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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mibolerone
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Accession:CHEBI:34849 term browser browse the term
Definition:An androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17.
Synonyms:exact_synonym: 17beta-hydroxy-7alpha,17-dimethylestr-4-en-3-one
 related_synonym: (7alpha,17beta)-17-hydroxy-7,17-dimethylestr-4-en-3-one;   17-beta-Hydroxy-7-alpha,17-dimethylestr-4-en-3-one;   7alpha-17alpha-dimethyl-19-nortestosterone;   Formula=C20H30O2;   InChI=1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1;   InChIKey=PTQMMNYJKCSPET-OMHQDGTGSA-N;   NSC 72260;   SMILES=[H][C@]12CCC(=O)C=C1C[C@@H](C)[C@]1([H])[C@]2([H])CC[C@@]2(C)[C@@]1([H])CC[C@]2(C)O;   U 10997;   U-10,997;   mibolerona;   miboleronum
 xref: Beilstein:5565683;   CAS:3704-09-4;   KEGG:C14255;   KEGG:D05025
 xref_mesh: MESH:C100075
 xref: PMID:18515094;   PMID:18770362;   PMID:209430;   PMID:2151880;   PMID:2410244;   PMID:2417401;   PMID:2422638;   PMID:3265669;   PMID:3930306;   PMID:3934110;   PMID:405963;   PMID:4070927;   PMID:565606;   PMID:6254486;   PMID:869826;   PMID:921032;   Patent:US2002012694;   Patent:US2002193359;   Patent:US4412993;   Patent:US5342834;   Reaxys:5565683;   Wikipedia:Mibolerone


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mibolerone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 increases expression ISO mibolerone results in increased expression of ADI1 mRNA; mibolerone results in increased expression of ADI1 protein CTD PMID:17786183 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
increases phosphorylation
increases expression
increases localization
increases activity
affects localization
ISO
EXP
[mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV4 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA]; [Quercetin co-treated with mibolerone] promotes the reaction [AR protein binds to JUN protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; mibolerone inhibits the reaction [bicalutamide results in increased expression of AR protein]; mibolerone promotes the reaction [SP1 protein binds to AR protein]; nilutamide inhibits the reaction [mibolerone affects the localization of AR protein]; pyrazolanthrone affects the reaction [Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]]; Quercetin affects the reaction [mibolerone affects the localization of AR protein]; Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]; Quercetin inhibits the reaction [mibolerone results in increased phosphorylation of AR protein]; Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]]; retigeric acid B inhibits the reaction [mibolerone results in increased expression of AR protein]
mibolerone binds to AR protein
EGF protein promotes the reaction [mibolerone binds to AR protein]
mibolerone results in increased localization of AR protein
mibolerone results in increased activity of AR protein
CTD PMID:8798622 PMID:8912815 PMID:12676605 PMID:14565775 PMID:15253041 PMID:15466214 PMID:15509168 PMID:15661808 PMID:17075824 PMID:17606915 PMID:17723170 PMID:18644453 PMID:20148354 PMID:20692244 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [mibolerone binds to AR protein] CTD PMID:8912815 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Etv4 ETS variant transcription factor 4 multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV4 protein results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr10:89,685,058...89,700,300
Ensembl chr10:89,685,058...89,700,283
JBrowse link
G Etv5 ETS variant transcription factor 5 multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Quercetin co-treated with mibolerone] promotes the reaction [AR protein binds to JUN protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]; [Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein] CTD PMID:20148354 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mir196b microRNA 196b decreases expression ISO mibolerone results in decreased expression of MIR196B mRNA CTD PMID:25846647 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140
JBrowse link
G Mir210 microRNA 210 increases expression ISO mibolerone results in increased expression of MIR210 mRNA CTD PMID:25846647 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Mir221 microRNA 221 decreases expression ISO mibolerone results in decreased expression of MIR221 mRNA CTD PMID:25846647 NCBI chr  X:3,684,480...3,684,588
Ensembl chr  X:3,684,480...3,684,588
JBrowse link
G Mir30a microRNA 30a decreases expression ISO mibolerone results in decreased expression of MIR30A mRNA CTD PMID:25846647 NCBI chr 9:29,542,635...29,542,705
Ensembl chr 9:29,542,635...29,542,705
JBrowse link
G Mir99a microRNA 99a decreases expression ISO mibolerone results in decreased expression of MIR99A mRNA CTD PMID:25846647 NCBI chr11:16,052,153...16,052,233
Ensembl chr11:16,052,153...16,052,233
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV4 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA]; mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA] CTD PMID:8798622 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO mibolerone results in decreased expression of MMP7 mRNA CTD PMID:8798622 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
increases expression
ISO Flufenamic Acid inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA]; Piroxicam inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA] CTD PMID:10537180 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]] CTD PMID:14633711 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]; mibolerone promotes the reaction [SP1 protein binds to AR protein]; Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]] CTD PMID:15661808 PMID:20148354 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO mibolerone results in increased expression of VEGFA mRNA CTD PMID:25846647 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        molecular messenger 18301
          hormone 18072
            anabolic agent 481
              mibolerone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          3-oxo steroid 9283
                                            3-oxo-Delta(4) steroid 8425
                                              mibolerone 19
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