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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heptachlor
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Accession:CHEBI:34785 term browser browse the term
Definition:A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.
Synonyms:exact_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene
 related_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene;   1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene;   3-chlorochlordene;   Formula=C10H5Cl7;   Heptachlorane;   Heptamul;   InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H;   InChIKey=FRCCEHPWNOQAEU-UHFFFAOYSA-N;   SMILES=ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
 xref: Beilstein:2058523;   CAS:76-44-8;   KEGG:C14185
 xref_mesh: MESH:D006533
 xref: PMID:24177859;   PMID:24577234;   PPDB:378;   Reaxys:2058523;   Wikipedia:Heptachlor


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heptachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Heptachlor results in increased expression of ABCB1 mRNA CTD PMID:24464585 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Heptachlor results in increased expression of ABCC1 mRNA CTD PMID:23153324 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
ISO Heptachlor results in decreased activity of ABCC2 protein
Heptachlor results in increased expression of ABCC2 mRNA
CTD PMID:24464585 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression EXP Heptachlor results in decreased expression of ABCC6 mRNA CTD PMID:23153324 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO Heptachlor results in decreased activity of ABCG2 protein CTD PMID:24464585 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Alb albumin decreases expression ISO Heptachlor results in decreased expression of ALB mRNA CTD PMID:22902829 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alcam activated leukocyte cell adhesion molecule decreases expression EXP Heptachlor results in decreased expression of ALCAM mRNA CTD PMID:23153324 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Aqp11 aquaporin 11 decreases expression EXP Heptachlor results in decreased expression of AQP11 mRNA CTD PMID:23153324 NCBI chr 1:162,703,394...162,713,560
Ensembl chr 1:162,703,442...162,713,610
JBrowse link
G Aqp9 aquaporin 9 decreases expression EXP Heptachlor results in decreased expression of AQP9 mRNA CTD PMID:23153324 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Heptachlor binds to AR protein
Heptachlor inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD PMID:14565775, PMID:26022396 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP Heptachlor results in decreased expression of ATP6V0E2 mRNA CTD PMID:23153324 NCBI chr 4:78,168,117...78,171,265
Ensembl chr 4:78,168,117...78,171,265
JBrowse link
G Aurkb aurora kinase B increases expression EXP Heptachlor results in increased expression of AURKB mRNA CTD PMID:23153324 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Heptachlor results in increased expression of BCAT1 mRNA CTD PMID:23153324 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Heptachlor results in increased expression of BCL2 protein CTD PMID:14678745 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C1qa complement C1q A chain decreases expression EXP Heptachlor results in decreased expression of C1QA mRNA CTD PMID:23153324 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Ccnb1 cyclin B1 increases expression EXP Heptachlor results in increased expression of CCNB1 mRNA CTD PMID:23153324 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Heptachlor results in increased expression of CCNB2 mRNA CTD PMID:23153324 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO Heptachlor results in decreased expression of CDH1 mRNA; Heptachlor results in decreased expression of CDH1 protein
Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
CTD PMID:22902829 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression EXP Heptachlor results in increased expression of CDKN3 mRNA CTD PMID:23153324 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cenpe centromere protein E increases expression EXP Heptachlor results in increased expression of CENPE mRNA CTD PMID:23153324 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Cfd complement factor D decreases expression EXP Heptachlor results in decreased expression of CFD mRNA CTD PMID:23153324 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit decreases expression EXP Heptachlor results in decreased expression of CHRNA1 mRNA CTD PMID:23153324 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Heptachlor results in increased expression of COL1A1 mRNA CTD PMID:22902829 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B decreases expression EXP Heptachlor results in decreased expression of COX5B mRNA CTD PMID:23153324 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
Heptachlor results in increased expression of CTNNB1 protein
CTD PMID:22902829 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein] CTD PMID:14678745 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Heptachlor results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G E2f8 E2F transcription factor 8 increases expression EXP Heptachlor results in increased expression of E2F8 mRNA CTD PMID:23153324 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Ect2 epithelial cell transforming 2 increases expression EXP Heptachlor results in increased expression of ECT2 mRNA CTD PMID:23153324 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 increases expression EXP Heptachlor results in increased expression of ELOVL7 mRNA CTD PMID:23153324 NCBI chr 2:40,373,211...40,386,643
Ensembl chr 2:40,373,211...40,386,669
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
increases expression
ISO
EXP
Heptachlor results in increased activity of ESR1 protein
Heptachlor inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
Heptachlor results in increased expression of ESR1
CTD PMID:26022396, PMID:26139245, PMID:27240701, PMID:28531659 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Heptachlor results in increased activity of ESR2 protein CTD PMID:15064155, PMID:26139245 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression EXP Heptachlor results in increased expression of EZH2 mRNA CTD PMID:23153324 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Faah fatty acid amide hydrolase decreases expression EXP Heptachlor results in decreased expression of FAAH mRNA CTD PMID:23153324 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fmnl2 formin-like 2 increases expression EXP Heptachlor results in increased expression of FMNL2 mRNA CTD PMID:23153324 NCBI chr 3:38,400,409...38,677,637
Ensembl chr 3:38,559,914...38,675,878
JBrowse link
G Fn1 fibronectin 1 increases expression
decreases expression
ISO
EXP
Heptachlor results in increased expression of FN1 protein
Heptachlor results in decreased expression of FN1 mRNA
CTD PMID:22902829, PMID:23153324 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA] CTD PMID:28385489 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Heptachlor results in decreased expression of GJA1 protein CTD PMID:8738476 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 decreases expression EXP Heptachlor results in decreased expression of HIPK2 mRNA CTD PMID:23153324 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Hk2 hexokinase 2 increases expression EXP Heptachlor results in increased expression of HK2 mRNA CTD PMID:23153324 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Heptachlor results in decreased expression of HRAS mRNA CTD PMID:1771636 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Heptachlor results in decreased expression of IGF1 mRNA CTD PMID:23153324 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression EXP Heptachlor results in decreased expression of IL13RA1 mRNA CTD PMID:23153324 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Heptachlor results in increased expression of ITGA5 mRNA CTD PMID:22902829 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO Heptachlor results in increased phosphorylation of JUN protein CTD PMID:15888667 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif18b kinesin family member 18B increases expression EXP Heptachlor results in increased expression of KIF18B mRNA CTD PMID:23153324 NCBI chr10:91,008,294...91,027,760
Ensembl chr10:91,008,269...91,027,738
JBrowse link
G Lrrc1 leucine rich repeat containing 1 increases expression EXP Heptachlor results in increased expression of LRRC1 mRNA CTD PMID:23153324 NCBI chr 8:84,721,621...84,835,074
Ensembl chr 8:84,720,551...84,835,060
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP Heptachlor results in increased expression of MAD2L1 mRNA CTD PMID:23153324 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Heptachlor results in decreased expression of MAOB mRNA CTD PMID:23153324 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
decreases expression
ISO Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein
Heptachlor results in decreased expression of MAP2K1 protein
CTD PMID:9704902, PMID:15888667 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO Heptachlor results in decreased expression of MAP3K1 protein CTD PMID:9704902 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions
ISO
EXP
Heptachlor results in decreased expression of MAPK1 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]
CTD PMID:9704902, PMID:14678745, PMID:15888667 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions
ISO
EXP
Heptachlor results in decreased expression of MAPK3 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]
CTD PMID:9704902, PMID:14678745, PMID:15888667 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmd monocyte to macrophage differentiation-associated increases expression EXP Heptachlor results in increased expression of MMD mRNA CTD PMID:23153324 NCBI chr10:77,687,964...77,783,737
Ensembl chr10:77,755,216...77,783,779
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP Heptachlor results in increased expression of MMP9 mRNA CTD PMID:23153324 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression EXP Heptachlor results in decreased expression of NNT mRNA CTD PMID:23153324 NCBI chr 2:52,189,523...52,283,095
Ensembl chr 2:52,189,529...52,282,548
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Heptachlor binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Heptachlor results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nt5dc2 5'-nucleotidase domain containing 2 increases expression EXP Heptachlor results in increased expression of NT5DC2 mRNA CTD PMID:23153324 NCBI chr16:7,212,488...7,220,541
Ensembl chr16:7,212,488...7,220,540
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 decreases expression EXP Heptachlor results in decreased expression of ORAI1 mRNA CTD PMID:23153324 NCBI chr12:38,981,903...38,995,570
Ensembl chr12:38,981,927...38,995,570
JBrowse link
G P2rx4 purinergic receptor P2X 4 decreases expression EXP Heptachlor results in decreased expression of P2RX4 mRNA CTD PMID:23153324 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Heptachlor results in decreased expression of PDK4 mRNA CTD PMID:23153324 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
EXP
ISO
Heptachlor results in increased expression of PGR
Heptachlor inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]
CTD PMID:26022396, PMID:27240701 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases activity
increases activity
ISO Heptachlor results in decreased activity of PI4KA protein
Heptachlor results in increased activity of PI4KA protein
CTD PMID:14994277 NCBI chr11:87,858,323...87,975,549
Ensembl chr11:87,858,453...87,973,422
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Heptachlor affects the localization of and results in increased activity of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein] CTD PMID:14678745 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Heptachlor affects the localization of and results in increased activity of PRKCD protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein] CTD PMID:14678745 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression EXP Heptachlor results in decreased expression of PSMB9 mRNA CTD PMID:23153324 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression EXP Heptachlor results in decreased expression of PTGER3 mRNA CTD PMID:23153324 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression EXP Heptachlor results in increased expression of PTTG1 mRNA CTD PMID:23153324 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Heptachlor results in increased phosphorylation of and results in increased activity of RAF1 protein CTD PMID:15888667 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Heptachlor results in decreased expression of RB1 protein CTD PMID:10048758 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression EXP Heptachlor results in increased expression of RFC4 mRNA CTD PMID:23153324 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043
JBrowse link
G Sgms1 sphingomyelin synthase 1 decreases expression EXP Heptachlor results in decreased expression of SGMS1 mRNA CTD PMID:23153324 NCBI chr 1:250,692,448...250,951,685
Ensembl chr 1:250,691,370...250,951,697
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO
EXP
Heptachlor results in decreased expression of SLC10A1 mRNA CTD PMID:23153324, PMID:24464585 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Heptachlor results in decreased expression of SLC16A1 mRNA CTD PMID:23153324 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression EXP Heptachlor results in decreased expression of SLC16A4 mRNA CTD PMID:23153324 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502
JBrowse link
G Slc16a7 solute carrier family 16 member 7 decreases expression EXP Heptachlor results in decreased expression of SLC16A7 mRNA CTD PMID:23153324 NCBI chr 7:68,438,341...68,606,312
Ensembl chr 7:68,446,193...68,549,763
JBrowse link
G Slc17a2 solute carrier family 17, member 2 decreases expression EXP Heptachlor results in decreased expression of SLC17A2 mRNA CTD PMID:23153324 NCBI chr17:43,567,528...43,584,228
Ensembl chr17:43,567,528...43,584,152
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression EXP Heptachlor results in decreased expression of SLC17A3 mRNA CTD PMID:23153324 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression ISO Heptachlor results in increased expression of SLC18A2 mRNA; Heptachlor results in increased expression of SLC18A2 protein CTD PMID:10499361, PMID:16112329, PMID:18577399 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc19a2 solute carrier family 19 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC19A2 mRNA CTD PMID:23153324 NCBI chr13:82,552,586...82,566,586
Ensembl chr13:82,552,550...82,566,586
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Heptachlor results in decreased activity of SLC22A1 protein CTD PMID:24464585 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression EXP Heptachlor results in decreased expression of SLC25A1 mRNA CTD PMID:23153324 NCBI chr11:87,204,248...87,207,265
Ensembl chr11:87,204,175...87,207,264
JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression EXP Heptachlor results in decreased expression of SLC29A1 mRNA CTD PMID:23153324 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC2A2 mRNA CTD PMID:23153324 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Heptachlor results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc30a5 solute carrier family 30 member 5 decreases expression EXP Heptachlor results in decreased expression of SLC30A5 mRNA CTD PMID:23153324 NCBI chr 2:30,815,683...30,845,796
Ensembl chr 2:30,815,703...30,846,149
JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC31A2 mRNA CTD PMID:23153324 NCBI chr 5:78,120,606...78,131,111
Ensembl chr 5:78,120,607...78,131,114
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC34A2 mRNA CTD PMID:23153324 NCBI chr14:60,257,211...60,276,516
Ensembl chr14:60,256,712...60,276,794
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP Heptachlor results in decreased expression of SLC37A4 mRNA CTD PMID:23153324 NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024
JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression EXP Heptachlor results in increased expression of SLC38A1 mRNA CTD PMID:23153324 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Slc5a6 solute carrier family 5 member 6 decreases expression EXP Heptachlor results in decreased expression of SLC5A6 mRNA CTD PMID:23153324 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases expression
ISO
EXP
Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Heptachlor results in increased expression of SLC6A3 mRNA; Heptachlor results in increased expression of SLC6A3 protein
CTD PMID:10499361, PMID:11294980, PMID:11719704, PMID:12428726, PMID:16112329, PMID:18577399 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc7a2 solute carrier family 7 member 2 decreases expression EXP Heptachlor results in decreased expression of SLC7A2 mRNA CTD PMID:23153324 NCBI chr16:54,459,409...54,513,349
Ensembl chr16:54,460,067...54,513,349
JBrowse link
G Slc7a6 solute carrier family 7 member 6 decreases expression EXP Heptachlor results in decreased expression of SLC7A6 mRNA CTD PMID:23153324 NCBI chr19:38,152,225...38,179,149
Ensembl chr19:38,162,515...38,179,149
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Heptachlor results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Heptachlor results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein] CTD PMID:14678745 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgm2 transglutaminase 2 decreases expression EXP Heptachlor results in decreased expression of TGM2 mRNA CTD PMID:23153324 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Th tyrosine hydroxylase increases expression ISO Heptachlor results in increased expression of TH protein CTD PMID:16112329 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Heptachlor results in decreased expression of TP53 protein CTD PMID:9544696 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression EXP Heptachlor results in increased expression of TRIP13 mRNA CTD PMID:23153324 NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
JBrowse link
G Tspo translocator protein increases expression EXP Heptachlor results in increased expression of TSPO CTD PMID:14699885 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression EXP Heptachlor results in decreased expression of UQCRH mRNA CTD PMID:23153324 NCBI chr 5:134,919,040...134,927,235
Ensembl chr 5:134,919,044...134,927,235
JBrowse link
G Vim vimentin increases expression ISO Heptachlor results in increased expression of VIM mRNA; Heptachlor results in increased expression of VIM protein CTD PMID:22902829 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 decreases expression EXP Heptachlor results in decreased expression of WFDC2 mRNA CTD PMID:23153324 NCBI chr 3:161,018,497...161,045,469
Ensembl chr 3:161,018,511...161,024,209
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        agrochemical 14435
          heptachlor 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      polycyclic arene 16879
                                        ortho-fused polycyclic arene 9641
                                          ortho-fused bicyclic arene 2395
                                            1H-indene 112
                                              heptachlor 110
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.