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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenitrothion
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Accession:CHEBI:34757 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Synonyms:related_synonym: Formula=C9H12NO5PS;   InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3;   InChIKey=ZNOLGFHPUIJIMJ-UHFFFAOYSA-N;   MEP;   O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate;   O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate;   O,O-dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate;   SMILES=COP(=S)(OC)Oc1ccc(c(C)c1)[N+]([O-])=O
 xref: Beilstein:1887367;   CAS:122-14-5;   HMDB:HMDB0041893;   KEGG:C14442
 xref_mesh: MESH:D005278
 xref: PMID:11201171;   PMID:16628916;   PMID:23668748;   PPDB:299;   Reaxys:1887367;   Wikipedia:Fenitrothion


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fenitrothion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fenitrothion CTD PMID:12765240 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
Fenitrothion results in decreased activity of ACHE protein
Quercetin inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]
CTD PMID:2086312 PMID:6933967 PMID:32034696 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
increases expression
affects binding
ISO Dihydrotestosterone inhibits the reaction [Fenitrothion results in increased activity of AR protein]; Fenitrothion analog binds to and results in decreased activity of AR protein; Fenitrothion inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]
Fenitrothion results in decreased activity of AR protein
Fenitrothion results in increased expression of AR mRNA
Fenitrothion binds to AR protein
CTD PMID:11222873 PMID:12676613 PMID:15064155 PMID:15253041 PMID:18324785 PMID:21251949 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Fenitrothion results in increased expression of BAX mRNA; Fenitrothion results in increased expression of BAX protein
Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]
CTD PMID:32034696 PMID:32572764 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Fenitrothion results in increased expression of BCL2 mRNA
Fenitrothion results in decreased expression of BCL2 mRNA
Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]
CTD PMID:21298709 PMID:32572764 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CASP3 mRNA; Fenitrothion results in increased expression of CASP3 protein
Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]
CTD PMID:32034696 PMID:32572764 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
decreases expression
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased expression of CAT mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased activity of CAT protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]
Fenitrothion results in decreased expression of CAT mRNA; Fenitrothion results in decreased expression of CAT protein
CTD PMID:26264430 PMID:30578656 PMID:32034696 PMID:32572764 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CD68 protein
[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein; Plant Extracts inhibits the reaction [[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein]; Plant Extracts inhibits the reaction [Fenitrothion results in increased expression of CD68 protein]
CTD PMID:30578656 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
ISO Fenitrothion results in decreased activity of CYP1A1 protein
Fenitrothion results in increased expression of CYP1A1 mRNA
CTD PMID:15620088 PMID:20183062 PMID:21298709 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO Fenitrothion results in increased expression of CYP1A2 mRNA
Fenitrothion results in decreased activity of CYP1A2 protein
CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
decreases activity
multiple interactions
ISO Fenitrothion results in increased expression of CYP2B6 mRNA
Fenitrothion results in decreased activity of CYP2B6 protein
Fenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Fenitrothion results in decreased activity of CYP2C8 protein CTD PMID:20183062 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Fenitrothion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases secretion
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein] CTD PMID:30578656 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]
Fenitrothion results in decreased activity of GSR protein
CTD PMID:30578656 PMID:32034696 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA] CTD PMID:26264430 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD3B2 mRNA] CTD PMID:26264430 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Ifng interferon gamma decreases expression ISO Fenitrothion results in decreased expression of IFNG protein CTD PMID:12108020 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 decreases expression ISO Fenitrothion results in decreased expression of IL2 protein CTD PMID:12108020 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
Fenitrothion results in decreased activity of LCAT protein
CTD PMID:4847537 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions
EXP Fenitrothion results in decreased secretion of LHB protein
Quercetin inhibits the reaction [Fenitrothion results in decreased secretion of LHB protein]
CTD PMID:26264430 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mgll monoglyceride lipase decreases activity ISO Fenitrothion analog results in decreased activity of MGLL protein CTD PMID:16449251 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Fenitrothion analog results in decreased activity of NCEH1 protein CTD PMID:16449251 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of NR5A1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]
CTD PMID:26264430 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP Fenitrothion results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
decreases activity
EXP Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of PON1 protein]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA] CTD PMID:32572764 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of SOD1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of SOD1 mRNA]
CTD PMID:26264430 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link

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  CHEBI ontology 19810
    role 19758
      application 19420
        agrochemical 14503
          fenitrothion 32
Path 2
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  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      chalcogen 19391
                        oxygen atom 19353
                          oxygen molecular entity 19353
                            hydroxides 19103
                              oxoacid 18235
                                pnictogen oxoacid 10181
                                  phosphorus oxoacid 9072
                                    phosphoric acids 7831
                                      phosphoric acid 7831
                                        phosphoric acid derivative 7511
                                          phosphate 7511
                                            organic phosphate 7510
                                              organic thiophosphate 2874
                                                fenitrothion 32
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