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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:NS 1619
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Accession:CHEBI:34879 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Synonyms:related_synonym: 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one;   1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone;   5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole;   Formula=C15H8F6N2O2;   InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25);   InChIKey=YLFMCMWKHSDUCT-UHFFFAOYSA-N;   NS1619;   SMILES=Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
 xref: CAS:153587-01-0;   KEGG:C13833;   LINCS:LSM-3206
 xref_mesh: MESH:C086491
 xref: PMID:15543339;   PMID:18706395;   PMID:21415309;   PMID:21441626;   PMID:24398773;   PMID:24497961;   PMID:24813114;   PMID:7534190;   PMID:7589189;   PMID:9151934;   Reaxys:8165035



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NS 1619 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]] CTD PMID:21413024 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO NS 1619 binds to and results in increased activity of KCNMA1 protein; NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions ISO NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
JBrowse link

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  CHEBI ontology 19740
    role 19713
      biological role 19711
        biophysical role 13803
          membrane transport modulator 13639
            potassium channel modulator 394
              potassium channel opener 29
                NS 1619 4
Path 2
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  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    main group molecular entity 19686
                      s-block molecular entity 19541
                        hydrogen molecular entity 19534
                          hydrides 19019
                            organic hydride 18632
                              organic fundamental parent 18632
                                hydrocarbon 18375
                                  halohydrocarbon 15386
                                    haloalkane 12099
                                      fluoroalkane 7765
                                        fluoromethanes 6703
                                          tetrafluoromethane 6703
                                            trifluoromethyl group 6703
                                              (trifluoromethyl)benzenes 6703
                                                NS 1619 4
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