mRNA
TP53 protein affects the reaction [nickel chloride results in increased expression of MCL1 mRNA]
CTD PMID:17312168 PMID:22546817 PMID:23566959 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO nickel chloride results in decreased expression of MCM2 mRNA CTD PMID:17312168 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO nickel chloride results in decreased expression of MCM4 mRNA CTD PMID:17312168 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 affects expression EXP nickel chloride affects the expression of MCM5 mRNA CTD PMID:22546817 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression EXP nickel chloride affects the expression of MCM6 mRNA CTD PMID:22546817 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 affects expression EXP nickel chloride affects the expression of MDC1 mRNA CTD PMID:22546817 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831
JBrowse link
G Mdh2 malate dehydrogenase 2 increases activity ISO nickel chloride results in increased activity of MDH2 protein CTD PMID:17018869 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mdk midkine affects expression EXP nickel chloride affects the expression of MDK mRNA CTD PMID:22546817 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
affects expression
increases expression
ISO
EXP
TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA]
nickel chloride affects the expression of MDM2 mRNA
CTD PMID:22546817 PMID:23566959 PMID:28552779 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdm4 MDM4 regulator of p53 decreases expression
affects expression
ISO
EXP
nickel chloride results in decreased expression of MDM4 protein
nickel chloride affects the expression of MDM4 mRNA
CTD PMID:22546817 PMID:23566959 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Med13 mediator complex subunit 13 decreases expression ISO nickel chloride results in decreased expression of MED13 mRNA CTD PMID:17312168 NCBI chr10:73,702,327...73,787,084
Ensembl chr10:73,702,327...73,787,083
JBrowse link
G Men1 menin 1 affects expression EXP nickel chloride affects the expression of MEN1 mRNA CTD PMID:22546817 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase decreases expression ISO nickel chloride results in decreased expression of MERTK mRNA CTD PMID:17312168 NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444
JBrowse link
G Mex3b mex-3 RNA binding family member B affects expression EXP nickel chloride affects the expression of MEX3B mRNA CTD PMID:22110744 NCBI chr 1:144,831,523...144,835,758
Ensembl chr 1:144,831,523...144,835,747
JBrowse link
G Mgarp mitochondria-localized glutamic acid-rich protein affects expression EXP nickel chloride affects the expression of MGARP mRNA CTD PMID:22110744 NCBI chr 2:140,444,963...140,453,719
Ensembl chr 2:140,444,965...140,453,107
JBrowse link
G MGC105649 hypothetical LOC302884 increases expression ISO nickel chloride results in increased expression of C15ORF48 mRNA CTD PMID:21455298 NCBI chr 3:114,772,603...114,776,156
Ensembl chr 3:114,772,603...114,776,155
JBrowse link
G Mgll monoglyceride lipase affects expression EXP nickel chloride affects the expression of MGLL mRNA CTD PMID:22110744 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in increased expression of MIR21 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in increased expression of MIR21 mRNA]; [nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of RECK protein; [nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of SPRY2 protein CTD PMID:26026961 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir210 microRNA 210 increases expression ISO nickel chloride results in increased expression of MIR210 mRNA CTD PMID:24577088 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Mix23 mitochondrial matrix import factor 23 affects expression EXP nickel chloride affects the expression of MIX23 mRNA CTD PMID:22110744 NCBI chr11:67,598,419...67,618,704
Ensembl chr11:67,598,419...67,618,704
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 multiple interactions ISO HIF1A affects the reaction [nickel chloride results in increased expression of MKNK1 mRNA] CTD PMID:12729255 NCBI chr 5:134,691,852...134,730,887
Ensembl chr 5:134,691,881...134,730,893
JBrowse link
G Mlh1 mutL homolog 1 affects expression
decreases expression
EXP
ISO
nickel chloride affects the expression of MLH1 mRNA
nickel chloride results in decreased expression of MLH1 mRNA; nickel chloride results in decreased expression of MLH1 protein
CTD PMID:22546817 PMID:28472268 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO nickel chloride results in increased expression of MMP2 protein CTD PMID:21473897 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
increases activity
ISO nickel chloride results in increased expression of MMP9 protein
chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; nickel chloride results in increased expression of and results in increased activity of MMP9 protein; Quercetin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; SC 514 inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]
nickel chloride results in increased activity of MMP9 protein
CTD PMID:21473897 PMID:26962057 PMID:30016632 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Moap1 modulator of apoptosis 1 decreases expression ISO nickel chloride results in decreased expression of MOAP1 mRNA CTD PMID:17312168 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of MPO protein; [nickel chloride results in increased abundance of Nickel] which results in increased activity of MPO protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of MPO protein] CTD PMID:31639282 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrps6 mitochondrial ribosomal protein S6 decreases expression ISO nickel chloride results in decreased expression of MRPS6 mRNA CTD PMID:17312168 NCBI chr11:32,208,246...32,263,999
Ensembl chr11:32,211,115...32,263,899
JBrowse link
G Mrs2 magnesium transporter MRS2 decreases expression ISO nickel chloride results in decreased expression of MRS2 mRNA CTD PMID:17312168 NCBI chr17:42,064,271...42,083,602
Ensembl chr17:42,064,376...42,082,300
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO nickel chloride results in decreased expression of MSMO1 mRNA CTD PMID:17312168 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions
decreases expression
ISO Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] CTD PMID:21419151 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions
decreases expression
ISO Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA] CTD PMID:21419151 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Mt1 metallothionein 1 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of MT1 mRNA
nickel chloride affects the expression of MT1A mRNA
CTD PMID:12729255 PMID:22110744 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of MT2A mRNA
nickel chloride results in increased expression of MT2A mRNA
CTD PMID:22110744 PMID:26378417 PMID:28472268 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtch1 mitochondrial carrier 1 affects expression EXP nickel chloride affects the expression of MTCH1 mRNA CTD PMID:22546817 NCBI chr20:6,937,341...6,961,165
Ensembl chr20:6,937,347...6,961,162
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO nickel chloride results in increased expression of MTHFD2 mRNA CTD PMID:17312168 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mtmr7 myotubularin related protein 7 affects expression EXP nickel chloride affects the expression of MTMR7 mRNA CTD PMID:22110744 NCBI chr16:54,765,214...54,856,255
Ensembl chr16:54,765,325...54,856,225
JBrowse link
G Mttp microsomal triglyceride transfer protein affects expression EXP nickel chloride affects the expression of MTTP mRNA CTD PMID:22110744 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO nickel chloride results in increased expression of MXI1 mRNA CTD PMID:17312168 PMID:21455298 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Mybl2 MYB proto-oncogene like 2 affects expression EXP nickel chloride affects the expression of MYBL2 mRNA CTD PMID:22546817 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of MYC mRNA
nickel chloride results in increased expression of MYC protein
CTD PMID:22110744 PMID:22546817 PMID:28552779 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mycbp2 MYC binding protein 2 affects expression EXP nickel chloride affects the expression of MYCBP2 mRNA CTD PMID:22110744 NCBI chr15:87,405,472...87,450,812
NCBI chr15:93,678,062...93,901,556
Ensembl chr15:87,506,959...93,868,301
JBrowse link
G Mycl MYCL proto-oncogene, bHLH transcription factor affects expression EXP nickel chloride affects the expression of MYCL mRNA CTD PMID:22546817 NCBI chr 5:140,691,947...140,698,837
Ensembl chr 5:140,692,779...140,698,609
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor affects expression EXP nickel chloride affects the expression of MYCN mRNA CTD PMID:22546817 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions
ISO nickel chloride results in increased expression of MYD88 mRNA; nickel chloride results in increased expression of MYD88 protein
chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]; MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of CXCL8 protein]; MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]
CTD PMID:21473897 PMID:24080332 PMID:30016632 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit decreases expression ISO nickel chloride results in decreased expression of NAA10 mRNA CTD PMID:16705796 NCBI chr  X:156,863,655...156,868,950
Ensembl chr  X:156,863,754...156,868,950
JBrowse link
G Nabp1 nucleic acid binding protein 1 affects expression EXP nickel chloride affects the expression of NABP1 mRNA CTD PMID:22110744 NCBI chr 9:55,049,893...55,057,784
Ensembl chr 9:55,050,203...55,057,658
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase affects expression EXP nickel chloride affects the expression of NAMPT mRNA CTD PMID:22110744 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nav2 neuron navigator 2 increases expression ISO nickel chloride results in increased expression of NAV2 mRNA CTD PMID:17312168 NCBI chr 1:104,575,765...104,941,554
Ensembl chr 1:104,576,589...104,941,552
JBrowse link
G Ncam1 neural cell adhesion molecule 1 multiple interactions ISO nickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 mRNA]; nickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 protein] CTD PMID:25614230 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions
increases expression
affects expression
ISO
EXP
[nickel chloride co-treated with VHL protein] results in increased expression of NDRG1 mRNA
nickel chloride results in increased expression of NDRG1 mRNA; nickel chloride results in increased expression of NDRG1 protein
[nickel chloride co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA; AKT1 protein affects the reaction [nickel chloride results in increased expression of NDRG1 protein]; HIF1A affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]
nickel chloride affects the expression of NDRG1 mRNA
CTD PMID:10646848 PMID:10910041 PMID:12729255 PMID:12767066 PMID:14729612 PMID:18792914 PMID:21455298 PMID:21828359 PMID:22110744 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Ndrg2 NDRG family member 2 affects expression EXP nickel chloride affects the expression of NDRG2 mRNA CTD PMID:22110744 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Nek2 NIMA-related kinase 2 affects expression EXP nickel chloride affects the expression of NEK2 mRNA CTD PMID:22546817 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nek3 NIMA-related kinase 3 affects expression EXP nickel chloride affects the expression of NEK3 mRNA CTD PMID:22546817 NCBI chr16:74,781,371...74,806,567
Ensembl chr16:74,785,281...74,806,149
JBrowse link
G Nf2 neurofibromin 2 affects expression EXP nickel chloride affects the expression of NF2 mRNA CTD PMID:22546817 NCBI chr14:84,996,905...85,088,547
Ensembl chr14:84,996,905...85,088,523
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
affects localization
ISO Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of NFE2L2 protein]; lipopolysaccharide A promotes the reaction [nickel chloride affects the localization of NFE2L2 protein]; Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of NFE2L2 protein]; nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of NFE2L2 protein] CTD PMID:16806455 PMID:18437699 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of NFIL3 mRNA
nickel chloride results in increased expression of NFIL3 mRNA
CTD PMID:17312168 PMID:22110744 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
affects expression
ISO
EXP
nickel chloride results in increased expression of NFKB1 mRNA
[nickel chloride results in increased abundance of Nickel] which results in increased expression of NFKB1 protein; nickel chloride binds to and affects the localization of NFKB1 protein
nickel chloride affects the expression of NFKB1 mRNA
CTD PMID:17312168 PMID:22546817 PMID:23844176 PMID:30724446 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 increases expression ISO nickel chloride results in increased expression of NFKB2 mRNA CTD PMID:17312168 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
increases phosphorylation
multiple interactions
increases expression
ISO nickel chloride results in decreased expression of NFKBIA mRNA
nickel chloride results in increased phosphorylation of NFKBIA protein
[nickel chloride results in increased phosphorylation of NFKBIA protein] inhibits the reaction [nickel chloride results in increased expression of CXCL8 protein]; [nickel chloride results in increased phosphorylation of NFKBIA protein] inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]; Quercetin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]; SC 514 inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
nickel chloride results in increased expression of NFKBIA mRNA
CTD PMID:16982623 PMID:17312168 PMID:17547211 PMID:24080332 PMID:25803856 PMID:30016632 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfya nuclear transcription factor Y subunit alpha increases expression ISO nickel chloride results in increased expression of NFYA mRNA CTD PMID:17547211 NCBI chr 9:14,551,752...14,577,002
Ensembl chr 9:14,551,758...14,576,967
JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma affects expression EXP nickel chloride affects the expression of NFYC mRNA CTD PMID:22546817 NCBI chr 5:139,687,442...139,760,154
Ensembl chr 5:139,687,448...139,749,050
JBrowse link
G Nhej1 nonhomologous end-joining factor 1 affects expression ISO nickel chloride affects the expression of NHEJ1 mRNA CTD PMID:28472268 NCBI chr 9:82,230,230...82,327,923
Ensembl chr 9:82,230,232...82,327,534
JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 affects expression EXP nickel chloride affects the expression of NLRC4 mRNA CTD PMID:22546817 NCBI chr 6:22,167,874...22,194,755
Ensembl chr 6:22,167,919...22,194,250
JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 multiple interactions ISO nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NLRP12 mRNA] CTD PMID:23090859 NCBI chr 1:64,506,750...64,543,908
Ensembl chr 1:64,506,735...64,534,912
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]
[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein]
CTD PMID:24158569 PMID:31943712 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 affects expression EXP nickel chloride affects the expression of NME3 mRNA CTD PMID:22110744 PMID:22546817 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nmt2 N-myristoyltransferase 2 increases expression EXP nickel chloride results in increased expression of NMT2 mRNA CTD PMID:24619124 NCBI chr17:78,919,235...78,966,013
Ensembl chr17:78,921,793...78,962,476
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 multiple interactions ISO nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA] CTD PMID:23090859 NCBI chr 4:85,123,965...85,175,206
Ensembl chr 4:85,123,960...85,174,951
JBrowse link
G Nol3 nucleolar protein 3 affects expression EXP nickel chloride affects the expression of NOL3 mRNA CTD PMID:22546817 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of NOS2 mRNA]
nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]
CTD PMID:8975779 PMID:18830972 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO nickel chloride inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]; nickel chloride inhibits the reaction [fluorene results in increased expression of NOS3 protein]; nickel chloride inhibits the reaction [naphthalene results in increased expression of NOS3 protein] CTD PMID:15183461 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Notch1 notch receptor 1 affects expression
increases expression
EXP
ISO
nickel chloride affects the expression of NOTCH1 mRNA
nickel chloride results in increased expression of NOTCH1 protein
CTD PMID:22546817 PMID:26962057 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nox1 NADPH oxidase 1 increases expression ISO nickel chloride results in increased expression of NOX1 protein CTD PMID:22648416 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases expression
ISO nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]
nickel chloride results in decreased expression of NQO1 mRNA
CTD PMID:14645679 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO nickel chloride results in decreased expression of NR0B2 mRNA CTD PMID:17547211 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 affects expression EXP nickel chloride affects the expression of NR2F6 mRNA CTD PMID:22546817 NCBI chr16:19,769,968...19,777,414
Ensembl chr16:19,769,968...19,777,414
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO nickel chloride results in increased expression of NR3C1 mRNA CTD PMID:17312168 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nradd neurotrophin receptor associated death domain affects expression EXP nickel chloride affects the expression of NRADD mRNA CTD PMID:22546817 NCBI chr 8:118,890,402...118,893,712
Ensembl chr 8:118,890,399...118,893,702
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO nickel chloride results in increased expression of NRG1 mRNA CTD PMID:17312168 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO nickel chloride results in decreased expression of NRP1 mRNA CTD PMID:12839937 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Ntn1 netrin 1 affects expression EXP nickel chloride affects the expression of NTN1 mRNA CTD PMID:22546817 NCBI chr10:54,761,925...54,982,072
Ensembl chr10:54,761,871...54,967,585
JBrowse link
G Nucb2 nucleobindin 2 decreases expression
affects expression
ISO
EXP
nickel chloride results in decreased expression of NUCB2 mRNA
nickel chloride affects the expression of NUCB2 mRNA
CTD PMID:17547211 PMID:22110744 NCBI chr 1:185,106,773...185,143,278
Ensembl chr 1:185,104,656...185,143,272
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 affects expression EXP nickel chloride affects the expression of NUCKS1 mRNA CTD PMID:22546817 NCBI chr13:48,679,726...48,709,663
Ensembl chr13:48,679,774...48,705,575
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex affects expression EXP nickel chloride affects the expression of NUF2 mRNA CTD PMID:22546817 NCBI chr13:87,818,456...87,847,223
Ensembl chr13:87,818,391...87,847,263
JBrowse link
G Nup43 nucleoporin 43 decreases expression ISO nickel chloride results in decreased expression of NUP43 mRNA CTD PMID:17312168 NCBI chr 1:1,771,468...1,781,554
Ensembl chr 1:1,771,710...1,782,091
JBrowse link
G Oga O-GlcNAcase increases expression ISO nickel chloride results in increased expression of OGA mRNA CTD PMID:17312168 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
JBrowse link
G Ogdh oxoglutarate dehydrogenase affects expression EXP nickel chloride affects the expression of OGDH mRNA CTD PMID:22110744 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Ogfrl1 opioid growth factor receptor-like 1 increases expression ISO nickel chloride results in increased expression of OGFRL1 mRNA CTD PMID:17312168 NCBI chr 9:29,634,178...29,647,903
Ensembl chr 9:29,634,179...29,647,903
JBrowse link
G Olfml2a olfactomedin-like 2A affects expression EXP nickel chloride affects the expression of OLFML2A mRNA CTD PMID:22110744 NCBI chr 3:23,223,468...23,259,318
Ensembl chr 3:23,223,479...23,259,321
JBrowse link
G Optn optineurin increases expression ISO nickel chloride results in increased expression of OPTN mRNA CTD PMID:17312168 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP nickel chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] CTD PMID:16190872 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G P2ry2 purinergic receptor P2Y2 affects expression EXP nickel chloride affects the expression of P2RY2 mRNA CTD PMID:22110744 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression
affects expression
ISO
EXP
nickel chloride results in increased expression of P4HA1 mRNA
nickel chloride affects the expression of P4HA1 mRNA
CTD PMID:21455298 PMID:22110744 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 multiple interactions
increases expression
affects expression
ISO
EXP
HIF1A affects the reaction [nickel chloride results in increased expression of P4HA2 mRNA]
nickel chloride affects the expression of P4HA2 mRNA
CTD PMID:12426141 PMID:12729255 PMID:12839937 PMID:22110744 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G Pank1 pantothenate kinase 1 affects expression EXP nickel chloride affects the expression of PANK1 mRNA CTD PMID:22110744 NCBI chr 1:253,115,400...253,189,643
Ensembl chr 1:253,119,112...253,185,533
JBrowse link
G Pank3 pantothenate kinase 3 decreases expression ISO nickel chloride results in decreased expression of PANK3 mRNA CTD PMID:17312168 NCBI chr10:20,591,432...20,615,258
Ensembl chr10:20,591,432...20,615,258
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha affects expression EXP nickel chloride affects the expression of PARD6A mRNA CTD PMID:22546817 NCBI chr19:37,668,133...37,670,450
Ensembl chr19:37,668,133...37,672,729
JBrowse link
G Parm1 prostate androgen-regulated mucin-like protein 1 affects expression EXP nickel chloride affects the expression of PARM1 mRNA CTD PMID:22546817 NCBI chr14:17,972,914...18,076,870
Ensembl chr14:17,969,219...18,076,907
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP
ISO
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]; fumonisin B1 inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]
[TP53 mutant form results in decreased susceptibility to nickel chloride] which results in decreased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]; cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of PARP1 protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of PARP1 protein]
CTD PMID:21828359 PMID:21843586 PMID:22172632 PMID:23566959 PMID:24448832 PMID:28552779 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 affects expression EXP nickel chloride affects the expression of PBLD mRNA CTD PMID:22110744 NCBI chr20:27,103,300...27,118,650
Ensembl chr20:27,103,317...27,117,663
JBrowse link
G Pcgf5 polycomb group ring finger 5 affects expression EXP nickel chloride affects the expression of PCGF5 mRNA CTD PMID:22110744 NCBI chr 1:254,974,688...255,090,925
Ensembl chr 1:254,974,789...255,086,207
JBrowse link
G Pclaf PCNA clamp associated factor affects expression EXP nickel chloride affects the expression of PCLAF mRNA CTD PMID:22110744 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pctp phosphatidylcholine transfer protein affects expression EXP nickel chloride affects the expression of PCTP mRNA CTD PMID:22110744 NCBI chr10:77,491,445...77,537,268
Ensembl chr10:77,491,454...77,512,032
JBrowse link
G Pdcd5 programmed cell death 5 affects expression EXP nickel chloride affects the expression of PDCD5 mRNA CTD PMID:22546817 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
JBrowse link
G Pdcd6 programmed cell death 6 affects expression EXP nickel chloride affects the expression of PDCD6 mRNA CTD PMID:22546817 NCBI chr 1:31,576,183...31,591,852
Ensembl chr 1:31,576,183...31,591,849
JBrowse link
G Pdcd7 programmed cell death 7 affects expression EXP nickel chloride affects the expression of PDCD7 mRNA CTD PMID:22546817 NCBI chr 8:70,860,671...70,875,471
Ensembl chr 8:70,860,671...70,875,471
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of PDGFB protein CTD PMID:18437699 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO nickel chloride results in decreased expression of PDIA4 mRNA CTD PMID:17547211 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535