Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glyoxal
go back to main search page
Accession:CHEBI:34779 term browser browse the term
Definition:The dialdehyde that is the smallest possible and which consists of ethane having oxo groups on both carbons.
Synonyms:related_synonym: 1,2-Ethanedione;   Biformal;   Biformyl;   Diformal;   Diformyl;   Ethanedial;   Formula=C2H2O2;   InChI=1S/C2H2O2/c3-1-2-4/h1-2H;   InChIKey=LEQAOMBKQFMDFZ-UHFFFAOYSA-N;   Oxalaldehyde;   SMILES=[H]C(=O)C([H])=O;   ethane-1,2-dial;   glyoxal aldehyde;   glyoxylaldehyde;   oxal
 xref: Beilstein:1732463;   CAS:107-22-2
 xref_mesh: MESH:D006037
 xref: PMID:11833298;   PMID:15899002;   PMID:18343213;   PMID:18533367;   PMID:23180757;   PMID:23531876;   PMID:23543734;   PMID:23990306;   PMID:9506998;   Reaxys:1732463;   Wikipedia:Glyoxal


show annotations for term's descendants           Sort by:
 
glyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases degradation
ISO Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]
Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
Glyoxal results in increased degradation of ABCA1 protein
CTD PMID:15983222 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Glyoxal CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Glyoxal CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
increases expression
ISO Glyoxal results in increased activity of AKR1C2 promoter
Glyoxal results in increased expression of AKR1C2 mRNA
CTD PMID:21195160, PMID:25724174 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein] CTD PMID:15983222 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Glyoxal results in increased expression of ATF3 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression
EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of CAMP protein]
Glyoxal results in increased expression of CAMP protein
CTD PMID:29496360 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Cat catalase decreases response to substance EXP CAT protein results in decreased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Glyoxal results in decreased expression of COL1A1 mRNA CTD PMID:28760545 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Ctss cathepsin S decreases activity ISO Glyoxal results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Defb2 defensin beta 2 multiple interactions
increases expression
EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of DEFB2 protein]
Glyoxal results in increased expression of DEFB2 protein
CTD PMID:29496360 NCBI chr16:75,227,468...75,241,303
Ensembl chr16:75,227,468...75,241,303
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Glyoxal results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Glyoxal results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Glyoxal results in increased expression of HMOX1 mRNA CTD PMID:23445166, PMID:25724174 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Glyoxal results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of IFNG mRNA CTD PMID:29496360 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 increases expression ISO Glyoxal results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il6 interleukin 6 affects expression ISO Glyoxal analog affects the expression of IL6 mRNA CTD PMID:20200221 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Glyoxal promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA CTD PMID:29496360 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Glyoxal results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          glyoxal 22
            glyoxime 0
            indole-3-glyoxal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            formyl group 7845
                                              aldehyde 7845
                                                dialdehyde 117
                                                  glyoxal 22
                                                    glyoxime 0
                                                    indole-3-glyoxal 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.