Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glyoxal
go back to main search page
Accession:CHEBI:34779 term browser browse the term
Definition:The dialdehyde that is the smallest possible and which consists of ethane having oxo groups on both carbons.
Synonyms:related_synonym: 1,2-Ethanedione;   Biformal;   Biformyl;   Diformal;   Diformyl;   Ethanedial;   Formula=C2H2O2;   InChI=1S/C2H2O2/c3-1-2-4/h1-2H;   InChIKey=LEQAOMBKQFMDFZ-UHFFFAOYSA-N;   Oxalaldehyde;   SMILES=[H]C(=O)C([H])=O;   ethane-1,2-dial;   glyoxal aldehyde;   glyoxylaldehyde;   oxal
 xref: Beilstein:1732463;   CAS:107-22-2
 xref_mesh: MESH:D006037
 xref: PMID:11833298;   PMID:15899002;   PMID:18343213;   PMID:18533367;   PMID:23180757;   PMID:23531876;   PMID:23543734;   PMID:23990306;   PMID:9506998;   Reaxys:1732463;   Wikipedia:Glyoxal

show annotations for term's descendants           Sort by:
 
glyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases degradation		 ISO Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]
Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
Glyoxal results in increased degradation of ABCA1 protein		 CTD PMID:15983222 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Glyoxal CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Glyoxal CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
increases expression		 ISO Glyoxal results in increased activity of AKR1C2 promoter
Glyoxal results in increased expression of AKR1C2 mRNA		 CTD PMID:21195160, PMID:25724174 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein] CTD PMID:15983222 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Glyoxal results in increased expression of ATF3 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression		 EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of CAMP protein]
Glyoxal results in increased expression of CAMP protein		 CTD PMID:29496360 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518 		JBrowse link
G Cat catalase decreases response to substance EXP CAT protein results in decreased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Glyoxal results in decreased expression of COL1A1 mRNA CTD PMID:28760545 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Ctss cathepsin S decreases activity ISO Glyoxal results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458 		JBrowse link
G Defb2 defensin beta 2 multiple interactions
increases expression		 EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of DEFB2 protein]
Glyoxal results in increased expression of DEFB2 protein		 CTD PMID:29496360 NCBI chr16:75,227,468...75,241,303
Ensembl chr16:75,227,468...75,241,303 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Glyoxal results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Glyoxal results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Glyoxal results in increased expression of HMOX1 mRNA CTD PMID:23445166, PMID:25724174 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Glyoxal results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of IFNG mRNA CTD PMID:29496360 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il18 interleukin 18 increases expression ISO Glyoxal results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il6 interleukin 6 affects expression ISO Glyoxal analog affects the expression of IL6 mRNA CTD PMID:20200221 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Glyoxal promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA CTD PMID:29496360 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Glyoxal results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          glyoxal 22
            glyoxime 0
            indole-3-glyoxal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            formyl group 7845
                                              aldehyde 7845
                                                dialdehyde 117
                                                  glyoxal 22
                                                    glyoxime 0
                                                    indole-3-glyoxal 0
paths to the root

Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.