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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenthion
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Accession:CHEBI:34761 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen atom of the hydroxy group is replaced by a 3-methyl-4-(methylsulfanyl)phenyl group. It exhibits acaricidal and insecticidal activities.
Synonyms:exact_synonym: O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] phosphorothioate
 related_synonym: 4-Methylmercapto-3-methylphenyl dimethyl thiophosphate;   Formula=C10H15O3PS2;   InChI=1S/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3;   InChIKey=PNVJTZOFSHSLTO-UHFFFAOYSA-N;   MPP;   Mercaptophos;   O,O-Dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothioate;   O,O-Dimethyl O-4-methylthio-m-tolyl phosphorothioate;   O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl thiophosphate;   O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] thiophosphate;   Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) ester;   SMILES=COP(=S)(OC)Oc1ccc(SC)c(C)c1
 xref: Beilstein:1974129;   CAS:55-38-9;   HMDB:HMDB0033209;   KEGG:C14420;   KEGG:D07950;   LINCS:LSM-25615
 xref_mesh: MESH:D005284
 xref: PMID:11048676;   PMID:18558709;   PPDB:310;   Reaxys:1974129;   VSDB:310;   Wikipedia:Fenthion


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fenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 Fenthion results in decreased activity of ACHE protein CTD PMID:1855619 PMID:14976351 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Fenthion results in decreased activity of BCHE protein CTD PMID:24052565 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Fenthion results in decreased expression of BRCA1 mRNA CTD PMID:33221015 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Fenthion results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fenthion binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Fenthion binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO Fenthion results in increased activity of ESRRG protein CTD PMID:20143881 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation ISO FMO1 protein results in increased oxidation of Fenthion CTD PMID:14976351 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of FOS mRNA CTD PMID:21538558 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Fenthion results in increased expression of GADD45A mRNA CTD PMID:21538558 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Fenthion results in increased expression of H2AX protein CTD PMID:33221015 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Fenthion results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of JUN mRNA CTD PMID:21538558 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Fenthion results in increased expression of MYC mRNA CTD PMID:21538558 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Fenthion binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Fenthion results in increased expression of NR4A1 CTD PMID:21538558 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO Fenthion results in increased expression of PPARG mRNA
Fenthion binds to and results in increased activity of PPARG protein		 CTD PMID:32473317 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Fenthion results in increased expression of PPP1R15A mRNA CTD PMID:21538558 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase multiple interactions
decreases expression		 ISO [terbufos co-treated with Fenthion] results in increased expression of RAD18 mRNA
Fenthion results in decreased expression of RAD18 mRNA		 CTD PMID:33221015 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069 		JBrowse link
G Rad51 RAD51 recombinase decreases expression
multiple interactions		 ISO Fenthion results in decreased expression of RAD51 mRNA; Fenthion results in decreased expression of RAD51 protein
Fenthion inhibits the reaction [terbufos results in decreased expression of RAD51 protein]; terbufos inhibits the reaction [Fenthion results in decreased expression of RAD51 protein]		 CTD PMID:33221015 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Fenthion results in increased expression of SOCS3 mRNA CTD PMID:21538558 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Fenthion results in increased expression of TNFAIP3 mRNA CTD PMID:21538558 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Xrcc2 X-ray repair cross complementing 2 decreases expression
multiple interactions		 ISO Fenthion results in decreased expression of XRCC2 mRNA; Fenthion results in decreased expression of XRCC2 protein
[terbufos co-treated with Fenthion] results in increased expression of XRCC2 mRNA		 CTD PMID:33221015 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 increases expression
multiple interactions		 ISO Fenthion results in increased expression of XRCC6 mRNA
[terbufos co-treated with Fenthion] results in decreased expression of XRCC6 mRNA; [terbufos co-treated with Fenthion] results in decreased expression of XRCC6 protein		 CTD PMID:33221015 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        agrochemical 15233
          fenthion 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      chalcogen 19732
                        oxygen atom 19674
                          oxygen molecular entity 19674
                            hydroxides 19454
                              oxoacid 18744
                                pnictogen oxoacid 11007
                                  phosphorus oxoacid 9818
                                    phosphoric acids 8644
                                      phosphoric acid 8639
                                        phosphoric acid derivative 8348
                                          phosphate 8348
                                            organic phosphate 8342
                                              organic thiophosphate 3833
                                                fenthion 27
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