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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenamic acid
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Accession:CHEBI:34756 term browser browse the term
Definition:An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs.
Synonyms:exact_synonym: 2-(phenylamino)benzoic acid
 related_synonym: 2-anilinobenzoic acid;   2-carboxydiphenylamine;   DPC;   Diphenylamine-2-carboxylic acid;   Formula=C13H11NO2;   InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16);   InChIKey=ZWJINEZUASEZBH-UHFFFAOYSA-N;   N-phenyl-ortho-aminobenzoic acid;   N-phenylanthranilic acid;   SMILES=OC(=O)c1ccccc1Nc1ccccc1;   ortho-anilinobenzoic acid;   phenylanthranilic acid
 xref: CAS:91-40-7;   KEGG:C13697;   LINCS:LSM-6670
 xref_mesh: MESH:C001209
 xref: PMID:18970610;   PMID:20049895;   PMID:20183850;   PMID:21123756;   PMID:22301952;   Patent:US5212189;   Reaxys:1456607;   Wikipedia:Fenamic_acid



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fenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to fenamic acid CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO fenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity
ISO
EXP
fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; fenamic acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]
fenamic acid results in decreased activity of CFTR protein
CTD PMID:14502435 PMID:14668136 PMID:15020588 PMID:15277574 PMID:15857825 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP fenamic acid results in increased expression of HAVCR1 mRNA CTD PMID:23142791 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Krt14 keratin 14 increases expression EXP fenamic acid results in increased expression of KRT14 mRNA CTD PMID:23142791 NCBI chr10:85,137,932...85,141,990
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP fenamic acid results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Mir210 microRNA 210 affects expression EXP fenamic acid affects the expression of MIR210 CTD PMID:30169741 NCBI chr 1:196,326,343...196,326,452 JBrowse link
G Mir34c microRNA 34c increases expression EXP fenamic acid results in increased expression of MIR34C CTD PMID:33367795 NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP fenamic acid results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fenamic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:10783394 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO fenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biophysical role 13180
          membrane transport modulator 12995
            fenamic acid 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        aromatic carboxylic acid 11735
                                          benzoic acids 11709
                                            aminobenzoic acid 1633
                                              anthranilic acid 1504
                                                fenamic acid 15
paths to the root