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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isophorone
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Accession:CHEBI:34800 term browser browse the term
Definition:A cyclic ketone, the structure of which is that of cyclohex-2-en-1-one substituted by methyl groups at positions 3, 5 and 5.
Synonyms:exact_synonym: 3,5,5-trimethylcyclohex-2-en-1-one
 related_synonym: 1,1,3-Trimethyl-3-cyclohexene-5-one;   3,5,5-Trimethyl-2-cyclohexen-1-on;   Formula=C9H14O;   InChI=1S/C9H14O/c1-7-4-8(10)6-9(2,3)5-7/h4H,5-6H2,1-3H3;   InChIKey=HJOVHMDZYOCNQW-UHFFFAOYSA-N;   Isoacetophorone;   Isoforone;   Isooctopherone;   Izoforon;   SMILES=CC1=CC(=O)CC(C)(C)C1
 xref: CAS:78-59-1;   HMDB:HMDB0031195;   KEGG:C14743;   KNApSAcK:C00030540
 xref_mesh: MESH:C005940
 xref: PMID:23183344;   PMID:23472460;   PMID:23506080;   PMID:23923622;   PPDB:1351;   Reaxys:1280721;   Wikipedia:Isophorone



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isophorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgr progesterone receptor multiple interactions ISO isophorone binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:14,354,398...14,413,271 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO isophorone binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO isophorone results in increased activity of TRPV1 protein CTD PMID:27545873 NCBI chr10:58,349,936...58,375,021 JBrowse link
isophorone diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO isophorone diisocyanate results in increased expression of IL10 protein CTD PMID:19422874 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il13 interleukin 13 increases secretion ISO isophorone diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:38,290,926...38,293,483 JBrowse link
G Il1b interleukin 1 beta decreases expression ISO isophorone diisocyanate results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2 interleukin 2 multiple interactions ISO [isophorone diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO isophorone diisocyanate results in increased expression of IL4 protein
isophorone diisocyanate results in increased secretion of IL4 protein
CTD PMID:17693426 PMID:19422874 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 affects the susceptibility to isophorone diisocyanate CTD PMID:23564646 NCBI chr 3:81,001,529...81,031,165 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        solvent 17264
          isophorone 9
            isophorone diisocyanate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbonyl compound 18938
                                    ketone 17284
                                      alpha,beta-unsaturated ketone 9987
                                        enone 9987
                                          isophorone 9
                                            isophorone diisocyanate 6
paths to the root