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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Moxestrol
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Accession:CHEBI:34857 term browser browse the term
Definition:A 3-hydroxy steroid that has formula C21H26O3.
Synonyms:related_synonym: 11beta-Methoxy-17alpha-ethinylestradiol;   17alpha-Ethinyl-11beta-methoxy-1,3,5(10)-estratrien-3,17-diol;   Formula=C21H26O3;   InChI=1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1;   InChIKey=MTMZZIPTQITGCY-OLGWUGKESA-N;   RU-16117;   SMILES=CO[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#C)[C@@H]2CCc3cc(O)ccc3[C@@H]12;   moxesterol;   moxestrel
 xref: CAS:34816-55-2;   Drug_Central:3366;   KEGG:C14757
 xref_mesh: MESH:C011310


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Moxestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO alisol B 23-acetate inhibits the reaction [moxestrol results in increased secretion of ALPL protein] CTD PMID:26040663 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity		 ISO moxestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein]; moxestrol promotes the reaction [ESR1 protein binds to TFF1 protein]
moxestrol results in increased activity of ESR1 protein		 CTD PMID:9048584 PMID:10875235 PMID:14617632 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 EXP moxestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
Moxestrol binds to Esr2 protein		 CTD
RGD		 PMID:9048584 PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO IL1B protein inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA] CTD PMID:12177049 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Prl prolactin increases expression EXP moxestrol analog results in increased expression of PRL protein CTD PMID:3780563 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Serpinb9 serpin family B member 9 multiple interactions
increases expression		 ISO Cycloheximide promotes the reaction [moxestrol results in increased expression of SERPINB9 mRNA]; fulvestrant inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]; IL1B protein inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]; moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein]; Tamoxifen analog inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]
moxestrol results in increased expression of SERPINB9 mRNA; moxestrol results in increased expression of SERPINB9 protein		 CTD PMID:10681578 PMID:12177049 PMID:14617632 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO moxestrol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO moxestrol promotes the reaction [ESR1 protein binds to TFF1 protein]
moxestrol results in increased expression of TFF1 mRNA		 CTD PMID:14617632 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      molecular entity 19919
        polyatomic entity 19876
          heteroatomic molecular entity 19834
            hydroxides 19389
              organic hydroxy compound 18997
                hydroxy steroid 14470
                  3-hydroxy steroid 12811
                    Moxestrol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic polycyclic compound 17271
                                  steroid 14723
                                    hydroxy steroid 14470
                                      3-hydroxy steroid 12811
                                        Moxestrol 8
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