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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenitrothion
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Accession:CHEBI:34757 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Synonyms:related_synonym: Formula=C9H12NO5PS;   InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3;   InChIKey=ZNOLGFHPUIJIMJ-UHFFFAOYSA-N;   MEP;   O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate;   O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate;   O,O-dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate;   SMILES=COP(=S)(OC)Oc1ccc(c(C)c1)[N+]([O-])=O
 xref: Beilstein:1887367;   CAS:122-14-5;   HMDB:HMDB0041893;   KEGG:C14442
 xref_mesh: MESH:D005278
 xref: PMID:11201171;   PMID:16628916;   PMID:23668748;   PPDB:299;   Reaxys:1887367;   Wikipedia:Fenitrothion


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fenitrothion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fenitrothion CTD PMID:12765240 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Ache acetylcholinesterase decreases activity
decreases expression
multiple interactions
ISO
EXP
Fenitrothion results in decreased activity of ACHE protein
Fenitrothion results in decreased expression of ACHE protein
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]
CTD PMID:2086312 PMID:6933967 PMID:30639957 PMID:31173782 PMID:32034696 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
increases expression
affects binding
ISO Dihydrotestosterone inhibits the reaction [Fenitrothion results in increased activity of AR protein]; Fenitrothion analog binds to and results in decreased activity of AR protein; Fenitrothion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]
Fenitrothion results in decreased activity of AR protein
Fenitrothion results in increased expression of AR mRNA
Fenitrothion binds to AR protein
CTD PMID:11222873 PMID:12676613 PMID:15064155 PMID:15253041 PMID:18324785 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Fenitrothion results in increased expression of BAX mRNA; Fenitrothion results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]
CTD PMID:31173782 PMID:32034696 PMID:32572764 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Fenitrothion results in increased expression of BCL2 mRNA
Fenitrothion results in decreased expression of BCL2 mRNA
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]
CTD PMID:21298709 PMID:31173782 PMID:32572764 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CASP3 mRNA; Fenitrothion results in increased expression of CASP3 protein
[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP3 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]
CTD PMID:31173782 PMID:32034696 PMID:32572764 PMID:33393722 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
EXP [Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP9 mRNA]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP9 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP9 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP9 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP9 mRNA] CTD PMID:33393722 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
decreases expression
EXP [Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in decreased activity of CAT protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased activity of CAT protein]; Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased activity of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased expression of CAT mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased activity of CAT protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]
Fenitrothion results in decreased expression of CAT mRNA; Fenitrothion results in decreased expression of CAT protein
CTD PMID:26264430 PMID:30578656 PMID:32034696 PMID:32572764 PMID:33393722 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CD68 protein
[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein; Plant Extracts inhibits the reaction [[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein]; Plant Extracts inhibits the reaction [Fenitrothion results in increased expression of CD68 protein]
CTD PMID:30578656 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CDKN1A mRNA
[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CDKN1A mRNA]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN1A mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CDKN1A mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN1A mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CDKN1A mRNA]
CTD PMID:33393722 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
increases expression
ISO
EXP
Fenitrothion results in decreased activity of CYP1A1 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
CTD PMID:15620088 PMID:20183062 PMID:21298709 PMID:30639957 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO Fenitrothion results in increased expression of CYP1A2 mRNA
Fenitrothion results in decreased activity of CYP1A2 protein
CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
decreases activity
multiple interactions
ISO Fenitrothion results in increased expression of CYP2B6 mRNA
Fenitrothion results in decreased activity of CYP2B6 protein
Fenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity
multiple interactions
ISO Fenitrothion results in decreased activity of CYP2C9 protein
Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]
CTD PMID:20183062 PMID:22634058 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Fenitrothion results in decreased activity of CYP2C8 protein CTD PMID:20183062
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Fenitrothion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
increases activity
increases expression
ISO Fenitrothion results in decreased activity of CYP3A4 protein
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA
Fenitrothion results in increased activity of CYP3A4 protein
Fenitrothion results in increased expression of CYP3A4 mRNA
CTD PMID:17293382 PMID:20183062 PMID:22310298 PMID:25028461 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fenitrothion binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Fenitrothion binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases secretion
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein] CTD PMID:30578656 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of GFAP protein] CTD PMID:31173782 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
decreases activity
decreases expression
EXP [Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased activity of GSR protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of GSR protein]; Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased activity of GSR protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of GSR protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased activity of GSR protein]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]
Fenitrothion results in decreased activity of GSR protein
CTD PMID:30578656 PMID:32034696 PMID:33393722 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of GSTA4 mRNA] CTD PMID:30639957 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA] CTD PMID:26264430 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD3B2 mRNA] CTD PMID:26264430 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Ifng interferon gamma decreases expression ISO Fenitrothion results in decreased expression of IFNG protein CTD PMID:12108020 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of IL1B protein] CTD PMID:30639957 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression
increases secretion
multiple interactions
ISO
EXP
Fenitrothion results in decreased expression of IL2 protein
Fenitrothion results in increased secretion of IL2 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of IL2 protein]
CTD PMID:12108020 PMID:31173782 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
Fenitrothion results in decreased activity of LCAT protein
CTD PMID:4847537 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions
EXP Fenitrothion results in decreased secretion of LHB protein
Quercetin inhibits the reaction [Fenitrothion results in decreased secretion of LHB protein]
CTD PMID:26264430 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mgll monoglyceride lipase decreases activity ISO Fenitrothion analog results in decreased activity of MGLL protein CTD PMID:16449251 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Fenitrothion analog results in decreased activity of NCEH1 protein CTD PMID:16449251 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein; Fenitrothion binds to and results in increased activity of NR1I2 protein CTD PMID:25028461 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of NR5A1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]
CTD PMID:26264430 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP Fenitrothion results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
decreases activity
EXP Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of PON1 protein]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA] CTD PMID:32572764 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fenitrothion binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of SOD1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of SOD1 mRNA]
CTD PMID:26264430 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Fenitrothion binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Fenitrothion binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of TNF protein] CTD PMID:30639957 PMID:31173782 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP [Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TP53 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of TP53 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TP53 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA] CTD PMID:31173782 PMID:33393722 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        agrochemical 15039
          fenitrothion 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              oxoacid 18488
                                pnictogen oxoacid 10688
                                  phosphorus oxoacid 9669
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8171
                                          phosphate 8170
                                            organic phosphate 8169
                                              organic thiophosphate 3715
                                                fenitrothion 46
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