CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: heptanal
Accession: CHEBI:34787
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Definition: An n-alkanal resulting from the oxidation of the alcoholic hydroxy group of heptan-1-ol to the corresponding aldehyde. An endogenous aldehyde coming from membrane lipid oxidation, it is found in the blood of lung cancer patients and has been regarded as a potential biomarker of lung cancer.
Synonyms: related_synonym: Aldehyde C-7; Enanthal; Enanthaldehyde; Enanthic aldehyde; Formula=C7H14O; Heptaldehyde; Heptanaldehyde; Heptyl aldehyde; Heptylaldehyde; InChI=1S/C7H14O/c1-2-3-4-5-6-7-8/h7H,2-6H2,1H3; InChIKey=FXHGMKSSBGDXIY-UHFFFAOYSA-N; N-C6H13CHO; N-Heptanal; N-Heptylaldehyde; Oenanthal; Oenanthaldehyde; Oenanthic aldehyde; Oenanthol; SMILES=CCCCCCC=O; n-Heptaldehyde
xref: AGR:IND92060298; CAS:111-71-7; HMDB:HMDB0031475; KEGG:C14390; KNApSAcK:C00034880
xref_mesh: MESH:C046204
xref: PMID:13684163; PMID:13802512; PMID:15556514; PMID:20120041; PMID:22626821; PMID:24401388; PMID:24421258; PMID:28292517; PMID:28366212; PMID:29526787; Wikipedia:Heptanal
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Acot9
acyl-CoA thioesterase 9
increases methylation
ISO
heptanal results in increased methylation of ACOT9 gene
CTD
PMID:30002397
NCBI chr X:43,543,069...43,592,200
Ensembl chr X:43,543,070...43,592,200
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Aire
autoimmune regulator
increases methylation
ISO
heptanal results in increased methylation of AIRE gene
CTD
PMID:30002397
NCBI chr20:11,365,630...11,380,636
Ensembl chr20:11,365,697...11,380,631
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Akr1b1
aldo-keto reductase family 1 member B
affects reduction increases reduction
ISO
AKR1B1 protein affects the reduction of heptanal AKR1B1 protein results in increased reduction of heptanal
CTD
PMID:9890881 PMID:11306073
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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B3galt4
Beta-1,3-galactosyltransferase 4
decreases expression
ISO
heptanal results in decreased expression of B3GALT4 mRNA
CTD
PMID:25014914
NCBI chr20:5,446,104...5,447,679
Ensembl chr20:5,446,104...5,447,673
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Bmp10
bone morphogenetic protein 10
increases methylation
ISO
heptanal results in increased methylation of BMP10 gene
CTD
PMID:30002397
NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
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Ca9
carbonic anhydrase 9
decreases expression
ISO
heptanal results in decreased expression of CA9 mRNA
CTD
PMID:25014914
NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
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Ccna1
cyclin A1
increases methylation
ISO
heptanal results in increased methylation of CCNA1 gene
CTD
PMID:30002397
NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
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Ccnb1ip1
cyclin B1 interacting protein 1
increases methylation
ISO
heptanal results in increased methylation of CCNB1IP1 gene
CTD
PMID:30002397
NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
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Cemip
cell migration inducing hyaluronidase
increases expression
ISO
heptanal results in increased expression of CEMIP mRNA
CTD
PMID:25014914
NCBI chr 1:146,069,774...146,226,320
Ensembl chr 1:146,069,771...146,226,462
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Cep85
centrosomal protein 85
increases methylation
ISO
heptanal results in increased methylation of CEP85 gene
CTD
PMID:30002397
NCBI chr 5:152,359,693...152,406,530
Ensembl chr 5:152,359,700...152,406,518
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Chd3
chromodomain helicase DNA binding protein 3
increases methylation
ISO
heptanal results in increased methylation of CHD3 gene
CTD
PMID:30002397
NCBI chr10:55,943,467...55,970,417
Ensembl chr10:55,943,446...55,965,216
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Cox17
cytochrome c oxidase copper chaperone COX17
increases methylation
ISO
heptanal results in increased methylation of COX17 gene
CTD
PMID:30002397
NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
heptanal results in increased expression of CYP1A1 mRNA
CTD
PMID:25014914
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Dnaaf2
dynein, axonemal, assembly factor 2
increases methylation
ISO
heptanal results in increased methylation of DNAAF2 gene
CTD
PMID:30002397
NCBI chr 6:91,481,439...91,490,189
Ensembl chr 6:91,481,954...91,490,366
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Gna15
G protein subunit alpha 15
increases response to substance multiple interactions
ISO
GNA15 protein results in increased susceptibility to heptanal [GNA15 protein results in increased susceptibility to heptanal] which results in increased activity of OLFR2 protein
CTD
PMID:9875846
NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251
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Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
increases methylation
ISO
heptanal results in increased methylation of HSD17B11 gene
CTD
PMID:30002397
NCBI chr14:7,054,724...7,104,567
Ensembl chr14:7,073,445...7,104,566
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Jchain
joining chain of multimeric IgA and IgM
increases methylation
ISO
heptanal results in increased methylation of JCHAIN gene
CTD
PMID:30002397
NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
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Kcnf1
potassium voltage-gated channel modifier subfamily F member 1
increases methylation
ISO
heptanal results in increased methylation of KCNF1 gene
CTD
PMID:30002397
NCBI chr 6:42,471,060...42,473,738
Ensembl chr 6:42,471,066...42,473,738
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Kif7
kinesin family member 7
increases methylation
ISO
heptanal results in increased methylation of KIF7 gene
CTD
PMID:30002397
NCBI chr 1:141,434,183...141,452,592
Ensembl chr 1:141,434,625...141,451,075
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Lhfpl3
LHFPL tetraspan subfamily member 3
increases methylation
ISO
heptanal results in increased methylation of LHFPL3 gene
CTD
PMID:30002397
NCBI chr 4:8,537,590...8,994,097
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LOC100911376
olfactory receptor 226-like
multiple interactions increases activity
ISO
[GNA15 protein results in increased susceptibility to heptanal] which results in increased activity of OLFR2 protein heptanal results in increased activity of OLFR2 protein
CTD
PMID:9875846
NCBI chr 1:171,059,028...171,060,011
Ensembl chr 1:148,846,679...148,847,662 Ensembl chr 1:148,846,679...148,847,662
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LOC100911842
uncharacterized LOC100911842
decreases methylation
ISO
heptanal results in decreased methylation of C9ORF57 gene
CTD
PMID:30002397
NCBI chr 1:239,150,948...239,156,067
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Lrrc74a
leucine rich repeat containing 74A
increases methylation
ISO
heptanal results in increased methylation of LRRC74A gene
CTD
PMID:30002397
NCBI chr 6:110,681,551...110,776,904
Ensembl chr 6:110,749,705...110,776,775
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Mfn1
mitofusin 1
increases methylation
ISO
heptanal results in increased methylation of MFN1 gene
CTD
PMID:30002397
NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
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Mir128-1
microRNA 128-1
increases methylation
ISO
heptanal results in increased methylation of MIR128-1 gene
CTD
PMID:30002397
NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
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Mrps18a
mitochondrial ribosomal protein S18A
increases methylation
ISO
heptanal results in increased methylation of MRPS18A gene
CTD
PMID:30002397
NCBI chr 9:17,238,354...17,254,845
Ensembl chr 9:17,238,385...17,254,949
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Myt1
myelin transcription factor 1
increases methylation
ISO
heptanal results in increased methylation of MYT1 gene
CTD
PMID:30002397
NCBI chr 3:177,281,365...177,341,550
Ensembl chr 3:177,310,753...177,341,547
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Nfxl1
nuclear transcription factor, X-box binding-like 1
increases methylation
ISO
heptanal results in increased methylation of NFXL1 gene
CTD
PMID:30002397
NCBI chr14:38,192,462...38,233,852
Ensembl chr14:38,192,446...38,233,852
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Nmbr
neuromedin B receptor
increases methylation
ISO
heptanal results in increased methylation of NMBR gene
CTD
PMID:30002397
NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
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Nuf2
NUF2 component of NDC80 kinetochore complex
increases methylation
ISO
heptanal results in increased methylation of NUF2 gene
CTD
PMID:30002397
NCBI chr13:87,818,456...87,847,223
Ensembl chr13:87,818,391...87,847,263
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Olr1597
olfactory receptor 1597
increases methylation
ISO
heptanal results in increased methylation of OR10Z1 gene
CTD
PMID:30002397
NCBI chr13:92,342,255...92,343,196
Ensembl chr13:92,342,255...92,343,196
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Pcdha10
protocadherin alpha 10
increases methylation
ISO
heptanal results in increased methylation of PCDHA10 gene
CTD
PMID:30002397
NCBI chr18:30,010,918...30,215,896
Ensembl chr18:29,987,206...30,215,897
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Pcdha9
protocadherin alpha 9
increases methylation
ISO
heptanal results in increased methylation of PCDHA9 gene
CTD
PMID:30002397
NCBI chr18:30,004,565...30,215,897
Ensembl chr18:29,987,206...30,215,897
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Pde4a
phosphodiesterase 4A
increases methylation
ISO
heptanal results in increased methylation of PDE4A gene
CTD
PMID:30002397
NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
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Pex2
peroxisomal biogenesis factor 2
increases methylation
ISO
heptanal results in increased methylation of PEX2 gene
CTD
PMID:30002397
NCBI chr 2:98,251,756...98,269,185
Ensembl chr 2:98,252,925...98,269,184
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Phactr1
phosphatase and actin regulator 1
increases methylation
ISO
heptanal results in increased methylation of PHACTR1 gene
CTD
PMID:30002397
NCBI chr17:23,245,423...23,761,207
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Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
increases methylation
ISO
heptanal results in increased methylation of PIK3C2A gene
CTD
PMID:30002397
NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
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Plppr5
phospholipid phosphatase related 5
increases methylation
ISO
heptanal results in increased methylation of PLPPR5 gene
CTD
PMID:30002397
NCBI chr 2:219,895,141...220,102,333
Ensembl chr 2:219,896,765...220,101,791
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
increases methylation
ISO
heptanal results in increased methylation of PRKACB gene
CTD
PMID:30002397
NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
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Reg1a
regenerating family member 1 alpha
increases methylation
ISO
heptanal results in increased methylation of REG1A gene
CTD
PMID:30002397
NCBI chr 4:109,497,962...109,500,626
Ensembl chr 4:109,497,962...109,501,082
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Sbsn
suprabasin
increases expression
ISO
heptanal results in increased expression of SBSN mRNA
CTD
PMID:25014914
NCBI chr 1:89,202,527...89,206,994
Ensembl chr 1:89,202,527...89,206,994
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Slc39a5
solute carrier family 39 member 5
decreases expression
ISO
heptanal results in decreased expression of SLC39A5 mRNA
CTD
PMID:25014914
NCBI chr 7:2,813,875...2,819,917
Ensembl chr 7:2,813,875...2,819,299
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Slk
STE20-like kinase
increases methylation
ISO
heptanal results in increased methylation of SLK gene
CTD
PMID:30002397
NCBI chr 1:267,359,761...267,415,735
Ensembl chr 1:267,359,830...267,412,810
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Snca
synuclein alpha
increases methylation
ISO
heptanal results in increased methylation of SNCA gene
CTD
PMID:30002397
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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Spink4
serine peptidase inhibitor, Kazal type 4
increases methylation
ISO
heptanal results in increased methylation of SPINK4 gene
CTD
PMID:30002397
NCBI chr 5:57,238,221...57,252,654
Ensembl chr 5:57,239,086...57,250,662
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Stpg4
sperm-tail PG-rich repeat containing 4
increases methylation
ISO
heptanal results in increased methylation of STPG4 gene
CTD
PMID:30002397
NCBI chr 6:11,014,596...11,063,509
Ensembl chr 6:11,022,034...11,063,092
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Tdrkh
tudor and KH domain containing
increases methylation
ISO
heptanal results in increased methylation of TDRKH gene
CTD
PMID:30002397
NCBI chr 2:195,649,813...195,674,217
Ensembl chr 2:195,651,930...195,674,616
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Thumpd3
THUMP domain containing 3
increases methylation
ISO
heptanal results in increased methylation of THUMPD3 gene
CTD
PMID:30002397
NCBI chr 4:144,985,850...145,010,164
Ensembl chr 4:144,985,880...145,008,831
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Trim27
tripartite motif-containing 27
increases methylation
ISO
heptanal results in increased methylation of TRIM27 gene
CTD
PMID:30002397
NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212
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Ubxn4
UBX domain protein 4
increases methylation
ISO
heptanal results in increased methylation of UBXN4 gene
CTD
PMID:30002397
NCBI chr13:44,956,963...44,989,653
Ensembl chr13:44,957,014...44,990,535
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Wdr75
WD repeat domain 75
increases methylation
ISO
heptanal results in increased methylation of WDR75 gene
CTD
PMID:30002397
NCBI chr 9:52,687,845...52,717,808
Ensembl chr 9:52,687,868...52,717,809
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Zfhx2
zinc finger homeobox 2
increases methylation
ISO
heptanal results in increased methylation of ZFHX2 gene
CTD
PMID:30002397
NCBI chr15:33,719,313...33,752,665
Ensembl chr15:33,720,701...33,752,665
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