CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: glyoxal
Accession: CHEBI:34779
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Definition: The dialdehyde that is the smallest possible and which consists of ethane having oxo groups on both carbons.
Synonyms: related_synonym: 1,2-Ethanedione; Biformal; Biformyl; Diformal; Diformyl; Ethanedial; Formula=C2H2O2; InChI=1S/C2H2O2/c3-1-2-4/h1-2H; InChIKey=LEQAOMBKQFMDFZ-UHFFFAOYSA-N; Oxalaldehyde; SMILES=[H]C(=O)C([H])=O; ethane-1,2-dial; glyoxal aldehyde; glyoxylaldehyde; oxal
xref: CAS:107-22-2; FooDB:FDB007802; KEGG:C14448
xref_mesh: MESH:D006037
xref: MetaCyc:CPD-8887; PDBeChem:GXT; PMID:11833298; PMID:15899002; PMID:18343213; PMID:18533367; PMID:23180757; PMID:23531876; PMID:23543734; PMID:23990306; PMID:9506998; PPDB:272; Reaxys:1732463; Wikipedia:Glyoxal
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Abca1
ATP binding cassette subfamily A member 1
multiple interactions increases degradation
ISO
Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein] Glyoxal results in increased degradation of ABCA1 protein
CTD
PMID:15983222
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
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Akr1b1
aldo-keto reductase family 1 member B1
increases reduction
ISO
AKR1B1 protein results in increased reduction of Glyoxal
CTD
PMID:10510318
NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315
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Akr1b15
aldo-keto reductase family 1 member B15
multiple interactions
EXP
[AKR1B8 protein co-treated with NADP] affects the reduction of Glyoxal
CTD
PMID:18845131
NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349
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Akr1c2
aldo-keto reductase family 1, member C2
increases activity increases expression
ISO
Glyoxal results in increased activity of AKR1C2 promoter Glyoxal results in increased expression of AKR1C2 mRNA
CTD
PMID:21195160 PMID:25724174
NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686
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Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal
CTD
PMID:21334317
NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219
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Apoa1
apolipoprotein A1
multiple interactions
ISO
Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD
PMID:15983222
NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729
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Atf3
activating transcription factor 3
increases expression
ISO
Glyoxal results in increased expression of ATF3 mRNA
CTD
PMID:23999411 PMID:27965148
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
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Camp
cathelicidin antimicrobial peptide
multiple interactions increases expression
EXP
Glyoxal promotes the reaction [Capsaicin results in increased expression of CAMP protein] Glyoxal results in increased expression of CAMP protein
CTD
PMID:29496360
NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:118,720,184...118,721,998
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Cat
catalase
decreases response to substance
EXP
CAT protein results in decreased susceptibility to Glyoxal
CTD
PMID:21334317
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
Glyoxal results in decreased expression of COL1A1 mRNA
CTD
PMID:28760545
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
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Ctss
cathepsin S
decreases activity
ISO
Glyoxal results in decreased activity of CTSS protein
CTD
PMID:16671891
NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
[CYP2C19 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal
CTD
PMID:33253783
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
multiple interactions
ISO
[CYP2C8 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal
CTD
PMID:33253783
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal
CTD
PMID:33253783
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
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Defb2
defensin beta 2
multiple interactions increases expression
EXP
Glyoxal promotes the reaction [Capsaicin results in increased expression of DEFB2 protein] Glyoxal results in increased expression of DEFB2 protein
CTD
PMID:29496360
NCBI chr16:76,934,341...76,948,284
Ensembl chr16:76,934,337...76,948,299
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Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Glyoxal results in increased expression of DNAJB4 mRNA
CTD
PMID:23999411 PMID:27965148
NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Glyoxal results in increased expression of GCLM mRNA
CTD
PMID:27965148
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
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Hmox1
heme oxygenase 1
increases expression
ISO
Glyoxal results in increased expression of HMOX1 mRNA
CTD
PMID:23445166 PMID:25724174
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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Hspa6l-ps1
heat shock protein family A (Hsp70) member 6 like, pseudogene 1
increases expression
ISO
Glyoxal results in increased expression of HSPA6 mRNA
CTD
PMID:23999411
NCBI chr13:85,805,911...85,807,052
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
Glyoxal results in increased expression of HSPH1 mRNA
CTD
PMID:23999411
NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891
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Ifng
interferon gamma
multiple interactions
EXP
[Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of IFNG mRNA
CTD
PMID:29496360
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il18
interleukin 18
increases expression
ISO
Glyoxal results in increased expression of IL18 protein
CTD
PMID:23063874
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
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Il1a
interleukin 1 alpha
increases expression
ISO
Glyoxal results in increased expression of IL1A mRNA
CTD
PMID:33715048
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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Il1b
interleukin 1 beta
increases expression
ISO
Glyoxal results in increased expression of IL1B mRNA
CTD
PMID:33715048
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il6
interleukin 6
affects expression
ISO
Glyoxal analog affects the expression of IL6 mRNA
CTD
PMID:20200221
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Mapt
microtubule-associated protein tau
multiple interactions
ISO
Glyoxal promotes the reaction [MAPT protein binds to MAPT protein]
CTD
PMID:17082178
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
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Tnf
tumor necrosis factor
multiple interactions
EXP
[Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA
CTD
PMID:29496360
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Glyoxal results in increased expression of TXNRD1 mRNA
CTD
PMID:23445166
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
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