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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenamic acid
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Accession:CHEBI:34756 term browser browse the term
Definition:An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs.
Synonyms:exact_synonym: 2-(phenylamino)benzoic acid
 related_synonym: 2-anilinobenzoic acid;   2-carboxydiphenylamine;   DPC;   Diphenylamine-2-carboxylic acid;   Formula=C13H11NO2;   InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16);   InChIKey=ZWJINEZUASEZBH-UHFFFAOYSA-N;   N-phenyl-ortho-aminobenzoic acid;   N-phenylanthranilic acid;   SMILES=OC(=O)c1ccccc1Nc1ccccc1;   ortho-anilinobenzoic acid;   phenylanthranilic acid
 xref: CAS:91-40-7;   KEGG:C13697;   LINCS:LSM-6670
 xref_mesh: MESH:C001209
 xref: PMID:18970610;   PMID:20049895;   PMID:20183850;   PMID:21123756;   PMID:22301952;   Patent:US5212189;   Reaxys:1456607;   Wikipedia:Fenamic_acid


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fenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to fenamic acid CTD PMID:12147693 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO fenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity
ISO
EXP
fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; fenamic acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]
fenamic acid results in decreased activity of CFTR protein
CTD PMID:14502435, PMID:14668136, PMID:15020588, PMID:15277574, PMID:15857825, PMID:15921678, PMID:15986093, PMID:16038730, PMID:18230692 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP fenamic acid results in increased expression of HAVCR1 mRNA CTD PMID:23142791 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Krt14 keratin 14 increases expression EXP fenamic acid results in increased expression of KRT14 mRNA CTD PMID:23142791 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP fenamic acid results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Mir210 microRNA 210 affects expression EXP fenamic acid affects the expression of MIR210 CTD PMID:30169741 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP fenamic acid results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fenamic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:10783394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO fenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biophysical role 12283
          membrane transport modulator 12064
            fenamic acid 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            aminobenzoic acid 1614
                                              anthranilic acid 1488
                                                fenamic acid 12
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