CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: isophorone
Accession: CHEBI:34800
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Definition: A cyclic ketone, the structure of which is that of cyclohex-2-en-1-one substituted by methyl groups at positions 3, 5 and 5.
Synonyms: exact_synonym: 3,5,5-trimethylcyclohex-2-en-1-one
related_synonym: 1,1,3-Trimethyl-3-cyclohexene-5-one; 3,5,5-Trimethyl-2-cyclohexen-1-on; Formula=C9H14O; InChI=1S/C9H14O/c1-7-4-8(10)6-9(2,3)5-7/h4H,5-6H2,1-3H3; InChIKey=HJOVHMDZYOCNQW-UHFFFAOYSA-N; Isoacetophorone; Isoforone; Isooctopherone; Izoforon; SMILES=CC1=CC(=O)CC(C)(C)C1
xref: CAS:78-59-1; HMDB:HMDB0031195; KEGG:C14743; KNApSAcK:C00030540
xref_mesh: MESH:C005940
xref: PMID:23183344; PMID:23472460; PMID:23506080; PMID:23923622; PPDB:1351; Reaxys:1280721; Wikipedia:Isophorone
G
Pgr
progesterone receptor
multiple interactions
ISO
isophorone binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:14,354,398...14,413,271
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
isophorone binds to and results in decreased activity of PPARG protein
CTD
PMID:27633901
NCBI chr 4:150,095,743...150,221,104
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
increases activity
ISO
isophorone results in increased activity of TRPV1 protein
CTD
PMID:27545873
NCBI chr10:58,349,936...58,375,021
G
Il10
interleukin 10
increases expression
ISO
isophorone diisocyanate results in increased expression of IL10 protein
CTD
PMID:19422874
NCBI chr13:45,024,921...45,029,586
G
Il13
interleukin 13
increases secretion
ISO
isophorone diisocyanate results in increased secretion of IL13 protein
CTD
PMID:17693426
NCBI chr10:38,290,926...38,293,483
G
Il1b
interleukin 1 beta
decreases expression
ISO
isophorone diisocyanate results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:137,030,200...137,036,581
G
Il2
interleukin 2
multiple interactions
ISO
[isophorone diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:121,932,968...121,937,672
G
Il4
interleukin 4
increases expression increases secretion
ISO
isophorone diisocyanate results in increased expression of IL4 protein isophorone diisocyanate results in increased secretion of IL4 protein
CTD
PMID:17693426 PMID:19422874
NCBI chr10:38,272,003...38,277,549
G
Nfe2l2
NFE2 like bZIP transcription factor 2
affects response to substance
ISO
NFE2L2 affects the susceptibility to isophorone diisocyanate
CTD
PMID:23564646
NCBI chr 3:81,001,529...81,031,165
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