CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: fenthion
Accession: CHEBI:34761
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Definition: An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen atom of the hydroxy group is replaced by a 3-methyl-4-(methylsulfanyl)phenyl group. It exhibits acaricidal and insecticidal activities.
Synonyms: exact_synonym: O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] phosphorothioate
related_synonym: 4-Methylmercapto-3-methylphenyl dimethyl thiophosphate; Formula=C10H15O3PS2; InChI=1S/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3; InChIKey=PNVJTZOFSHSLTO-UHFFFAOYSA-N; MPP; Mercaptophos; O,O-Dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothioate; O,O-Dimethyl O-4-methylthio-m-tolyl phosphorothioate; O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl thiophosphate; O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] thiophosphate; Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) ester; SMILES=COP(=S)(OC)Oc1ccc(SC)c(C)c1
xref: Beilstein:1974129; CAS:55-38-9; HMDB:HMDB0033209; KEGG:C14420; KEGG:D07950; LINCS:LSM-25615
xref_mesh: MESH:D005284
xref: PMID:11048676; PMID:18558709; PPDB:310; Reaxys:1974129; VSDB:310; Wikipedia:Fenthion
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Ache
acetylcholinesterase
decreases activity
ISO EXP
Fenthion results in decreased activity of ACHE protein
CTD
PMID:1855619 PMID:14976351
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:15064155 PMID:18324785
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Bche
butyrylcholinesterase
decreases activity
ISO
Fenthion results in decreased activity of BCHE protein
CTD
PMID:24052565
NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
affects metabolic processing
ISO
CYP3A4 protein affects the metabolism of Fenthion
CTD
PMID:17110060
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects metabolic processing
ISO
CYP3A5 protein affects the metabolism of Fenthion
CTD
PMID:17110060
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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Dio1
iodothyronine deiodinase 1
decreases activity
ISO
Fenthion results in decreased activity of DIO1 protein
CTD
PMID:29228274
NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
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Esrrg
estrogen-related receptor gamma
increases activity
ISO
Fenthion results in increased activity of ESRRG protein
CTD
PMID:20143881
NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
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Fmo1
flavin containing dimethylaniline monoxygenase 1
increases oxidation
ISO
FMO1 protein results in increased oxidation of Fenthion
CTD
PMID:14976351
NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Fenthion results in increased expression of FOS mRNA
CTD
PMID:21538558
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
Fenthion results in increased expression of GADD45A mRNA
CTD
PMID:21538558
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
EXP
Fenthion results in increased expression of HSP90AA1 mRNA alternative form
CTD
PMID:8792849
NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 Ensembl chr 6:135,107,271...135,112,775
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Fenthion results in increased expression of JUN mRNA
CTD
PMID:21538558
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
ISO
Fenthion results in increased expression of MYC mRNA
CTD
PMID:21538558
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
Fenthion results in increased expression of NR4A1
CTD
PMID:21538558
NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Fenthion results in increased expression of PPARG mRNA
CTD
PMID:32473317
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
Fenthion results in increased expression of PPP1R15A mRNA
CTD
PMID:21538558
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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Socs3
suppressor of cytokine signaling 3
increases expression
ISO
Fenthion results in increased expression of SOCS3 mRNA
CTD
PMID:21538558
NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
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Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Fenthion results in increased expression of TNFAIP3 mRNA
CTD
PMID:21538558
NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
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