CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: heptachlor
Accession: CHEBI:34785
browse the term
Definition: A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.
Synonyms: exact_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene
related_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene; 1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene; 3-chlorochlordene; Formula=C10H5Cl7; Heptachlorane; Heptamul; InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H; InChIKey=FRCCEHPWNOQAEU-UHFFFAOYSA-N; SMILES=ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
xref: Beilstein:2058523; CAS:76-44-8; KEGG:C14185
xref_mesh: MESH:D006533
xref: PMID:24177859; PMID:24577234; PPDB:378; Reaxys:2058523; Wikipedia:Heptachlor
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
Heptachlor results in increased expression of ABCB1 mRNA
CTD
PMID:24464585
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
increases expression
EXP
Heptachlor results in increased expression of ABCC1 mRNA
CTD
PMID:23153324
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
decreases activity increases expression
ISO
Heptachlor results in decreased activity of ABCC2 protein Heptachlor results in increased expression of ABCC2 mRNA
CTD
PMID:24464585
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc6
ATP binding cassette subfamily C member 6
decreases expression
EXP
Heptachlor results in decreased expression of ABCC6 mRNA
CTD
PMID:23153324
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Abcg2
ATP binding cassette subfamily G member 2
decreases activity
ISO
Heptachlor results in decreased activity of ABCG2 protein
CTD
PMID:24464585
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Acta2
actin alpha 2, smooth muscle
increases expression
ISO
Heptachlor results in increased expression of ACTA2 mRNA; Heptachlor results in increased expression of ACTA2 protein
CTD
PMID:30719927
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Alb
albumin
decreases expression
ISO
Heptachlor results in decreased expression of ALB mRNA
CTD
PMID:22902829
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alcam
activated leukocyte cell adhesion molecule
decreases expression
EXP
Heptachlor results in decreased expression of ALCAM mRNA
CTD
PMID:23153324
NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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Aqp11
aquaporin 11
decreases expression
EXP
Heptachlor results in decreased expression of AQP11 mRNA
CTD
PMID:23153324
NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725
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Aqp9
aquaporin 9
decreases expression
EXP
Heptachlor results in decreased expression of AQP9 mRNA
CTD
PMID:23153324
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Ar
androgen receptor
affects binding multiple interactions
EXP ISO
Heptachlor binds to AR protein Heptachlor inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD
PMID:14565775 PMID:26022396
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atp6v0e2
ATPase, H+ transporting V0 subunit e2
decreases expression
EXP
Heptachlor results in decreased expression of ATP6V0E2 mRNA
CTD
PMID:23153324
NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
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Atp8b1
ATPase phospholipid transporting 8B1
multiple interactions
ISO
[Insecticides results in increased abundance of Heptachlor] which affects the methylation of ATP8B1 gene
CTD
PMID:34516295
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Aurkb
aurora kinase B
increases expression
EXP
Heptachlor results in increased expression of AURKB mRNA
CTD
PMID:23153324
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Bcat1
branched chain amino acid transaminase 1
increases expression
EXP
Heptachlor results in increased expression of BCAT1 mRNA
CTD
PMID:23153324
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Heptachlor results in increased expression of BCL2 protein
CTD
PMID:14678745
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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C1qa
complement C1q A chain
decreases expression
EXP
Heptachlor results in decreased expression of C1QA mRNA
CTD
PMID:23153324
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions
EXP
Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]
CTD
PMID:28385489
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Ccnb1
cyclin B1
increases expression
EXP
Heptachlor results in increased expression of CCNB1 mRNA
CTD
PMID:23153324
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnb2
cyclin B2
increases expression
EXP
Heptachlor results in increased expression of CCNB2 mRNA
CTD
PMID:23153324
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Cdh1
cadherin 1
decreases expression multiple interactions
ISO
Heptachlor results in decreased expression of CDH1 mRNA; Heptachlor results in decreased expression of CDH1 protein Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
CTD
PMID:22902829 PMID:30719927
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdkn3
cyclin-dependent kinase inhibitor 3
increases expression
EXP
Heptachlor results in increased expression of CDKN3 mRNA
CTD
PMID:23153324
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cenpe
centromere protein E
increases expression
EXP
Heptachlor results in increased expression of CENPE mRNA
CTD
PMID:23153324
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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Cfd
complement factor D
decreases expression
EXP
Heptachlor results in decreased expression of CFD mRNA
CTD
PMID:23153324
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
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Chrna1
cholinergic receptor nicotinic alpha 1 subunit
decreases expression
EXP
Heptachlor results in decreased expression of CHRNA1 mRNA
CTD
PMID:23153324
NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
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Col1a1
collagen type I alpha 1 chain
increases expression
ISO
Heptachlor results in increased expression of COL1A1 mRNA
CTD
PMID:22902829
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Cox5b
cytochrome c oxidase subunit 5B
decreases expression
EXP
Heptachlor results in decreased expression of COX5B mRNA
CTD
PMID:23153324
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
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Ctnnb1
catenin beta 1
multiple interactions increases expression
ISO
Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein] Heptachlor results in increased expression of CTNNB1 protein
CTD
PMID:22902829
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cycs
cytochrome c, somatic
multiple interactions
EXP
Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein]
CTD
PMID:14678745
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
Heptachlor results in decreased activity of CYP19A1 protein
CTD
PMID:16996190
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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E2f8
E2F transcription factor 8
increases expression
EXP
Heptachlor results in increased expression of E2F8 mRNA
CTD
PMID:23153324
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
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Ect2
epithelial cell transforming 2
increases expression
EXP
Heptachlor results in increased expression of ECT2 mRNA
CTD
PMID:23153324
NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
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Elovl7
ELOVL fatty acid elongase 7
increases expression
EXP
Heptachlor results in increased expression of ELOVL7 mRNA
CTD
PMID:23153324
NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845
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Esr1
estrogen receptor 1
increases activity increases expression multiple interactions
ISO EXP
Heptachlor results in increased activity of ESR1 protein Heptachlor results in increased expression of ESR1 Heptachlor inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
CTD
PMID:26022396 PMID:26139245 PMID:27240701 PMID:28531659
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
increases activity
ISO
Heptachlor results in increased activity of ESR2 protein
CTD
PMID:15064155 PMID:26139245
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Exoc5
exocyst complex component 5
multiple interactions
ISO
[Insecticides results in increased abundance of Heptachlor] which affects the methylation of EXOC5 gene
CTD
PMID:34516295
NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
increases expression
EXP
Heptachlor results in increased expression of EZH2 mRNA
CTD
PMID:23153324
NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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Faah
fatty acid amide hydrolase
decreases expression
EXP
Heptachlor results in decreased expression of FAAH mRNA
CTD
PMID:23153324
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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Fmnl2
formin-like 2
increases expression
EXP
Heptachlor results in increased expression of FMNL2 mRNA
CTD
PMID:23153324
NCBI chr 3:37,348,791...37,624,746
Ensembl chr 3:37,348,574...37,624,754
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Fn1
fibronectin 1
increases expression decreases expression
ISO EXP
Heptachlor results in increased expression of FN1 protein Heptachlor results in decreased expression of FN1 mRNA
CTD
PMID:22902829 PMID:23153324
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Gap43
growth associated protein 43
multiple interactions
EXP
Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]
CTD
PMID:28385489
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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Gja1
gap junction protein, alpha 1
decreases expression
ISO
Heptachlor results in decreased expression of GJA1 protein
CTD
PMID:8738476
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Hipk2
homeodomain interacting protein kinase 2
decreases expression
EXP
Heptachlor results in decreased expression of HIPK2 mRNA
CTD
PMID:23153324
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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Hk2
hexokinase 2
increases expression
EXP
Heptachlor results in increased expression of HK2 mRNA
CTD
PMID:23153324
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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Hras
HRas proto-oncogene, GTPase
decreases expression
ISO
Heptachlor results in decreased expression of HRAS mRNA
CTD
PMID:1771636
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Igf1
insulin-like growth factor 1
decreases expression
EXP
Heptachlor results in decreased expression of IGF1 mRNA
CTD
PMID:23153324
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il13ra1
interleukin 13 receptor subunit alpha 1
decreases expression
EXP
Heptachlor results in decreased expression of IL13RA1 mRNA
CTD
PMID:23153324
NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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Ins1
insulin 1
affects secretion
EXP
Heptachlor affects the secretion of INS1 protein
CTD
PMID:31923579
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Itga5
integrin subunit alpha 5
increases expression
ISO
Heptachlor results in increased expression of ITGA5 mRNA
CTD
PMID:22902829
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation
ISO
Heptachlor results in increased phosphorylation of JUN protein
CTD
PMID:15888667
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kif18b
kinesin family member 18B
increases expression
EXP
Heptachlor results in increased expression of KIF18B mRNA
CTD
PMID:23153324
NCBI chr10:87,870,424...87,889,895
Ensembl chr10:87,870,428...87,889,850
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Lrrc1
leucine rich repeat containing 1
increases expression
EXP
Heptachlor results in increased expression of LRRC1 mRNA
CTD
PMID:23153324
NCBI chr 8:78,239,897...78,407,347
Ensembl chr 8:78,239,900...78,406,490
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Mad2l1
mitotic arrest deficient 2 like 1
increases expression
EXP
Heptachlor results in increased expression of MAD2L1 mRNA
CTD
PMID:23153324
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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Maob
monoamine oxidase B
decreases expression
EXP
Heptachlor results in decreased expression of MAOB mRNA
CTD
PMID:23153324
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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Map2
microtubule-associated protein 2
multiple interactions
ISO
Heptachlor promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA]
CTD
PMID:32949729
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Map2k1
mitogen activated protein kinase kinase 1
multiple interactions decreases expression
ISO
Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein Heptachlor results in decreased expression of MAP2K1 protein
CTD
PMID:9704902 PMID:15888667
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
multiple interactions
ISO
Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 protein
CTD
PMID:15888667
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Map3k1
mitogen-activated protein kinase kinase kinase 1
decreases expression
ISO
Heptachlor results in decreased expression of MAP3K1 protein
CTD
PMID:9704902
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Mapk1
mitogen activated protein kinase 1
decreases expression multiple interactions
ISO EXP
Heptachlor results in decreased expression of MAPK1 protein Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]
CTD
PMID:9704902 PMID:14678745 PMID:15888667
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases expression multiple interactions
ISO EXP
Heptachlor results in decreased expression of MAPK3 protein Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]
CTD
PMID:9704902 PMID:14678745 PMID:15888667
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmd
monocyte to macrophage differentiation-associated
increases expression
EXP
Heptachlor results in increased expression of MMD mRNA
CTD
PMID:23153324
NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
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Mmp9
matrix metallopeptidase 9
increases expression
EXP
Heptachlor results in increased expression of MMP9 mRNA
CTD
PMID:23153324
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nanog
Nanog homeobox
multiple interactions
ISO
Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of NANOG mRNA]
CTD
PMID:32949729
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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Ngf
nerve growth factor
multiple interactions
EXP
Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA]
CTD
PMID:28385489
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nnt
nicotinamide nucleotide transhydrogenase
decreases expression
EXP
Heptachlor results in decreased expression of NNT mRNA
CTD
PMID:23153324
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Heptachlor binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Heptachlor results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nt5dc2
5'-nucleotidase domain containing 2
increases expression
EXP
Heptachlor results in increased expression of NT5DC2 mRNA
CTD
PMID:23153324
NCBI chr16:6,322,485...6,330,538
Ensembl chr16:6,322,236...6,330,537
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Orai1
ORAI calcium release-activated calcium modulator 1
decreases expression
EXP
Heptachlor results in decreased expression of ORAI1 mRNA
CTD
PMID:23153324
NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
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P2rx4
purinergic receptor P2X 4
decreases expression
EXP
Heptachlor results in decreased expression of P2RX4 mRNA
CTD
PMID:23153324
NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
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Pax6
paired box 6
multiple interactions
ISO
Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]
CTD
PMID:32949729
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pdk4
pyruvate dehydrogenase kinase 4
decreases expression
EXP
Heptachlor results in decreased expression of PDK4 mRNA
CTD
PMID:23153324
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Pgr
progesterone receptor
increases expression multiple interactions
EXP ISO
Heptachlor results in increased expression of PGR Heptachlor inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]
CTD
PMID:26022396 PMID:27240701
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pi4ka
phosphatidylinositol 4-kinase alpha
decreases activity increases activity
ISO
Heptachlor results in decreased activity of PI4KA protein Heptachlor results in increased activity of PI4KA protein
CTD
PMID:14994277
NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080
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Pou5f1
POU class 5 homeobox 1
multiple interactions
ISO
Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA]
CTD
PMID:32949729
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Prkca
protein kinase C, alpha
multiple interactions
EXP
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Heptachlor affects the localization of and results in increased activity of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]
CTD
PMID:14678745
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Prkcd
protein kinase C, delta
multiple interactions
EXP
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Heptachlor affects the localization of and results in increased activity of PRKCD protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]
CTD
PMID:14678745
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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Psmb9
proteasome 20S subunit beta 9
decreases expression
EXP
Heptachlor results in decreased expression of PSMB9 mRNA
CTD
PMID:23153324
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Ptger3
prostaglandin E receptor 3
decreases expression
EXP
Heptachlor results in decreased expression of PTGER3 mRNA
CTD
PMID:23153324
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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Pttg1
PTTG1 regulator of sister chromatid separation, securin
increases expression
EXP
Heptachlor results in increased expression of PTTG1 mRNA
CTD
PMID:23153324
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
Heptachlor results in increased phosphorylation of and results in increased activity of RAF1 protein
CTD
PMID:15888667
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Rb1
RB transcriptional corepressor 1
decreases expression
ISO
Heptachlor results in decreased expression of RB1 protein
CTD
PMID:10048758
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rfc4
replication factor C subunit 4
increases expression
EXP
Heptachlor results in increased expression of RFC4 mRNA
CTD
PMID:23153324
NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
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Sgms1
sphingomyelin synthase 1
decreases expression
EXP
Heptachlor results in decreased expression of SGMS1 mRNA
CTD
PMID:23153324
NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO EXP
Heptachlor results in decreased expression of SLC10A1 mRNA
CTD
PMID:23153324 PMID:24464585
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc16a1
solute carrier family 16 member 1
decreases expression
EXP
Heptachlor results in decreased expression of SLC16A1 mRNA
CTD
PMID:23153324
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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Slc16a4
solute carrier family 16, member 4
decreases expression
EXP
Heptachlor results in decreased expression of SLC16A4 mRNA
CTD
PMID:23153324
NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
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Slc16a7
solute carrier family 16 member 7
decreases expression
EXP
Heptachlor results in decreased expression of SLC16A7 mRNA
CTD
PMID:23153324
NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994
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Slc17a2
solute carrier family 17, member 2
decreases expression
EXP
Heptachlor results in decreased expression of SLC17A2 mRNA
CTD
PMID:23153324
NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325
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Slc17a3
solute carrier family 17 member 3
decreases expression
EXP
Heptachlor results in decreased expression of SLC17A3 mRNA
CTD
PMID:23153324
NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
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Slc18a2
solute carrier family 18 member A2
increases expression
ISO
Heptachlor results in increased expression of SLC18A2 mRNA; Heptachlor results in increased expression of SLC18A2 protein
CTD
PMID:10499361 PMID:16112329 PMID:18577399
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc19a2
solute carrier family 19 member 2
decreases expression
EXP
Heptachlor results in decreased expression of SLC19A2 mRNA
CTD
PMID:23153324
NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
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Slc22a1
solute carrier family 22 member 1
decreases activity
ISO
Heptachlor results in decreased activity of SLC22A1 protein
CTD
PMID:24464585
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc25a1
solute carrier family 25 member 1
decreases expression
EXP
Heptachlor results in decreased expression of SLC25A1 mRNA
CTD
PMID:23153324
NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781
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Slc29a1
solute carrier family 29 member 1
decreases expression
EXP
Heptachlor results in decreased expression of SLC29A1 mRNA
CTD
PMID:23153324
NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
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Slc2a2
solute carrier family 2 member 2
decreases expression
EXP
Heptachlor results in decreased expression of SLC2A2 mRNA
CTD
PMID:23153324
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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Slc2a4
solute carrier family 2 member 4
decreases expression
EXP
Heptachlor results in decreased expression of SLC2A4 protein
CTD
PMID:31923579
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc30a5
solute carrier family 30 member 5
decreases expression
EXP
Heptachlor results in decreased expression of SLC30A5 mRNA
CTD
PMID:23153324
NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934
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Slc31a2
solute carrier family 31 member 2
decreases expression
EXP
Heptachlor results in decreased expression of SLC31A2 mRNA
CTD
PMID:23153324
NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
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Slc34a2
solute carrier family 34 member 2
decreases expression
EXP
Heptachlor results in decreased expression of SLC34A2 mRNA
CTD
PMID:23153324
NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
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Slc37a4
solute carrier family 37 member 4
decreases expression
EXP
Heptachlor results in decreased expression of SLC37A4 mRNA
CTD
PMID:23153324
NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
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Slc38a1
solute carrier family 38, member 1
increases expression
EXP
Heptachlor results in increased expression of SLC38A1 mRNA
CTD
PMID:23153324
NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
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Slc5a6
solute carrier family 5 member 6
decreases expression
EXP
Heptachlor results in decreased expression of SLC5A6 mRNA
CTD
PMID:23153324
NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
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Slc6a3
solute carrier family 6 member 3
multiple interactions increases expression
ISO EXP
Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine] Heptachlor results in increased expression of SLC6A3 protein Heptachlor results in increased expression of SLC6A3 mRNA; Heptachlor results in increased expression of SLC6A3 protein
CTD
PMID:10499361 PMID:11294980 PMID:11719704 PMID:12428726 PMID:16112329 PMID:18577399 More...
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slc7a2
solute carrier family 7 member 2
decreases expression
EXP
Heptachlor results in decreased expression of SLC7A2 mRNA
CTD
PMID:23153324
NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
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Slc7a6
solute carrier family 7 member 6
decreases expression
EXP
Heptachlor results in decreased expression of SLC7A6 mRNA
CTD
PMID:23153324
NCBI chr19:34,073,472...34,100,268
Ensembl chr19:34,074,286...34,100,268
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Smad2
SMAD family member 2
increases expression
ISO
Heptachlor results in increased expression of SMAD2 mRNA; Heptachlor results in increased expression of SMAD2 protein modified form
CTD
PMID:30719927
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad3
SMAD family member 3
increases expression
ISO
Heptachlor results in increased expression of SMAD3 mRNA; Heptachlor results in increased expression of SMAD3 protein modified form
CTD
PMID:30719927
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Sult1a1
sulfotransferase family 1A member 1
decreases expression
EXP
Heptachlor results in decreased expression of SULT1A1 mRNA
CTD
PMID:9566755
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Sult2a1
sulfotransferase family 2A member 1
decreases expression
EXP
Heptachlor results in decreased expression of SULT2A1 mRNA
CTD
PMID:9566755
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Tgfb1
transforming growth factor, beta 1
multiple interactions increases expression
EXP ISO
Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein] Heptachlor results in increased expression of TGFB1 mRNA
CTD
PMID:14678745 PMID:30719927
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgm2
transglutaminase 2
decreases expression
EXP
Heptachlor results in decreased expression of TGM2 mRNA
CTD
PMID:23153324
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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Th
tyrosine hydroxylase
increases expression
ISO
Heptachlor results in increased expression of TH protein
CTD
PMID:16112329
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tp53
tumor protein p53
decreases expression
ISO
Heptachlor results in decreased expression of TP53 protein
CTD
PMID:9544696
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trip13
thyroid hormone receptor interactor 13
increases expression
EXP
Heptachlor results in increased expression of TRIP13 mRNA
CTD
PMID:23153324
NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
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Tspo
translocator protein
increases expression
EXP
Heptachlor results in increased expression of TSPO
CTD
PMID:14699885
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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Tubb3
tubulin, beta 3 class III
multiple interactions
EXP
Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA]
CTD
PMID:28385489
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Uqcrh
ubiquinol-cytochrome c reductase hinge protein
decreases expression
EXP
Heptachlor results in decreased expression of UQCRH mRNA
CTD
PMID:23153324
NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
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Vim
vimentin
increases expression
ISO
Heptachlor results in increased expression of VIM mRNA; Heptachlor results in increased expression of VIM protein
CTD
PMID:22902829
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Wfdc2
WAP four-disulfide core domain 2
decreases expression
EXP
Heptachlor results in decreased expression of WFDC2 mRNA
CTD
PMID:23153324
NCBI chr 3:153,286,946...153,314,832
Ensembl chr 3:153,286,131...153,292,807
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