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Term:NS 1619
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Accession:CHEBI:34879 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Synonyms:related_synonym: 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one;   1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone;   5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole;   Formula=C15H8F6N2O2;   InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25);   InChIKey=YLFMCMWKHSDUCT-UHFFFAOYSA-N;   NS1619;   SMILES=Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
 xref: CAS:153587-01-0 "ChemIDplus";   CAS:153587-01-0 "KEGG COMPOUND";   KEGG:C13833;   LINCS:LSM-3206
 xref_mesh: MESH:C086491
 xref: PMID:15543339 "Europe PMC";   PMID:18706395 "Europe PMC";   PMID:21415309 "Europe PMC";   PMID:21441626 "Europe PMC";   PMID:24398773 "Europe PMC";   PMID:24497961 "Europe PMC";   PMID:24813114 "Europe PMC";   PMID:7534190 "Europe PMC";   PMID:7589189 "Europe PMC";   PMID:9151934 "Europe PMC";   Reaxys:8165035 "Reaxys"

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NS 1619 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6480464
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 JBrowse link 15 344,204 1,048,849 RGD:6480464
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 JBrowse link 10 18,910,586 18,922,856 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biophysical role 12104
          membrane transport modulator 11868
            potassium channel modulator 339
              potassium channel opener 17
                NS 1619 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  alkane 12481
                                    methane 9407
                                      halomethane 9407
                                        fluoromethanes 6272
                                          fluoroform 6272
                                            trifluoromethyl group 6272
                                              (trifluoromethyl)benzenes 6272
                                                NS 1619 4
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