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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:3478 term browser browse the term
Definition:A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms:exact_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid;   CCL;   Cefaclor anhydrous;   Cephaclor;   Formula=C15H14ClN3O4S;   InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1;   InChIKey=QYIYFLOTGYLRGG-GPCCPHFNSA-N;   SMILES=[H][C@]12SCC(Cl)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O;   cefaclorum
 alt_id: CHEBI:472656
 xref: Beilstein:3632473;   CAS:53994-73-3;   DrugBank:DB00833;   Drug_Central:525;   HMDB:HMDB0014971;   KEGG:C06877;   KEGG:D00256;   LINCS:LSM-5368
 xref_mesh: MESH:D002433
 xref: PMID:10230635;   PMID:10930630;   PMID:11963587;   PMID:12485718;   PMID:12569987;   PMID:15812119;   PMID:18969055;   PMID:29017833;   Patent:DE2408698;   Patent:US3925372;   Reaxys:3632473;   Wikipedia:Cefaclor

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cefaclor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Cefaclor inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Cefaclor results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Cefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:16098483 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions
ISO SLC22A8 protein results in increased uptake of Cefaclor
Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD PMID:16098483 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            antibacterial drug 3162
              cefaclor 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          cefaclor 3
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