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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefadroxil
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Accession:CHEBI:3479 term browser browse the term
Definition:A cephalosporin bearing methyl and (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms:exact_synonym: 7beta-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CDX;   Cefadroxil anhydrous;   Cephadroxil;   D-Cefadroxil;   Formula=C16H17N3O5S;   InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1;   InChIKey=BOEGTKLJZSQCCD-UEKVPHQBSA-N;   SMILES=[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O;   cefadroxilo;   cefadroxilum
 xref: Beilstein:5933893;   CAS:50370-12-2;   DrugBank:DB01140;   Drug_Central:526;   KEGG:C06878;   KEGG:D00257;   LINCS:LSM-5722
 xref_mesh: MESH:D002434
 xref: PMID:12833570;   PMID:21425867;   PMID:23224978;   PMID:23959853;   PMID:24080658;   PMID:24412692;   PMID:24667741;   PMID:29017833;   PMID:9131470;   Patent:DE2216113;   Patent:NL6812382;   Patent:US3489752;   Patent:US3816253;   Reaxys:5393893;   Wikipedia:Cefadroxil
 cyclic_relationship: is_conjugate_acid_of CHEBI:53669


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cefadroxil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO Cefadroxil results in increased expression of CYP3A4 mRNA; Cefadroxil results in increased expression of CYP3A4 protein CTD PMID:18505790 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        antimicrobial agent 17373
          antibacterial agent 13457
            antibacterial drug 3174
              cefadroxil 1
                cefadroxil monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        carboacyl group 17416
                                          univalent carboacyl group 17416
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                lactam 8049
                                                  beta-lactam 794
                                                    beta-lactam antibiotic 779
                                                      cephem 544
                                                        cephalosporin 543
                                                          cefadroxil 1
                                                            cefadroxil monohydrate 0
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