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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:heptachlor
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Accession:CHEBI:34785 term browser browse the term
Definition:A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.
Synonyms:exact_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene
 related_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene;   1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene;   3-chlorochlordene;   Formula=C10H5Cl7;   Heptachlorane;   Heptamul;   InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H;   InChIKey=FRCCEHPWNOQAEU-UHFFFAOYSA-N;   SMILES=ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
 xref: Beilstein:2058523;   CAS:76-44-8;   KEGG:C14185
 xref_mesh: MESH:D006533
 xref: PMID:24177859;   PMID:24577234;   PPDB:378;   Reaxys:2058523;   Wikipedia:Heptachlor


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heptachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO Heptachlor results in increased expression of ABCB1 mRNA CTD PMID:24464585 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 increases expression ISO Heptachlor results in increased expression of ABCC1 mRNA CTD PMID:23153324 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 decreases activity
increases expression		 ISO Heptachlor results in decreased activity of ABCC2 protein
Heptachlor results in increased expression of ABCC2 mRNA		 CTD PMID:24464585 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 decreases expression ISO Heptachlor results in decreased expression of ABCC6 mRNA CTD PMID:23153324 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases activity ISO Heptachlor results in decreased activity of ABCG2 protein CTD PMID:24464585 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta increases expression ISO Heptachlor results in increased expression of ACTA2 mRNA; Heptachlor results in increased expression of ACTA2 protein CTD PMID:30719927 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Alb albumin decreases expression ISO Heptachlor results in decreased expression of ALB mRNA CTD PMID:22902829 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule decreases expression ISO Heptachlor results in decreased expression of ALCAM mRNA CTD PMID:23153324 NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437 		JBrowse link
G Aqp11 aquaporin 11 decreases expression ISO Heptachlor results in decreased expression of AQP11 mRNA CTD PMID:23153324 NCBI chr 7:97,375,586...97,387,454
Ensembl chr 7:97,373,213...97,387,496 		JBrowse link
G Aqp9 aquaporin 9 decreases expression ISO Heptachlor results in decreased expression of AQP9 mRNA CTD PMID:23153324 NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 ISO Heptachlor binds to AR protein
Heptachlor inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]		 CTD PMID:14565775 PMID:26022396 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 decreases expression ISO Heptachlor results in decreased expression of ATP6V0E2 mRNA CTD PMID:23153324 NCBI chr 6:48,514,503...48,518,735
Ensembl chr 6:48,514,549...48,518,735 		JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 multiple interactions ISO [Insecticides results in increased abundance of Heptachlor] which affects the methylation of ATP8B1 gene CTD PMID:34516295 NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Heptachlor results in increased expression of AURKB mRNA CTD PMID:23153324 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490 		JBrowse link
G Bcat1 branched chain aminotransferase 1, cytosolic increases expression ISO Heptachlor results in increased expression of BCAT1 mRNA CTD PMID:23153324 NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression ISO Heptachlor results in increased expression of BCL2 protein CTD PMID:14678745 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression ISO Heptachlor results in decreased expression of C1QA mRNA CTD PMID:23153324 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Heptachlor results in increased expression of CCNB1 mRNA CTD PMID:23153324 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Heptachlor results in increased expression of CCNB2 mRNA CTD PMID:23153324 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829 		JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions		 ISO Heptachlor results in decreased expression of CDH1 mRNA; Heptachlor results in decreased expression of CDH1 protein
Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]		 CTD PMID:22902829 PMID:30719927 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdkn3 cyclin dependent kinase inhibitor 3 increases expression ISO Heptachlor results in increased expression of CDKN3 mRNA CTD PMID:23153324 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126 		JBrowse link
G Cenpe centromere protein E increases expression ISO Heptachlor results in increased expression of CENPE mRNA CTD PMID:23153324 NCBI chr 3:134,918,324...134,979,301
Ensembl chr 3:134,918,298...134,979,372 		JBrowse link
G Cfd complement factor D decreases expression ISO Heptachlor results in decreased expression of CFD mRNA CTD PMID:23153324 NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit decreases expression ISO Heptachlor results in decreased expression of CHRNA1 mRNA CTD PMID:23153324 NCBI chr 2:73,393,625...73,410,682
Ensembl chr 2:73,393,559...73,410,682 		JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression ISO Heptachlor results in increased expression of COL1A1 mRNA CTD PMID:22902829 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B decreases expression ISO Heptachlor results in decreased expression of COX5B mRNA CTD PMID:23153324 NCBI chr 1:36,730,568...36,732,469
Ensembl chr 1:36,730,530...36,732,762 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 ISO Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
Heptachlor results in increased expression of CTNNB1 protein		 CTD PMID:22902829 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein] CTD PMID:14678745 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Heptachlor results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Heptachlor results in increased expression of E2F8 mRNA CTD PMID:23153324 NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344 		JBrowse link
G Ect2 ect2 oncogene increases expression ISO Heptachlor results in increased expression of ECT2 mRNA CTD PMID:23153324 NCBI chr 3:27,151,371...27,207,971
Ensembl chr 3:27,151,371...27,208,027 		JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 increases expression ISO Heptachlor results in increased expression of ELOVL7 mRNA CTD PMID:23153324 NCBI chr13:108,350,860...108,423,643
Ensembl chr13:108,350,938...108,422,217 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases activity
increases expression
multiple interactions		 ISO Heptachlor results in increased activity of ESR1 protein
Heptachlor results in increased expression of ESR1
Heptachlor inhibits the reaction [Estradiol results in increased activity of ESR1 protein]		 CTD PMID:26022396 PMID:26139245 PMID:27240701 PMID:28531659 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) increases activity ISO Heptachlor results in increased activity of ESR2 protein CTD PMID:15064155 PMID:26139245 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Exoc5 exocyst complex component 5 multiple interactions ISO [Insecticides results in increased abundance of Heptachlor] which affects the methylation of EXOC5 gene CTD PMID:34516295 NCBI chr14:49,249,379...49,304,124
Ensembl chr14:49,241,547...49,304,110 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression ISO Heptachlor results in increased expression of EZH2 mRNA CTD PMID:23153324 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275 		JBrowse link
G Faah fatty acid amide hydrolase decreases expression ISO Heptachlor results in decreased expression of FAAH mRNA CTD PMID:23153324 NCBI chr 4:115,853,866...115,876,034
Ensembl chr 4:115,824,342...115,875,123 		JBrowse link
G Fmnl2 formin-like 2 increases expression ISO Heptachlor results in increased expression of FMNL2 mRNA CTD PMID:23153324 NCBI chr 2:52,747,743...53,023,816
Ensembl chr 2:52,747,872...53,023,816 		JBrowse link
G Fn1 fibronectin 1 increases expression
decreases expression		 ISO Heptachlor results in increased expression of FN1 protein
Heptachlor results in decreased expression of FN1 mRNA		 CTD PMID:22902829 PMID:23153324 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA] CTD PMID:28385489 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Heptachlor results in decreased expression of GJA1 protein CTD PMID:8738476 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 decreases expression ISO Heptachlor results in decreased expression of HIPK2 mRNA CTD PMID:23153324 NCBI chr 6:38,664,447...38,853,236
Ensembl chr 6:38,671,325...38,853,099 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO Heptachlor results in increased expression of HK2 mRNA CTD PMID:23153324 NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene decreases expression ISO Heptachlor results in decreased expression of HRAS mRNA CTD PMID:1771636 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Heptachlor results in decreased expression of IGF1 mRNA CTD PMID:23153324 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il13ra1 interleukin 13 receptor, alpha 1 decreases expression ISO Heptachlor results in decreased expression of IL13RA1 mRNA CTD PMID:23153324 NCBI chr  X:35,375,761...35,434,915
Ensembl chr  X:35,375,763...35,434,912 		JBrowse link
G Ins1 insulin I affects secretion ISO Heptachlor affects the secretion of INS1 protein CTD PMID:31923579 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) increases expression ISO Heptachlor results in increased expression of ITGA5 mRNA CTD PMID:22902829 NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190 		JBrowse link
G Jun jun proto-oncogene increases phosphorylation ISO Heptachlor results in increased phosphorylation of JUN protein CTD PMID:15888667 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kif18b kinesin family member 18B increases expression ISO Heptachlor results in increased expression of KIF18B mRNA CTD PMID:23153324 NCBI chr11:102,796,344...102,815,960
Ensembl chr11:102,796,355...102,815,950 		JBrowse link
G Lrrc1 leucine rich repeat containing 1 increases expression ISO Heptachlor results in increased expression of LRRC1 mRNA CTD PMID:23153324 NCBI chr 9:77,338,103...77,453,749
Ensembl chr 9:77,338,105...77,452,152 		JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 increases expression ISO Heptachlor results in increased expression of MAD2L1 mRNA CTD PMID:23153324 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204 		JBrowse link
G Maob monoamine oxidase B decreases expression ISO Heptachlor results in decreased expression of MAOB mRNA CTD PMID:23153324 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Heptachlor promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions
decreases expression		 ISO Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein
Heptachlor results in decreased expression of MAP2K1 protein		 CTD PMID:9704902 PMID:15888667 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 multiple interactions ISO Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO Heptachlor results in decreased expression of MAP3K1 protein CTD PMID:9704902 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases expression
multiple interactions		 ISO Heptachlor results in decreased expression of MAPK1 protein
Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]		 CTD PMID:9704902 PMID:14678745 PMID:15888667 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases expression
multiple interactions		 ISO Heptachlor results in decreased expression of MAPK3 protein
Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]		 CTD PMID:9704902 PMID:14678745 PMID:15888667 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mmd monocyte to macrophage differentiation-associated increases expression ISO Heptachlor results in increased expression of MMD mRNA CTD PMID:23153324 NCBI chr11:90,078,513...90,169,399
Ensembl chr11:90,140,282...90,169,415 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Heptachlor results in increased expression of MMP9 mRNA CTD PMID:23153324 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nanog Nanog homeobox multiple interactions ISO Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of NANOG mRNA] CTD PMID:32949729 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Heptachlor results in decreased expression of NNT mRNA CTD PMID:23153324 NCBI chr13:119,472,063...119,545,793
Ensembl chr13:119,471,984...119,545,533
Ensembl chr13:119,471,984...119,545,533 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP
ISO		 Heptachlor binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Heptachlor results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nt5dc2 5'-nucleotidase domain containing 2 increases expression ISO Heptachlor results in increased expression of NT5DC2 mRNA CTD PMID:23153324 NCBI chr14:30,853,046...30,861,081
Ensembl chr14:30,853,010...30,861,081 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 decreases expression ISO Heptachlor results in decreased expression of ORAI1 mRNA CTD PMID:23153324 NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 decreases expression ISO Heptachlor results in decreased expression of P2RX4 mRNA CTD PMID:23153324 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 decreases expression ISO Heptachlor results in decreased expression of PDK4 mRNA CTD PMID:23153324 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO Heptachlor results in increased expression of PGR
Heptachlor inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]		 CTD PMID:26022396 PMID:27240701 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases activity
increases activity		 ISO Heptachlor results in decreased activity of PI4KA protein
Heptachlor results in increased activity of PI4KA protein		 CTD PMID:14994277 NCBI chr16:17,098,215...17,224,178
Ensembl chr16:17,098,215...17,224,178 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 multiple interactions ISO Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] CTD PMID:32949729 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Heptachlor affects the localization of and results in increased activity of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein] CTD PMID:14678745 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Heptachlor affects the localization of and results in increased activity of PRKCD protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein] CTD PMID:14678745 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) decreases expression ISO Heptachlor results in decreased expression of PSMB9 mRNA CTD PMID:23153324 NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) decreases expression ISO Heptachlor results in decreased expression of PTGER3 mRNA CTD PMID:23153324 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
G Pttg1 pituitary tumor-transforming gene 1 increases expression ISO Heptachlor results in increased expression of PTTG1 mRNA CTD PMID:23153324 NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions ISO Heptachlor results in increased phosphorylation of and results in increased activity of RAF1 protein CTD PMID:15888667 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Heptachlor results in decreased expression of RB1 protein CTD PMID:10048758 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rfc4 replication factor C (activator 1) 4 increases expression ISO Heptachlor results in increased expression of RFC4 mRNA CTD PMID:23153324 NCBI chr16:22,932,698...22,946,480
Ensembl chr16:22,932,693...22,946,487 		JBrowse link
G Sgms1 sphingomyelin synthase 1 decreases expression ISO Heptachlor results in decreased expression of SGMS1 mRNA CTD PMID:23153324 NCBI chr19:32,100,127...32,367,285
Ensembl chr19:32,100,127...32,367,114 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO Heptachlor results in decreased expression of SLC10A1 mRNA CTD PMID:23153324 PMID:24464585 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 decreases expression ISO Heptachlor results in decreased expression of SLC16A1 mRNA CTD PMID:23153324 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778 		JBrowse link
G Slc16a4 solute carrier family 16 (monocarboxylic acid transporters), member 4 decreases expression ISO Heptachlor results in decreased expression of SLC16A4 mRNA CTD PMID:23153324 NCBI chr 3:107,198,543...107,219,437
Ensembl chr 3:107,198,546...107,219,431 		JBrowse link
G Slc16a7 solute carrier family 16 (monocarboxylic acid transporters), member 7 decreases expression ISO Heptachlor results in decreased expression of SLC16A7 mRNA CTD PMID:23153324 NCBI chr10:125,055,139...125,225,455
Ensembl chr10:125,055,139...125,225,334 		JBrowse link
G Slc17a2 solute carrier family 17 (sodium phosphate), member 2 decreases expression ISO Heptachlor results in decreased expression of SLC17A2 mRNA CTD PMID:23153324 NCBI chr13:23,990,924...24,009,174
Ensembl chr13:23,990,976...24,009,163 		JBrowse link
G Slc17a3 solute carrier family 17 (sodium phosphate), member 3 decreases expression ISO Heptachlor results in decreased expression of SLC17A3 mRNA CTD PMID:23153324 NCBI chr13:24,020,905...24,044,701
Ensembl chr13:24,023,417...24,044,699 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 increases expression EXP Heptachlor results in increased expression of SLC18A2 mRNA; Heptachlor results in increased expression of SLC18A2 protein CTD PMID:10499361 PMID:16112329 PMID:18577399 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc19a2 solute carrier family 19 (thiamine transporter), member 2 decreases expression ISO Heptachlor results in decreased expression of SLC19A2 mRNA CTD PMID:23153324 NCBI chr 1:164,076,615...164,092,954
Ensembl chr 1:164,076,615...164,092,954 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 decreases activity ISO Heptachlor results in decreased activity of SLC22A1 protein CTD PMID:24464585 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 decreases expression ISO Heptachlor results in decreased expression of SLC25A1 mRNA CTD PMID:23153324 NCBI chr16:17,743,075...17,746,083
Ensembl chr16:17,743,087...17,746,083 		JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 decreases expression ISO Heptachlor results in decreased expression of SLC29A1 mRNA CTD PMID:23153324 NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 decreases expression ISO Heptachlor results in decreased expression of SLC2A2 mRNA CTD PMID:23153324 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 decreases expression ISO Heptachlor results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc30a5 solute carrier family 30 (zinc transporter), member 5 decreases expression ISO Heptachlor results in decreased expression of SLC30A5 mRNA CTD PMID:23153324 NCBI chr13:100,939,153...100,969,988
Ensembl chr13:100,939,156...100,969,935 		JBrowse link
G Slc31a2 solute carrier family 31, member 2 decreases expression ISO Heptachlor results in decreased expression of SLC31A2 mRNA CTD PMID:23153324 NCBI chr 4:62,198,630...62,216,649
Ensembl chr 4:62,180,799...62,216,648 		JBrowse link
G Slc34a2 solute carrier family 34 (sodium phosphate), member 2 decreases expression ISO Heptachlor results in decreased expression of SLC34A2 mRNA CTD PMID:23153324 NCBI chr 5:53,206,695...53,229,006
Ensembl chr 5:53,195,423...53,229,006 		JBrowse link
G Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 decreases expression ISO Heptachlor results in decreased expression of SLC37A4 mRNA CTD PMID:23153324 NCBI chr 9:44,308,243...44,314,263
Ensembl chr 9:44,308,149...44,314,265 		JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression ISO Heptachlor results in increased expression of SLC38A1 mRNA CTD PMID:23153324 NCBI chr15:96,469,299...96,541,396
Ensembl chr15:96,469,299...96,540,794 		JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 decreases expression ISO Heptachlor results in decreased expression of SLC5A6 mRNA CTD PMID:23153324 NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions
increases expression		 EXP
ISO		 Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Heptachlor results in increased expression of SLC6A3 protein
Heptachlor results in increased expression of SLC6A3 mRNA; Heptachlor results in increased expression of SLC6A3 protein		 CTD PMID:10499361 PMID:11294980 PMID:11719704 PMID:12428726 PMID:16112329 More... NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 decreases expression ISO Heptachlor results in decreased expression of SLC7A2 mRNA CTD PMID:23153324 NCBI chr 8:41,315,404...41,375,107
Ensembl chr 8:41,315,433...41,375,345 		JBrowse link
G Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 decreases expression ISO Heptachlor results in decreased expression of SLC7A6 mRNA CTD PMID:23153324 NCBI chr 8:106,894,718...106,925,346
Ensembl chr 8:106,895,489...106,925,338 		JBrowse link
G Smad2 SMAD family member 2 increases expression ISO Heptachlor results in increased expression of SMAD2 mRNA; Heptachlor results in increased expression of SMAD2 protein modified form CTD PMID:30719927 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO Heptachlor results in increased expression of SMAD3 mRNA; Heptachlor results in increased expression of SMAD3 protein modified form CTD PMID:30719927 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 decreases expression ISO Heptachlor results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein]
Heptachlor results in increased expression of TGFB1 mRNA		 CTD PMID:14678745 PMID:30719927 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgm2 transglutaminase 2, C polypeptide decreases expression ISO Heptachlor results in decreased expression of TGM2 mRNA CTD PMID:23153324 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356 		JBrowse link
G Th tyrosine hydroxylase increases expression EXP Heptachlor results in increased expression of TH protein CTD PMID:16112329 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression ISO Heptachlor results in increased expression of TRIP13 mRNA CTD PMID:23153324 NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903 		JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO Heptachlor results in decreased expression of TP53 protein CTD PMID:9544696 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tspo translocator protein increases expression ISO Heptachlor results in increased expression of TSPO CTD PMID:14699885 NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Heptachlor results in decreased expression of UQCRH mRNA CTD PMID:23153324 NCBI chr 4:115,924,162...115,932,267
Ensembl chr 4:115,924,162...115,932,268 		JBrowse link
G Vim vimentin increases expression ISO Heptachlor results in increased expression of VIM mRNA; Heptachlor results in increased expression of VIM protein CTD PMID:22902829 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 decreases expression ISO Heptachlor results in decreased expression of WFDC2 mRNA CTD PMID:23153324 NCBI chr 2:164,404,635...164,410,430
Ensembl chr 2:164,404,333...164,410,430 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21760
        agrochemical 16967
          heptachlor 119
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21717
                        hydrogen molecular entity 21634
                          hydrides 20777
                            organic hydride 20333
                              organic fundamental parent 20333
                                hydrocarbon 19911
                                  cyclic hydrocarbon 17957
                                    arene 17936
                                      polycyclic arene 17728
                                        ortho-fused polycyclic arene 10041
                                          ortho-fused bicyclic arene 2422
                                            1H-indene 121
                                              heptachlor 119
paths to the root