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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glyoxal
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Accession:CHEBI:34779 term browser browse the term
Definition:The dialdehyde that is the smallest possible and which consists of ethane having oxo groups on both carbons.
Synonyms:related_synonym: 1,2-Ethanedione;   Biformal;   Biformyl;   Diformal;   Diformyl;   Ethanedial;   Formula=C2H2O2;   InChI=1S/C2H2O2/c3-1-2-4/h1-2H;   InChIKey=LEQAOMBKQFMDFZ-UHFFFAOYSA-N;   Oxalaldehyde;   SMILES=[H]C(=O)C([H])=O;   ethane-1,2-dial;   glyoxal aldehyde;   glyoxylaldehyde;   oxal
 xref: Beilstein:1732463;   CAS:107-22-2;   FooDB:FDB007802;   KEGG:C14448
 xref_mesh: MESH:D006037
 xref: MetaCyc:CPD-8887;   PDBeChem:GXT;   PMID:11833298;   PMID:15899002;   PMID:18343213;   PMID:18533367;   PMID:23180757;   PMID:23531876;   PMID:23543734;   PMID:23990306;   PMID:9506998;   PPDB:272;   Reaxys:1732463;   Wikipedia:Glyoxal


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glyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases degradation		 ISO Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]
Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
Glyoxal results in increased degradation of ABCA1 protein		 CTD PMID:15983222 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Glyoxal CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Glyoxal CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
increases expression		 ISO Glyoxal results in increased activity of AKR1C2 promoter
Glyoxal results in increased expression of AKR1C2 mRNA		 CTD PMID:21195160 PMID:25724174 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein] CTD PMID:15983222 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Glyoxal results in increased expression of ATF3 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression		 EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of CAMP protein]
Glyoxal results in increased expression of CAMP protein		 CTD PMID:29496360 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Cat catalase decreases response to substance EXP CAT protein results in decreased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Glyoxal results in decreased expression of COL1A1 mRNA CTD PMID:28760545 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Ctss cathepsin S decreases activity ISO Glyoxal results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal CTD PMID:33253783 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [CYP2C8 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal CTD PMID:33253783
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal CTD PMID:33253783 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Defb2 defensin beta 2 multiple interactions
increases expression		 EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of DEFB2 protein]
Glyoxal results in increased expression of DEFB2 protein		 CTD PMID:29496360 NCBI chr16:70,231,945...70,245,784
Ensembl chr16:70,231,945...70,245,784 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Glyoxal results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Glyoxal results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Glyoxal results in increased expression of HMOX1 mRNA CTD PMID:23445166 PMID:25724174 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Glyoxal results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of IFNG mRNA CTD PMID:29496360 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il18 interleukin 18 increases expression ISO Glyoxal results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Glyoxal results in increased expression of IL1A mRNA CTD PMID:33715048 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Glyoxal results in increased expression of IL1B mRNA CTD PMID:33715048 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 affects expression ISO Glyoxal analog affects the expression of IL6 mRNA CTD PMID:20200221 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO Glyoxal results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Glyoxal promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA CTD PMID:29496360 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Glyoxal results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      application 19477
        pesticide 17132
          glyoxal 28
            glyoxime 0
            indole-3-glyoxal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        carboacyl group 17487
                                          univalent carboacyl group 17487
                                            formyl group 8799
                                              aldehyde 8799
                                                dialdehyde 127
                                                  glyoxal 28
                                                    glyoxime 0
                                                    indole-3-glyoxal 0
paths to the root