Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethisterone
go back to main search page
Accession:CHEBI:34749 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Synonyms:exact_synonym: (17alpha)-17-hydroxypregn-4-en-20-yn-3-one
 related_synonym: 17-beta-hydroxy-17-alpha-ethynyl-4-androsten-3-one;   17-ethynyl-17beta-hydroxyandrost-4-en-3-one;   17-hydroxy-17alpha-pregn-4-en-20-yn-3-one;   17alpha-ethinyltestosterone;   17alpha-ethynyl-17beta-hydroxyandrost-4-en-3-one;   17alpha-ethynyltestosterone;   Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h1,13,16-18,23H,5-12H2,2-3H3/t16-,17+,18+,19+,20+,21+/m1/s1;   InChIKey=CHNXZKVNWQUJIB-CEGNMAFCSA-N;   Lutocylol;   Nugestoral;   Ora-Lutin;   Pranone;   Prodroxan;   Produxan;   Progestab;   Progestoral;   SMILES=C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@]2(O)C#C;   Syngestrotabs;   Trosinone;   aethisteron;   aethisteronum;   anhydrohydroxyprogesterone;   anhydroxyprogesterone;   ethisteronum;   ethynyltestosterone;   etisterona
 xref: CAS:434-03-7;   Drug_Central:1084;   HMDB:HMDB0060580;   KEGG:C14487
 xref_mesh: MESH:D005003
 xref: PMID:13494335;   PMID:374128;   PMID:8327560;   Reaxys:1889895;   Wikipedia:Ethisterone


show annotations for term's descendants           Sort by:
 
ethisterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the reaction [Ethisterone results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Ethisterone results in increased expression of SGK1 mRNA] CTD PMID:33405908 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [Ethisterone results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Ethisterone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Ethisterone results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [Ethisterone results in increased expression of SGK1 mRNA]; Fulvestrant inhibits the reaction [Ethisterone results in increased expression of SGK1 mRNA] CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        organic group 18737
          3-oxo-Delta(4)-steroid group 8420
            3-oxo-Delta(4) steroid 8420
              ethisterone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        oxo steroid 9720
                                          3-oxo steroid 9279
                                            3-oxo-Delta(4) steroid 8420
                                              testosterone 3620
                                                ethisterone 4
paths to the root