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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isophorone
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Accession:CHEBI:34800 term browser browse the term
Definition:A cyclic ketone, the structure of which is that of cyclohex-2-en-1-one substituted by methyl groups at positions 3, 5 and 5.
Synonyms:exact_synonym: 3,5,5-trimethylcyclohex-2-en-1-one
 related_synonym: 1,1,3-Trimethyl-3-cyclohexene-5-one;   3,5,5-Trimethyl-2-cyclohexen-1-on;   Formula=C9H14O;   InChI=1S/C9H14O/c1-7-4-8(10)6-9(2,3)5-7/h4H,5-6H2,1-3H3;   InChIKey=HJOVHMDZYOCNQW-UHFFFAOYSA-N;   Isoacetophorone;   Isoforone;   Isooctopherone;   Izoforon;   SMILES=CC1=CC(=O)CC(C)(C)C1
 xref: Beilstein:1280721;   CAS:78-59-1;   HMDB:HMDB0031195;   KEGG:C14743;   KNApSAcK:C00030540
 xref_mesh: MESH:C005940
 xref: PMID:23183344;   PMID:23472460;   PMID:23506080;   PMID:23923622;   PPDB:1351;   Reaxys:1280721;   Wikipedia:Isophorone



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isophorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgr progesterone receptor multiple interactions ISO isophorone binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO isophorone binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO isophorone results in increased activity of TRPV1 protein CTD PMID:27545873 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
isophorone diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO isophorone diisocyanate results in increased expression of IL10 protein CTD PMID:19422874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases secretion ISO isophorone diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO isophorone diisocyanate results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [isophorone diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO isophorone diisocyanate results in increased expression of IL4 protein
isophorone diisocyanate results in increased secretion of IL4 protein
CTD PMID:17693426 PMID:19422874 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 affects the susceptibility to isophorone diisocyanate CTD PMID:23564646 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        solvent 16663
          isophorone 9
            isophorone diisocyanate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      ketone 17091
                                        alpha,beta-unsaturated ketone 9960
                                          enone 9960
                                            isophorone 9
                                              isophorone diisocyanate 6
paths to the root