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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:NS 1619
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Accession:CHEBI:34879 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Synonyms:related_synonym: 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one;   1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone;   5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole;   Formula=C15H8F6N2O2;   InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25);   InChIKey=YLFMCMWKHSDUCT-UHFFFAOYSA-N;   NS1619;   SMILES=Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
 xref: CAS:153587-01-0;   KEGG:C13833;   LINCS:LSM-3206
 xref_mesh: MESH:C086491
 xref: PMID:15543339;   PMID:18706395;   PMID:21415309;   PMID:21441626;   PMID:24398773;   PMID:24497961;   PMID:24813114;   PMID:7534190;   PMID:7589189;   PMID:9151934;   Reaxys:8165035



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NS 1619 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]] CTD PMID:21413024 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO NS 1619 binds to and results in increased activity of KCNMA1 protein; NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions ISO NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
JBrowse link

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  CHEBI ontology 19808
    role 19757
      biological role 19757
        biophysical role 13091
          membrane transport modulator 12904
            potassium channel modulator 363
              potassium channel opener 25
                NS 1619 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    main group molecular entity 19704
                      s-block molecular entity 19489
                        hydrogen molecular entity 19484
                          hydrides 18841
                            organic hydride 18350
                              organic fundamental parent 18350
                                hydrocarbon 18061
                                  halohydrocarbon 14052
                                    haloalkane 11707
                                      fluoroalkane 7214
                                        fluoromethanes 6411
                                          tetrafluoromethane 6411
                                            trifluoromethyl group 6411
                                              (trifluoromethyl)benzenes 6411
                                                NS 1619 4
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