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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heptachlor
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Accession:CHEBI:34785 term browser browse the term
Definition:A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.
Synonyms:exact_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene
 related_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene;   1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene;   3-chlorochlordene;   Formula=C10H5Cl7;   Heptachlorane;   Heptamul;   InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H;   InChIKey=FRCCEHPWNOQAEU-UHFFFAOYSA-N;   SMILES=ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
 xref: Beilstein:2058523;   CAS:76-44-8;   KEGG:C14185
 xref_mesh: MESH:D006533
 xref: PMID:24177859;   PMID:24577234;   PPDB:378;   Reaxys:2058523;   Wikipedia:Heptachlor


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heptachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Heptachlor results in increased expression of ABCB1 mRNA CTD PMID:24464585 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Heptachlor results in increased expression of ABCC1 mRNA CTD PMID:23153324 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
ISO Heptachlor results in decreased activity of ABCC2 protein
Heptachlor results in increased expression of ABCC2 mRNA
CTD PMID:24464585 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression EXP Heptachlor results in decreased expression of ABCC6 mRNA CTD PMID:23153324 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO Heptachlor results in decreased activity of ABCG2 protein CTD PMID:24464585 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Heptachlor results in increased expression of ACTA2 mRNA; Heptachlor results in increased expression of ACTA2 protein CTD PMID:30719927 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Alb albumin decreases expression ISO Heptachlor results in decreased expression of ALB mRNA CTD PMID:22902829 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alcam activated leukocyte cell adhesion molecule decreases expression EXP Heptachlor results in decreased expression of ALCAM mRNA CTD PMID:23153324 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Aqp11 aquaporin 11 decreases expression EXP Heptachlor results in decreased expression of AQP11 mRNA CTD PMID:23153324 NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725
JBrowse link
G Aqp9 aquaporin 9 decreases expression EXP Heptachlor results in decreased expression of AQP9 mRNA CTD PMID:23153324 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Heptachlor binds to AR protein
Heptachlor inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD PMID:14565775 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP Heptachlor results in decreased expression of ATP6V0E2 mRNA CTD PMID:23153324 NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
JBrowse link
G Aurkb aurora kinase B increases expression EXP Heptachlor results in increased expression of AURKB mRNA CTD PMID:23153324 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Heptachlor results in increased expression of BCAT1 mRNA CTD PMID:23153324 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Heptachlor results in increased expression of BCL2 protein CTD PMID:14678745 NCBI chr13:22,689,783...22,853,920 JBrowse link
G C1qa complement C1q A chain decreases expression EXP Heptachlor results in decreased expression of C1QA mRNA CTD PMID:23153324 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Ccnb1 cyclin B1 increases expression EXP Heptachlor results in increased expression of CCNB1 mRNA CTD PMID:23153324 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Heptachlor results in increased expression of CCNB2 mRNA CTD PMID:23153324 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO Heptachlor results in decreased expression of CDH1 mRNA; Heptachlor results in decreased expression of CDH1 protein
Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
CTD PMID:22902829 PMID:30719927 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression EXP Heptachlor results in increased expression of CDKN3 mRNA CTD PMID:23153324 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cenpe centromere protein E increases expression EXP Heptachlor results in increased expression of CENPE mRNA CTD PMID:23153324 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cfd complement factor D decreases expression EXP Heptachlor results in decreased expression of CFD mRNA CTD PMID:23153324 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit decreases expression EXP Heptachlor results in decreased expression of CHRNA1 mRNA CTD PMID:23153324 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Heptachlor results in increased expression of COL1A1 mRNA CTD PMID:22902829 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B decreases expression EXP Heptachlor results in decreased expression of COX5B mRNA CTD PMID:23153324 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
Heptachlor results in increased expression of CTNNB1 protein
CTD PMID:22902829 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein] CTD PMID:14678745 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Heptachlor results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G E2f8 E2F transcription factor 8 increases expression EXP Heptachlor results in increased expression of E2F8 mRNA CTD PMID:23153324 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Ect2 epithelial cell transforming 2 increases expression EXP Heptachlor results in increased expression of ECT2 mRNA CTD PMID:23153324 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 increases expression EXP Heptachlor results in increased expression of ELOVL7 mRNA CTD PMID:23153324 NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
increases expression
ISO
EXP
Heptachlor results in increased activity of ESR1 protein
Heptachlor inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
Heptachlor results in increased expression of ESR1
CTD PMID:26022396 PMID:26139245 PMID:27240701 PMID:28531659 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Heptachlor results in increased activity of ESR2 protein CTD PMID:15064155 PMID:26139245 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression EXP Heptachlor results in increased expression of EZH2 mRNA CTD PMID:23153324 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Faah fatty acid amide hydrolase decreases expression EXP Heptachlor results in decreased expression of FAAH mRNA CTD PMID:23153324 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Fmnl2 formin-like 2 increases expression EXP Heptachlor results in increased expression of FMNL2 mRNA CTD PMID:23153324 NCBI chr 3:37,348,791...37,624,746
Ensembl chr 3:37,348,574...37,624,754
JBrowse link
G Fn1 fibronectin 1 increases expression
decreases expression
ISO
EXP
Heptachlor results in increased expression of FN1 protein
Heptachlor results in decreased expression of FN1 mRNA
CTD PMID:22902829 PMID:23153324 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA] CTD PMID:28385489 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Heptachlor results in decreased expression of GJA1 protein CTD PMID:8738476 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 decreases expression EXP Heptachlor results in decreased expression of HIPK2 mRNA CTD PMID:23153324 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
JBrowse link
G Hk2 hexokinase 2 increases expression EXP Heptachlor results in increased expression of HK2 mRNA CTD PMID:23153324 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Heptachlor results in decreased expression of HRAS mRNA CTD PMID:1771636 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Heptachlor results in decreased expression of IGF1 mRNA CTD PMID:23153324 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression EXP Heptachlor results in decreased expression of IL13RA1 mRNA CTD PMID:23153324 NCBI chr  X:115,348,860...115,408,682
Ensembl chr  X:115,348,860...115,408,681
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Heptachlor results in increased expression of ITGA5 mRNA CTD PMID:22902829 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO Heptachlor results in increased phosphorylation of JUN protein CTD PMID:15888667 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kif18b kinesin family member 18B increases expression EXP Heptachlor results in increased expression of KIF18B mRNA CTD PMID:23153324 NCBI chr10:87,870,424...87,889,895
Ensembl chr10:87,870,428...87,889,850
JBrowse link
G Lrrc1 leucine rich repeat containing 1 increases expression EXP Heptachlor results in increased expression of LRRC1 mRNA CTD PMID:23153324 NCBI chr 8:78,239,897...78,407,347
Ensembl chr 8:78,239,900...78,406,490
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP Heptachlor results in increased expression of MAD2L1 mRNA CTD PMID:23153324 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Heptachlor results in decreased expression of MAOB mRNA CTD PMID:23153324 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Heptachlor promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
decreases expression
ISO Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein
Heptachlor results in decreased expression of MAP2K1 protein
CTD PMID:9704902 PMID:15888667 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO Heptachlor results in decreased expression of MAP3K1 protein CTD PMID:9704902 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions
ISO
EXP
Heptachlor results in decreased expression of MAPK1 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]
CTD PMID:9704902 PMID:14678745 PMID:15888667 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions
ISO
EXP
Heptachlor results in decreased expression of MAPK3 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]
CTD PMID:9704902 PMID:14678745 PMID:15888667 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmd monocyte to macrophage differentiation-associated increases expression EXP Heptachlor results in increased expression of MMD mRNA CTD PMID:23153324 NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP Heptachlor results in increased expression of MMP9 mRNA CTD PMID:23153324 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nanog Nanog homeobox multiple interactions ISO Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of NANOG mRNA] CTD PMID:32949729 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression EXP Heptachlor results in decreased expression of NNT mRNA CTD PMID:23153324 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Heptachlor binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Heptachlor results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nt5dc2 5'-nucleotidase domain containing 2 increases expression EXP Heptachlor results in increased expression of NT5DC2 mRNA CTD PMID:23153324 NCBI chr16:6,322,485...6,330,538
Ensembl chr16:6,322,236...6,330,537
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 decreases expression EXP Heptachlor results in decreased expression of ORAI1 mRNA CTD PMID:23153324 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
JBrowse link
G P2rx4 purinergic receptor P2X 4 decreases expression EXP Heptachlor results in decreased expression of P2RX4 mRNA CTD PMID:23153324 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G Pax6 paired box 6 multiple interactions ISO Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Heptachlor results in decreased expression of PDK4 mRNA CTD PMID:23153324 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
EXP
ISO
Heptachlor results in increased expression of PGR
Heptachlor inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]
CTD PMID:26022396 PMID:27240701 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases activity
increases activity
ISO Heptachlor results in decreased activity of PI4KA protein
Heptachlor results in increased activity of PI4KA protein
CTD PMID:14994277 NCBI chr11:83,609,136...83,726,876
Ensembl chr11:83,609,069...83,724,080
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] CTD PMID:32949729 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Heptachlor affects the localization of and results in increased activity of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein] CTD PMID:14678745 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Heptachlor affects the localization of and results in increased activity of PRKCD protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein] CTD PMID:14678745 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression EXP Heptachlor results in decreased expression of PSMB9 mRNA CTD PMID:23153324 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression EXP Heptachlor results in decreased expression of PTGER3 mRNA CTD PMID:23153324 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression EXP Heptachlor results in increased expression of PTTG1 mRNA CTD PMID:23153324 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Heptachlor results in increased phosphorylation of and results in increased activity of RAF1 protein CTD PMID:15888667 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Heptachlor results in decreased expression of RB1 protein CTD PMID:10048758 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression EXP Heptachlor results in increased expression of RFC4 mRNA CTD PMID:23153324 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Sgms1 sphingomyelin synthase 1 decreases expression EXP Heptachlor results in decreased expression of SGMS1 mRNA CTD PMID:23153324 NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO
EXP
Heptachlor results in decreased expression of SLC10A1 mRNA CTD PMID:23153324 PMID:24464585 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Heptachlor results in decreased expression of SLC16A1 mRNA CTD PMID:23153324 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression EXP Heptachlor results in decreased expression of SLC16A4 mRNA CTD PMID:23153324 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Slc16a7 solute carrier family 16 member 7 decreases expression EXP Heptachlor results in decreased expression of SLC16A7 mRNA CTD PMID:23153324 NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994
JBrowse link
G Slc17a2 solute carrier family 17, member 2 decreases expression EXP Heptachlor results in decreased expression of SLC17A2 mRNA CTD PMID:23153324 NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression EXP Heptachlor results in decreased expression of SLC17A3 mRNA CTD PMID:23153324 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression ISO Heptachlor results in increased expression of SLC18A2 mRNA; Heptachlor results in increased expression of SLC18A2 protein CTD PMID:10499361 PMID:16112329 PMID:18577399 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc19a2 solute carrier family 19 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC19A2 mRNA CTD PMID:23153324 NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Heptachlor results in decreased activity of SLC22A1 protein CTD PMID:24464585 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression EXP Heptachlor results in decreased expression of SLC25A1 mRNA CTD PMID:23153324 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781
JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression EXP Heptachlor results in decreased expression of SLC29A1 mRNA CTD PMID:23153324 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC2A2 mRNA CTD PMID:23153324 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Heptachlor results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc30a5 solute carrier family 30 member 5 decreases expression EXP Heptachlor results in decreased expression of SLC30A5 mRNA CTD PMID:23153324 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934
JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC31A2 mRNA CTD PMID:23153324 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC34A2 mRNA CTD PMID:23153324 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP Heptachlor results in decreased expression of SLC37A4 mRNA CTD PMID:23153324 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression EXP Heptachlor results in increased expression of SLC38A1 mRNA CTD PMID:23153324 NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
JBrowse link
G Slc5a6 solute carrier family 5 member 6 decreases expression EXP Heptachlor results in decreased expression of SLC5A6 mRNA CTD PMID:23153324 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases expression
ISO
EXP
Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Heptachlor results in increased expression of SLC6A3 mRNA; Heptachlor results in increased expression of SLC6A3 protein
CTD PMID:10499361 PMID:11294980 PMID:11719704 PMID:12428726 PMID:16112329 More... NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc7a2 solute carrier family 7 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC7A2 mRNA CTD PMID:23153324 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
JBrowse link
G Slc7a6 solute carrier family 7 member 6 decreases expression EXP Heptachlor results in decreased expression of SLC7A6 mRNA CTD PMID:23153324 NCBI chr19:34,073,472...34,100,268
Ensembl chr19:34,074,286...34,100,268
JBrowse link
G Smad2 SMAD family member 2 increases expression ISO Heptachlor results in increased expression of SMAD2 mRNA; Heptachlor results in increased expression of SMAD2 protein modified form CTD PMID:30719927 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 increases expression ISO Heptachlor results in increased expression of SMAD3 mRNA; Heptachlor results in increased expression of SMAD3 protein modified form CTD PMID:30719927 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Heptachlor results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Heptachlor results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP
ISO
Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein]
Heptachlor results in increased expression of TGFB1 mRNA
CTD PMID:14678745 PMID:30719927 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgm2 transglutaminase 2 decreases expression EXP Heptachlor results in decreased expression of TGM2 mRNA CTD PMID:23153324 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Th tyrosine hydroxylase increases expression ISO Heptachlor results in increased expression of TH protein CTD PMID:16112329 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Heptachlor results in decreased expression of TP53 protein CTD PMID:9544696 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression EXP Heptachlor results in increased expression of TRIP13 mRNA CTD PMID:23153324 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
JBrowse link
G Tspo translocator protein increases expression EXP Heptachlor results in increased expression of TSPO CTD PMID:14699885 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression EXP Heptachlor results in decreased expression of UQCRH mRNA CTD PMID:23153324 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link
G Vim vimentin increases expression ISO Heptachlor results in increased expression of VIM mRNA; Heptachlor results in increased expression of VIM protein CTD PMID:22902829 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 decreases expression EXP Heptachlor results in decreased expression of WFDC2 mRNA CTD PMID:23153324 NCBI chr 3:153,286,946...153,314,832
Ensembl chr 3:153,286,131...153,292,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        agrochemical 15039
          heptachlor 117
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            organic hydride 18354
                              organic fundamental parent 18354
                                hydrocarbon 18065
                                  cyclic hydrocarbon 17077
                                    arene 17073
                                      polycyclic arene 16892
                                        ortho-fused polycyclic arene 9662
                                          ortho-fused bicyclic arene 2415
                                            1H-indene 119
                                              heptachlor 117
paths to the root