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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenthion
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Accession:CHEBI:34761 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen atom of the hydroxy group is replaced by a 3-methyl-4-(methylsulfanyl)phenyl group. It exhibits acaricidal and insecticidal activities.
Synonyms:exact_synonym: O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] phosphorothioate
 related_synonym: 4-Methylmercapto-3-methylphenyl dimethyl thiophosphate;   Formula=C10H15O3PS2;   InChI=1S/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3;   InChIKey=PNVJTZOFSHSLTO-UHFFFAOYSA-N;   MPP;   Mercaptophos;   O,O-Dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothioate;   O,O-Dimethyl O-4-methylthio-m-tolyl phosphorothioate;   O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl thiophosphate;   O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] thiophosphate;   Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) ester;   SMILES=COP(=S)(OC)Oc1ccc(SC)c(C)c1
 xref: Beilstein:1974129;   CAS:55-38-9;   HMDB:HMDB0033209;   KEGG:C14420;   KEGG:D07950;   LINCS:LSM-25615
 xref_mesh: MESH:D005284
 xref: PMID:11048676;   PMID:18558709;   PPDB:310;   Reaxys:1974129;   VSDB:310;   Wikipedia:Fenthion

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fenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 Fenthion results in decreased activity of ACHE protein CTD PMID:1855619 PMID:14976351 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Fenthion results in decreased activity of BCHE protein CTD PMID:24052565 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Fenthion results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO Fenthion results in increased activity of ESRRG protein CTD PMID:20143881 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation ISO FMO1 protein results in increased oxidation of Fenthion CTD PMID:14976351 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of FOS mRNA CTD PMID:21538558 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Fenthion results in increased expression of GADD45A mRNA CTD PMID:21538558 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Fenthion results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of JUN mRNA CTD PMID:21538558 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Fenthion results in increased expression of MYC mRNA CTD PMID:21538558 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Fenthion results in increased expression of NR4A1 CTD PMID:21538558 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Fenthion results in increased expression of PPARG mRNA CTD PMID:32473317 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Fenthion results in increased expression of PPP1R15A mRNA CTD PMID:21538558 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Fenthion results in increased expression of SOCS3 mRNA CTD PMID:21538558 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Fenthion results in increased expression of TNFAIP3 mRNA CTD PMID:21538558 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        agrochemical 14672
          fenthion 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      chalcogen 19382
                        oxygen atom 19345
                          oxygen molecular entity 19345
                            hydroxides 19071
                              oxoacid 18269
                                pnictogen oxoacid 10312
                                  phosphorus oxoacid 9233
                                    phosphoric acids 7953
                                      phosphoric acid 7953
                                        phosphoric acid derivative 7632
                                          phosphate 7632
                                            organic phosphate 7631
                                              organic thiophosphate 2895
                                                fenthion 18
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