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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:3478 term browser browse the term
Definition:A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms:exact_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid;   CCL;   Cefaclor anhydrous;   Cephaclor;   Formula=C15H14ClN3O4S;   InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1;   InChIKey=QYIYFLOTGYLRGG-GPCCPHFNSA-N;   SMILES=[H][C@]12SCC(Cl)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O;   cefaclorum
 alt_id: CHEBI:472656
 xref: Beilstein:3632473;   CAS:53994-73-3;   DrugBank:DB00833;   Drug_Central:525;   HMDB:HMDB0014971;   KEGG:C06877;   KEGG:D00256;   LINCS:LSM-5368
 xref_mesh: MESH:D002433
 xref: PMID:10230635;   PMID:10930630;   PMID:11963587;   PMID:12485718;   PMID:12569987;   PMID:15812119;   PMID:18969055;   PMID:29017833;   Patent:DE2408698;   Patent:US3925372;   Reaxys:3632473;   Wikipedia:Cefaclor

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cefaclor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Cefaclor inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Cefaclor results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Cefaclor results in increased expression of CYP3A4 mRNA; Cefaclor results in increased expression of CYP3A4 protein CTD PMID:18505790 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Cefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions
ISO SLC22A8 protein results in increased uptake of Cefaclor
Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          antibacterial agent 14104
            antibacterial drug 3201
              cefaclor 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        carboacyl group 17658
                                          univalent carboacyl group 17658
                                            carbamoyl group 17492
                                              carboxamide 17492
                                                lactam 8344
                                                  beta-lactam 798
                                                    beta-lactam antibiotic 783
                                                      cephem 548
                                                        cephalosporin 547
                                                          cefaclor 4
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